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Gene: CACNB1 (calcium voltage-gated channel auxiliary subunit beta 1) Homo sapiens
Symbol: CACNB1
Name: calcium voltage-gated channel auxiliary subunit beta 1
Description: The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CAB1; CACNLB1; calcium channel voltage-dependent subunit beta 1; calcium channel, L type, beta 1 polypeptide; calcium channel, voltage-dependent, beta 1 subunit; CCHLB1; dihydropyridine-sensitive L-type, calcium channel beta-1 subunit; MGC41896; voltage-dependent L-type calcium channel subunit beta-1
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381739,173,456 - 39,197,703 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371737,329,709 - 37,353,956 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361734,583,235 - 34,607,427 (-)NCBINCBI36hg18NCBI36
Build 341734,586,914 - 34,607,427NCBI
Celera1733,990,617 - 34,014,805 (-)NCBI
Cytogenetic Map17q12NCBI
HuRef1733,125,170 - 33,149,131 (-)NCBIHuRef
CHM1_11737,565,987 - 37,590,231 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CACNB1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68552
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2019-08-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.