Dpys (dihydropyrimidinase) - Rat Genome Database
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Gene: Dpys (dihydropyrimidinase) Mus musculus
Analyze
Symbol: Dpys
Name: dihydropyrimidinase
RGD ID: 68542
MGI Page MGI
Description: Exhibits phosphoprotein binding activity. Predicted to be involved in beta-alanine metabolic process; thymine catabolic process; and uracil catabolic process. Predicted to localize to cytosol and protein-containing complex. Is expressed in cranium. Human ortholog(s) of this gene implicated in dihydropyrimidinase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human DPYS (dihydropyrimidinase); PARTICIPATES IN beta-alanine metabolic pathway; beta-ureidopropionase deficiency pathway; carnosinemia pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 2,3,7,8-tetrabromodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1200017I10Rik; 1300004I01Rik; DHP; DHPase; dihydropyrimidine amidohydrolase; hydantoinase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391539,631,881 - 39,720,866 (-)NCBIGRCm39mm39
GRCm381539,768,485 - 39,857,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1539,768,487 - 39,857,470 (-)EnsemblGRCm38mm10GRCm38
MGSCv371539,600,031 - 39,689,016 (-)NCBIGRCm37mm9NCBIm37
MGSCv361539,598,559 - 39,687,541 (-)NCBImm8
Celera1540,252,611 - 40,341,397 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IDA,ISO,ISS)
protein-containing complex  (ISO)

Molecular Function

References

Additional References at PubMed
PMID:5472365   PMID:8307005   PMID:10349636   PMID:10956643   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:14610273   PMID:14681479   PMID:15489334   PMID:16141072  
PMID:16141073   PMID:16919269   PMID:17062627   PMID:18799693   PMID:21267068   PMID:21677750   PMID:21873635   PMID:32325033  


Genomics

Comparative Map Data
Dpys
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391539,631,881 - 39,720,866 (-)NCBIGRCm39mm39
GRCm381539,768,485 - 39,857,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1539,768,487 - 39,857,470 (-)EnsemblGRCm38mm10GRCm38
MGSCv371539,600,031 - 39,689,016 (-)NCBIGRCm37mm9NCBIm37
MGSCv361539,598,559 - 39,687,541 (-)NCBImm8
Celera1540,252,611 - 40,341,397 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
DPYS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8104,330,324 - 104,467,055 (-)EnsemblGRCh38hg38GRCh38
GRCh388104,379,429 - 104,467,074 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378105,391,659 - 105,479,283 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh378105,391,652 - 105,479,281 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368105,460,829 - 105,548,453 (-)NCBINCBI36hg18NCBI36
Build 348105,460,828 - 105,548,453NCBI
Celera8101,578,319 - 101,665,933 (-)NCBI
Cytogenetic Map8q22.3NCBI
HuRef8100,592,683 - 100,680,266 (-)NCBIHuRef
CHM1_18105,432,468 - 105,520,073 (-)NCBICHM1_1
Dpys
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2770,822,648 - 70,929,255 (-)NCBI
Rnor_6.0 Ensembl778,769,807 - 78,847,974 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0778,769,918 - 78,847,941 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0778,796,405 - 78,873,615 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4775,368,238 - 75,446,160 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1775,449,118 - 75,466,890 (-)NCBI
Celera767,904,867 - 67,982,691 (-)NCBICelera
Cytogenetic Map7q31NCBI
Dpys
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541728,185,407 - 28,244,307 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541728,183,771 - 28,244,309 (-)NCBIChiLan1.0ChiLan1.0
DPYS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18103,160,922 - 103,248,303 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8103,160,922 - 103,248,303 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08101,008,090 - 101,096,234 (-)NCBIMhudiblu_PPA_v0panPan3
DPYS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl135,583,801 - 5,659,463 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1135,583,795 - 5,659,355 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dpys
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647039,564,431 - 39,637,394 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPYS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl432,789,460 - 32,879,489 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1432,791,152 - 32,879,489 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2435,528,834 - 35,616,166 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DPYS
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1899,216,623 - 99,303,969 (-)NCBI
ChlSab1.1 Ensembl899,216,354 - 99,303,282 (-)Ensembl
Dpys
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476320,618,515 - 20,680,790 (-)NCBI

Position Markers
Dpys  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15B3.1UniSTS
cM Map1515.53UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401902Sicd2_mseizure-induced cell death 2 (mouse)Not determined15344490771325689Mouse
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined346021278717086Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined346021278717086Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined346021278717086Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15346021278717086Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15346021278717086Mouse
26884384Skwq12_mskull length QTL 12, 16 week (mouse)15610000050900000Mouse
26884387Skwq8_mskull length QTL 8, 10 week (mouse)15610000068400000Mouse
26884412Bzwq10_mbi-zygomatic width QTL 10, 10 week (mouse)15610000071600000Mouse
26884417Bzwq4_mbi-zygomatic width QTL 4, 5 week (mouse)15610000072600000Mouse
27226786Feml11_mfemur length 11, 5 week (mouse)15610000076000000Mouse
27095932Ulnl11_mulna length 11, 16 week (mouse)15610000076500000Mouse
27226717Tibw4_mtibia width 4, proximal, 10 week (mouse)15610000078800000Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15610000086800000Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156100000100900000Mouse
26884429Zlq6_mzygomatic length QTL 6, 10 week (mouse)15680000045100000Mouse
27226721Tibw8_mtibia width 8, proximal, 16 week (mouse)15690000076000000Mouse
27226773Tibl16_mtibia length 16, 10 week (mouse)15690000076000000Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15690000084700000Mouse
27095940Ulnl8_mulna length 8, 10 week (mouse)15720000055400000Mouse
27226759Feml17_mfemur length 17, 10 week (mouse)15760000055400000Mouse
27226755Feml22_mfemur length 22, 16 week (mouse)15760000059400000Mouse
26884439Sklq11_mskull length QTL 11, 10 week (mouse)15810000047800000Mouse
4140994Shali3_msurvival time to hyperoxic acute lung injury 3 (mouse)Not determined927293643448484Mouse
10412172Habiir5_mhyperoxic acute lung injury imprinted region 5 (mouse)Not determined15927293643448484Mouse
4141192Ssrq2_mstress response QTL 2 (mouse)Not determined927293656323454Mouse
1301433Rapop5_mradiation-induced apoptosis 5 (mouse)Not determined15927293679590561Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402117102988123Mouse
1302165Yv_myellow value (mouse)Not determined151384686047847002Mouse
1301020Pheo_mpheomelanin (mouse)Not determined151384686047847002Mouse
1301951Eila3_methanol induced locomotor activity 3 (mouse)Not determined151492744148927610Mouse
4141423Nstr2_mnerve sheath tumor resistance QTL 2 (mouse)Not determined1492744148927610Mouse
1302007Bbaa14_mB.burgdorferi-associated arthritis 14 (mouse)Not determined151492744148927610Mouse
1301499Bdln2_mbody length 2 (mouse)Not determined151564519749645324Mouse
12859288Criq1_mCitrobacter rodentium infection QTL 1 (mouse)151603380850033808Mouse
26884423Zlq10_mzygomatic length QTL 10, 16 week (mouse)152060000050900000Mouse
14928313Manh78_mmandible shape 78 (mouse)152148439755484397Mouse
12859289Criq3_mCitrobacter rodentium infection QTL 3 (mouse)152273036956730369Mouse
4142160Femwf10_mfemur work to failure 10 (mouse)Not determined2302961857029764Mouse
1301557Bbaa22_mB.burgdorferi-associated arthritis 22 (mouse)Not determined152459917658599409Mouse
1300967Bdt6_mbone density traits 6 (mouse)Not determined152543241059432532Mouse
4141409Radsvq1_mradiation sensitivity QTL 1 (mouse)Not determined2562158259621582Mouse
1301345Bgeq14_mbody growth early QTL 14 (mouse)Not determined152644838460448484Mouse
1300772Bglq16_mbody growth late QTL 16 (mouse)Not determined152644838460448484Mouse
1357514Mbis3_mMycobacterium bovis-induced systemic lupus erythematosus 3 (mouse)Not determined162644838460448484Mouse
1301406Egrd2_mearly growth rate (mouse)Not determined152644838460448484Mouse
27226800Scvln20_msacral vertebrae length 2, 16 week (mouse)152660000066500000Mouse
1301450Bpq6_mblood pressure QTL 6 (mouse)Not determined152841925062419343Mouse
1357512Bsbob5_mBSB obesity 5 (mouse)Not determined152841925062419343Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800000102100000Mouse
26884392Humsd8_mhumerus midshaft diameter 8, 16 week (mouse)152930000076200000Mouse
26884452Sklq17_mskull length QTL 17, 16 week (mouse)153020000058100000Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578270103517472Mouse
1300578Cd8ts3_mCD8 T cell subset 3 (mouse)Not determined153414129868141408Mouse
1301324Cdif_mcolor difference (mouse)Not determined153611251070112623Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800000086800000Mouse
13801028Toa2_mtesticular oocyte appearance 2 (mouse)153872288443172395Mouse
1301580Hrq2_mheart rate quantitative locus 2 (mouse)Not determined153923699973237197Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:658
Count of miRNA genes:418
Interacting mature miRNAs:461
Transcripts:ENSMUST00000022915, ENSMUST00000110306, ENSMUST00000150196, ENSMUST00000155859
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000022915   ⟹   ENSMUSP00000022915
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1539,768,487 - 39,857,467 (-)Ensembl
RefSeq Acc Id: ENSMUST00000110306   ⟹   ENSMUSP00000105935
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1539,782,697 - 39,857,470 (-)Ensembl
RefSeq Acc Id: ENSMUST00000150196
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1539,855,877 - 39,857,470 (-)Ensembl
RefSeq Acc Id: ENSMUST00000155859   ⟹   ENSMUSP00000114708
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1539,782,705 - 39,793,251 (-)Ensembl
RefSeq Acc Id: NM_001164466   ⟹   NP_001157938
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391539,646,093 - 39,720,866 (-)NCBI
GRCm381539,782,697 - 39,857,470 (-)NCBI
MGSCv371539,600,031 - 39,689,016 (-)RGD
Celera1540,252,611 - 40,341,397 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_022722   ⟹   NP_073559
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391539,631,881 - 39,720,866 (-)NCBI
GRCm381539,768,485 - 39,857,470 (-)ENTREZGENE
MGSCv371539,600,031 - 39,689,016 (-)RGD
Celera1540,252,611 - 40,341,397 (-)RGD
cM Map15 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_073559   ⟸   NM_022722
- UniProtKB: Q9EQF5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001157938   ⟸   NM_001164466
- UniProtKB: Q9EQF5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000105935   ⟸   ENSMUST00000110306
RefSeq Acc Id: ENSMUSP00000022915   ⟸   ENSMUST00000022915
RefSeq Acc Id: ENSMUSP00000114708   ⟸   ENSMUST00000155859
Protein Domains
Amidohydro-rel

Promoters
RGD ID:6825935
Promoter ID:MM_KWN:18340
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_001164466,   NM_022722,   OTTMUST00000083314
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361539,688,721 - 39,689,221 (-)MPROMDB
RGD ID:8683650
Promoter ID:EPDNEW_M19856
Type:multiple initiation site
Name:Dpys_1
Description:Mus musculus dihydropyrimidinase , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381539,857,470 - 39,857,530EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1928679 AgrOrtholog
Ensembl Genes ENSMUSG00000022304 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000022915 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000105935 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000114708 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000022915 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000110306 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000155859 UniProtKB/TrEMBL
Gene3D-CATH 2.30.40.10 UniProtKB/Swiss-Prot
InterPro Amidohydro-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hydantoinase/dihydroPyrase UniProtKB/Swiss-Prot
  Metal-dep_hydrolase_composite UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metal_Hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:64705 UniProtKB/Swiss-Prot
MGD MGI:1928679 ENTREZGENE
NCBI Gene 64705 ENTREZGENE
Pfam Amidohydro_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB DPYS RGD
PhenoGen Dpys PhenoGen
Superfamily-SCOP SSF51338 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51556 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs D-hydantoinase UniProtKB/Swiss-Prot
UniProt DPYS_MOUSE UniProtKB/Swiss-Prot
  F6ZLZ4_MOUSE UniProtKB/TrEMBL
  Q8K0X3_MOUSE UniProtKB/TrEMBL
  Q9EQF5 ENTREZGENE
UniProt Secondary Q99PP1 UniProtKB/Swiss-Prot
  Q9DBK3 UniProtKB/Swiss-Prot
  Q9DBP7 UniProtKB/Swiss-Prot