Dpys (dihydropyrimidinase) - Rat Genome Database

Name: Dpys
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Dpys (dihydropyrimidinase) Mus musculus

Analyze

Symbol:

Dpys

Name:

dihydropyrimidinase

RGD ID:

68542

MGI Page

MGI

Description:

Exhibits phosphoprotein binding activity. Predicted to be involved in beta-alanine metabolic process; thymine catabolic process; and uracil catabolic process. Predicted to localize to cytosol and protein-containing complex. Is expressed in cranium. Human ortholog(s) of this gene implicated in dihydropyrimidinase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human DPYS (dihydropyrimidinase); PARTICIPATES IN beta-alanine metabolic pathway; beta-ureidopropionase deficiency pathway; carnosinemia pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 2,3,7,8-tetrabromodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

1200017I10Rik; 1300004I01Rik; DHP; DHPase; dihydropyrimidine amidohydrolase; hydantoinase

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DPYS (dihydropyrimidinase)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Dpys (dihydropyrimidinase)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Dpys (dihydropyrimidinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DPYS (dihydropyrimidinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DPYS (dihydropyrimidinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dpys (dihydropyrimidinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DPYS (dihydropyrimidinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	DPYS (dihydropyrimidinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dpys (dihydropyrimidinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CRMP1 (collapsin response mediator protein 1)	HGNC	OrthoMCL
Homo sapiens (human):	DPYSL2 (dihydropyrimidinase like 2)	HGNC	OrthoMCL
Homo sapiens (human):	DPYSL4 (dihydropyrimidinase like 4)	HGNC	OrthoMCL
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Dpys (dihydropyrimidinase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	DPYS (dihydropyrimidinase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Danio rerio (zebrafish):	dpys (dihydropyrimidinase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam\|ZFIN)
Drosophila melanogaster (fruit fly):	CRMP	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Caenorhabditis elegans (roundworm):	dhp-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup)
Caenorhabditis elegans (roundworm):	dhp-2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	39,631,881 - 39,720,866 (-)	NCBI	GRCm39		mm39
GRCm38	15	39,768,485 - 39,857,470 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	39,768,487 - 39,857,470 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	39,600,031 - 39,689,016 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	15	39,598,559 - 39,687,541 (-)	NCBI			mm8
Celera	15	40,252,611 - 40,341,397 (-)	NCBI		Celera
Cytogenetic Map	15	B3.1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

dihydropyrimidinase deficiency (ISO)

Experimental Liver Cirrhosis (ISO)

purine-pyrimidine metabolic disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (ISO)

1,1-dichloroethene (EXP)

1,2-dimethylhydrazine (EXP)

1-naphthyl isothiocyanate (ISO)

2,3,7,8-tetrabromodibenzodioxine (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (ISO)

2,6-dinitrotoluene (ISO)

3,3',4,4'-tetrachlorobiphenyl (EXP)

3-chloropropane-1,2-diol (ISO)

4,4'-diaminodiphenylmethane (ISO)

acetamide (ISO)

aflatoxin B1 (EXP,ISO)

aflatoxin B2 (ISO)

ammonium chloride (ISO)

antirheumatic drug (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (EXP)

carbon nanotube (EXP)

clofibrate (ISO)

clofibric acid (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

cyclosporin A (EXP,ISO)

decabromodiphenyl ether (ISO)

diazinon (ISO)

endosulfan (ISO)

glafenine (ISO)

gliotoxin (ISO)

graphite (ISO)

hydrogen chloride (EXP)

hydrogen peroxide (ISO)

monosodium L-glutamate (EXP)

N-nitrosodiethylamine (ISO)

N-nitrosodimethylamine (ISO)

nefazodone (ISO)

nimesulide (ISO)

O-methyleugenol (ISO)

paracetamol (EXP,ISO)

pentachlorophenol (EXP)

perfluorononanoic acid (ISO)

perfluorooctanoic acid (ISO)

phenethyl caffeate (ISO)

phenobarbital (EXP)

pirinixic acid (EXP,ISO)

potassium dichromate (EXP)

sodium arsenite (ISO)

succimer (EXP)

sulindac (ISO)

tetrachloroethene (EXP)

tetrachloromethane (EXP,ISO)

thioacetamide (ISO)

titanium dioxide (EXP)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

beta-alanine metabolic process (ISO,ISS)

CMP catabolic process (IDA)

dCMP catabolic process (IDA)

dTMP catabolic process (ISO)

dUMP catabolic process (IDA)

pyrimidine nucleobase catabolic process (IBA,ISO)

thymine catabolic process (ISO,ISS)

UMP catabolic process (IDA)

uracil catabolic process (ISO,ISS)

uracil metabolic process (ISO)

Cellular Component

cytoplasm (IEA)

cytosol (IDA,ISO,ISS)

protein-containing complex (ISO)

Molecular Function

amino acid binding (ISO,ISS)

dihydropyrimidinase activity (IBA,IDA,ISO,ISS,TAS)

hydrolase activity (IEA)

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds (IEA)

identical protein binding (ISO)

metal ion binding (IEA)

phosphoprotein binding (IPI)

protein binding (ISO)

thymine binding (ISO,ISS)

uracil binding (ISO,ISS)

zinc ion binding (ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

beta-alanine metabolic pathway (IEA,ISO)

beta-ureidopropionase deficiency pathway (ISO)

carnosinemia pathway (ISO)

dihydropyrimidinase deficiency pathway (ISO)

GABA aminotransferase deficiency pathway (ISO)

mitochondrial neurogastrointestinal encephalopathy syndrome pathway (ISO)

orotic aciduria 1 pathway (ISO)

pantothenic acid metabolic pathway (IEA)

pyrimidine metabolic pathway (IEA,ISO)

References

References - curated


1.	Hamajima N, etal., Am J Hum Genet. 1998 Sep;63(3):717-26.
2.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3.	MGD and Homologene mouse data transfer
4.	MGD data from the GO Consortium
5.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6.	OMIM Disease Annotation Pipeline
7.	Pipeline to import KEGG annotations from KEGG into RGD
8.	Pipeline to import SMPDB annotations from SMPDB into RGD
9.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	RGD automated import pipeline for gene-chemical interactions
11.	Tamaki N, etal., Br J Nutr. 1995 May;73(5):711-22.

Additional References at PubMed

PMID:5472365	PMID:8307005	PMID:10349636	PMID:10956643	PMID:11042159	PMID:11076861	PMID:12477932	PMID:12520002	PMID:14610273	PMID:14681479	PMID:15489334	PMID:16141072
PMID:16141073	PMID:16919269	PMID:17062627	PMID:18799693	PMID:21267068	PMID:21677750	PMID:21873635	PMID:32325033

Genomics

Comparative Map Data

Dpys
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	39,631,881 - 39,720,866 (-)	NCBI	GRCm39		mm39
GRCm38	15	39,768,485 - 39,857,470 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	39,768,487 - 39,857,470 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	39,600,031 - 39,689,016 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	15	39,598,559 - 39,687,541 (-)	NCBI			mm8
Celera	15	40,252,611 - 40,341,397 (-)	NCBI		Celera
Cytogenetic Map	15	B3.1	NCBI

DPYS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	8	104,330,324 - 104,467,055 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	8	104,379,429 - 104,467,074 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	8	105,391,659 - 105,479,283 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	8	105,391,652 - 105,479,281 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	105,460,829 - 105,548,453 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	8	105,460,828 - 105,548,453	NCBI
Celera	8	101,578,319 - 101,665,933 (-)	NCBI
Cytogenetic Map	8	q22.3	NCBI
HuRef	8	100,592,683 - 100,680,266 (-)	NCBI		HuRef
CHM1_1	8	105,432,468 - 105,520,073 (-)	NCBI		CHM1_1

Dpys
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	70,822,648 - 70,929,255 (-)	NCBI
Rnor_6.0 Ensembl	7	78,769,807 - 78,847,974 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	7	78,769,918 - 78,847,941 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	7	78,796,405 - 78,873,615 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	75,368,238 - 75,446,160 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	7	75,449,118 - 75,466,890 (-)	NCBI
Celera	7	67,904,867 - 67,982,691 (-)	NCBI		Celera
Cytogenetic Map	7	q31	NCBI

Dpys
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955417	28,185,407 - 28,244,307 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955417	28,183,771 - 28,244,309 (-)	NCBI	ChiLan1.0	ChiLan1.0

DPYS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	8	103,160,922 - 103,248,303 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	103,160,922 - 103,248,303 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	8	101,008,090 - 101,096,234 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

DPYS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	13	5,583,801 - 5,659,463 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	13	5,583,795 - 5,659,355 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Dpys
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936470	39,564,431 - 39,637,394 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DPYS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	32,789,460 - 32,879,489 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	32,791,152 - 32,879,489 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	35,528,834 - 35,616,166 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DPYS
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	99,216,623 - 99,303,969 (-)	NCBI
ChlSab1.1 Ensembl	8	99,216,354 - 99,303,282 (-)	Ensembl

Dpys
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624763	20,618,515 - 20,680,790 (-)	NCBI

Position Markers

Dpys

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	15	B3.1	UniSTS
cM Map	15	15.53	UniSTS

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10401902	Sicd2_m	seizure-induced cell death 2 (mouse)			Not determined		15	3444907	71325689	Mouse
4141952	W3q7_m	weight 3 weeks QTL 7 (mouse)			Not determined			3460212	78717086	Mouse
4142448	Tailq6_m	tail length QTL 6 (mouse)			Not determined			3460212	78717086	Mouse
4142252	Tailaq4_m	tail length adjusted QTL 4 (mouse)			Not determined			3460212	78717086	Mouse
1357559	Scfq2_m	subcutaneous fat pad weight QTL 2 (mouse)			Not determined		15	3460212	78717086	Mouse
1357659	Epfpq4_m	epididymal fat percentage QTL 4 (mouse)			Not determined		15	3460212	78717086	Mouse
26884384	Skwq12_m	skull length QTL 12, 16 week (mouse)					15	6100000	50900000	Mouse
26884387	Skwq8_m	skull length QTL 8, 10 week (mouse)					15	6100000	68400000	Mouse
26884412	Bzwq10_m	bi-zygomatic width QTL 10, 10 week (mouse)					15	6100000	71600000	Mouse
26884417	Bzwq4_m	bi-zygomatic width QTL 4, 5 week (mouse)					15	6100000	72600000	Mouse
27226786	Feml11_m	femur length 11, 5 week (mouse)					15	6100000	76000000	Mouse
27095932	Ulnl11_m	ulna length 11, 16 week (mouse)					15	6100000	76500000	Mouse
27226717	Tibw4_m	tibia width 4, proximal, 10 week (mouse)					15	6100000	78800000	Mouse
27226734	Tibmd5_m	tibia midshaft diameter 5, 10 week (mouse)					15	6100000	86800000	Mouse
26884442	Sklq6_m	skull length QTL 6, 5 week (mouse)					15	6100000	100900000	Mouse
26884429	Zlq6_m	zygomatic length QTL 6, 10 week (mouse)					15	6800000	45100000	Mouse
27226721	Tibw8_m	tibia width 8, proximal, 16 week (mouse)					15	6900000	76000000	Mouse
27226773	Tibl16_m	tibia length 16, 10 week (mouse)					15	6900000	76000000	Mouse
27226777	Tibl8_m	tibia length 8, 5 week (mouse)					15	6900000	84700000	Mouse
27095940	Ulnl8_m	ulna length 8, 10 week (mouse)					15	7200000	55400000	Mouse
27226759	Feml17_m	femur length 17, 10 week (mouse)					15	7600000	55400000	Mouse
27226755	Feml22_m	femur length 22, 16 week (mouse)					15	7600000	59400000	Mouse
26884439	Sklq11_m	skull length QTL 11, 10 week (mouse)					15	8100000	47800000	Mouse
4140994	Shali3_m	survival time to hyperoxic acute lung injury 3 (mouse)			Not determined			9272936	43448484	Mouse
10412172	Habiir5_m	hyperoxic acute lung injury imprinted region 5 (mouse)			Not determined		15	9272936	43448484	Mouse
4141192	Ssrq2_m	stress response QTL 2 (mouse)			Not determined			9272936	56323454	Mouse
1301433	Rapop5_m	radiation-induced apoptosis 5 (mouse)			Not determined		15	9272936	79590561	Mouse
1357526	Hyplip2_m	hyperlipidemia 2 (mouse)			Not determined		15	12402117	102988123	Mouse
1302165	Yv_m	yellow value (mouse)			Not determined		15	13846860	47847002	Mouse
1301020	Pheo_m	pheomelanin (mouse)			Not determined		15	13846860	47847002	Mouse
1301951	Eila3_m	ethanol induced locomotor activity 3 (mouse)			Not determined		15	14927441	48927610	Mouse
4141423	Nstr2_m	nerve sheath tumor resistance QTL 2 (mouse)			Not determined			14927441	48927610	Mouse
1302007	Bbaa14_m	B.burgdorferi-associated arthritis 14 (mouse)			Not determined		15	14927441	48927610	Mouse
1301499	Bdln2_m	body length 2 (mouse)			Not determined		15	15645197	49645324	Mouse
12859288	Criq1_m	Citrobacter rodentium infection QTL 1 (mouse)					15	16033808	50033808	Mouse
26884423	Zlq10_m	zygomatic length QTL 10, 16 week (mouse)					15	20600000	50900000	Mouse
14928313	Manh78_m	mandible shape 78 (mouse)					15	21484397	55484397	Mouse
12859289	Criq3_m	Citrobacter rodentium infection QTL 3 (mouse)					15	22730369	56730369	Mouse
4142160	Femwf10_m	femur work to failure 10 (mouse)			Not determined			23029618	57029764	Mouse
1301557	Bbaa22_m	B.burgdorferi-associated arthritis 22 (mouse)			Not determined		15	24599176	58599409	Mouse
1300967	Bdt6_m	bone density traits 6 (mouse)			Not determined		15	25432410	59432532	Mouse
4141409	Radsvq1_m	radiation sensitivity QTL 1 (mouse)			Not determined			25621582	59621582	Mouse
1301345	Bgeq14_m	body growth early QTL 14 (mouse)			Not determined		15	26448384	60448484	Mouse
1300772	Bglq16_m	body growth late QTL 16 (mouse)			Not determined		15	26448384	60448484	Mouse
1357514	Mbis3_m	Mycobacterium bovis-induced systemic lupus erythematosus 3 (mouse)			Not determined		16	26448384	60448484	Mouse
1301406	Egrd2_m	early growth rate (mouse)			Not determined		15	26448384	60448484	Mouse
27226800	Scvln20_m	sacral vertebrae length 2, 16 week (mouse)					15	26600000	66500000	Mouse
1301450	Bpq6_m	blood pressure QTL 6 (mouse)			Not determined		15	28419250	62419343	Mouse
1357512	Bsbob5_m	BSB obesity 5 (mouse)			Not determined		15	28419250	62419343	Mouse
26884425	Cvht2_m	cranial vault height 2, 5 week (mouse)					15	28800000	102100000	Mouse
26884392	Humsd8_m	humerus midshaft diameter 8, 16 week (mouse)					15	29300000	76200000	Mouse
26884452	Sklq17_m	skull length QTL 17, 16 week (mouse)					15	30200000	58100000	Mouse
1558985	Eae32_m	experimental allergic encephalomyelitis susceptibility 32 (mouse)			Not determined		15	32578270	103517472	Mouse
1300578	Cd8ts3_m	CD8 T cell subset 3 (mouse)			Not determined		15	34141298	68141408	Mouse
1301324	Cdif_m	color difference (mouse)			Not determined		15	36112510	70112623	Mouse
27226729	Tibmd2_m	tibia midshaft diameter 2, 5 week (mouse)					15	38000000	86800000	Mouse
13801028	Toa2_m	testicular oocyte appearance 2 (mouse)					15	38722884	43172395	Mouse
1301580	Hrq2_m	heart rate quantitative locus 2 (mouse)			Not determined		15	39236999	73237197	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	658
Count of miRNA genes:	418
Interacting mature miRNAs:	461
Transcripts:	ENSMUST00000022915, ENSMUST00000110306, ENSMUST00000150196, ENSMUST00000155859
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001164466	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_022722	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC158567	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC158776	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF227731	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF249296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK004822	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK004899	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC029718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC037086	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466541	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000022915 ⟹ ENSMUSP00000022915

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	15	39,768,487 - 39,857,467 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000110306 ⟹ ENSMUSP00000105935

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	15	39,782,697 - 39,857,470 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000150196

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	15	39,855,877 - 39,857,470 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000155859 ⟹ ENSMUSP00000114708

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	15	39,782,705 - 39,793,251 (-)	Ensembl

RefSeq Acc Id:

NM_001164466 ⟹ NP_001157938

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	15	39,646,093 - 39,720,866 (-)	NCBI
GRCm38	15	39,782,697 - 39,857,470 (-)	NCBI
MGSCv37	15	39,600,031 - 39,689,016 (-)	RGD
Celera	15	40,252,611 - 40,341,397 (-)	RGD
cM Map	15		ENTREZGENE

Sequence:

show sequence

ACCAGAGATCTGCCCGCCTTCAGCCCAGCGGGAGAGGGAGTTCTGGCACAGTTCGTGGAGAGCT
TAAAGGAAAGCCAACTTTGTTCGCAGTCCCCAGCGCCCTGGACCATGGCACCACAGGGACGACT
TCTCATCCGCGGGGGTCGCATTGTCAATGACGACTTCTCACAGGTGGCCGATGTGCTAGTGGAG
GACGGCGTGGTGCGGGCGCTGGGACGGGACCTGCTGCCTCCTGAGGACGCATCTCGGGGGCTGC
GAATCCTAGATGCAGCGGGCAAGCTCGTCCTGCCCGGGGGCATCGACACGCACACGCACATGCA
ATTCCCGTTCATGGGCTCGCAGTCAGTGGACGACTTCTACCAGGGCACCAAGGCTGCTTTGGCA
GGAGGCACCACCATGATCATTGATTTTGCCATTCCTCAGAAAGGCAGCTCCCTCATCGAGGCCT
TTGAGACTTGGCGCAACTGGGCAGACCCGAAAGTCTGCTGTGACTATAGCCTGCATGTGGCAGT
GACGTGGTGGAGCGACAAGGTAAAAGAAGAAATGAAAACCCTTGCCCGAGATAAAGGCGTTAAC
TCTTTCAAGATGTTTATGGCCTACAAAGGTCTGTACATGGTGCAAGACGAGCAGCTGTATGCGG
CCTTCTCTCAGTGCAAGGAGATAGGAGCGATTGCTCAGGTGCACGCCGAGAATGGAGATTTGAT
TGCAGAGGGAGCAAAGAAGATGCTGGCACTGGGGATAACAGGCCCTGAGGGGCACGAGCTGTGC
CGTCCAGAAGCAGTGGAGGCAGAGGCCACCCTGAGAGCCATCACCATAGCCAGCGCTGTGAACT
GCCCTTTATACGTCGTGCATGTGATGAGCAAATCTGCAGCGAAGGTGGTAGCCGATGCGAGGAG
AGCAGGAAATGTGGTCTATGGAGAACCAATTGCAGCGGGTCTCGGCACTGATGGCAGACAGTAC
TGGAGTGAAGAATGGAGCCATGCAGCCCACCATGTCATGGGTCCCCCACTGAGACCCGATCCTT
TAACACCTGGCTTTCTTATGGATCTGTTGGCTAATGGCGATTTGACCACAACAGGGAGTGACAA
CTGCACTTTTAACACCTGCCAAAAAGCTCTAGGGAAGGATGACTTCACTAAGATTCCCAATGGG
GTGAATGGTGTCGAGGACAGGATGTCGGTGATATGGGAAAAGGGCGTGCACAGTGGTAAAATGG
ATGAAAACAGGTTTGTGGCAGTTACCAGCACAAACGCAGCCAAAATCTTTAATCTTTATCCGAA
AAAAGGAAGAATAGCTGTAGGCTCAGATGCTGACATTGTGATCTGGGACCCAGAAGCAACAAGG
AGGATCTCAGCCAAAACTCATCATCAGGCCGTTAACTTCAACATCTTCGAGGGCATGGTTTGTC
ACGGGGTGCCCCTGGTGACTATTTCAAGAGGCAGAGTGGTGTATGAAGCAGGTGTTTTCAACGT
CACAGCAGGACATGGGAAGTTTATTCCCCGCCAACCCTTTGCCGAATACATTTACAAACGAATC
AAGCAGCGAGACCAGACCTGCACACCTGTGCCCGTGAAGCGCGCCCCCTACAAGGGAGAAGTCA
CCACACTGAAAGCCAGAGAGACAAAAGAAGATGACACTGCTGGAACCAGGATGCAGGGCCACTC
CTGATCTGGATGCTGGAGTTAAGCAAGTGCAAGGCAAAGGCAGAGCAAAGGCTCTGAGGCGCCT
CTTCCCGCCATGCCGCCAACCCCTGGAGAAACACCTGCTATTTCAACTCCCCAAGATCCTTTAG
GAAAAATCATTGCTCTAGGCCTCTTTGATTTTTCTCTCAAAAGCAATAGCTGTCTGCCTCACTG
TGCCTTTGTTGCTGTGGAAGACTGAAGATATAAATGAGCATTACTGGGACGGGACGTCTGCGTG
AAGACTCACTGGAGATTCCTTTCAAATGCCATCTTTCTGTACACTAGATTTCTTTCTTTGGATC
CTTAAAGATTTCTTTCCAGTGTAAAGGTTTTATTTGTTTTGTTTTAATGTCTATATTTGTTTGA
AAAAAATCACTGTGATTTTACATTTCACCACAATTAATAAACATTGGGAGCTTCATTCTGTA

hide sequence

RefSeq Acc Id:

NM_022722 ⟹ NP_073559

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	15	39,631,881 - 39,720,866 (-)	NCBI
GRCm38	15	39,768,485 - 39,857,470 (-)	ENTREZGENE
MGSCv37	15	39,600,031 - 39,689,016 (-)	RGD
Celera	15	40,252,611 - 40,341,397 (-)	RGD
cM Map	15		ENTREZGENE

Sequence:

show sequence

ACCAGAGATCTGCCCGCCTTCAGCCCAGCGGGAGAGGGAGTTCTGGCACAGTTCGTGGAGAGCT
TAAAGGAAAGCCAACTTTGTTCGCAGTCCCCAGCGCCCTGGACCATGGCACCACAGGGACGACT
TCTCATCCGCGGGGGTCGCATTGTCAATGACGACTTCTCACAGGTGGCCGATGTGCTAGTGGAG
GACGGCGTGGTGCGGGCGCTGGGACGGGACCTGCTGCCTCCTGAGGACGCATCTCGGGGGCTGC
GAATCCTAGATGCAGCGGGCAAGCTCGTCCTGCCCGGGGGCATCGACACGCACACGCACATGCA
ATTCCCGTTCATGGGCTCGCAGTCAGTGGACGACTTCTACCAGGGCACCAAGGCTGCTTTGGCA
GGAGGCACCACCATGATCATTGATTTTGCCATTCCTCAGAAAGGCAGCTCCCTCATCGAGGCCT
TTGAGACTTGGCGCAACTGGGCAGACCCGAAAGTCTGCTGTGACTATAGCCTGCATGTGGCAGT
GACGTGGTGGAGCGACAAGGTAAAAGAAGAAATGAAAACCCTTGCCCGAGATAAAGGCGTTAAC
TCTTTCAAGATGTTTATGGCCTACAAAGGTCTGTACATGGTGCAAGACGAGCAGCTGTATGCGG
CCTTCTCTCAGTGCAAGGAGATAGGAGCGATTGCTCAGGTGCACGCCGAGAATGGAGATTTGAT
TGCAGAGGGAGCAAAGAAGATGCTGGCACTGGGGATAACAGGCCCTGAGGGGCACGAGCTGTGC
CGTCCAGAAGCAGTGGAGGCAGAGGCCACCCTGAGAGCCATCACCATAGCCAGCGCTGTGAACT
GCCCTTTATACGTCGTGCATGTGATGAGCAAATCTGCAGCGAAGGTGGTAGCCGATGCGAGGAG
AGCAGGAAATGTGGTCTATGGAGAACCAATTGCAGCGGGTCTCGGCACTGATGGCAGACAGTAC
TGGAGTGAAGAATGGAGCCATGCAGCCCACCATGTCATGGGTCCCCCACTGAGACCCGATCCTT
TAACACCTGGCTTTCTTATGGATCTGTTGGCTAATGGCGATTTGACCACAACAGGGAGTGACAA
CTGCACTTTTAACACCTGCCAAAAAGCTCTAGGGAAGGATGACTTCACTAAGATTCCCAATGGG
GTGAATGGTGTCGAGGACAGGATGTCGGTGATATGGGAAAAGGGCGTGCACAGTGGTAAAATGG
ATGAAAACAGGTTTGTGGCAGTTACCAGCACAAACGCAGCCAAAATCTTTAATCTTTATCCGAA
AAAAGGAAGAATAGCTGTAGGCTCAGATGCTGACATTGTGATCTGGGACCCAGAAGCAACAAGG
AGGATCTCAGCCAAAACTCATCATCAGGCCGTTAACTTCAACATCTTCGAGGGCATGGTTTGTC
ACGGGGTGCCCCTGGTGACTATTTCAAGAGGCAGAGTGGTGTATGAAGCAGGTGTTTTCAACGT
CACAGCAGGACATGGGAAGTTTATTCCCCGCCAACCCTTTGCCGAATACATTTACAAACGAATC
AAGCAGCGAGACCAGACCTGCACACCTGTGCCCGTGAAGCGCGCCCCCTACAAGGGAGAAGTCA
CCACACTGAAAGCCAGAGAGACAAAAGAAGATGACACTGCTGGAACCAGGATGCAGGGCCACTC
CTGATCTGGATGCTGGAGTTAAGCAAGTGCAAGGTTTCTGAAAGACAGCCAAGATGAAGTAGGA
GGAAAGGAAGGTTTAGGCACCAGCTCTGCTTCAAGCTCATTAGGAACGGTTGATCCAAAGAGCC
CAGTAGAGAAAACATGCTGATGTACTGTGCAGCAAAGACCTGCGTTCAAGTCTGCTTCTGGAAC
AAGCTTCTCTGTGCTTCAGTTTCCTCATTCCTAAAACTGCAATACCATCAGAAATTTGGTGAGA
TGTTACACTCAGTAATGTGCCCGACACCCAGCAAGGATAGTAAGACTTACTATGTTTTCTGGGA
AGAGCTGATTTGAGCCAGGAGGGAGAAGGACTTGGGTCACCTCACAACAGCACCTGAATAATAA
ACTCATTCTCTAAATTCTGAGTTCAGCATTTTTTTAAAAAAATTCATTACATCAAGGATTTTGA
AAGAATATGTATTTTCTTCAACATATTAATGCATCCATTTGCAACACACGGGGCCTTATTATTC
CTGTATAAACACTTTTCTATGACGCTTTCCTTTTCAAAACAATTTCGATTGATTTCTTTCTCCT
CTAATTAATATATCATGTTTACAGCCAGTGCACCGCTTGCTGTGGAGAAGCAAGACTTCAATTT
TCAGGTCGTCTGCCACTGACACCACACTCTGGCTTTAAACTGTATGAAATTACACATGACATTT
AGAACTGAATAACGGTTCCAATTGCCTCTGAAAAAGAACATTTCTTTTGACCTAATGTTATCTT
CCCCCCCTTTCAGAAAATAAATCACACTAATACCCCAAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001157938	(Get FASTA)	NCBI Sequence Viewer
	NP_073559	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG37999	(Get FASTA)	NCBI Sequence Viewer
	AAH29718	(Get FASTA)	NCBI Sequence Viewer
	AAH37086	(Get FASTA)	NCBI Sequence Viewer
	AAK00644	(Get FASTA)	NCBI Sequence Viewer
	BAB23593	(Get FASTA)	NCBI Sequence Viewer
	BAB23654	(Get FASTA)	NCBI Sequence Viewer
	EDL08773	(Get FASTA)	NCBI Sequence Viewer
	EDL08774	(Get FASTA)	NCBI Sequence Viewer
	Q9EQF5	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_073559 ⟸ NM_022722

- UniProtKB:

Q9EQF5 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MAPQGRLLIRGGRIVNDDFSQVADVLVEDGVVRALGRDLLPPEDASRGLRILDAAGKLVLPGGI
DTHTHMQFPFMGSQSVDDFYQGTKAALAGGTTMIIDFAIPQKGSSLIEAFETWRNWADPKVCCD
YSLHVAVTWWSDKVKEEMKTLARDKGVNSFKMFMAYKGLYMVQDEQLYAAFSQCKEIGAIAQVH
AENGDLIAEGAKKMLALGITGPEGHELCRPEAVEAEATLRAITIASAVNCPLYVVHVMSKSAAK
VVADARRAGNVVYGEPIAAGLGTDGRQYWSEEWSHAAHHVMGPPLRPDPLTPGFLMDLLANGDL
TTTGSDNCTFNTCQKALGKDDFTKIPNGVNGVEDRMSVIWEKGVHSGKMDENRFVAVTSTNAAK
IFNLYPKKGRIAVGSDADIVIWDPEATRRISAKTHHQAVNFNIFEGMVCHGVPLVTISRGRVVY
EAGVFNVTAGHGKFIPRQPFAEYIYKRIKQRDQTCTPVPVKRAPYKGEVTTLKARETKEDDTAG
TRMQGHS

hide sequence

RefSeq Acc Id:

NP_001157938 ⟸ NM_001164466

- UniProtKB:

Q9EQF5 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MAPQGRLLIRGGRIVNDDFSQVADVLVEDGVVRALGRDLLPPEDASRGLRILDAAGKLVLPGGI
DTHTHMQFPFMGSQSVDDFYQGTKAALAGGTTMIIDFAIPQKGSSLIEAFETWRNWADPKVCCD
YSLHVAVTWWSDKVKEEMKTLARDKGVNSFKMFMAYKGLYMVQDEQLYAAFSQCKEIGAIAQVH
AENGDLIAEGAKKMLALGITGPEGHELCRPEAVEAEATLRAITIASAVNCPLYVVHVMSKSAAK
VVADARRAGNVVYGEPIAAGLGTDGRQYWSEEWSHAAHHVMGPPLRPDPLTPGFLMDLLANGDL
TTTGSDNCTFNTCQKALGKDDFTKIPNGVNGVEDRMSVIWEKGVHSGKMDENRFVAVTSTNAAK
IFNLYPKKGRIAVGSDADIVIWDPEATRRISAKTHHQAVNFNIFEGMVCHGVPLVTISRGRVVY
EAGVFNVTAGHGKFIPRQPFAEYIYKRIKQRDQTCTPVPVKRAPYKGEVTTLKARETKEDDTAG
TRMQGHS

hide sequence

RefSeq Acc Id:

ENSMUSP00000105935 ⟸ ENSMUST00000110306

RefSeq Acc Id:

ENSMUSP00000022915 ⟸ ENSMUST00000022915

RefSeq Acc Id:

ENSMUSP00000114708 ⟸ ENSMUST00000155859

Protein Domains

Amidohydro-rel

Promoters

RGD ID:

6825935

Promoter ID:

MM_KWN:18340

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Liver

Transcripts:

NM_001164466, NM_022722, OTTMUST00000083314

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	15	39,688,721 - 39,689,221 (-)	MPROMDB

RGD ID:

8683650

Promoter ID:

EPDNEW_M19856

Type:

multiple initiation site

Name:

Dpys_1

Description:

Mus musculus dihydropyrimidinase , transcript variant 2, mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	15	39,857,470 - 39,857,530	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1928679	AgrOrtholog
Ensembl Genes	ENSMUSG00000022304	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000022915	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUSP00000105935	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUSP00000114708	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000022915	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUST00000110306	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUST00000155859	UniProtKB/TrEMBL
Gene3D-CATH	2.30.40.10	UniProtKB/Swiss-Prot
InterPro	Amidohydro-rel	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Hydantoinase/dihydroPyrase	UniProtKB/Swiss-Prot
	Metal-dep_hydrolase_composite	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Metal_Hydrolase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:64705	UniProtKB/Swiss-Prot
MGD	MGI:1928679	ENTREZGENE
NCBI Gene	64705	ENTREZGENE
Pfam	Amidohydro_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	DPYS	RGD
PhenoGen	Dpys	PhenoGen
Superfamily-SCOP	SSF51338	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF51556	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs	D-hydantoinase	UniProtKB/Swiss-Prot
UniProt	DPYS_MOUSE	UniProtKB/Swiss-Prot
	F6ZLZ4_MOUSE	UniProtKB/TrEMBL
	Q8K0X3_MOUSE	UniProtKB/TrEMBL
	Q9EQF5	ENTREZGENE
UniProt Secondary	Q99PP1	UniProtKB/Swiss-Prot
	Q9DBK3	UniProtKB/Swiss-Prot
	Q9DBP7	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)