Ruvbl1 (RuvB-like protein 1) - Rat Genome Database
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Gene: Ruvbl1 (RuvB-like protein 1) Mus musculus
Analyze
Symbol: Ruvbl1
Name: RuvB-like protein 1
RGD ID: 68538
MGI Page MGI
Description: Is expressed in several structures, including branchial arch; limb; liver; maxillary process; and sensory organ. Orthologous to human RUVBL1 (RuvB like AAA ATPase 1); PARTICIPATES IN INO80 family mediated chromatin remodeling pathway; Wnt signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2510009G06Rik; 49 kDa TATA box-binding protein-interacting protein; 49 kDa TBP-interacting protein; DNA helicase p50; Pon; Pontin 52; Pontin52; ruvB-like 1; Tip; Tip49a
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm3086   Gm5837   Gm7499  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39688,442,391 - 88,474,548 (+)NCBIGRCm39mm39
GRCm39 Ensembl688,442,391 - 88,474,554 (+)Ensembl
GRCm38688,465,409 - 88,497,566 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl688,465,409 - 88,497,572 (+)EnsemblGRCm38mm10GRCm38
MGSCv37688,415,417 - 88,447,560 (+)NCBIGRCm37mm9NCBIm37
MGSCv36688,431,107 - 88,463,207 (+)NCBImm8
Celera690,403,044 - 90,439,348 (+)NCBICelera
Cytogenetic Map6D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:9843967   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15489334   PMID:15782199   PMID:15800025   PMID:16141072  
PMID:16141073   PMID:17110338   PMID:17277741   PMID:17636026   PMID:17967808   PMID:18372249   PMID:19299493   PMID:19345177   PMID:19423573   PMID:20059953   PMID:20211142   PMID:20362541  
PMID:21589869   PMID:21677750   PMID:21873635   PMID:22371176   PMID:24146773   PMID:24302573   PMID:24457600   PMID:24680824   PMID:25428364   PMID:25857206   PMID:26365490   PMID:26496610  
PMID:26639898   PMID:26711270   PMID:27746211   PMID:28378742   PMID:29113992   PMID:29959317   PMID:30196744   PMID:30498063   PMID:31077711   PMID:31186351   PMID:32098917   PMID:33293536  


Genomics

Comparative Map Data
Ruvbl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39688,442,391 - 88,474,548 (+)NCBIGRCm39mm39
GRCm39 Ensembl688,442,391 - 88,474,554 (+)Ensembl
GRCm38688,465,409 - 88,497,566 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl688,465,409 - 88,497,572 (+)EnsemblGRCm38mm10GRCm38
MGSCv37688,415,417 - 88,447,560 (+)NCBIGRCm37mm9NCBIm37
MGSCv36688,431,107 - 88,463,207 (+)NCBImm8
Celera690,403,044 - 90,439,348 (+)NCBICelera
Cytogenetic Map6D1NCBI
RUVBL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3128,064,778 - 128,153,914 (-)EnsemblGRCh38hg38GRCh38
GRCh383128,064,611 - 128,153,914 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373127,783,628 - 127,872,757 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363129,282,493 - 129,325,332 (-)NCBINCBI36hg18NCBI36
Build 343129,282,500 - 129,325,340NCBI
Celera3126,230,848 - 126,272,604 (-)NCBI
Cytogenetic Map3q21.3NCBI
HuRef3125,180,247 - 125,223,118 (-)NCBIHuRef
CHM1_13127,746,833 - 127,835,772 (-)NCBICHM1_1
Ruvbl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24120,932,486 - 120,967,400 (+)NCBI
Rnor_6.0 Ensembl4120,411,991 - 120,447,455 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04120,411,917 - 120,447,458 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04185,651,851 - 185,687,385 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44122,556,857 - 122,591,769 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14122,801,337 - 122,836,249 (+)NCBI
Celera4109,888,321 - 109,923,233 (+)NCBICelera
Cytogenetic Map4q34NCBI
Ruvbl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542915,598,465 - 15,633,713 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542915,598,465 - 15,632,290 (+)NCBIChiLan1.0ChiLan1.0
RUVBL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13132,486,229 - 132,528,925 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3132,486,229 - 132,528,918 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03125,120,524 - 125,200,859 (-)NCBIMhudiblu_PPA_v0panPan3
RUVBL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl202,095,786 - 2,137,579 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1202,095,807 - 2,137,528 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ruvbl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936798559,706 - 572,710 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RUVBL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1372,200,511 - 72,248,582 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11372,196,219 - 72,246,514 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RUVBL1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12252,887,374 - 52,967,728 (+)NCBI
ChlSab1.1 Ensembl2252,924,819 - 52,967,830 (+)Ensembl
Ruvbl1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624961427,836 - 460,887 (+)NCBI

Position Markers
D6Mit226  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38688,474,359 - 88,474,505UniSTSGRCm38
MGSCv37688,424,353 - 88,424,499UniSTSGRCm37
Celera690,414,252 - 90,414,417UniSTS
Cytogenetic Map6D1UniSTS
cM Map637.0UniSTS
Whitehead Genetic629.5UniSTS
Whitehead_YAC6 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686806805113544602Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687503360121503555Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:315
Count of miRNA genes:248
Interacting mature miRNAs:283
Transcripts:ENSMUST00000032165, ENSMUST00000129035
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC153694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF100694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK012170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ146900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000032165   ⟹   ENSMUSP00000032165
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl688,465,409 - 88,497,572 (+)Ensembl
RefSeq Acc Id: ENSMUST00000129035   ⟹   ENSMUSP00000117925
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl688,465,727 - 88,482,187 (+)Ensembl
RefSeq Acc Id: NM_019685   ⟹   NP_062659
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39688,442,391 - 88,474,548 (+)NCBI
GRCm38688,465,409 - 88,497,566 (+)NCBI
MGSCv37688,415,417 - 88,447,560 (+)RGD
Celera690,403,044 - 90,439,348 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062659   ⟸   NM_019685
- UniProtKB: P60122 (UniProtKB/Swiss-Prot),   Q3U1C2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000032165   ⟸   ENSMUST00000032165
RefSeq Acc Id: ENSMUSP00000117925   ⟸   ENSMUST00000129035
Protein Domains
AAA   TIP49

Promoters
RGD ID:6839955
Promoter ID:MM_KWN:46819
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:OTTMUST00000058579,   OTTMUST00000058580
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36688,415,121 - 88,415,621 (+)MPROMDB
RGD ID:6890372
Promoter ID:EPDNEW_M8637
Type:initiation region
Name:Ruvbl1_1
Description:Mus musculus RuvB-like protein 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38688,465,442 - 88,465,502EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1928760 AgrOrtholog
Ensembl Genes ENSMUSG00000030079 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000032165 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000117925 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000032165 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000129035 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.360 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RuvB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RuvB-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RUVBL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RUVBL2_DII UniProtKB/TrEMBL
  TIP49_P-loop UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56505 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1928760 ENTREZGENE
NCBI Gene 56505 ENTREZGENE
PANTHER PTHR11093 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11093:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TIP49 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIP49_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ruvbl1 PhenoGen
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50249 UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YW60_MOUSE UniProtKB/TrEMBL
  P60122 ENTREZGENE
  Q3U1C2 ENTREZGENE, UniProtKB/TrEMBL
  Q3UJN2_MOUSE UniProtKB/TrEMBL
  RUVB1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary O35753 UniProtKB/Swiss-Prot