GRID1-AS1 (GRID1 antisense RNA 1) - Rat Genome Database

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Gene: GRID1-AS1 (GRID1 antisense RNA 1) Homo sapiens
Analyze
Symbol: GRID1-AS1
Name: GRID1 antisense RNA 1
RGD ID: 6767246
HGNC Page HGNC:44131
Description: ASSOCIATED WITH genetic disease
Type: ncrna (Ensembl: lncRNA)
RefSeq Status: VALIDATED
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381085,577,731 - 85,607,215 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1085,577,731 - 85,607,213 (+)EnsemblGRCh38hg38GRCh38
GRCh371087,337,488 - 87,366,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera1081,332,928 - 81,362,415 (+)NCBICelera
Cytogenetic Map10q23.1NCBI
HuRef1081,183,380 - 81,212,812 (+)NCBIHuRef
CHM1_11087,619,617 - 87,649,101 (+)NCBICHM1_1
T2T-CHM13v2.01086,457,875 - 86,487,374 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
Additional References at PubMed
PMID:14702039  


Genomics

Variants

.
Variants in GRID1-AS1
9 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_017551.2(GRID1):c.2642A>G (p.Asn881Ser) single nucleotide variant Malignant melanoma [RCV000069055] Chr10:85602661 [GRCh38]
Chr10:87362418 [GRCh37]
Chr10:87352398 [NCBI36]
Chr10:10q23.1		 not provided
GRCh38/hg38 10q22.3-23.2(chr10:79925613-86951708)x1 copy number loss See cases [RCV000135348] Chr10:79925613..86951708 [GRCh38]
Chr10:81685369..88711465 [GRCh37]
Chr10:81675349..88701445 [NCBI36]
Chr10:10q22.3-23.2		 pathogenic
GRCh38/hg38 10q22.3-23.2(chr10:79802022-87068261)x1 copy number loss See cases [RCV000136565] Chr10:79802022..87068261 [GRCh38]
Chr10:81561459..88828018 [GRCh37]
Chr10:81263385..88817998 [NCBI36]
Chr10:10q22.3-23.2		 pathogenic
GRCh38/hg38 10q11.23-23.2(chr10:50729367-87147204)x3 copy number gain See cases [RCV000138007] Chr10:50729367..87147204 [GRCh38]
Chr10:52489127..88906961 [GRCh37]
Chr10:52159133..88896941 [NCBI36]
Chr10:10q11.23-23.2		 pathogenic
GRCh38/hg38 10q22.3-23.2(chr10:79689360-87223773)x1 copy number loss See cases [RCV000141724] Chr10:79689360..87223773 [GRCh38]
Chr10:81449116..88983530 [GRCh37]
Chr10:81119122..88973510 [NCBI36]
Chr10:10q22.3-23.2		 pathogenic
GRCh38/hg38 10q22.3-23.2(chr10:79881238-87180672)x1 copy number loss See cases [RCV000143178] Chr10:79881238..87180672 [GRCh38]
Chr10:81640994..88940429 [GRCh37]
Chr10:81630974..88930409 [NCBI36]
Chr10:10q22.3-23.2		 pathogenic
GRCh38/hg38 10q22.3-23.2(chr10:79882162-87068261)x1 copy number loss See cases [RCV000148069] Chr10:79882162..87068261 [GRCh38]
Chr10:81641918..88828018 [GRCh37]
Chr10:81631898..88817998 [NCBI36]
Chr10:10q22.3-23.2		 pathogenic
GRCh38/hg38 10q22.3-23.2(chr10:79719429-87358394)x1 copy number loss See cases [RCV000052534] Chr10:79719429..87358394 [GRCh38]
Chr10:81479185..89118151 [GRCh37]
Chr10:81149191..89108131 [NCBI36]
Chr10:10q22.3-23.2		 pathogenic
GRCh38/hg38 10q22.3-23.2(chr10:79802022-87358394)x1 copy number loss See cases [RCV000052537] Chr10:79802022..87358394 [GRCh38]
Chr10:81561459..89118151 [GRCh37]
Chr10:81541288..89108131 [NCBI36]
Chr10:10q22.3-23.2		 pathogenic
GRCh38/hg38 10q22.3-23.2(chr10:79882162-87068261)x1 copy number loss See cases [RCV000052539] Chr10:79882162..87068261 [GRCh38]
Chr10:81641918..88828018 [GRCh37]
Chr10:81631898..88817998 [NCBI36]
Chr10:10q22.3-23.2		 pathogenic|conflicting data from submitters
GRCh38/hg38 10q22.3-23.2(chr10:79898516-86964367)x1 copy number loss See cases [RCV000052541] Chr10:79898516..86964367 [GRCh38]
Chr10:81658272..88724124 [GRCh37]
Chr10:81648252..88714104 [NCBI36]
Chr10:10q22.3-23.2		 pathogenic
GRCh38/hg38 10q22.3-23.2(chr10:79898516-87358394)x1 copy number loss See cases [RCV000052542] Chr10:79898516..87358394 [GRCh38]
Chr10:81658272..89118151 [GRCh37]
Chr10:81648252..89108131 [NCBI36]
Chr10:10q22.3-23.2		 pathogenic
GRCh38/hg38 10q22.3-23.2(chr10:79898516-87109827)x1 copy number loss See cases [RCV000052544] Chr10:79898516..87109827 [GRCh38]
Chr10:81658272..88869584 [GRCh37]
Chr10:81648252..88859564 [NCBI36]
Chr10:10q22.3-23.2		 pathogenic
GRCh38/hg38 10q23.1-23.31(chr10:84925492-88002064)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052546]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052546]|See cases [RCV000052546] Chr10:84925492..88002064 [GRCh38]
Chr10:86685248..89761821 [GRCh37]
Chr10:86675228..89751801 [NCBI36]
Chr10:10q23.1-23.31		 pathogenic
GRCh38/hg38 10q22.3-23.2(chr10:79881238-87182117)x3 copy number gain See cases [RCV000053558] Chr10:79881238..87182117 [GRCh38]
Chr10:81640994..88941874 [GRCh37]
Chr10:81630974..88931854 [NCBI36]
Chr10:10q22.3-23.2		 pathogenic
GRCh38/hg38 10q23.1-23.31(chr10:84434981-89150802)x3 copy number gain See cases [RCV000053559] Chr10:84434981..89150802 [GRCh38]
Chr10:86194737..90910559 [GRCh37]
Chr10:86184717..90900539 [NCBI36]
Chr10:10q23.1-23.31		 pathogenic
NM_017551.3(GRID1):c.2984G>A (p.Gly995Asp) single nucleotide variant Inborn genetic diseases [RCV002648752] Chr10:85602319 [GRCh38]
Chr10:87362076 [GRCh37]
Chr10:10q23.1		 uncertain significance
NM_017551.3(GRID1):c.2690C>T (p.Ser897Leu) single nucleotide variant GRID1-associated neurodevelopmental disorder [RCV003228853] Chr10:85602613 [GRCh38]
Chr10:87362370 [GRCh37]
Chr10:10q23.1		 uncertain significance
NM_017551.3(GRID1):c.2950C>T (p.Pro984Ser) single nucleotide variant GRID1-associated neurodevelopmental disorder [RCV003228855] Chr10:85602353 [GRCh38]
Chr10:87362110 [GRCh37]
Chr10:10q23.1		 uncertain significance
NM_017551.3(GRID1):c.2855C>T (p.Pro952Leu) single nucleotide variant GRID1-associated neurodevelopmental disorder [RCV003228854] Chr10:85602448 [GRCh38]
Chr10:87362205 [GRCh37]
Chr10:10q23.1		 uncertain significance
NM_017551.3(GRID1):c.2753G>A (p.Arg918Gln) single nucleotide variant Inborn genetic diseases [RCV003305335] Chr10:85602550 [GRCh38]
Chr10:87362307 [GRCh37]
Chr10:10q23.1		 uncertain significance
NM_017551.3(GRID1):c.2939C>T (p.Pro980Leu) single nucleotide variant Inborn genetic diseases [RCV003365899] Chr10:85602364 [GRCh38]
Chr10:87362121 [GRCh37]
Chr10:10q23.1		 uncertain significance
NM_017551.3(GRID1):c.2636G>A (p.Arg879His) single nucleotide variant not provided [RCV003487883] Chr10:85602667 [GRCh38]
Chr10:87362424 [GRCh37]
Chr10:10q23.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:223
Count of miRNA genes:212
Interacting mature miRNAs:220
Transcripts:ENST00000443311
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 233
Low 3 3 467 3 6 3 191 3 342 9 175 473 25 164
Below cutoff 1267 1032 719 188 238 117 2840 982 2983 69 601 662 71 980 1823

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000443311
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1085,577,859 - 85,606,506 (+)Ensembl
RefSeq Acc Id: ENST00000628016
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1085,577,753 - 85,605,804 (+)Ensembl
RefSeq Acc Id: ENST00000630182
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1085,577,731 - 85,607,213 (+)Ensembl
RefSeq Acc Id: ENST00000668011
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1085,577,759 - 85,606,500 (+)Ensembl
RefSeq Acc Id: NR_038986
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381085,577,731 - 85,607,215 (+)NCBI
GRCh371087,337,488 - 87,366,972 (+)NCBI
HuRef1081,183,380 - 81,212,812 (+)NCBI
CHM1_11087,619,617 - 87,649,101 (+)NCBI
T2T-CHM13v2.01086,457,875 - 86,487,374 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC GRID1-AS1 COSMIC
Ensembl Genes ENSG00000234942 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000630182 ENTREZGENE
GTEx ENSG00000234942 GTEx
HGNC ID HGNC:44131 ENTREZGENE
Human Proteome Map GRID1-AS1 Human Proteome Map
NCBI Gene GRID1-AS1 ENTREZGENE
RNAcentral URS0000759C23 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-21 GRID1-AS1  GRID1 antisense RNA 1  GRID1-AS1  GRID1 antisense RNA 1 (non-protein coding)  Symbol and/or name change 5135510 APPROVED