C7h12orf75 (similar to human chromosome 12 open reading frame 75) - Rat Genome Database

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Gene: C7h12orf75 (similar to human chromosome 12 open reading frame 75) Rattus norvegicus
Analyze
Symbol: C7h12orf75 (Ensembl: LOC100910996)
Name: similar to human chromosome 12 open reading frame 75 (Ensembl:uncharacterized LOC100910996)
RGD ID: 6495714
Description: Orthologous to human C12orf75 (chromosome 12 open reading frame 75); INTERACTS WITH aflatoxin B1 (ortholog); all-trans-retinoic acid (ortholog); antirheumatic drug (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC691876; LOC100910996; LOC691876; OCC-1; Overexpressed in colon carcinoma 1 protein homolog; uncharacterized LOC100910996; uncharacterized protein LOC100910996
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8721,902,745 - 21,945,704 (-)NCBIGRCr8
mRatBN7.2720,015,102 - 20,058,448 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl720,015,102 - 20,057,975 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx721,984,560 - 22,027,383 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0724,147,308 - 24,190,130 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0723,924,313 - 23,967,134 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0725,737,979 - 26,180,359 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl725,737,979 - 25,743,537 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0725,873,245 - 25,878,804 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4722,182,219 - 22,200,385 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera717,219,692 - 17,263,022 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
C7h12orf75
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8721,902,745 - 21,945,704 (-)NCBIGRCr8
mRatBN7.2720,015,102 - 20,058,448 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl720,015,102 - 20,057,975 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx721,984,560 - 22,027,383 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0724,147,308 - 24,190,130 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0723,924,313 - 23,967,134 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0725,737,979 - 26,180,359 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl725,737,979 - 25,743,537 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0725,873,245 - 25,878,804 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4722,182,219 - 22,200,385 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera717,219,692 - 17,263,022 (-)NCBICelera
Cytogenetic Map7q13NCBI
C12orf75
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812105,330,691 - 105,371,518 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12105,235,290 - 105,396,097 (+)EnsemblGRCh38hg38GRCh38
GRCh3712105,724,469 - 105,765,296 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612104,154,183 - 104,289,427 (+)NCBINCBI36Build 36hg18NCBI36
Celera12105,388,672 - 105,429,552 (+)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12102,783,830 - 102,824,712 (+)NCBIHuRef
CHM1_112105,690,112 - 105,730,974 (+)NCBICHM1_1
T2T-CHM13v2.012105,292,506 - 105,333,339 (+)NCBIT2T-CHM13v2.0
1500009L16Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391083,558,560 - 83,598,626 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1083,558,729 - 83,598,626 (+)EnsemblGRCm39 Ensembl
GRCm381083,722,693 - 83,762,762 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1083,722,865 - 83,762,762 (+)EnsemblGRCm38mm10GRCm38
MGSCv371083,185,610 - 83,225,507 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361083,152,664 - 83,192,310 (+)NCBIMGSCv36mm8
Celera1085,709,974 - 85,750,013 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1041.3NCBI
CUNH12orf75
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540539,595,769 - 39,622,859 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540539,595,762 - 39,623,671 (+)NCBIChiLan1.0ChiLan1.0
C10H12orf75
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210113,401,052 - 113,442,206 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112113,397,436 - 113,438,868 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012102,913,263 - 102,954,656 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
C10H12orf75
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11033,093,491 - 33,100,926 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1033,013,174 - 33,050,168 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01033,935,462 - 33,972,458 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11033,670,306 - 33,707,315 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01033,954,607 - 33,991,564 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01034,147,987 - 34,184,951 (-)NCBIUU_Cfam_GSD_1.0
C5H12orf75
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl514,720,120 - 14,755,815 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1514,720,117 - 14,755,750 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2515,186,667 - 15,207,603 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CUNH12orf75
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111100,537,787 - 100,580,873 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037144,436,350 - 144,478,593 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUNH12orf75
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247503,708,392 - 3,738,404 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247503,708,392 - 3,738,426 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C7h12orf75
441 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)71816950526029351Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)71903280735526300Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat

Markers in Region
RH132397  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2720,015,367 - 20,015,557 (+)MAPPERmRatBN7.2
Rnor_6.0725,738,245 - 25,738,434NCBIRnor6.0
Rnor_5.0725,873,511 - 25,873,700UniSTSRnor5.0
RGSC_v3.4722,155,819 - 22,156,008UniSTSRGSC3.4
Celera717,219,958 - 17,220,147UniSTS
RH 3.4 Map7118.25UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 4 4 72 18 26
Low 3 35 17 6 4 6 5 5 2 17 15 11 5
Below cutoff 8 28 23 13 23 3 6 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000083450   ⟹   ENSRNOP00000075676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl720,015,102 - 20,057,975 (-)Ensembl
Rnor_6.0 Ensembl725,737,979 - 25,743,537 (-)Ensembl
RefSeq Acc Id: NM_001271382   ⟹   NP_001258311
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8721,902,745 - 21,945,549 (-)NCBI
mRatBN7.2720,015,102 - 20,057,913 (-)NCBI
Rnor_6.0725,737,979 - 26,180,246 (-)NCBI
Rnor_5.0725,873,245 - 25,878,804 (-)NCBI
Celera717,219,692 - 17,263,022 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765212   ⟹   XP_008763434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8721,902,749 - 21,945,704 (-)NCBI
mRatBN7.2720,015,106 - 20,058,448 (-)NCBI
Rnor_6.0725,737,979 - 26,180,359 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063262853   ⟹   XP_063118923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8721,902,749 - 21,945,704 (-)NCBI
RefSeq Acc Id: XM_063262854   ⟹   XP_063118924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8721,902,749 - 21,945,704 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001258311 (Get FASTA)   NCBI Sequence Viewer  
  XP_008763434 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118923 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118924 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM17086 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075676
  ENSRNOP00000075676.2
GenBank Protein P0CD96 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001258311   ⟸   NM_001271382
- UniProtKB: P0CD96 (UniProtKB/Swiss-Prot),   A0A0G2KB69 (UniProtKB/TrEMBL),   A6IFG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763434   ⟸   XM_008765212
- Peptide Label: isoform X1
- UniProtKB: P0CD96 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075676   ⟸   ENSRNOT00000083450
RefSeq Acc Id: XP_063118923   ⟸   XM_063262853
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063118924   ⟸   XM_063262854
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KB69-F1-model_v2 AlphaFold A0A0G2KB69 1-39 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:6495714 AgrOrtholog
BioCyc Gene G2FUF-34597 BioCyc
Ensembl Genes ENSRNOG00000060879 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083450 ENTREZGENE
  ENSRNOT00000083450.2 UniProtKB/TrEMBL
InterPro OCC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:100910996 UniProtKB/TrEMBL
NCBI Gene LOC100910996 ENTREZGENE
PANTHER OVEREXPRESSED IN COLON CARCINOMA 1 PROTEIN UniProtKB/Swiss-Prot
  OVEREXPRESSED IN COLON CARCINOMA 1 PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR38502 UniProtKB/TrEMBL
Pfam OCC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen C7h12orf75 PhenoGen
RatGTEx ENSRNOG00000060879 RatGTEx
UniProt A0A0G2KB69 ENTREZGENE, UniProtKB/TrEMBL
  A6IFG2 ENTREZGENE, UniProtKB/TrEMBL
  OCC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 C7h12orf75  similar to human chromosome 12 open reading frame 75  LOC100910996  uncharacterized LOC100910996  Symbol and Name Changed 1299863 APPROVED
2015-07-29 LOC100910996  uncharacterized LOC100910996  LOC691876  hypothetical protein LOC691876  Data merged from RGD:1594605 737654 PROVISIONAL
2012-07-05 LOC100910996  uncharacterized LOC100910996      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-06-15 LOC691876  hypothetical protein LOC691876  LOC687663  hypothetical protein LOC687663  Data merged from RGD:1583044 1643240 APPROVED
2006-11-20 LOC691876  hypothetical protein LOC691876      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687663  hypothetical protein LOC687663      Symbol and Name status set to provisional 70820 PROVISIONAL