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Gene: LOC100911548 (SPRY domain-containing SOCS box protein 2-like) Rattus norvegicus
Symbol: LOC100911548
Name: SPRY domain-containing SOCS box protein 2-like
RGD ID: 6492498
Description: Predicted to have ubiquitin ligase-substrate adaptor activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to localize to cytosol. Orthologous to human SPSB2 (splA/ryanodine receptor domain and SOCS box containing 2).
Type: protein-coding
RefSeq Status: MODEL
Also known as: SPRY domain-containing SOCS box protein 2
No known orthologs. homologs ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Note: LOC100911548 (GeneID: 100911548) appears to be a duplicate placement of Spsb2 (GeneID: 297592) on Rnor_6.0 (Annot. Release 105) that is absent from Rn_Celera and is not supported by syntenic regions in mouse and human. BLAST analysis of the underlying component AABR07066868.1 against the rat genome shows 88% coverage and 99% identity with NC_005103.4, at the location where Spsb2 is annotated. Annotation of Spsb2 (GeneID: 297592) at this location on Rnor_6.0 is supported by annotation on Rn_Celera and synteny with mouse and human. This apparent duplication could be explained by misassembly of several underlying components on Rnor_6.0. LOC100911548 is bracketed by two genes, Gpr116 and Gpr110, which serve as a useful frame of reference, on the rat reference assembly. The region between these two genes also includes several other genes with names beginning with "LOC". However, on the Celera assembly as well as at the syntenic region in the mouse genome, these "LOC" genes are not annotated between Gpr116 and Gpr110. This suggests that the underlying components for these "LOC" genes could be misassembled in Rnor_6.0, including AABR07066868.1, AABR07066869.1, and AABR07066870.1. [12 Mar 2015]
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0920,217,278 - 20,219,677 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl920,217,278 - 20,219,209 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0919,092,915 - 19,095,645 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene Ontology Annotations
References - curated


Position Markers
QTLs in Region (Rnor_6.0)


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on LOC100911548
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 6492498
Created: 2012-07-05
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.