MIR5581 (microRNA 5581) - Rat Genome Database

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Pathways
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Gene: MIR5581 (microRNA 5581) Homo sapiens
Analyze
Symbol: MIR5581
Name: microRNA 5581
RGD ID: 6483949
HGNC Page HGNC:43527
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38137,500,935 - 37,500,994 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl137,500,935 - 37,500,994 (-)EnsemblGRCh38hg38GRCh38
GRCh37137,966,536 - 37,966,595 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map1p34.3NCBI
HuRef136,083,320 - 36,083,379 (-)NCBIHuRef
CHM1_1138,082,663 - 38,082,722 (-)NCBICHM1_1
T2T-CHM13v2.0137,365,686 - 37,365,745 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:21911355   PMID:30825207  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p36.11-34.2(chr1:24381206-41401517)x3 copy number gain See cases [RCV000138891] Chr1:24381206..41401517 [GRCh38]
Chr1:24707696..41886350 [GRCh37]
Chr1:24580283..41658937 [NCBI36]
Chr1:1p36.11-34.2		 pathogenic
GRCh38/hg38 1p34.3(chr1:37443860-37704418)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053658]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053658]|See cases [RCV000053658] Chr1:37443860..37704418 [GRCh38]
Chr1:37909461..38170090 [GRCh37]
Chr1:37682048..37942677 [NCBI36]
Chr1:1p34.3		 benign
Single allele inversion Bilateral polymicrogyria [RCV003459046] Chr1:33246132..61045156 [GRCh38]
Chr1:1p35.1-31.3		 likely pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:46921
Count of gene targets:17598
Count of transcripts:38420
Interacting mature miRNAs:hsa-miR-5581-3p, hsa-miR-5581-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 76 7 60 45 338 49 44 39 90 47 121 154 3 2
Low 124 23 182 130 271 128 224 32 89 160 150 192 7 8 14 4
Below cutoff 2 4 4 6 5 5 1 3 4

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000580821
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl137,500,935 - 37,500,994 (-)Ensembl
RefSeq Acc Id: NR_049844
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38137,500,935 - 37,500,994 (-)NCBI
GRCh37137,966,536 - 37,966,595 (-)NCBI
HuRef136,083,320 - 36,083,379 (-)NCBI
CHM1_1138,082,663 - 38,082,722 (-)NCBI
T2T-CHM13v2.0137,365,686 - 37,365,745 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR5581 COSMIC
Ensembl Genes ENSG00000263675 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000580821 ENTREZGENE
GTEx ENSG00000263675 GTEx
HGNC ID HGNC:43527 ENTREZGENE
Human Proteome Map MIR5581 Human Proteome Map
miRBase MI0019136 ENTREZGENE
NCBI Gene MIR5581 ENTREZGENE
RNAcentral URS00001E2F7A RNACentral
  URS000075AD14 RNACentral
  URS000075EF33 RNACentral