MIR5699 (microRNA 5699) - Rat Genome Database
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Gene: MIR5699 (microRNA 5699) Homo sapiens
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Symbol: MIR5699
Name: microRNA 5699
RGD ID: 6483934
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-5699
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10641,689 - 641,778 (-)EnsemblGRCh38hg38GRCh38
GRCh3810641,689 - 641,778 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710687,629 - 687,718 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map10p15.3NCBI
HuRef10632,580 - 632,669 (-)NCBIHuRef
CHM1_110687,401 - 687,490 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:21037258   PMID:21980368   PMID:23034410  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:63654
Count of gene targets:20325
Count of transcripts:49922
Interacting mature miRNAs:hsa-miR-5699-3p, hsa-miR-5699-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1
Low 43 28 25 15 26 17 94 30 108 43 105 41 10 40 2
Below cutoff 44 25 19 8 11 9 60 37 71 17 62 30 1 21 26 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000578903
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10641,689 - 641,778 (-)Ensembl
RefSeq Acc Id: NR_049884
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810641,689 - 641,778 (-)NCBI
GRCh3710687,629 - 687,718 (-)NCBI
HuRef10632,580 - 632,669 (-)NCBI
CHM1_110687,401 - 687,490 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10p15.3-13(chr10:73856-12815915)x3 copy number gain See cases [RCV000135340] Chr10:73856..12815915 [GRCh38]
Chr10:119796..12857914 [GRCh37]
Chr10:109796..12897920 [NCBI36]
Chr10:10p15.3-13
pathogenic
GRCh38/hg38 10p15.3-15.2(chr10:90421-3058742)x1 copy number loss See cases [RCV000135585] Chr10:90421..3058742 [GRCh38]
Chr10:224406..3100934 [GRCh37]
Chr10:126361..3090934 [NCBI36]
Chr10:10p15.3-15.2
likely pathogenic
GRCh38/hg38 10p15.3-14(chr10:90421-11713049)x3 copy number gain See cases [RCV000135533] Chr10:90421..11713049 [GRCh38]
Chr10:224406..11755048 [GRCh37]
Chr10:126361..11795054 [NCBI36]
Chr10:10p15.3-14
pathogenic|uncertain significance
GRCh38/hg38 10p15.3-13(chr10:70478-15373336)x3 copy number gain See cases [RCV000137384] Chr10:70478..15373336 [GRCh38]
Chr10:224406..15415335 [GRCh37]
Chr10:106418..15455341 [NCBI36]
Chr10:10p15.3-13
uncertain significance
GRCh38/hg38 10p15.3(chr10:457461-770688)x1 copy number loss See cases [RCV000137770] Chr10:457461..770688 [GRCh38]
Chr10:503401..816628 [GRCh37]
Chr10:493401..806628 [NCBI36]
Chr10:10p15.3
likely benign
GRCh38/hg38 10p15.3(chr10:70478-1759743)x3 copy number gain See cases [RCV000138245] Chr10:70478..1759743 [GRCh38]
Chr10:224406..1801937 [GRCh37]
Chr10:106418..1791937 [NCBI36]
Chr10:10p15.3
uncertain significance
GRCh38/hg38 10p15.3(chr10:490764-770688)x3 copy number gain See cases [RCV000138351] Chr10:490764..770688 [GRCh38]
Chr10:536704..816628 [GRCh37]
Chr10:526704..806628 [NCBI36]
Chr10:10p15.3
uncertain significance
GRCh38/hg38 10p15.3-12.1(chr10:90205-26339978)x3 copy number gain See cases [RCV000138428] Chr10:90205..26339978 [GRCh38]
Chr10:224406..26628907 [GRCh37]
Chr10:126145..26668913 [NCBI36]
Chr10:10p15.3-12.1
pathogenic
GRCh38/hg38 10p15.3-15.2(chr10:538646-3636571)x1 copy number loss See cases [RCV000138321] Chr10:538646..3636571 [GRCh38]
Chr10:584586..3678763 [GRCh37]
Chr10:574586..3668763 [NCBI36]
Chr10:10p15.3-15.2
uncertain significance
GRCh38/hg38 10p15.3(chr10:490767-771136)x3 copy number gain See cases [RCV000139394] Chr10:490767..771136 [GRCh38]
Chr10:536707..817076 [GRCh37]
Chr10:526707..807076 [NCBI36]
Chr10:10p15.3
likely benign
GRCh38/hg38 10p15.3(chr10:70478-770688)x1 copy number loss See cases [RCV000139016] Chr10:70478..770688 [GRCh38]
Chr10:224406..816628 [GRCh37]
Chr10:106418..806628 [NCBI36]
Chr10:10p15.3
likely pathogenic
GRCh38/hg38 10p15.3-13(chr10:70478-13736564)x1 copy number loss See cases [RCV000138960] Chr10:70478..13736564 [GRCh38]
Chr10:224406..13778564 [GRCh37]
Chr10:106418..13818570 [NCBI36]
Chr10:10p15.3-13
pathogenic
GRCh38/hg38 10p15.3(chr10:70478-1042794)x1 copy number loss See cases [RCV000139192] Chr10:70478..1042794 [GRCh38]
Chr10:224406..1088734 [GRCh37]
Chr10:106418..1078734 [NCBI36]
Chr10:10p15.3
likely pathogenic
GRCh38/hg38 10p15.3-13(chr10:54086-13205916)x3 copy number gain See cases [RCV000142292] Chr10:54086..13205916 [GRCh38]
Chr10:100026..13247916 [GRCh37]
Chr10:90026..13287922 [NCBI36]
Chr10:10p15.3-13
pathogenic
GRCh38/hg38 10p15.3(chr10:54086-1600803)x1 copy number loss See cases [RCV000142235] Chr10:54086..1600803 [GRCh38]
Chr10:100026..1642998 [GRCh37]
Chr10:90026..1632998 [NCBI36]
Chr10:10p15.3
pathogenic
GRCh38/hg38 10p15.3-12.31(chr10:54086-19336980)x1 copy number loss See cases [RCV000143703] Chr10:54086..19336980 [GRCh38]
Chr10:100026..19625909 [GRCh37]
Chr10:90026..19665915 [NCBI36]
Chr10:10p15.3-12.31
pathogenic|likely pathogenic
GRCh38/hg38 10p15.3-14(chr10:90421-8442783)x3 copy number gain See cases [RCV000051107] Chr10:90421..8442783 [GRCh38]
Chr10:224406..8484746 [GRCh37]
Chr10:126361..8524752 [NCBI36]
Chr10:10p15.3-14
pathogenic
GRCh38/hg38 10p15.3-14(chr10:90421-6769994)x3 copy number gain See cases [RCV000051132] Chr10:90421..6769994 [GRCh38]
Chr10:224406..6811956 [GRCh37]
Chr10:126361..6851962 [NCBI36]
Chr10:10p15.3-14
pathogenic
GRCh38/hg38 10p15.3-15.1(chr10:69260-6209368)x1 copy number loss See cases [RCV000052493] Chr10:69260..6209368 [GRCh38]
Chr10:224406..6251331 [GRCh37]
Chr10:105200..6291337 [NCBI36]
Chr10:10p15.3-15.1
pathogenic
GRCh38/hg38 10p15.3(chr10:87458-2482736)x1 copy number loss See cases [RCV000052494] Chr10:87458..2482736 [GRCh38]
Chr10:224406..2524928 [GRCh37]
Chr10:123398..2514928 [NCBI36]
Chr10:10p15.3
pathogenic
GRCh38/hg38 10p15.3(chr10:90221-1843892)x1 copy number loss See cases [RCV000052495] Chr10:90221..1843892 [GRCh38]
Chr10:224406..1886086 [GRCh37]
Chr10:126161..1876086 [NCBI36]
Chr10:10p15.3
pathogenic
GRCh38/hg38 10p15.3-13(chr10:90421-15569528)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052496]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052496]|See cases [RCV000052496] Chr10:90421..15569528 [GRCh38]
Chr10:224406..15611527 [GRCh37]
Chr10:126361..15651533 [NCBI36]
Chr10:10p15.3-13
pathogenic
GRCh38/hg38 10p15.3(chr10:90421-2894483)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052498]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052498]|See cases [RCV000052498] Chr10:90421..2894483 [GRCh38]
Chr10:224406..2936675 [GRCh37]
Chr10:126361..2926675 [NCBI36]
Chr10:10p15.3
pathogenic
GRCh38/hg38 10p15.3-12.31(chr10:69261-19184047)x3 copy number gain See cases [RCV000053507] Chr10:69261..19184047 [GRCh38]
Chr10:224406..19472976 [GRCh37]
Chr10:105201..19512982 [NCBI36]
Chr10:10p15.3-12.31
pathogenic
GRCh38/hg38 10p15.3-12.2(chr10:90221-22567425)x3 copy number gain See cases [RCV000053508] Chr10:90221..22567425 [GRCh38]
Chr10:224406..22856354 [GRCh37]
Chr10:126161..22896360 [NCBI36]
Chr10:10p15.3-12.2
pathogenic
GRCh38/hg38 10p15.3-14(chr10:90421-7085100)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053511]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053511]|See cases [RCV000053511] Chr10:90421..7085100 [GRCh38]
Chr10:224406..7127062 [GRCh37]
Chr10:126361..7167068 [NCBI36]
Chr10:10p15.3-14
pathogenic
GRCh38/hg38 10p15.3-12.1(chr10:90421-29058318)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053512]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053512]|See cases [RCV000053512] Chr10:90421..29058318 [GRCh38]
Chr10:224406..29347247 [GRCh37]
Chr10:126361..29387253 [NCBI36]
Chr10:10p15.3-12.1
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR5699 COSMIC
Ensembl Genes ENSG00000263511 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000578903 ENTREZGENE
GTEx ENSG00000263511 GTEx
HGNC ID HGNC:43456 ENTREZGENE
Human Proteome Map MIR5699 Human Proteome Map
miRBase MI0019306 ENTREZGENE
NCBI Gene MIR5699 ENTREZGENE
RNAcentral URS0000331800 RNACentral
  URS000075E251 RNACentral
  URS000075E5A8 RNACentral