MIR5690 (microRNA 5690) - Rat Genome Database

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Pathways
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Gene: MIR5690 (microRNA 5690) Homo sapiens
Analyze
Symbol: MIR5690
Name: microRNA 5690
RGD ID: 6483901
HGNC Page HGNC:43490
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38635,664,717 - 35,664,789 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl635,664,717 - 35,664,789 (-)EnsemblGRCh38hg38GRCh38
GRCh37635,632,494 - 35,632,566 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map6p21.31NCBI
HuRef635,349,706 - 35,349,778 (-)NCBIHuRef
CHM1_1635,631,186 - 35,631,258 (-)NCBICHM1_1
T2T-CHM13v2.0635,484,473 - 35,484,545 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:21980368  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:13312
Count of gene targets:6678
Count of transcripts:11394
Interacting mature miRNAs:hsa-miR-5690
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 1 1
Medium 1 2 4 24 1 9 2 1
Low 48 18 92 72 198 73 57 28 47 76 86 74 1 2 19
Below cutoff 10 3 8 9 1 13 9 15 14 14 16 1 7 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000583739
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl635,664,717 - 35,664,789 (-)Ensembl
RefSeq Acc Id: NR_049873
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38635,664,717 - 35,664,789 (-)NCBI
GRCh37635,632,494 - 35,632,566 (-)NCBI
HuRef635,349,706 - 35,349,778 (-)NCBI
CHM1_1635,631,186 - 35,631,258 (-)NCBI
T2T-CHM13v2.0635,484,473 - 35,484,545 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR5690 COSMIC
Ensembl Genes ENSG00000265527 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000583739 ENTREZGENE
GTEx ENSG00000265527 GTEx
HGNC ID HGNC:43490 ENTREZGENE
Human Proteome Map MIR5690 Human Proteome Map
miRBase MI0019295 ENTREZGENE
NCBI Gene MIR5690 ENTREZGENE
RNAcentral URS000075B186 RNACentral
  URS000075F055 RNACentral