Taar7d (trace-amine-associated receptor 7d) - Rat Genome Database

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Gene: Taar7d (trace-amine-associated receptor 7d) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Taar7d
Name: trace-amine-associated receptor 7d
RGD ID: 631395
Description: Enables trace-amine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Is active in plasma membrane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ta15; Taar7c; taR-15; taR-7d; trace amine associated receptor 7d; trace amine receptor 15; trace amine receptor 7d; trace amine-associated receptor 7d; trace-amine-associated receptor 7c
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8123,228,573 - 23,229,649 (-)NCBIGRCr8
mRatBN7.2121,409,325 - 21,410,401 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,409,325 - 21,410,401 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx121,186,430 - 21,187,506 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,186,459 - 27,187,535 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,386,179 - 21,387,255 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,487,055 - 22,488,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,487,055 - 22,488,131 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,963,811 - 23,964,887 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,934,361 - 21,935,437 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1121,937,305 - 21,938,382 (-)NCBI
Celera120,159,807 - 20,160,883 (-)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
plasma membrane  (IBA,IDA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Trace amines: identification of a family of mammalian G protein-coupled receptors. Borowsky B, etal., Proc Natl Acad Sci U S A 2001 Jul 31;98(16):8966-71.
2. Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity. Ferrero DM, etal., ACS Chem Biol. 2012 Jul 20;7(7):1184-9. doi: 10.1021/cb300111e. Epub 2012 May 7.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Structural basis of amine odorant perception by a mammal olfactory receptor. Guo L, etal., Nature. 2023 Jun;618(7963):193-200. doi: 10.1038/s41586-023-06106-4. Epub 2023 May 24.
5. GOA pipeline RGD automated data pipeline
Additional References at PubMed
PMID:15718104   PMID:16584120   PMID:17556730  


Genomics

Variants

.
Variants in Taar7d
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:58
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000051416
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1592587724697545Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat


Expression

RNA-SEQ Expression

mesenchyme
renal system
reproductive system
2 2 16

Sequence


Ensembl Acc Id: ENSRNOT00000051416   ⟹   ENSRNOP00000049417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl121,409,325 - 21,410,401 (-)Ensembl
Rnor_6.0 Ensembl122,487,055 - 22,488,131 (-)Ensembl
RefSeq Acc Id: NM_175591   ⟹   NP_783181
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8123,228,573 - 23,229,649 (-)NCBI
mRatBN7.2121,409,325 - 21,410,401 (-)NCBI
Rnor_6.0122,487,055 - 22,488,131 (-)NCBI
Rnor_5.0123,963,811 - 23,964,887 (-)NCBI
RGSC_v3.4121,934,361 - 21,935,437 (-)RGD
Celera120,159,807 - 20,160,883 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_783181 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK71254 (Get FASTA)   NCBI Sequence Viewer  
  AAV70133 (Get FASTA)   NCBI Sequence Viewer  
  EDL87756 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000049417.1
GenBank Protein Q923X5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_783181   ⟸   NM_175591
- UniProtKB: Q923X5 (UniProtKB/Swiss-Prot),   Q5QD20 (UniProtKB/TrEMBL),   F7F7B0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000049417   ⟸   ENSRNOT00000051416
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q923X5-F1-model_v2 AlphaFold Q923X5 1-358 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631395 AgrOrtholog
BioCyc Gene G2FUF-62089 BioCyc
Ensembl Genes ENSRNOG00000045914 Ensembl
  ENSRNOG00000068797 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051416.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAAR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:294134 UniProtKB/TrEMBL
NCBI Gene 294134 ENTREZGENE
PANTHER HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRACE AMINE-ASSOCIATED RECEPTOR 7E-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Taar7d PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRACEAMINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045914 RatGTEx
  ENSRNOG00000068797 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F7F7B0 ENTREZGENE, UniProtKB/TrEMBL
  Q5QD20 ENTREZGENE, UniProtKB/TrEMBL
  Q923X5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-31 Taar7d  trace-amine-associated receptor 7d  Taar7c_predicted  trace-amine-associated receptor 7c_predicted  Symbol and Name updated 1299863 APPROVED
2008-03-24 Taar7c_predicted  trace-amine-associated receptor 7c_predicted  Taar7c  trace-amine-associated receptor 7c  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-24 Taar7d_predicted  trace-amine-associated receptor 7d_predicted  Taar7d  trace-amine-associated receptor 7d  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-24 Taar7c  trace-amine-associated receptor 7c  Taar7d_predicted  trace-amine-associated receptor 7d_predicted  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-23 Taar7d  trace-amine-associated receptor 7d  Ta15  trace amine receptor 15  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-02-11 Tar15  trace amine receptor 15      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function functions as neurotransmitters for biogenic amines along with the orphan receptor PNR 634071
gene_product member of the rhodopsin mammalian G protein-coupled receptor family 634071