Osbpl1a (oxysterol binding protein-like 1A) - Rat Genome Database

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Gene: Osbpl1a (oxysterol binding protein-like 1A) Rattus norvegicus
Analyze
Symbol: Osbpl1a
Name: oxysterol binding protein-like 1A
RGD ID: 628888
Description: Predicted to enable cholesterol binding activity and sterol transporter activity. Predicted to be involved in sterol transport. Predicted to be located in late endosome and organelle membrane contact site. Predicted to be active in cytosol; intracellular membrane-bounded organelle; and membrane. Orthologous to human OSBPL1A (oxysterol binding protein like 1A); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ORP-1; OSBP-related protein 1; oxysterol-binding protein-related protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2183,904,006 - 4,094,635 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,904,006 - 4,094,585 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,127,907 - 4,317,941 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0184,915,466 - 5,105,503 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0184,174,553 - 4,365,195 (-)NCBIRnor_WKY
Rnor_6.0184,097,011 - 4,294,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,097,012 - 4,294,136 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0184,089,698 - 4,282,305 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera183,960,347 - 4,144,308 (-)NCBICelera
Cytogenetic Map18p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
levofloxacin  (EXP)
methapyrilene  (ISO)
methidathion  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
ozone  (ISO)
parathion  (ISO)
permethrin  (EXP)
pirinixic acid  (ISO)
rac-lactic acid  (ISO)
selenium atom  (ISO)
simvastatin  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Structural basis of FFAT motif-mediated ER targeting. Kaiser SE, etal., Structure. 2005 Jul;13(7):1035-45.
4. Androgen-regulated expression of a novel member of the aldo-keto reductase superfamily in regrowing rat prostate. Nishi N, etal., Endocrinology 2000 Sep;141(9):3194-9.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport. Xu Y, etal., J Biol Chem 2001 May 25;276(21):18407-14.
Additional References at PubMed
PMID:16176980   PMID:17428193   PMID:19056867  


Genomics

Comparative Map Data
Osbpl1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2183,904,006 - 4,094,635 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,904,006 - 4,094,585 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,127,907 - 4,317,941 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0184,915,466 - 5,105,503 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0184,174,553 - 4,365,195 (-)NCBIRnor_WKY
Rnor_6.0184,097,011 - 4,294,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,097,012 - 4,294,136 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0184,089,698 - 4,282,305 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera183,960,347 - 4,144,308 (-)NCBICelera
Cytogenetic Map18p13NCBI
OSBPL1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381824,162,045 - 24,397,824 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1824,162,045 - 24,397,880 (-)EnsemblGRCh38hg38GRCh38
GRCh371821,742,009 - 21,977,788 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361819,996,007 - 20,231,788 (-)NCBINCBI36Build 36hg18NCBI36
Build 341819,996,010 - 20,231,788NCBI
Celera1818,558,319 - 18,792,861 (-)NCBICelera
Cytogenetic Map18q11.2NCBI
HuRef1818,598,065 - 18,833,825 (-)NCBIHuRef
CHM1_11821,669,277 - 21,904,868 (-)NCBICHM1_1
T2T-CHM13v2.01824,356,384 - 24,592,135 (-)NCBIT2T-CHM13v2.0
Osbpl1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391812,886,955 - 13,074,933 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1812,888,371 - 13,074,898 (-)EnsemblGRCm39 Ensembl
GRCm381812,753,898 - 12,941,871 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1812,755,314 - 12,941,841 (-)EnsemblGRCm38mm10GRCm38
MGSCv371812,914,537 - 13,100,229 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361812,899,197 - 13,084,889 (-)NCBIMGSCv36mm8
Celera1812,987,816 - 13,172,462 (-)NCBICelera
Cytogenetic Map18A1NCBI
Osbpl1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540212,530,135 - 12,718,703 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540212,530,130 - 12,718,703 (-)NCBIChiLan1.0ChiLan1.0
OSBPL1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11821,037,587 - 21,270,216 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1821,037,586 - 21,270,216 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01817,414,824 - 17,669,178 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
OSBPL1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1763,995,570 - 64,223,213 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl763,995,184 - 64,222,157 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha763,444,473 - 63,672,084 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0764,054,333 - 64,281,774 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl764,054,357 - 64,281,762 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1763,724,290 - 63,951,485 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0763,738,846 - 63,966,751 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0764,043,599 - 64,271,300 (+)NCBIUU_Cfam_GSD_1.0
Osbpl1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494460,070,367 - 60,269,932 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365503,545,941 - 3,745,716 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OSBPL1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6108,997,735 - 109,221,010 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16108,997,730 - 109,241,950 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26101,663,953 - 101,813,634 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OSBPL1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11856,122,942 - 56,370,730 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1856,144,766 - 56,369,599 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605030,889,832 - 31,120,382 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Osbpl1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247707,864,036 - 8,054,881 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247707,855,776 - 8,054,886 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RH134647  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2183,905,580 - 3,906,784 (+)MAPPERmRatBN7.2
Rnor_6.0184,097,677 - 4,098,880NCBIRnor6.0
Rnor_5.0184,090,364 - 4,091,567UniSTSRnor5.0
Celera183,961,013 - 3,962,216UniSTS
RH 3.4 Map1883.01UniSTS
RH141432  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2183,906,129 - 3,906,318 (+)MAPPERmRatBN7.2
Rnor_6.0184,098,226 - 4,098,414NCBIRnor6.0
Rnor_5.0184,090,913 - 4,091,101UniSTSRnor5.0
Celera183,961,562 - 3,961,750UniSTS
RH141518  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2183,913,347 - 3,913,567 (+)MAPPERmRatBN7.2
Rnor_6.0184,105,448 - 4,105,667NCBIRnor6.0
Rnor_5.0184,098,135 - 4,098,354UniSTSRnor5.0
Celera183,968,784 - 3,969,003UniSTS
RH 3.4 Map1881.11UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor surface area measurement (CMO:0002078)18224947722066430Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18224947722066430Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:21
Count of miRNA genes:21
Interacting mature miRNAs:21
Transcripts:ENSRNOT00000072478
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 43 57 41 19 41 7 8 74 35 41 11 7
Low 2 1 3 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_172023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB089316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000091909   ⟹   ENSRNOP00000072477
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl183,904,006 - 4,094,585 (-)Ensembl
Rnor_6.0 Ensembl184,097,012 - 4,294,136 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119742   ⟹   ENSRNOP00000087195
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl183,904,916 - 4,003,290 (-)Ensembl
RefSeq Acc Id: NM_172023   ⟹   NP_742020
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2183,904,915 - 4,094,555 (-)NCBI
Rnor_6.0184,097,011 - 4,294,136 (-)NCBI
Rnor_5.0184,089,698 - 4,282,305 (-)NCBI
Celera183,960,347 - 4,144,308 (-)RGD
Sequence:
RefSeq Acc Id: XM_039096596   ⟹   XP_038952524
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2183,904,006 - 4,094,635 (-)NCBI
RefSeq Acc Id: XM_039096597   ⟹   XP_038952525
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2183,904,006 - 4,094,635 (-)NCBI
RefSeq Acc Id: XM_039096598   ⟹   XP_038952526
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2183,904,006 - 4,085,815 (-)NCBI
RefSeq Acc Id: XM_039096599   ⟹   XP_038952527
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2183,904,006 - 4,085,739 (-)NCBI
RefSeq Acc Id: XM_039096600   ⟹   XP_038952528
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2183,904,006 - 4,094,627 (-)NCBI
RefSeq Acc Id: XM_039096601   ⟹   XP_038952529
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2183,904,006 - 4,039,113 (-)NCBI
RefSeq Acc Id: XM_039096602   ⟹   XP_038952530
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2183,904,006 - 4,042,276 (-)NCBI
RefSeq Acc Id: XM_039096603   ⟹   XP_038952531
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2183,904,006 - 4,039,109 (-)NCBI
RefSeq Acc Id: XM_039096604   ⟹   XP_038952532
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2184,014,826 - 4,086,798 (-)NCBI
RefSeq Acc Id: XM_039096605   ⟹   XP_038952533
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2183,904,006 - 4,012,387 (-)NCBI
RefSeq Acc Id: XM_039096606   ⟹   XP_038952534
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2183,904,006 - 4,012,382 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_742020   ⟸   NM_172023
- UniProtKB: Q8K4M9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072477   ⟸   ENSRNOT00000091909
RefSeq Acc Id: XP_038952525   ⟸   XM_039096597
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952524   ⟸   XM_039096596
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952528   ⟸   XM_039096600
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038952526   ⟸   XM_039096598
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038952527   ⟸   XM_039096599
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038952530   ⟸   XM_039096602
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038952529   ⟸   XM_039096601
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038952531   ⟸   XM_039096603
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038952533   ⟸   XM_039096605
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038952534   ⟸   XM_039096606
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038952532   ⟸   XM_039096604
- Peptide Label: isoform X7
RefSeq Acc Id: ENSRNOP00000087195   ⟸   ENSRNOT00000119742
Protein Domains
PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K4M9-F1-model_v2 AlphaFold Q8K4M9 1-950 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700642
Promoter ID:EPDNEW_R11165
Type:single initiation site
Name:Osbpl1a_1
Description:oxysterol binding protein-like 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0184,294,114 - 4,294,174EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628888 AgrOrtholog
BioCyc Gene G2FUF-8352 BioCyc
Ensembl Genes ENSRNOG00000054058 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000072477 ENTREZGENE
  ENSRNOP00000072477.2 UniProtKB/TrEMBL
  ENSRNOP00000087195 ENTREZGENE
  ENSRNOP00000087195.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091909 ENTREZGENE
  ENSRNOT00000091909.2 UniProtKB/TrEMBL
  ENSRNOT00000119742 ENTREZGENE
  ENSRNOT00000119742.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OSBP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oxysterol-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oxysterol-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:259221 UniProtKB/Swiss-Prot
NCBI Gene 259221 ENTREZGENE
PANTHER PTHR10972 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ank_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oxysterol_BP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Osbpl1a PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OSBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF144000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K327_RAT UniProtKB/TrEMBL
  A0A8I6GFS2_RAT UniProtKB/TrEMBL
  OSBL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Osbpl1a  oxysterol binding protein-like 1A      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Osbpl1a  oxysterol binding protein-like 1A      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in various adult rat tissues and also the ventral and dorsolateral prostates 631985
gene_process may be involved in growth-related processes in the prostate 631985