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Gene: Kcng3 (potassium voltage-gated channel modifier subfamily G member 3) Rattus norvegicus

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Symbol:

Kcng3

Name:

potassium voltage-gated channel modifier subfamily G member 3

RGD ID:

628832

Description:

Enables potassium channel regulator activity. Acts upstream of or within regulation of potassium ion transport. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Orthologous to human KCNG3 (potassium voltage-gated channel modifier subfamily G member 3); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Kv10.1; Kv6.3; potassium channel, voltage gated modifier subfamily G, member 3; potassium voltage-gated channel subfamily G member 3; potassium voltage-gated channel subfamily G memeber 3; potassium voltage-gated channel, subfamily G, member 3; potassium voltage-gated channel, subfamily G, memeber 3; voltage-gated potassium channel 6.3; voltage-gated potassium channel regulatory subunit KCNG3; voltage-gated potassium channel subunit Kv10.1; voltage-gated potassium channel subunit Kv6.3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	16,803,842 - 16,851,791 (+)	NCBI		GRCr8
mRatBN7.2	6	11,051,311 - 11,099,264 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	11,051,134 - 11,099,264 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	11,345,533 - 11,393,536 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	11,654,858 - 11,702,861 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	11,167,797 - 11,215,815 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	6,794,808 - 6,842,758 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	6,794,808 - 6,842,758 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	6,749,225 - 6,797,221 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	6,947,526 - 6,995,735 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	6,947,767 - 6,995,429 (-)	NCBI
Celera	6	10,756,043 - 10,803,960 (+)	NCBI		Celera
Cytogenetic Map	6	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Lynch syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aldehydo-D-glucose (ISO)

amitrole (EXP)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

butanal (ISO)

cadmium dichloride (ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

choline (ISO)

copper atom (ISO)

copper(0) (ISO)

D-glucose (ISO)

dorsomorphin (ISO)

fenvalerate (EXP)

folic acid (ISO)

fonofos (ISO)

fructose (ISO)

fulvestrant (ISO)

glucose (ISO)

glyphosate (EXP)

herbicide (ISO)

L-methionine (ISO)

leflunomide (ISO)

lipopolysaccharide (ISO)

methimazole (EXP)

Muraglitazar (EXP)

N-nitrosodiethylamine (EXP)

nickel sulfate (ISO)

paracetamol (EXP)

parathion (ISO)

pentanal (ISO)

phenethyl caffeate (EXP)

phenylmercury acetate (ISO)

propanal (ISO)

propiconazole (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

terbufos (ISO)

Tesaglitazar (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

troglitazone (EXP)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

action potential (IBA)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

potassium ion transmembrane transport (IBA,IEA)

potassium ion transport (IEA)

protein homooligomerization (IEA)

regulation of potassium ion transmembrane transport (IEA,ISO)

regulation of potassium ion transport (IEA,IGI,ISO,ISS)

transmembrane transport (IEA)

Cellular Component

cytoplasm (IEA)

endoplasmic reticulum (IEA,ISO)

membrane (IBA,IEA)

monoatomic ion channel complex (IEA)

plasma membrane (IEA,ISO,ISS)

voltage-gated potassium channel complex (IBA,IEA,ISO,ISS)

Molecular Function

monoatomic ion channel activity (IEA)

potassium channel activity (IEA)

potassium channel regulator activity (IBA,IEA,IGI,ISO,ISS)

protein binding (ISO)

voltage-gated potassium channel activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1.	Sano Y, etal., FEBS Lett 2002 Feb 13;512(1-3):230-4.
7.	Modification of Kv2.1 K+ currents by the silent Kv10 subunits.	Vega-Saenz de Miera EC Brain Res Mol Brain Res. 2004 Apr 7;123(1-2):91-103.

Additional References at PubMed

PMID:12060745	PMID:19074135

Genomics

Comparative Map Data

Kcng3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	16,803,842 - 16,851,791 (+)	NCBI		GRCr8
mRatBN7.2	6	11,051,311 - 11,099,264 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	11,051,134 - 11,099,264 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	11,345,533 - 11,393,536 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	11,654,858 - 11,702,861 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	11,167,797 - 11,215,815 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	6,794,808 - 6,842,758 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	6,794,808 - 6,842,758 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	6,749,225 - 6,797,221 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	6,947,526 - 6,995,735 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	6,947,767 - 6,995,429 (-)	NCBI
Celera	6	10,756,043 - 10,803,960 (+)	NCBI		Celera
Cytogenetic Map	6	q12	NCBI

KCNG3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	42,388,352 - 42,493,982 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	42,442,017 - 42,493,982 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	42,669,157 - 42,721,122 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	42,522,661 - 42,574,741 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	42,580,807 - 42,632,888	NCBI
Celera	2	42,509,472 - 42,561,403 (-)	NCBI		Celera
Cytogenetic Map	2	p21	NCBI
HuRef	2	42,403,435 - 42,455,714 (-)	NCBI		HuRef
CHM1_1	2	42,598,567 - 42,650,647 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	42,393,706 - 42,499,421 (-)	NCBI		T2T-CHM13v2.0

Kcng3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	83,881,452 - 83,939,595 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	83,893,386 - 83,939,324 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	83,574,023 - 83,631,995 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	83,585,957 - 83,631,895 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	83,985,297 - 84,031,235 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	83,494,283 - 83,540,221 (-)	NCBI		MGSCv36	mm8
Celera	17	87,928,594 - 87,993,545 (-)	NCBI		Celera
Cytogenetic Map	17	E4	NCBI
cM Map	17	53.64	NCBI

Kcng3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955441	9,816,209 - 9,860,707 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955441	9,813,391 - 9,859,960 (-)	NCBI	ChiLan1.0	ChiLan1.0

KCNG3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	83,914,398 - 84,019,873 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	83,918,371 - 84,023,846 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	42,513,259 - 42,593,248 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	43,392,545 - 43,443,078 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	43,392,545 - 43,443,084 (-)	Ensembl	panpan1.1		panPan2

KCNG3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	33,999,911 - 34,080,415 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	34,022,261 - 34,080,603 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	33,804,516 - 33,851,663 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	34,802,688 - 34,850,084 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	17	33,927,604 - 33,975,280 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	33,989,902 - 34,037,224 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	34,207,516 - 34,255,093 (-)	NCBI		UU_Cfam_GSD_1.0

Kcng3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	37,750,522 - 37,787,396 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936508	9,178,964 - 9,220,221 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936508	9,179,131 - 9,216,996 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KCNG3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	97,830,678 - 97,885,064 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	97,830,795 - 97,887,582 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	103,965,694 - 104,021,093 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KCNG3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	64,756,221 - 64,812,337 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	64,756,825 - 64,810,421 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	47,094,441 - 47,151,636 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kcng3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	24,130,784 - 24,173,631 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	24,127,981 - 24,173,728 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Kcng3
217 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	184
Count of miRNA genes:	142
Interacting mature miRNAs:	151
Transcripts:	ENSRNOT00000006094
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1	41223769	Rat
1549905	Stresp10	Stress response QTL 10	6.83	0.0066	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	6	1	27574569	Rat
8693699	Alc37	Alcohol consumption QTL 37	2.6	0.224	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	6	7964167	21301982	Rat
1331743	Uae28	Urinary albumin excretion QTL 28	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	1	34235784	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	54641141	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1	41223769	Rat
1578758	Tcas9	Tongue tumor susceptibility QTL 9	3.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	6	1	37618905	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	41223769	Rat
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	39036266	Rat
738024	Sach5	Saccharine consumption QTL 5	3.9	0.00039	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	6	1	43394190	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1	41223769	Rat
2293706	Bmd20	Bone mineral density QTL 20	4.3	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	5074497	19988050	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1	41223769	Rat
2292616	Ept15	Estrogen-induced pituitary tumorigenesis QTL 15	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	9843312	20338915	Rat
738023	Alc17	Alcohol consumption QTL 17	3.1	0.003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	6	1	27574569	Rat
1354616	Despr12	Despair related QTL 12		0.0012	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	6	1	27574569	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	1	42487980	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	1	42487980	Rat
7411584	Foco4	Food consumption QTL 4	4.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	42838846	Rat
2300176	Bmd51	Bone mineral density QTL 51	11.7	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	6	1	27574569	Rat
1300128	Rf16	Renal function QTL 16	3.89		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	34434305	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	72227641	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	1	42487980	Rat
1358190	Ept1	Estrogen-induced pituitary tumorigenesis QTL 1	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	9843312	20338915	Rat
2300190	Bmd52	Bone mineral density QTL 52	11.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	6	1	27574569	Rat
8693690	Alc35	Alcohol consumption QTL 35	2.2	0.606	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	6	7964167	21301982	Rat

Markers in Region

RH143571

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	11,051,670 - 11,051,894 (-)	MAPPER	mRatBN7.2
Rnor_6.0	6	6,842,175 - 6,842,398	NCBI	Rnor6.0
Rnor_5.0	6	6,796,638 - 6,796,861	UniSTS	Rnor5.0
RGSC_v3.4	6	6,995,152 - 6,995,375	UniSTS	RGSC3.4
Celera	6	10,756,359 - 10,756,582	UniSTS
RH 3.4 Map	14	478.49	UniSTS
Cytogenetic Map	6	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	7	30	99	62	59	30	25	30	6	164	75	79	43	60	29

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001033957	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_133426	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB070605	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC112092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF454549	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF454550	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000006094 ⟹ ENSRNOP00000006094

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	11,051,134 - 11,099,264 (+)	Ensembl
Rnor_6.0 Ensembl	6	6,794,808 - 6,842,758 (-)	Ensembl

RefSeq Acc Id:

NM_001033957 ⟹ NP_001029129

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	16,803,842 - 16,851,791 (+)	NCBI
mRatBN7.2	6	11,051,311 - 11,099,264 (+)	NCBI
Rnor_6.0	6	6,794,808 - 6,842,758 (-)	NCBI
Rnor_5.0	6	6,749,225 - 6,797,221 (-)	NCBI
RGSC_v3.4	6	6,947,526 - 6,995,735 (-)	RGD
Celera	6	10,756,043 - 10,803,960 (+)	NCBI

Sequence:

show sequence

CACCCCGTGCGCGCGGCGGGCAGGCCCCCGGGGCGGCCAGCCATGACCTTCGGGCGCGGCGGGG
CGGCCTCGGTGGTGCTGAACGTGGGCGGCGCCCGGTACTCGCTGTCCCGGGAGCTGCTCAAGGA
CTTCCCGCTGCGCCGTGTGAGCCGGCTGCACGGCTGCCGCTCGGAGCGCGACGTGCTCGAGGTG
TGCGACGACTACGACCGGGAGCGCAACGAGTACTTCTTCGACCGGCACTCGGAGGCCTTCGGCT
TCATCCTGCTGTACGTGCGCGGCCACGGGAAGCTGCGCTTCGCGCCGCGGATGTGCGAGCTCTC
CTTCTACAACGAGATGATCTACTGGGGCCTGGAGGGCGCGCACCTGGAGTACTGCTGCCAGCGC
CGCCTAGACGACCGCATGTCCGACACCCACACCTTCCACGCGGCAGAGGAGCTGGGCCGCGAGC
AGCCTCGTCCCACCGGGCCCGAGGCGGCTCCCTCCCGGCGCTGGCTGGAGCGCATGCGGCGGAC
CTTCGAGGAGCCCACGTCGTCGCTGGCCGCGCAGATCCTGGCCAGCGTGTCCGTGGTGTTCGTG
ATCGTGTCTATGGTGGTGCTGTGCGCCAGCACGCTGCCGGACTGGCGCGCGGCGGCCGCCGACA
ACCGCAGTCTGGATGACCGGAGCAGGATAATTGAAGCTATCTGCATAGGCTGGTTCACCGCGGA
GTGCATCGTGCGGTTCATCGTCTCCAAAAACAAGTGTGAGTTTGTCAAGAGACCCCTGAACATC
ATCGACTTACTGGCAATCACCCCCTATTACATCTCCGTGCTGATGACAGTGTTTACAGGCGAGA
ACTCTCAACTCCAGAGGGCTGGGGTCACCCTGAGGGTCCTCCGAATGATGCGGATCTTCTGGGT
GATTAAGCTTGCCCGGCACTTCATCGGCCTGCAGACCCTGGGCTTGACTCTCAAGCGATGCTAC
CGAGAGATGGTTATGTTGCTCGTCTTCATCTGTGTTGCTATGGCGATCTTCAGTGCACTCTCTC
AGCTCCTTGAGCACGGGTTGGACTTGGAGACGTCCAACAAGGACTTTGCCAGCATCCCCGCTGC
CTGCTGGTGGGTGATTATCTCTATGACTACAGTGGGCTATGGAGACATGTATCCTATCACAGTG
CCTGGAAGGATTCTTGGAGGAGTTTGTGTTGTCAGTGGGATCGTTCTGTTGGCATTACCTATCA
CTTTCATCTACCATAGCTTTGTGCAGTGCTACCACGAGCTCAAGTTTAGATCGGCTCGATATAG
TAGGAGCCTCTCCGCTGAGTTCCTGAATTAATGGGTTGCAAATCAGTCCTTGGGCACACTTCAT
CTGGTAGAGTCGACACTACTTCTTATTCACGTGTTTCTCCCTGGGTGAGCGCTACATGGCATTG
TCCTCCTGTTGGAAGGGTGACATTATCCTTCCCAGCTGAAGGGATAGAACAGTTTACTTACAGA
GTAGTCAAGACTGGGACCACACACACAGGACAGTGACAGGAGAGAGAACGCTAGGGCCTGGTCT
TATTCGGTCTCGTGGCC

hide sequence

RefSeq Acc Id:

NM_133426 ⟹ NP_596917

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	16,803,842 - 16,851,791 (+)	NCBI
mRatBN7.2	6	11,051,311 - 11,099,264 (+)	NCBI
Rnor_6.0	6	6,794,808 - 6,842,758 (-)	NCBI
Rnor_5.0	6	6,749,225 - 6,797,221 (-)	NCBI
RGSC_v3.4	6	6,947,526 - 6,995,735 (-)	RGD
Celera	6	10,756,043 - 10,803,960 (+)	NCBI

Sequence:

show sequence

CACCCCGTGCGCGCGGCGGGCAGGCCCCCGGGGCGGCCAGCCATGACCTTCGGGCGCGGCGGGG
CGGCCTCGGTGGTGCTGAACGTGGGCGGCGCCCGGTACTCGCTGTCCCGGGAGCTGCTCAAGGA
CTTCCCGCTGCGCCGTGTGAGCCGGCTGCACGGCTGCCGCTCGGAGCGCGACGTGCTCGAGGTG
TGCGACGACTACGACCGGGAGCGCAACGAGTACTTCTTCGACCGGCACTCGGAGGCCTTCGGCT
TCATCCTGCTGTACGTGCGCGGCCACGGGAAGCTGCGCTTCGCGCCGCGGATGTGCGAGCTCTC
CTTCTACAACGAGATGATCTACTGGGGCCTGGAGGGCGCGCACCTGGAGTACTGCTGCCAGCGC
CGCCTAGACGACCGCATGTCCGACACCCACACCTTCCACGCGGCAGAGGAGCTGGGCCGCGAGC
AGCCTCGTCCCACCGGGCCCGAGGCGGCTCCCTCCCGGCGCTGGCTGGAGCGCATGCGGCGGAC
CTTCGAGGAGCCCACGTCGTCGCTGGCCGCGCAGATCCTGGCCAGCGTGTCCGTGGTGTTCGTG
ATCGTGTCTATGGTGGTGCTGTGCGCCAGCACGCTGCCGGACTGGCGCGCGGCGGCCGCCGACA
ACCGCAGTCTGGATGACCGGAGCAGGTACTCCGCCAGCCCTGGGAGGGAGCCCTCCGGGATAAT
TGAAGCTATCTGCATAGGCTGGTTCACCGCGGAGTGCATCGTGCGGTTCATCGTCTCCAAAAAC
AAGTGTGAGTTTGTCAAGAGACCCCTGAACATCATCGACTTACTGGCAATCACCCCCTATTACA
TCTCCGTGCTGATGACAGTGTTTACAGGCGAGAACTCTCAACTCCAGAGGGCTGGGGTCACCCT
GAGGGTCCTCCGAATGATGCGGATCTTCTGGGTGATTAAGCTTGCCCGGCACTTCATCGGCCTG
CAGACCCTGGGCTTGACTCTCAAGCGATGCTACCGAGAGATGGTTATGTTGCTCGTCTTCATCT
GTGTTGCTATGGCGATCTTCAGTGCACTCTCTCAGCTCCTTGAGCACGGGTTGGACTTGGAGAC
GTCCAACAAGGACTTTGCCAGCATCCCCGCTGCCTGCTGGTGGGTGATTATCTCTATGACTACA
GTGGGCTATGGAGACATGTATCCTATCACAGTGCCTGGAAGGATTCTTGGAGGAGTTTGTGTTG
TCAGTGGGATCGTTCTGTTGGCATTACCTATCACTTTCATCTACCATAGCTTTGTGCAGTGCTA
CCACGAGCTCAAGTTTAGATCGGCTCGATATAGTAGGAGCCTCTCCGCTGAGTTCCTGAATTAA
TGGGTTGCAAATCAGTCCTTGGGCACACTTCATCTGGTAGAGTCGACACTACTTCTTATTCACG
TGTTTCTCCCTGGGTGAGCGCTACATGGCATTGTCCTCCTGTTGGAAGGGTGACATTATCCTTC
CCAGCTGAAGGGATAGAACAGTTTACTTACAGAGTAGTCAAGACTGGGACCACACACACAGGAC
AGTGACAGGAGAGAGAACGCTAGGGCCTGGTCTTATTCGGTCTCGTGGCC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001029129	(Get FASTA)	NCBI Sequence Viewer
	NP_596917	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAM93550	(Get FASTA)	NCBI Sequence Viewer
	AAM93551	(Get FASTA)	NCBI Sequence Viewer
	BAB85521	(Get FASTA)	NCBI Sequence Viewer
	EDM02724	(Get FASTA)	NCBI Sequence Viewer
	EDM02725	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000006094
GenBank Protein	Q8R523	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_596917 ⟸ NM_133426
- Peptide Label:	isoform 1
- UniProtKB:	Q8R523 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MTFGRGGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFD RHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTHTFHA AEELGREQPRPTGPEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCASTLPD WRAAAADNRSLDDRSRYSASPGREPSGIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDL LAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREM VMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFASIPAACWWVIISMTTVGYGDMYPITVPGR ILGGVCVVSGIVLLALPITFIYHSFVQCYHELKFRSARYSRSLSAEFLN hide sequence

RefSeq Acc Id:	NP_001029129 ⟸ NM_001033957
- Peptide Label:	isoform 2
- UniProtKB:	Q8R523 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MTFGRGGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFD RHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTHTFHA AEELGREQPRPTGPEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCASTLPD WRAAAADNRSLDDRSRIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVL MTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAM AIFSALSQLLEHGLDLETSNKDFASIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGI VLLALPITFIYHSFVQCYHELKFRSARYSRSLSAEFLN hide sequence

Ensembl Acc Id:

ENSRNOP00000006094 ⟸ ENSRNOT00000006094

Protein Domains

BTB Ion transport

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8R523-F1-model_v2	AlphaFold	Q8R523	1-433	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628832	AgrOrtholog
BioCyc Gene	G2FUF-38613	BioCyc
Ensembl Genes	ENSRNOG00000004535	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000006094	ENTREZGENE
Gene3D-CATH	1.10.287.70	UniProtKB/Swiss-Prot
	1.20.120.350	UniProtKB/Swiss-Prot
	Potassium Channel Kv1.1, Chain A	UniProtKB/Swiss-Prot
InterPro	BTB/POZ_dom	UniProtKB/Swiss-Prot
	Ion_trans_dom	UniProtKB/Swiss-Prot
	K_chnl_volt-dep_Kv	UniProtKB/Swiss-Prot
	K_chnl_volt-dep_Kv9	UniProtKB/Swiss-Prot
	SKP1/BTB/POZ_sf	UniProtKB/Swiss-Prot
	T1-type_BTB	UniProtKB/Swiss-Prot
	VG_K_chnl	UniProtKB/Swiss-Prot
	Volt_channel_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:171011	UniProtKB/Swiss-Prot
NCBI Gene	171011	ENTREZGENE
PANTHER	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY G MEMBER 3	UniProtKB/Swiss-Prot
	PTHR11537	UniProtKB/Swiss-Prot
Pfam	BTB_2	UniProtKB/Swiss-Prot
	Ion_trans	UniProtKB/Swiss-Prot
PhenoGen	Kcng3	PhenoGen
PRINTS	KCHANNEL	UniProtKB/Swiss-Prot
	KV9CHANNEL	UniProtKB/Swiss-Prot
	KVCHANNEL	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000004535	RatGTEx
SMART	BTB	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF54695	UniProtKB/Swiss-Prot
	Voltage-gated potassium channels	UniProtKB/Swiss-Prot
UniProt	A6H9L9_RAT	UniProtKB/TrEMBL
	A6H9M0_RAT	UniProtKB/TrEMBL
	F1LQV8_RAT	UniProtKB/TrEMBL
	KCNG3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-11	Kcng3	potassium voltage-gated channel modifier subfamily G member 3	Kcng3	potassium channel, voltage gated modifier subfamily G, member 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-01-26	Kcng3	potassium channel, voltage gated modifier subfamily G, member 3	Kcng3	potassium voltage-gated channel, subfamily G, member 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2003-04-09	Kcng3	potassium voltage-gated channel, subfamily G, member 3			Symbol and Name updated	629477	APPROVED
2003-03-12	Kcng3	potassium voltage-gated channel, subfamily G, member 3	Kv6.3	voltage-gated potassium channel 6.3	Data merged from RGD:620661	628472	PROVISIONAL
2003-02-27	Kcng3	voltage-gated potassium channel 6.3			Symbol and Name status set to provisional	70820	PROVISIONAL
2002-08-07	Kv6.3	voltage-gated potassium channel 6.3			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_physical_interaction	interacts with Kv2.1	727345
gene_process	decreases the deactivation rate of the Kv2.1 channels	727345

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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