Ush2a (usherin) - Rat Genome Database

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Gene: Ush2a (usherin) Rattus norvegicus
Analyze
Symbol: Ush2a
Name: usherin
RGD ID: 628777
Description: Predicted to enable collagen binding activity; identical protein binding activity; and myosin binding activity. Involved in retina development in camera-type eye. Located in several cellular components, including photoreceptor connecting cilium; photoreceptor inner segment; and stereocilium. Human ortholog(s) of this gene implicated in Usher syndrome (multiple); nonsyndromic deafness; and retinitis pigmentosa (multiple). Orthologous to human USH2A (usherin); PARTICIPATES IN auditory mechanotransduction pathway; retinitis pigmentosa pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC102554234; LOC289369; RGD1560269; similar to usherin isoform B; Usher syndrome 2A; Usher syndrome 2A (autosomal recessive, mild); Usher syndrome 2A (autosomal recessive, mild) homolog; Usher syndrome 2A (autosomal recessive, mild) homolog (human); Usher syndrome 2A homolog; Usher syndrome 2A homolog (human); usher syndrome type IIa protein homolog; usher syndrome type-2A protein homolog; usherin-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813102,368,783 - 103,035,230 (+)NCBIGRCr8
mRatBN7.21399,837,445 - 100,503,935 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1399,837,445 - 100,503,922 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13102,352,932 - 103,019,370 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013103,742,004 - 104,408,169 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013100,938,790 - 101,610,718 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013106,750,738 - 107,434,195 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13106,751,625 - 107,427,329 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013111,395,505 - 112,057,548 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413104,481,807 - 104,606,485 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113104,670,849 - 104,795,529 (+)NCBI
Celera1399,331,812 - 99,994,577 (+)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Four USH2A founder mutations underlie the majority of Usher syndrome type 2 cases among non-Ashkenazi Jews. Auslender N, etal., Genet Test. 2008 Jun;12(2):289-94. doi: 10.1089/gte.2007.0107.
2. Molecular and in silico analyses of the full-length isoform of usherin identify new pathogenic alleles in Usher type II patients. Baux D, etal., Hum Mutat. 2007 Aug;28(8):781-9.
3. Genes and mutations causing retinitis pigmentosa. Daiger SP, etal., Clin Genet. 2013 Aug;84(2):132-41. doi: 10.1111/cge.12203. Epub 2013 Jun 19.
4. An USH2A founder mutation is the major cause of Usher syndrome type 2 in Canadians of French origin and confirms common roots of Quebecois and Acadians. Ebermann I, etal., Eur J Hum Genet. 2009 Jan;17(1):80-4. doi: 10.1038/ejhg.2008.143. Epub 2008 Jul 30.
5. Mutation of a gene encoding a protein with extracellular matrix motifs in Usher syndrome type IIa. Eudy JD, etal., Science. 1998 Jun 12;280(5370):1753-7.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Identification of the mouse and rat orthologs of the gene mutated in Usher syndrome type IIA and the cellular source of USH2A mRNA in retina, a target tissue of the disease. Huang D, etal., Genomics 2002 Aug;80(2):195-203.
8. Novel USH2A compound heterozygous mutations cause RP/USH2 in a Chinese family. Liu X, etal., Mol Vis. 2010 Mar 17;16:454-61.
9. Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells. Liu X, etal., Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4413-8. Epub 2007 Mar 5.
10. Novel mutations in the long isoform of the USH2A gene in patients with Usher syndrome type II or non-syndromic retinitis pigmentosa. McGee TL, etal., J Med Genet. 2010 Jul;47(7):499-506. doi: 10.1136/jmg.2009.075143. Epub 2010 May 27.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Mutations in myosin VIIA (MYO7A) and usherin (USH2A) in Spanish patients with Usher syndrome types I and II, respectively. Najera C, etal., Hum Mutat. 2002 Jul;20(1):76-7.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Mutational spectrum in Usher syndrome type II. Ouyang XM, etal., Clin Genet. 2004 Apr;65(4):288-93.
15. Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2. Reiners J, etal., Hum Mol Genet. 2005 Dec 15;14(24):3933-43. Epub 2005 Nov 21.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Missense mutation in the USH2A gene: association with recessive retinitis pigmentosa without hearing loss. Rivolta C, etal., Am J Hum Genet. 2000 Jun;66(6):1975-8. Epub 2000 Apr 20.
20. Review series: The cell biology of hearing. Schwander M, etal., J Cell Biol. 2010 Jul 12;190(1):9-20. doi: 10.1083/jcb.201001138.
21. Usher syndrome type 2 caused by activation of an USH2A pseudoexon: implications for diagnosis and therapy. Vache C, etal., Hum Mutat. 2012 Jan;33(1):104-8. doi: 10.1002/humu.21634. Epub 2011 Nov 16.
22. The DFNB31 gene product whirlin connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1. van Wijk E, etal., Hum Mol Genet. 2006 Mar 1;15(5):751-65. Epub 2006 Jan 24.
23. Genomic structure and identification of novel mutations in usherin, the gene responsible for Usher syndrome type IIa. Weston MD, etal., Am J Hum Genet. 2000 Apr;66(4):1199-210. Epub 2000 Mar 22.
24. Genetic etiology study of the non-syndromic deafness in Chinese Hans by targeted next-generation sequencing. Yang T, etal., Orphanet J Rare Dis. 2013 Jun 14;8:85. doi: 10.1186/1750-1172-8-85.
Additional References at PubMed
PMID:10090909   PMID:12433396   PMID:14676276   PMID:15671307   PMID:16301217   PMID:17567809   PMID:17906286   PMID:20502675   PMID:21212183   PMID:24334608   PMID:25406310  


Genomics

Comparative Map Data
Ush2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813102,368,783 - 103,035,230 (+)NCBIGRCr8
mRatBN7.21399,837,445 - 100,503,935 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1399,837,445 - 100,503,922 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13102,352,932 - 103,019,370 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013103,742,004 - 104,408,169 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013100,938,790 - 101,610,718 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013106,750,738 - 107,434,195 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13106,751,625 - 107,427,329 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013111,395,505 - 112,057,548 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413104,481,807 - 104,606,485 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113104,670,849 - 104,795,529 (+)NCBI
Celera1399,331,812 - 99,994,577 (+)NCBICelera
Cytogenetic Map13q26NCBI
USH2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381215,622,891 - 216,423,448 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1215,622,891 - 216,423,448 (-)EnsemblGRCh38hg38GRCh38
GRCh371215,796,233 - 216,596,790 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361213,862,859 - 214,663,361 (-)NCBINCBI36Build 36hg18NCBI36
Build 341212,735,682 - 212,985,133NCBI
Celera1189,020,056 - 189,820,422 (-)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1186,470,498 - 187,272,188 (-)NCBIHuRef
CHM1_11217,068,567 - 217,869,890 (-)NCBICHM1_1
T2T-CHM13v2.01214,863,291 - 215,663,779 (-)NCBIT2T-CHM13v2.0
Ush2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391187,995,035 - 188,697,694 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1187,994,220 - 188,697,238 (+)EnsemblGRCm39 Ensembl
GRCm381188,262,838 - 188,965,497 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1188,262,023 - 188,965,041 (+)EnsemblGRCm38mm10GRCm38
MGSCv371190,086,717 - 190,788,920 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361189,963,822 - 190,665,716 (+)NCBIMGSCv36mm8
Celera1195,189,439 - 195,876,703 (+)NCBICelera
Cytogenetic Map1H6NCBI
cM Map192.29NCBI
Ush2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554061,838,885 - 2,496,980 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554061,837,831 - 2,499,664 (+)NCBIChiLan1.0ChiLan1.0
USH2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2132,981,404 - 33,782,083 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1132,939,322 - 33,739,723 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01191,193,130 - 191,994,664 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11196,048,086 - 196,850,216 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1196,048,086 - 196,850,216 (-)Ensemblpanpan1.1panPan2
USH2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13811,063,221 - 11,750,444 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3811,063,817 - 11,750,444 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3811,100,934 - 11,787,913 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03811,089,431 - 11,776,697 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3811,089,576 - 11,776,697 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13811,101,486 - 11,789,687 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03811,453,699 - 12,141,739 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03811,739,438 - 12,442,329 (-)NCBIUU_Cfam_GSD_1.0
Ush2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934460,113,945 - 60,848,953 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366282,123,957 - 2,858,872 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366282,123,917 - 2,859,958 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USH2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1105,825,591 - 6,662,733 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2107,790,789 - 8,411,655 (-)NCBISscrofa10.2Sscrofa10.2susScr3
USH2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12513,171,499 - 13,950,553 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2513,173,576 - 13,947,724 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605513,613,553 - 14,394,397 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ush2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462483549,877 - 758,640 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462483548,213 - 758,640 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ush2a
5337 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:128
Count of miRNA genes:103
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000004992
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat

Markers in Region
D13Got96  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21399,917,607 - 99,917,880 (+)MAPPERmRatBN7.2
Rnor_6.013106,835,467 - 106,835,739NCBIRnor6.0
Rnor_5.013111,474,382 - 111,474,654UniSTSRnor5.0
RGSC_v3.413104,507,255 - 104,507,528RGDRGSC3.4
RGSC_v3.413104,507,256 - 104,507,528UniSTSRGSC3.4
RGSC_v3.113104,696,299 - 104,696,571RGD
Celera1399,410,109 - 99,410,381UniSTS
RH 3.4 Map13663.2UniSTS
RH 3.4 Map13663.2RGD
RH 2.0 Map13731.9RGD
Cytogenetic Map13q26UniSTS
D13Got101  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.413104,872,569 - 104,872,815RGDRGSC3.4
RGSC_v3.413104,872,568 - 104,872,815UniSTSRGSC3.4
RGSC_v3.113105,061,612 - 105,061,858RGD
RH 3.4 Map13687.7UniSTS
RH 3.4 Map13687.7RGD
RH 2.0 Map13734.2RGD
Cytogenetic Map13q26UniSTS
RH137407  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1399,466,887 - 99,467,074UniSTS
RH 3.4 Map13682.2UniSTS
Cytogenetic Map13q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 3 3 3 20 15
Below cutoff 14 23 13 9 13 2 2 54 22 18 11 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001302219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001840774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY077844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000004992   ⟹   ENSRNOP00000004992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1399,837,445 - 100,503,922 (+)Ensembl
Rnor_6.0 Ensembl13106,751,625 - 107,427,329 (+)Ensembl
RefSeq Acc Id: NM_001302219   ⟹   NP_001289148
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813102,368,783 - 103,035,230 (+)NCBI
mRatBN7.21399,837,445 - 100,503,935 (+)NCBI
Rnor_6.013106,751,625 - 107,427,328 (+)NCBI
Celera1399,331,812 - 99,994,577 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001289148 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL78289 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004992
  ENSRNOP00000004992.8
GenBank Protein Q8K3K1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001289148   ⟸   NM_001302219
- Peptide Label: precursor
- UniProtKB: Q8K3K1 (UniProtKB/Swiss-Prot),   F1M2F9 (UniProtKB/Swiss-Prot),   A0A5H1ZRU3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004992   ⟸   ENSRNOT00000004992
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628777 AgrOrtholog
BioCyc Gene G2FUF-16924 BioCyc
Ensembl Genes ENSRNOG00000003738 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004992 ENTREZGENE
  ENSRNOT00000004992.8 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tie2 ligand-binding domain superfamily UniProtKB/Swiss-Prot
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LamG-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:289369 UniProtKB/TrEMBL
NCBI Gene Ush2a ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USHERIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ush2a PhenoGen
PRINTS EGFLAMININ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_LAM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_LAM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAMININ_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003738 RatGTEx
SMART EGF UniProtKB/TrEMBL
  EGF_Lam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LamG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LamGL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LamNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5H1ZRU3 ENTREZGENE, UniProtKB/TrEMBL
  F1M2F9 ENTREZGENE
  Q8K3K1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary F1M2F9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ush2a  usherin  LOC102554234  usherin-like  Data merged from RGD:7673532 737654 PROVISIONAL
2016-06-03 Ush2a  usherin  Ush2a  Usher syndrome 2A (autosomal recessive, mild)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102554234  usherin-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-10-02 Ush2a  Usher syndrome 2A (autosomal recessive, mild)  Ush2a  Usher syndrome 2A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-26 Ush2a  Usher syndrome 2A  Ush2a  Usher syndrome 2A homolog (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-16 Ush2a  Usher syndrome 2A homolog (human)  RGD1560269  similar to usherin isoform B   Data merged from RGD:1560269 737654 APPROVED
2008-12-15 Ush2a  Usher syndrome 2A homolog (human)  Ush2a  Usher syndrome 2A (autosomal recessive, mild) homolog (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560269  similar to usherin isoform B   RGD1560269_predicted  similar to usherin isoform B (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560269_predicted  similar to usherin isoform B (predicted)  LOC289369  similar to usherin isoform B  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC289369  similar to usherin isoform B      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-07-08 Ush2a  Usher syndrome 2A (autosomal recessive, mild) homolog (human)    Usher syndrome 2A (autosomal recessive, mild)  Name updated 1299863 APPROVED
2003-02-27 Ush2a  Usher syndrome 2A (autosomal recessive, mild)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a leader sequence, an amino-terminal globular domain, 10 laminin epidermal growth factor domains, and four carboxy-terminal fibronectin type III motifs 634438