 Gene Ontology Annotations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cellular Component
Molecular Function
Molecular Pathway Annotations |
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Analyze GeneStrainQTL List |
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Gene Annotator (Annotation Comparison) |
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MOET (Multi-Ontology Enrichement) |
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Cellular Component
Molecular Function
Molecular Pathway AnnotationsGene-Chemical Interaction Annotations
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Gene Ontology AnnotationsBiological Process
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Cellular Component
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Molecular Function
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Molecular Pathway AnnotationsReferences - curated| 1. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 2. | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 3. | RGD automated data pipeline |
| 4. | RGD automated import pipeline for gene-chemical interactions |
References - uncuratedGenomics
Comparative Map Data| Klhl12 (Rattus norvegicus - Norway rat) |
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| KLHL12 (Homo sapiens - human) |
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| Klhl12 (Mus musculus - house mouse) |
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| Klhl12 (Chinchilla lanigera - long-tailed chinchilla) |
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| KLHL12 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| KLHL12 (Canis lupus familiaris - dog) |
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| Klhl12 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| KLHL12 (Sus scrofa - pig) |
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| KLHL12 (Chlorocebus sabaeus - African green monkey) |
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| Klhl12 (Heterocephalus glaber - naked mole-rat) |
No map positions available. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Position Markers| RH129486 |
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| RH129888 |
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| RH137226 |
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QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
miRNA Target Status
Predicted Target Of
| The detailed report is available here: | | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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Expression
RNA-SEQ ExpressionHigh: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM
| alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
| High | |||||||||||||
| Medium | 3 | 33 | 40 | 25 | 18 | 25 | 1 | 3 | 74 | 35 | 41 | 11 | 1 |
| Low | 10 | 17 | 16 | 1 | 16 | 7 | 8 | 7 | |||||
| Below cutoff |
View RNA-SEQ Expression Data
Sequence
Nucleotide Sequences| RefSeq Transcripts | NM_153730 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| XM_006249843 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006249844 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006249845 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006249846 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_008769540 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017598679 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR07020989 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AABR07072327 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01075174 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01075175 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AC106215 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AJ133126 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| BC086983 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH473958 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| FQ210179 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| FQ227739 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| FQ232007 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Reference Sequences
| RefSeq Acc Id: | ENSRNOT00000005832 ⟹ ENSRNOP00000005832 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | NM_153730 ⟹ NP_714952 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Position: |
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| Sequence: |
GCGCTTGATGGGCGGCATTATGGCCCCTAAAGACATAATGACAAATACTCACGCCAAGTCCATChide sequence |
| RefSeq Acc Id: | XM_006249843 ⟹ XP_006249905 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Sequence: |
AGAGTTTACCACGGAGACTGCTCCGCGGCGGCTGGTCCGGGCGGCTGCGGCGGCGGCGCTCTGGhide sequence |
| RefSeq Acc Id: | XM_006249844 ⟹ XP_006249906 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Sequence: |
AGAGTTTACCACGGAGACTGCTCCGCGGCGGCTGGTCCGGGCGGCTGCGGCGGCGGCGCTCTGGhide sequence |
| RefSeq Acc Id: | XM_006249845 ⟹ XP_006249907 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Sequence: |
AGCCTAGAGTTTACCACGGAGACTGCTCCGCGGCGGCTGGTCCGGGCGGCTGCGGCGGCGGCGChide sequence |
| RefSeq Acc Id: | XM_006249846 ⟹ XP_006249908 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Sequence: |
TTTACCACGGAGACTGCTCCGCGGCGGCTGGTCCGGGCGGCTGCGGCGGCGGCGCTCTGGCTCChide sequence |
| RefSeq Acc Id: | XM_008769540 ⟹ XP_008767762 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| Sequence: |
GTTTACCACGGAGACTGCTCCGCGGCGGCTGGTCCGGGCGGCTGCGGCGGCGGCGCTCTGGCTChide sequence |
| RefSeq Acc Id: | XM_017598679 ⟹ XP_017454168 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| Sequence: |
GGGCGCGGCCCTGACACGCGCCCTTTCCCTTCTGCCCTCAGCCGGGGACGCGGCCTTCCCCCAGhide sequence |
Protein Sequences| Protein RefSeqs | NP_714952 | (Get FASTA) | NCBI Sequence Viewer |
| XP_006249905 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006249906 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006249907 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006249908 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_008767762 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017454168 | (Get FASTA) | NCBI Sequence Viewer | |
| GenBank Protein | AAH86983 | (Get FASTA) | NCBI Sequence Viewer |
| CAC79640 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM09724 | (Get FASTA) | NCBI Sequence Viewer | |
| Q8R2H4 | (Get FASTA) | NCBI Sequence Viewer |
Reference Sequences
| RefSeq Acc Id: | NP_714952 ⟸ NM_153730 |
| - UniProtKB: | Q8R2H4 (UniProtKB/Swiss-Prot) |
| - Sequence: |
MGGIMAPKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTShide sequence |
| RefSeq Acc Id: | XP_006249907 ⟸ XM_006249845 |
| - Peptide Label: | isoform X2 |
| - UniProtKB: | Q8R2H4 (UniProtKB/Swiss-Prot) |
| - Sequence: |
MGGIMAPKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTShide sequence |
| RefSeq Acc Id: | XP_006249906 ⟸ XM_006249844 |
| - Peptide Label: | isoform X1 |
| - Sequence: |
MGGIMAPKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTShide sequence |
| RefSeq Acc Id: | XP_006249908 ⟸ XM_006249846 |
| - Peptide Label: | isoform X3 |
| - Sequence: |
MEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFAETHNChide sequence |
| RefSeq Acc Id: | XP_006249905 ⟸ XM_006249843 |
| - Peptide Label: | isoform X1 |
| - Sequence: |
MGGIMAPKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTShide sequence |
| RefSeq Acc Id: | XP_008767762 ⟸ XM_008769540 |
| - Peptide Label: | isoform X3 |
| - Sequence: |
MEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFAETHNChide sequence |
| RefSeq Acc Id: | XP_017454168 ⟸ XM_017598679 |
| - Peptide Label: | isoform X2 |
| - UniProtKB: | Q8R2H4 (UniProtKB/Swiss-Prot) |
| - Sequence: |
MGGIMAPKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTShide sequence |
| RefSeq Acc Id: | ENSRNOP00000005832 ⟸ ENSRNOT00000005832 |
Protein Domains
BACK BTB
TranscriptomeStrain Variation
Strain Sequence Variants (Rnor 6.0)
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Damaging VariantsAssembly: Rnor_5.0
| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 13 | 56341019 | 56341020 | G | A | snv | LE/Stm (KyushuU), LE/Stm (Illumina) (KNAW), LE/Stm (SOLiD) (KNAW) |
Assembly: Rnor_6.0
| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 13 | 51284354 | 51284355 | G | A | snv | LE/Stm (RGD) |
Additional Information
External Database Links| Database | Acc Id | Source(s) |
| AGR Gene | RGD:628717 | AgrOrtholog |
| Ensembl Genes | ENSRNOG00000004193 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000005832 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000005832 | ENTREZGENE, UniProtKB/TrEMBL |
| Gene3D-CATH | 2.120.10.80 | UniProtKB/Swiss-Prot |
| IMAGE_CLONE | IMAGE:7133597 | IMAGE-MGC_LOAD |
| InterPro | BACK | UniProtKB/Swiss-Prot |
| BTB-kelch_protein | UniProtKB/Swiss-Prot | |
| BTB/POZ_dom | UniProtKB/Swiss-Prot | |
| Kelch-typ_b-propeller | UniProtKB/Swiss-Prot | |
| Kelch_1 | UniProtKB/Swiss-Prot | |
| SKP1/BTB/POZ_sf | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:266772 | UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:93127 | IMAGE-MGC_LOAD |
| NCBI Gene | 266772 | ENTREZGENE |
| Pfam | BACK | UniProtKB/Swiss-Prot |
| BTB | UniProtKB/Swiss-Prot | |
| Kelch_1 | UniProtKB/Swiss-Prot | |
| PhenoGen | Klhl12 | PhenoGen |
| PIRSF | Kelch-like_protein_gigaxonin | UniProtKB/Swiss-Prot |
| PROSITE | BTB | UniProtKB/Swiss-Prot |
| SMART | BACK | UniProtKB/Swiss-Prot |
| BTB | UniProtKB/Swiss-Prot | |
| Kelch | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | SSF117281 | UniProtKB/Swiss-Prot |
| SSF54695 | UniProtKB/Swiss-Prot | |
| UniGene | Rn.15513 | ENTREZGENE |
| UniProt | A0A140TA97_RAT | UniProtKB/TrEMBL |
| KLH12_RAT | UniProtKB/Swiss-Prot, ENTREZGENE | |
| UniProt Secondary | F8WG02 | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2013-02-06 | Klhl12 | kelch-like family member 12 | Klhl12 | kelch-like 12 (Drosophila) | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2004-09-10 | Klhl12 | kelch-like 12 (Drosophila) | C3ip1 | kelch-like protein C3IP1 | Symbol and Name updated | 1299863 | APPROVED |
| 2004-02-26 | C3ip1 | kelch-like protein C3IP1 | Symbol and Name status set to approved | 625702 | APPROVED | ||
| 2003-02-27 | C3ip1 | kelch-like protein C3IP1 | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
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| More on Klhl12 | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
| RGD Object Information | |
| RGD ID: | 628717 |
| Created: | 2003-02-27 |
| Species: | Rattus norvegicus |
| Last Modified: | 2020-03-04 |
| Status: | ACTIVE |
