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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Klhl12 | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | KLHL12 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of KLHL12 mRNA | CTD | PMID:22079256 | Klhl12 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Klhl12 (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of KLHL12 mRNA | CTD | PMID:22206623 | Klhl12 | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of KLHL12 mRNA | CTD | PMID:32741896 | Klhl12 | Rat | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of KLHL12 mRNA | CTD | PMID:32741896 | Klhl12 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Klhl12 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of KLHL12 mRNA | CTD | PMID:21570461 | Klhl12 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KLHL12 mRNA | CTD | PMID:33387578 | Klhl12 | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of KLHL12 mRNA | CTD | PMID:21346803 | Klhl12 | Rat | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of KLHL12 mRNA | CTD | PMID:21346803 | Klhl12 | Rat | 2-methylcholine | affects expression | ISO | KLHL12 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of KLHL12 mRNA | CTD | PMID:21179406 | Klhl12 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Klhl12 (Mus musculus) | 6480464 | bisphenol S results in increased expression of KLHL12 mRNA | CTD | PMID:33297965 | Klhl12 | Rat | 5-aza-2'-deoxycytidine | affects expression | ISO | KLHL12 (Homo sapiens) | 6480464 | Decitabine affects the expression of KLHL12 mRNA | CTD | PMID:23300844 | Klhl12 | Rat | acrylamide | increases expression | ISO | KLHL12 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of KLHL12 mRNA | CTD | PMID:32763439 | Klhl12 | Rat | aflatoxin B1 | increases expression | ISO | KLHL12 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of KLHL12 mRNA | CTD | PMID:27153756 | Klhl12 | Rat | all-trans-retinoic acid | decreases expression | ISO | KLHL12 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of KLHL12 mRNA | CTD | PMID:21934132 | Klhl12 | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of KLHL12 mRNA | CTD | PMID:16483693 | Klhl12 | Rat | aristolochic acid A | decreases expression | ISO | KLHL12 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of KLHL12 mRNA | CTD | PMID:33212167 | Klhl12 | Rat | benzene | increases expression | ISO | KLHL12 (Homo sapiens) | 6480464 | Benzene results in increased expression of KLHL12 mRNA | CTD | PMID:19162166 | Klhl12 | Rat | benzo[a]pyrene | decreases methylation | ISO | KLHL12 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of KLHL12 3' UTR | CTD | PMID:27901495 | Klhl12 | Rat | benzo[a]pyrene | decreases methylation | ISO | Klhl12 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased methylation of KLHL12 exon; Benzo(a)pyrene results in decreased methylation of KLHL12 more ... | CTD | PMID:27901495 | Klhl12 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | KLHL12 (Homo sapiens) | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KLHL12 mRNA | CTD | PMID:19150397 | Klhl12 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of KLHL12 mRNA | CTD | PMID:25181051 | Klhl12 | Rat | butanal | decreases expression | ISO | KLHL12 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of KLHL12 mRNA | CTD | PMID:26079696 | Klhl12 | Rat | cadmium atom | multiple interactions | ISO | KLHL12 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of KLHL12 more ... | CTD | PMID:35301059 | Klhl12 | Rat | cadmium dichloride | multiple interactions | ISO | KLHL12 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of KLHL12 more ... | CTD | PMID:35301059 | Klhl12 | Rat | CGP 52608 | multiple interactions | ISO | KLHL12 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to KLHL12 gene] | CTD | PMID:28238834 | Klhl12 | Rat | choline | multiple interactions | ISO | Klhl12 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Klhl12 | Rat | cisplatin | affects expression | ISO | KLHL12 (Homo sapiens) | 6480464 | Cisplatin affects the expression of KLHL12 mRNA | CTD | PMID:23300844 | Klhl12 | Rat | cisplatin | increases expression | ISO | KLHL12 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of KLHL12 mRNA | CTD | PMID:27392435 | Klhl12 | Rat | cisplatin | multiple interactions | ISO | KLHL12 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of KLHL12 mRNA | CTD | PMID:27392435 | Klhl12 | Rat | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of KLHL12 mRNA | CTD | PMID:20187946 | Klhl12 | Rat | doxorubicin | affects expression | ISO | KLHL12 (Homo sapiens) | 6480464 | Doxorubicin affects the expression of KLHL12 mRNA | CTD | PMID:29803840 | Klhl12 | Rat | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of KLHL12 mRNA | CTD | PMID:29391264 | Klhl12 | Rat | ethyl methanesulfonate | increases expression | ISO | KLHL12 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of KLHL12 mRNA | CTD | PMID:23649840 | Klhl12 | Rat | folic acid | multiple interactions | ISO | Klhl12 (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of KLHL12 mRNA; [Methionine deficiency co-treated more ... | CTD | PMID:20938992|PMID:22206623 | Klhl12 | Rat | L-methionine | multiple interactions | ISO | Klhl12 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Klhl12 | Rat | methyl methanesulfonate | increases expression | ISO | KLHL12 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of KLHL12 mRNA | CTD | PMID:23649840 | Klhl12 | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of KLHL12 mRNA | CTD | PMID:25729387 | Klhl12 | Rat | oxaliplatin | decreases expression | EXP | | 6480464 | oxaliplatin results in decreased expression of KLHL12 mRNA | CTD | PMID:25729387 | Klhl12 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of KLHL12 mRNA | CTD | PMID:33387578 | Klhl12 | Rat | pentanal | decreases expression | ISO | KLHL12 (Homo sapiens) | 6480464 | pentanal results in decreased expression of KLHL12 mRNA | CTD | PMID:26079696 | Klhl12 | Rat | perfluorohexanesulfonic acid | decreases expression | ISO | Klhl12 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in decreased expression of KLHL12 mRNA | CTD | PMID:37995155 | Klhl12 | Rat | potassium chromate | decreases expression | ISO | KLHL12 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of KLHL12 mRNA | CTD | PMID:22079256 | Klhl12 | Rat | potassium chromate | multiple interactions | ISO | KLHL12 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of KLHL12 mRNA | CTD | PMID:22079256 | Klhl12 | Rat | potassium dichromate | decreases expression | ISO | Klhl12 (Mus musculus) | 6480464 | Potassium Dichromate results in decreased expression of KLHL12 mRNA | CTD | PMID:23608068 | Klhl12 | Rat | resveratrol | multiple interactions | ISO | KLHL12 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of KLHL12 mRNA | CTD | PMID:23557933 | Klhl12 | Rat | sodium fluoride | decreases expression | ISO | Klhl12 (Mus musculus) | 6480464 | Sodium Fluoride results in decreased expression of KLHL12 mRNA | CTD | PMID:27862939 | Klhl12 | Rat | sunitinib | increases expression | ISO | KLHL12 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of KLHL12 mRNA | CTD | PMID:31533062 | Klhl12 | Rat | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of KLHL12 mRNA | CTD | PMID:32741896 | Klhl12 | Rat | titanium dioxide | decreases methylation | ISO | Klhl12 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of KLHL12 gene | CTD | PMID:35295148 | Klhl12 | Rat | topotecan | decreases expression | EXP | | 6480464 | Topotecan results in decreased expression of KLHL12 mRNA | CTD | PMID:25729387 | Klhl12 | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of KLHL12 mRNA | CTD | PMID:25729387 | Klhl12 | Rat | trovafloxacin | increases expression | ISO | Klhl12 (Mus musculus) | 6480464 | trovafloxacin results in increased expression of KLHL12 mRNA | CTD | PMID:35537566 | Klhl12 | Rat | valproic acid | decreases expression | ISO | KLHL12 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of KLHL12 mRNA | CTD | PMID:23179753 | Klhl12 | Rat | valproic acid | affects expression | ISO | KLHL12 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of KLHL12 mRNA | CTD | PMID:25979313 | Klhl12 | Rat | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of KLHL12 mRNA | CTD | PMID:22615374 | |