Brs3 (bombesin receptor subtype 3) - Rat Genome Database

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Gene: Brs3 (bombesin receptor subtype 3) Rattus norvegicus
Analyze
Symbol: Brs3
Name: bombesin receptor subtype 3 (Ensembl:bombesin-like receptor 3)
RGD ID: 628645
Description: Predicted to enable neuropeptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in neuron projection; neuronal cell body; and plasma membrane. Orthologous to human BRS3 (bombesin receptor subtype 3); INTERACTS WITH ammonium chloride; bisphenol A; fluoxetine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: bombesin receptor subtype-3; bombesin-like receptor 3; BRS-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X134,906,817 - 134,932,321 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX134,906,784 - 134,930,983 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX137,123,452 - 137,127,830 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X140,678,073 - 140,682,451 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X138,247,469 - 138,251,847 (+)NCBIRnor_WKY
Rnor_6.0X159,484,953 - 159,510,944 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX159,505,344 - 159,511,021 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X154,114,756 - 154,140,734 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X141,688,650 - 141,693,028 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X141,762,082 - 141,766,461 (+)NCBI
CeleraX142,968,657 - 142,973,035 (+)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. The distribution of the orphan bombesin receptor subtype-3 in the rat CNS. Jennings CA, etal., Neuroscience. 2003;120(2):309-24.
4. Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3). Liu J, etal., Biochemistry 2002 Jul 16;41(28):8954-60.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity. Ohki-Hamazaki H, etal., Nature 1997 Nov 13;390(6656):165-9.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15140764   PMID:15726424   PMID:22911445   PMID:29402494  


Genomics

Comparative Map Data
Brs3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X134,906,817 - 134,932,321 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX134,906,784 - 134,930,983 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX137,123,452 - 137,127,830 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X140,678,073 - 140,682,451 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X138,247,469 - 138,251,847 (+)NCBIRnor_WKY
Rnor_6.0X159,484,953 - 159,510,944 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX159,505,344 - 159,511,021 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X154,114,756 - 154,140,734 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X141,688,650 - 141,693,028 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X141,762,082 - 141,766,461 (+)NCBI
CeleraX142,968,657 - 142,973,035 (+)NCBICelera
Cytogenetic MapXq37NCBI
BRS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X136,487,947 - 136,493,780 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX136,487,947 - 136,493,780 (+)EnsemblGRCh38hg38GRCh38
GRCh37X135,570,106 - 135,575,939 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X135,397,791 - 135,402,264 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X135,295,644 - 135,300,118NCBI
CeleraX135,933,763 - 135,938,238 (+)NCBICelera
Cytogenetic MapXq26.3NCBI
HuRefX124,840,740 - 124,845,212 (+)NCBIHuRef
CHM1_1X135,481,778 - 135,486,251 (+)NCBICHM1_1
T2T-CHM13v2.0X134,796,688 - 134,802,523 (+)NCBIT2T-CHM13v2.0
Brs3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X56,088,434 - 56,094,118 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX56,088,434 - 56,094,118 (+)EnsemblGRCm39 Ensembl
GRCm38X57,043,074 - 57,048,758 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX57,043,074 - 57,048,758 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X54,296,251 - 54,301,935 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X53,389,858 - 53,395,542 (+)NCBIMGSCv36mm8
CeleraX43,522,304 - 43,527,988 (+)NCBICelera
Cytogenetic MapXA6NCBI
Brs3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554898,627,569 - 8,631,810 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554898,627,569 - 8,631,810 (-)NCBIChiLan1.0ChiLan1.0
BRS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X135,883,613 - 135,888,069 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX135,883,613 - 135,888,069 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X125,617,592 - 125,623,411 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BRS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X106,838,893 - 106,844,877 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX106,838,890 - 106,843,728 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX92,659,589 - 92,664,069 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X108,818,684 - 108,823,165 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX108,818,528 - 108,824,578 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X105,959,634 - 105,964,095 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X108,151,435 - 108,155,900 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X107,791,869 - 107,796,352 (+)NCBIUU_Cfam_GSD_1.0
Brs3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X104,825,895 - 104,831,805 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651310,784,181 - 10,788,680 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493651310,784,181 - 10,788,679 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX111,615,564 - 111,620,124 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X111,615,695 - 111,620,124 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X127,473,443 - 127,479,313 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BRS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X111,488,422 - 111,496,637 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX111,489,165 - 111,493,375 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606549,172,883 - 49,177,291 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Brs3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480810,652,776 - 10,658,498 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480810,652,817 - 10,658,434 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Brs3
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:62
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000001164
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system reproductive system respiratory system
High
Medium
Low 2 2 2 2 29 7
Below cutoff 26 18 12 18 21 6 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001164   ⟹   ENSRNOP00000001164
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX134,906,784 - 134,930,983 (+)Ensembl
Rnor_6.0 EnsemblX159,505,344 - 159,511,021 (+)Ensembl
RefSeq Acc Id: NM_152845   ⟹   NP_690058
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X134,926,604 - 134,930,983 (+)NCBI
Rnor_6.0X159,505,232 - 159,509,610 (+)NCBI
Rnor_5.0X154,114,756 - 154,140,734 (+)NCBI
RGSC_v3.4X141,688,650 - 141,693,028 (+)RGD
CeleraX142,968,657 - 142,973,035 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257677   ⟹   XP_006257739
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X134,906,817 - 134,932,321 (+)NCBI
Rnor_6.0X159,484,953 - 159,510,944 (+)NCBI
Rnor_5.0X154,114,756 - 154,140,734 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_690058 (Get FASTA)   NCBI Sequence Viewer  
  XP_006257739 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAM95932 (Get FASTA)   NCBI Sequence Viewer  
  EDL75133 (Get FASTA)   NCBI Sequence Viewer  
  Q8K418 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_690058   ⟸   NM_152845
- UniProtKB: Q8K418 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006257739   ⟸   XM_006257677
- Peptide Label: isoform X1
- UniProtKB: A0A8L2PYQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001164   ⟸   ENSRNOT00000001164
Protein Domains
G_PROTEIN_RECEP_F1_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K418-F1-model_v2 AlphaFold Q8K418 1-399 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628645 AgrOrtholog
BioCyc Gene G2FUF-912 BioCyc
Ensembl Genes ENSRNOG00000000873 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000001164 ENTREZGENE
  ENSRNOP00000001164.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001164 ENTREZGENE
  ENSRNOT00000001164.6 UniProtKB/TrEMBL
InterPro Bombesin_rcpt_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bombsn_rcpt-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:260319 UniProtKB/Swiss-Prot
NCBI Gene 260319 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB BRS3 RGD
PhenoGen Brs3 PhenoGen
PRINTS BOMBESIN3R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BOMBESINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2PYQ4 ENTREZGENE, UniProtKB/TrEMBL
  BRS3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-15 Brs3  bombesin receptor subtype 3  Brs3  bombesin-like receptor 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Brs3  bombesin-like receptor 3      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Brs3  bombesin-like receptor 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology has 80% identity with the human homolog BRS-3 632031