Advanced Search (OLGA)

Gene: Cbr3 (carbonyl reductase 3) Rattus rattus

Analyze

Symbol:

Cbr3

Name:

carbonyl reductase 3

RGD ID:

625899349

Description:

ENCODES a protein that exhibits 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity (ortholog); carbonyl reductase (NADPH) activity (ortholog); NADPH binding (ortholog); INVOLVED IN cognition (ortholog); phylloquinone catabolic process (ortholog); PARTICIPATES IN doxorubicin pharmacokinetics pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); Familial Platelet Disorder with Associated Myeloid Malignancy (ortholog); Mouth Neoplasms (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

carbonyl reductase [NADPH] 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CBR3 (carbonyl reductase 3)	NCBI	Ortholog
Mus musculus (house mouse):	Cbr3 (carbonyl reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cbr3 (carbonyl reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cbr3 (carbonyl reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CBR3 (carbonyl reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CBR3 (carbonyl reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cbr3 (carbonyl reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CBR3 (carbonyl reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CBR3 (carbonyl reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cbr3 (carbonyl reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Rrattus_CSIRO_v1 - Rrattus_CSIRO_v1 Assembly

Position:

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	50,945,959 - 50,954,683 (-)	NCBI		Rrattus_CSIRO_v1

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

Familial Platelet Disorder with Associated Myeloid Malignancy (ISO)

Mouth Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cognition (ISO)

phylloquinone catabolic process (ISO)

Cellular Component

cytosol (ISO)

nucleoplasm (ISO)

Molecular Function

3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity (ISO)

carbonyl reductase (NADPH) activity (ISO)

NADPH binding (ISO)

NADPH dehydrogenase (quinone) activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

doxorubicin pharmacokinetics pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Cbr3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	50,945,959 - 50,954,683 (-)	NCBI		Rrattus_CSIRO_v1

CBR3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	36,135,079 - 36,146,562 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	36,135,079 - 36,146,566 (+)	Ensembl			hg38	GRCh38
GRCh37	21	37,507,377 - 37,518,860 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	36,429,133 - 36,440,730 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	21	36,364,264 - 36,440,724	NCBI
Celera	21	22,706,132 - 22,717,559 (+)	NCBI		Celera
Cytogenetic Map	21	q22.12	NCBI
HuRef	21	22,984,935 - 22,996,359 (+)	NCBI		HuRef
CHM1_1	21	37,069,046 - 37,080,642 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	21	34,518,104 - 34,529,412 (+)	NCBI		T2T-CHM13v2.0

Cbr3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	93,480,107 - 93,487,879 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	93,480,103 - 93,487,878 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	16	93,683,219 - 93,690,991 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	93,683,215 - 93,690,990 (+)	Ensembl			mm10	GRCm38
MGSCv37	16	93,683,464 - 93,691,236 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	16	93,571,759 - 93,579,527 (+)	NCBI		MGSCv36	mm8
Celera	16	94,777,963 - 94,785,655 (+)	NCBI		Celera
Cytogenetic Map	16	C4	NCBI
cM Map	16	54.58	NCBI

Cbr3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	46,478,295 - 46,486,555 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	46,478,274 - 46,486,558 (+)	Ensembl				GRCr8
mRatBN7.2	11	33,008,615 - 33,016,877 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	33,008,615 - 33,016,875 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	41,662,664 - 41,670,924 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	34,334,206 - 34,342,467 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	33,484,246 - 33,492,418 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	33,909,417 - 33,917,674 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	33,909,439 - 33,917,674 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	37,500,661 - 37,508,918 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	33,913,961 - 33,922,221 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	35,427,193 - 35,435,432 (-)	NCBI		Celera
RGSC_v3.1	11	33,961,819 - 33,978,463 (+)	NCBI
Cytogenetic Map	11	q11	NCBI

Cbr3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	35,419,674 - 35,428,270 (+)	Ensembl
ChiLan1.0	NW_004955407	35,419,674 - 35,428,270 (+)	NCBI	ChiLan1.0	ChiLan1.0

CBR3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	32,256,031 - 32,267,414 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	27,115,995 - 27,128,098 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	22,505,647 - 22,516,938 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	35,865,374 - 35,876,717 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	35,865,374 - 35,876,717 (+)	Ensembl			panPan2	panpan1.1

CBR3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	31,416,441 - 31,423,797 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	31,416,333 - 31,423,739 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	30,472,787 - 30,480,043 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	30,713,351 - 30,720,605 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	30,713,139 - 30,720,547 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	30,585,631 - 30,592,893 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	30,599,689 - 30,606,933 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	31,090,527 - 31,097,817 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cbr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	30,998,820 - 31,006,047 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936500	6,458,721 - 6,591,928 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936500	6,461,776 - 6,469,063 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CBR3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	199,830,668 - 199,840,442 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	199,830,690 - 199,840,444 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	209,842,863 - 209,852,618 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CBR3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	80,158,842 - 80,164,208 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	80,158,806 - 80,164,248 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666054	7,988,123 - 7,999,978 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cbr3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	27,294,222 - 27,305,109 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624745	27,298,714 - 27,305,606 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_032900397	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAAIVD010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_032900397 ⟹ XP_032756288

Type:

CODING

Position:

Black Rat Assembly	Chr	Position (strand)	Source
Rrattus_CSIRO_v1	4	50,945,959 - 50,954,683 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_032756288	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_032756288 ⟸ XM_032900397

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	Cbr3	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB