Cul3 (cullin 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cul3 (cullin 3) Rattus rattus
Analyze
Symbol: Cul3
Name: cullin 3
RGD ID: 625853988
Description: ENCODES a protein that exhibits cyclin binding (ortholog); identical protein binding (ortholog); Notch binding (ortholog); INVOLVED IN anaphase-promoting complex-dependent catabolic process (ortholog); cell migration (ortholog); cell morphogenesis (ortholog); PARTICIPATES IN nuclear factor, erythroid 2 like 2 signaling pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; Wnt signaling, canonical pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal dominant pseudohypoaldosteronism type 1 (ortholog); developmental and epileptic encephalopathy 11 (ortholog); FOUND IN centrosome (ortholog); Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cullin-3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Rrattus_CSIRO_v1 - Rrattus_CSIRO_v1 Assembly
Position:
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14153,303,041 - 153,377,377 (-)NCBIRrattus_CSIRO_v1



Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anaphase-promoting complex-dependent catabolic process  (ISO)
cell migration  (ISO)
cell morphogenesis  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to oxidative stress  (ISO)
COPII vesicle coating  (ISO)
embryonic cleavage  (ISO)
endoplasmic reticulum to Golgi vesicle-mediated transport  (ISO)
fibroblast apoptotic process  (ISO)
gastrulation  (ISO)
gene expression  (ISO)
in utero embryonic development  (ISO)
inflammatory response  (ISO)
integrin-mediated signaling pathway  (ISO)
kidney development  (ISO)
liver morphogenesis  (ISO)
mitotic cell cycle  (ISO)
mitotic metaphase chromosome alignment  (ISO)
negative regulation of Rho protein signal transduction  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of type I interferon production  (ISO)
nuclear protein quality control by the ubiquitin-proteasome system  (ISO)
positive regulation of cytokinesis  (ISO)
positive regulation of mitotic cell cycle phase transition  (ISO)
positive regulation of mitotic metaphase/anaphase transition  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of TORC1 signaling  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein autoubiquitination  (ISO)
protein catabolic process  (ISO)
protein destabilization  (ISO)
protein K48-linked ubiquitination  (ISO)
protein monoubiquitination  (ISO)
protein polyubiquitination  (ISO)
protein ubiquitination  (ISO)
regulation of cellular response to insulin stimulus  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation protein catabolic process at postsynapse  (ISO)
stem cell division  (ISO)
stress fiber assembly  (ISO)
trophectodermal cellular morphogenesis  (ISO)
ubiquitin-dependent protein catabolic process  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Cul3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14153,303,041 - 153,377,377 (-)NCBIRrattus_CSIRO_v1
CUL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382224,470,150 - 224,585,363 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2224,470,150 - 224,585,397 (-)Ensemblhg38GRCh38
GRCh372225,334,867 - 225,450,080 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362225,043,113 - 225,158,358 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342225,160,373 - 225,275,619NCBI
Celera2219,099,731 - 219,215,637 (-)NCBICelera
Cytogenetic Map2q36.2NCBI
HuRef2217,186,560 - 217,301,844 (-)NCBIHuRef
CHM1_12225,341,500 - 225,456,770 (-)NCBICHM1_1
T2T-CHM13v2.02224,952,401 - 225,067,578 (-)NCBIT2T-CHM13v2.0
Cul3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39180,242,640 - 80,318,426 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl180,242,640 - 80,318,197 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38180,264,923 - 80,340,690 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl180,264,923 - 80,340,480 (-)Ensemblmm10GRCm38
MGSCv37180,263,393 - 80,337,005 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36180,145,842 - 80,219,467 (-)NCBIMGSCv36mm8
Celera180,291,823 - 80,365,420 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map141.24NCBI
Cul3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8989,040,987 - 89,118,775 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl989,040,987 - 89,118,427 (-)EnsemblGRCr8
mRatBN7.2981,592,641 - 81,670,428 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl981,592,641 - 81,670,462 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx990,022,642 - 90,100,355 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0995,151,541 - 95,229,253 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0993,534,067 - 93,611,783 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0986,044,485 - 86,129,066 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl986,044,485 - 86,129,329 (-)Ensemblrn6Rnor6.0
Rnor_5.0985,794,367 - 85,853,471 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4979,574,062 - 79,634,396 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera979,070,793 - 79,129,030 (-)NCBICelera
RGSC_v3.1979,757,935 - 79,837,198 (-)NCBI
Cytogenetic Map9q34NCBI
Cul3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554539,564,522 - 9,629,976 (+)Ensembl
ChiLan1.0NW_0049554539,546,554 - 9,629,976 (+)NCBIChiLan1.0ChiLan1.0
CUL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213127,089,437 - 127,200,964 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B127,104,406 - 127,215,480 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B111,714,533 - 111,827,080 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B230,289,195 - 230,373,537 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B230,289,195 - 230,378,991 (-)EnsemblpanPan2panpan1.1
CUL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12537,730,903 - 37,819,851 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2537,733,229 - 37,800,886 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2538,338,004 - 38,427,804 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02537,967,156 - 38,056,983 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2537,968,235 - 38,057,261 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12537,907,667 - 37,997,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02537,748,392 - 37,838,350 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02537,923,140 - 38,012,960 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cul3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303179,724,396 - 179,788,614 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365696,065,367 - 6,132,316 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365696,067,230 - 6,131,467 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CUL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15126,189,851 - 126,287,005 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115126,191,605 - 126,287,148 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215139,621,601 - 139,781,465 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CUL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110110,425,895 - 110,541,431 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10110,425,076 - 110,541,538 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604088,866,367 - 88,980,363 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cul3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624823766,780 - 852,727 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624823767,347 - 854,065 (+)NCBIHetGla 1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_032901449   ⟹   XP_032757340
Type: CODING
Position:
Black Rat AssemblyChrPosition (strand)Source
Rrattus_CSIRO_v14153,303,041 - 153,377,377 (-)NCBI
RefSeq Acc Id: XM_032901450   ⟹   XP_032757341
Type: CODING
Position:
Black Rat AssemblyChrPosition (strand)Source
Rrattus_CSIRO_v14153,303,041 - 153,377,327 (-)NCBI
RefSeq Acc Id: XM_032901451   ⟹   XP_032757342
Type: CODING
Position:
Black Rat AssemblyChrPosition (strand)Source
Rrattus_CSIRO_v14153,303,041 - 153,358,246 (-)NCBI
Protein Sequences
Protein RefSeqs XP_032757340 (Get FASTA)   NCBI Sequence Viewer  
  XP_032757341 (Get FASTA)   NCBI Sequence Viewer  
  XP_032757342 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_032757340   ⟸   XM_032901449
- Peptide Label: isoform X1
RefSeq Acc Id: XP_032757341   ⟸   XM_032901450
- Peptide Label: isoform X2
RefSeq Acc Id: XP_032757342   ⟸   XM_032901451
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
NCBI Gene Cul3 ENTREZGENE