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Gene: Ptpro (protein tyrosine phosphatase, receptor type, O) Mus musculus
Symbol: Ptpro
Name: protein tyrosine phosphatase, receptor type, O
Description: Exhibits Wnt-protein binding activity; protein homodimerization activity; and protein tyrosine phosphatase activity. Involved in several processes, including peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; plasma membrane bounded cell projection organization; and slit diaphragm assembly. Localizes to several cellular components, including GABA-ergic synapse; integral component of postsynaptic density membrane; and lateral plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and spinal cord. Human ortholog(s) of this gene implicated in nephrotic syndrome type 6. Orthologous to human PTPRO (protein tyrosine phosphatase receptor type O); INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D28; GLEPP1; glomerular epithelial protein 1; protein tyrosine phosphatase U2; protein tyrosine phosphatase, non-receptor type 15; PTPase U2; PTPBK; Ptpn15; PTPoc; PTPphi; PTPROt; PTPU2; R-PTP-O; receptor protein tyrosine phosphatase RO; receptor-type tyrosine-protein phosphatase O
Homo sapiens (human) : PTPRO (protein tyrosine phosphatase receptor type O)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ptpro (protein tyrosine phosphatase, receptor type, O)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptpro (protein tyrosine phosphatase receptor type O)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPRO (protein tyrosine phosphatase receptor type O)
Canis lupus familiaris (dog) : PTPRO (protein tyrosine phosphatase receptor type O)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptpro (protein tyrosine phosphatase receptor type O)
Sus scrofa (pig) : PTPRO (protein tyrosine phosphatase receptor type O)
Chlorocebus sabaeus (African green monkey) : PTPRO (protein tyrosine phosphatase receptor type O)
Heterocephalus glaber (naked mole-rat) : Ptpro (protein tyrosine phosphatase receptor type O)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl6137,252,319 - 137,463,233 (+)EnsemblGRCm38mm10GRCm38
GRCm386137,252,299 - 137,464,634 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376137,200,820 - 137,413,155 (+)NCBIGRCm37mm9NCBIm37
MGSCv366137,216,661 - 137,427,429 (+)NCBImm8
Celera6140,313,708 - 140,529,181 (+)NCBICelera
Cytogenetic Map6G1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Ptpro
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62360
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.