Extl3 (exostosin-like glycosyltransferase 3) - Rat Genome Database

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Gene: Extl3 (exostosin-like glycosyltransferase 3) Mus musculus
Analyze
Symbol: Extl3
Name: exostosin-like glycosyltransferase 3
RGD ID: 62357
MGI Page MGI
Description: Predicted to have transferase activity, transferring glycosyl groups. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process and positive regulation of cell growth. Predicted to localize to Golgi apparatus; endoplasmic reticulum; and membrane. Is expressed in several structures, including alimentary system; central nervous system; heart; metanephros; and sensory organ. Orthologous to human EXTL3 (exostosin like glycosyltransferase 3); PARTICIPATES IN heparan sulfate biosynthetic pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2900009G18Rik; AU040105; exostoses (multiple)-like 3; exostoses-like 3; exostosin; exostosin-like 3; Ext1l; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; KIAA0519; mKIAA0519; multiple exostosis-like protein 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391465,289,508 - 65,387,349 (-)NCBIGRCm39mm39
GRCm39 Ensembl1465,289,509 - 65,387,304 (-)Ensembl
GRCm381465,052,059 - 65,149,899 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1465,052,060 - 65,149,855 (-)EnsemblGRCm38mm10GRCm38
MGSCv371465,670,896 - 65,716,943 (-)NCBIGRCm37mm9NCBIm37
MGSCv361464,006,173 - 64,034,585 (-)NCBImm8
Celera1462,814,500 - 62,860,622 (-)NCBICelera
Cytogenetic Map14D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:14610273   PMID:14618397   PMID:14681479   PMID:15246697   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:16602821   PMID:18799693   PMID:19336225   PMID:21267068   PMID:21873635   PMID:22158612   PMID:24803591   PMID:28378742   PMID:32201365  


Genomics

Comparative Map Data
Extl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391465,289,508 - 65,387,349 (-)NCBIGRCm39mm39
GRCm39 Ensembl1465,289,509 - 65,387,304 (-)Ensembl
GRCm381465,052,059 - 65,149,899 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1465,052,060 - 65,149,855 (-)EnsemblGRCm38mm10GRCm38
MGSCv371465,670,896 - 65,716,943 (-)NCBIGRCm37mm9NCBIm37
MGSCv361464,006,173 - 64,034,585 (-)NCBImm8
Celera1462,814,500 - 62,860,622 (-)NCBICelera
Cytogenetic Map14D1NCBI
EXTL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl828,600,469 - 28,755,599 (+)EnsemblGRCh38hg38GRCh38
GRCh38828,607,736 - 28,755,599 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37828,559,018 - 28,613,116 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36828,615,072 - 28,667,121 (+)NCBINCBI36hg18NCBI36
Build 34828,615,071 - 28,667,121NCBI
Celera827,519,006 - 27,571,052 (+)NCBI
Cytogenetic Map8p21.1NCBI
HuRef827,104,516 - 27,156,747 (+)NCBIHuRef
CHM1_1828,761,018 - 28,813,245 (+)NCBICHM1_1
Extl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21539,294,033 - 39,384,086 (-)NCBI
Rnor_6.0 Ensembl1548,422,492 - 48,445,592 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01548,420,419 - 48,465,171 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01552,167,241 - 52,307,996 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41544,400,139 - 44,424,584 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11544,415,838 - 44,440,284 (-)NCBI
Celera1538,971,658 - 38,994,995 (-)NCBICelera
Cytogenetic Map15p12-p11NCBI
Extl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540351,076,319 - 51,102,435 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540351,076,323 - 51,102,435 (+)NCBIChiLan1.0ChiLan1.0
EXTL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1825,079,531 - 25,233,599 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl825,174,414 - 25,233,599 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0827,983,700 - 28,035,879 (+)NCBIMhudiblu_PPA_v0panPan3
EXTL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12528,788,803 - 28,833,964 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2528,790,506 - 28,937,647 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2529,437,368 - 29,587,684 (-)NCBI
ROS_Cfam_1.02528,944,632 - 29,095,861 (-)NCBI
UMICH_Zoey_3.12528,905,043 - 29,055,721 (-)NCBI
UNSW_CanFamBas_1.02528,790,655 - 28,940,548 (-)NCBI
UU_Cfam_GSD_1.02528,953,232 - 29,105,065 (-)NCBI
Extl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049437,108,930 - 7,137,757 (-)NCBI
SpeTri2.0NW_0049366751,448,381 - 1,479,735 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EXTL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1412,437,515 - 12,563,544 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11412,437,551 - 12,563,548 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21413,660,607 - 13,712,760 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EXTL3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1826,729,772 - 26,861,953 (+)NCBI
ChlSab1.1 Ensembl826,821,141 - 26,864,926 (+)Ensembl
Vero_WHO_p1.0NW_02366605215,268,419 - 15,404,953 (-)NCBI
Extl3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475823,257,623 - 23,370,782 (+)NCBI

Position Markers
AU040105  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381465,052,316 - 65,052,410UniSTSGRCm38
MGSCv371465,671,153 - 65,671,247UniSTSGRCm37
Celera1462,814,757 - 62,814,851UniSTS
Cytogenetic Map14D1UniSTS
Extl3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381465,076,673 - 65,076,981UniSTSGRCm38
MGSCv371465,695,510 - 65,695,818UniSTSGRCm37
Celera1462,839,158 - 62,839,466UniSTS
Cytogenetic Map14D1UniSTS
cM Map14 UniSTS
Extl3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14D1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420837405121032392Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142101238271648361Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143060000087700000Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143532384068548287Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143719272871192863Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4009986274099862Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144272496776725144Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144272496776725144Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144279982176799969Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144282839876828596Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144282839876828596Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144921797683218107Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145204453586044676Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145352385687524089Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145370000087700000Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145584494189845069Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145630930590309501Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1457942183101622037Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146216002096160240Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:989
Count of miRNA genes:569
Interacting mature miRNAs:674
Transcripts:ENSMUST00000022550
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001360385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_018788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006519284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006519286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC124489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC155172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF083550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK019308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC038525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC065073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF539474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ129577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO044892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000022550   ⟹   ENSMUSP00000022550
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1465,052,060 - 65,098,106 (-)Ensembl
RefSeq Acc Id: ENSMUST00000223989
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1465,077,750 - 65,149,855 (-)Ensembl
RefSeq Acc Id: ENSMUST00000225633   ⟹   ENSMUSP00000153547
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1465,052,063 - 65,098,105 (-)Ensembl
RefSeq Acc Id: NM_001360385   ⟹   NP_001347314
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391465,289,508 - 65,335,555 (-)NCBI
GRCm381465,052,059 - 65,098,106 (-)NCBI
Sequence:
RefSeq Acc Id: NM_018788   ⟹   NP_061258
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391465,289,508 - 65,335,555 (-)NCBI
GRCm381465,052,059 - 65,098,106 (-)NCBI
MGSCv371465,670,896 - 65,716,943 (-)RGD
Celera1462,814,500 - 62,860,622 (-)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006519284   ⟹   XP_006519347
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391465,289,508 - 65,387,349 (-)NCBI
GRCm381465,052,059 - 65,149,899 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006519286   ⟹   XP_006519349
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391465,289,508 - 65,387,340 (-)NCBI
GRCm381465,052,059 - 65,149,886 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_061258   ⟸   NM_018788
- UniProtKB: Q6P1H4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006519347   ⟸   XM_006519284
- Peptide Label: isoform X1
- UniProtKB: Q6P1H4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006519349   ⟸   XM_006519286
- Peptide Label: isoform X1
- UniProtKB: Q6P1H4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001347314   ⟸   NM_001360385
RefSeq Acc Id: ENSMUSP00000153547   ⟸   ENSMUST00000225633
RefSeq Acc Id: ENSMUSP00000022550   ⟸   ENSMUST00000022550
Protein Domains
Exostosin   Glyco_transf_64

Promoters
RGD ID:8682754
Promoter ID:EPDNEW_M19408
Type:initiation region
Name:Extl3_1
Description:Mus musculus exostoses -like 3 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381465,098,053 - 65,098,113EPDNEW
RGD ID:6824909
Promoter ID:MM_KWN:17233
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   Brain,   Kidney,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000111165
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361465,694,801 - 65,696,637 (-)MPROMDB
RGD ID:6824908
Promoter ID:MM_KWN:17234
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000022550,   NM_018788_EXTL3,   UC007UIX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361465,699,351 - 65,699,851 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1860765 AgrOrtholog
Ensembl Genes ENSMUSG00000021978 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000022550 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000153547 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000022550 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000225633 UniProtKB/TrEMBL
Gene3D-CATH 3.90.550.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Exostosin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Exostosin_GT47 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GT64 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-diphossugar_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1860765 ENTREZGENE
NCBI Gene 54616 ENTREZGENE
PANTHER PTHR11062 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Exostosin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_transf_64 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Extl3 PhenoGen
Superfamily-SCOP SSF53448 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt EXTL3_MOUSE UniProtKB/Swiss-Prot
  Q3UUW7_MOUSE UniProtKB/TrEMBL
  Q5DU26_MOUSE UniProtKB/TrEMBL
  Q6P1H4 ENTREZGENE, UniProtKB/TrEMBL
  Q9WVL6 ENTREZGENE
UniProt Secondary E9QKN8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-10 Extl3  exostosin-like glycosyltransferase 3  Extl3  exostoses (multiple)-like 3  Symbol and/or name change 5135510 APPROVED