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Gene: Dctn1 (dynactin 1) Mus musculus
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Symbol: Dctn1
Name: dynactin 1
Description: Exhibits microtubule binding activity. Involved in melanosome transport. Localizes to the cell leading edge; microtubule cytoskeleton; and protein-containing complex. Predicted to colocalize with the cell cortex and retromer complex. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and distal hereditary motor neuronopathy type 7B. Is expressed in brain; embryo; and head. Orthologous to human DCTN1 (dynactin subunit 1); PARTICIPATES IN mitochondria transport pathway; N-cadherin signaling pathway; Huntington's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; dibutyl phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 150 kDa dynein-associated polypeptide; AL022633; DAP-150; DP-150; dynactin 1, retrograde axonal transport; dynactin subunit 1; Glued; p150; p150-glued; p150
Orthologs:
Homo sapiens (human) : DCTN1 (dynactin subunit 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dctn1 (dynactin subunit 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dctn1 (dynactin subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DCTN1 (dynactin subunit 1)
Canis lupus familiaris (dog) : DCTN1 (dynactin subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dctn1 (dynactin subunit 1)
Sus scrofa (pig) : DCTN1 (dynactin subunit 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38683,165,909 - 83,200,118 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37683,129,583 - 83,150,112 (+)NCBIGRCm37mm9NCBIm37
MGSCv36683,145,512 - 83,165,628 (+)NCBImm8
Celera685,148,828 - 85,183,062 (+)NCBICelera
Cytogenetic Map6 C3NCBI
cM Map635.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Dctn1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62330
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.