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Gene: Dctn1 (dynactin 1) Mus musculus
Symbol: Dctn1
Name: dynactin 1
Description: Exhibits microtubule binding activity. Involved in melanosome transport. Localizes to the cell leading edge; microtubule cytoskeleton; and protein-containing complex. Predicted to colocalize with the cell cortex and retromer complex. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and distal hereditary motor neuronopathy type 7B. Is expressed in brain; embryo; and head. Orthologous to human DCTN1 (dynactin subunit 1); PARTICIPATES IN mitochondria transport pathway; N-cadherin signaling pathway; Huntington's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; dibutyl phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 150 kDa dynein-associated polypeptide; AL022633; DAP-150; DP-150; dynactin 1, retrograde axonal transport; dynactin subunit 1; Glued; p150; p150-glued; p150
Homo sapiens (human) : DCTN1 (dynactin subunit 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dctn1 (dynactin subunit 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dctn1 (dynactin subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DCTN1 (dynactin subunit 1)
Canis lupus familiaris (dog) : DCTN1 (dynactin subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dctn1 (dynactin subunit 1)
Sus scrofa (pig) : DCTN1 (dynactin subunit 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38683,165,909 - 83,200,118 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37683,129,583 - 83,150,112 (+)NCBIGRCm37mm9NCBIm37
MGSCv36683,145,512 - 83,165,628 (+)NCBImm8
Celera685,148,828 - 85,183,062 (+)NCBICelera
Cytogenetic Map6 C3NCBI
cM Map635.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Dctn1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62330
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.