Adam7 (a disintegrin and metallopeptidase domain 7) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Adam7 (a disintegrin and metallopeptidase domain 7) Mus musculus
Analyze
Symbol: Adam7
Name: a disintegrin and metallopeptidase domain 7
RGD ID: 62324
MGI Page MGI
Description: Enables endopeptidase activity. Involved in several processes, including epididymis development; positive regulation of flagellated sperm motility; and positive regulation of sperm capacitation. Located in plasma membrane. Is active in cell surface. Orthologous to human ADAM7 (ADAM metallopeptidase domain 7).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 9230104J12Rik; a disintegrin and metalloprotease domain (ADAM) 7; a disintegrin and metalloprotease domain 7; ADAM 7; disintegrin and metalloproteinase domain-containing protein 7; EA; EAP1; EAPI; epididymal apical protein I; RIKEN cDNA 9230104J12 gene
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391468,734,785 - 68,771,138 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1468,734,785 - 68,771,190 (-)EnsemblGRCm39 Ensembl
GRCm381468,497,336 - 68,533,689 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1468,497,336 - 68,533,741 (-)EnsemblGRCm38mm10GRCm38
MGSCv371469,115,393 - 69,151,746 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361467,450,666 - 67,487,005 (-)NCBIMGSCv36mm8
Celera1466,256,851 - 66,298,230 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1435.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
infertility  (IMP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM7. Choi H, etal., Biol Reprod. 2015 Sep;93(3):70. doi: 10.1095/biolreprod.115.130252. Epub 2015 Aug 5.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8163572   PMID:9322939   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11514362   PMID:12466851   PMID:15574878   PMID:15883027   PMID:16141072   PMID:16141073  
PMID:16407499   PMID:17268172   PMID:19855936   PMID:20945367   PMID:21267068   PMID:21677750   PMID:21873635   PMID:24079728   PMID:32325033  


Genomics

Comparative Map Data
Adam7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391468,734,785 - 68,771,138 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1468,734,785 - 68,771,190 (-)EnsemblGRCm39 Ensembl
GRCm381468,497,336 - 68,533,689 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1468,497,336 - 68,533,741 (-)EnsemblGRCm38mm10GRCm38
MGSCv371469,115,393 - 69,151,746 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361467,450,666 - 67,487,005 (-)NCBIMGSCv36mm8
Celera1466,256,851 - 66,298,230 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1435.69NCBI
ADAM7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38824,441,026 - 24,509,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl824,440,930 - 24,526,970 (+)EnsemblGRCh38hg38GRCh38
GRCh37824,298,539 - 24,367,078 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36824,354,454 - 24,422,171 (+)NCBINCBI36Build 36hg18NCBI36
Build 34824,354,483 - 24,422,163NCBI
Celera823,262,089 - 23,329,678 (+)NCBICelera
Cytogenetic Map8p21.2NCBI
HuRef822,843,132 - 22,911,489 (+)NCBIHuRef
CHM1_1824,500,664 - 24,569,228 (+)NCBICHM1_1
T2T-CHM13v2.0824,716,154 - 24,784,481 (+)NCBIT2T-CHM13v2.0
Adam7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81547,009,176 - 47,057,581 (-)NCBIGRCr8
mRatBN7.21542,833,796 - 42,882,201 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1542,833,796 - 42,882,201 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1544,698,442 - 44,746,847 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01545,848,669 - 45,897,074 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01544,294,050 - 44,342,457 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01549,418,946 - 49,467,174 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1549,418,946 - 49,467,174 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01553,152,057 - 53,200,285 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41548,184,131 - 48,232,533 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11548,199,910 - 48,248,313 (-)NCBI
Celera1542,467,652 - 42,515,952 (-)NCBICelera
Cytogenetic Map15p11NCBI
Adam7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540347,465,916 - 47,517,627 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540347,465,916 - 47,521,251 (+)NCBIChiLan1.0ChiLan1.0
ADAM7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2742,949,998 - 43,018,649 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1818,684,146 - 18,752,785 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0823,710,208 - 23,778,026 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1820,627,325 - 20,695,009 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl820,627,325 - 20,713,165 (+)Ensemblpanpan1.1panPan2
ADAM7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12532,946,074 - 33,008,142 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2532,926,553 - 33,008,123 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2533,530,284 - 33,592,739 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02533,151,429 - 33,214,291 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2533,131,958 - 33,214,119 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12533,099,596 - 33,162,450 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02532,956,827 - 33,019,064 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02533,114,757 - 33,177,349 (-)NCBIUU_Cfam_GSD_1.0
Adam7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494310,798,686 - 10,845,986 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365557,724,565 - 7,770,149 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365557,724,565 - 7,770,986 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl148,483,329 - 8,554,869 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1148,484,391 - 8,554,879 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2149,524,174 - 9,565,214 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1822,573,508 - 22,631,657 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl822,574,681 - 22,633,039 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605219,542,447 - 19,609,926 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475819,567,659 - 19,630,082 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475819,538,558 - 19,630,082 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adam7
1126 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:388
Count of miRNA genes:271
Interacting mature miRNAs:314
Transcripts:ENSMUST00000022640, ENSMUST00000128069
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1458179640101859473Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146239746096397680Mouse
10043888Cia51_mcollagen induced arthritis QTL 51 (mouse)Not determined146610389368785736Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
11039527Ccc2_mcolitis susceptibility in the Collaborative Cross 2 (mouse)145991861294138217Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse

Markers in Region
AF013107  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381468,497,350 - 68,497,497UniSTSGRCm38
MGSCv371469,115,407 - 69,115,554UniSTSGRCm37
Celera1466,256,865 - 66,257,012UniSTS
Cytogenetic Map14D2UniSTS
Whitehead/MRC_RH14780.04UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000022640   ⟹   ENSMUSP00000022640
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1468,734,785 - 68,771,138 (-)Ensembl
GRCm38.p6 Ensembl1468,497,336 - 68,533,689 (-)Ensembl
Ensembl Acc Id: ENSMUST00000128069
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1468,735,277 - 68,747,420 (-)Ensembl
GRCm38.p6 Ensembl1468,497,828 - 68,509,971 (-)Ensembl
Ensembl Acc Id: ENSMUST00000225673
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1468,770,450 - 68,771,190 (-)Ensembl
GRCm38.p6 Ensembl1468,533,001 - 68,533,741 (-)Ensembl
RefSeq Acc Id: NM_007402   ⟹   NP_031428
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391468,734,785 - 68,771,138 (-)NCBI
GRCm381468,497,336 - 68,533,689 (-)ENTREZGENE
MGSCv371469,115,393 - 69,151,746 (-)RGD
Celera1466,256,851 - 66,298,230 (-)RGD
cM Map14 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_031428 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53368 (Get FASTA)   NCBI Sequence Viewer  
  AGR55479 (Get FASTA)   NCBI Sequence Viewer  
  AGR55480 (Get FASTA)   NCBI Sequence Viewer  
  BAE37982 (Get FASTA)   NCBI Sequence Viewer  
  EDL35960 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000022640
  ENSMUSP00000022640.8
GenBank Protein O35227 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_031428   ⟸   NM_007402
- Peptide Label: preproprotein
- UniProtKB: F8VQC6 (UniProtKB/Swiss-Prot),   O35227 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000022640   ⟸   ENSMUST00000022640
Protein Domains
Disintegrin   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35227-F1-model_v2 AlphaFold O35227 1-789 view protein structure

Promoters
RGD ID:8682834
Promoter ID:EPDNEW_M19448
Type:initiation region
Name:Adam7_1
Description:Mus musculus a disintegrin and metallopeptidase domain 7 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381468,533,741 - 68,533,801EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107247 AgrOrtholog
Ensembl Genes ENSMUSG00000022056 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000022640 ENTREZGENE
  ENSMUST00000022640.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.390.10 UniProtKB/Swiss-Prot
  4.10.70.10 UniProtKB/Swiss-Prot
InterPro ADAM_Cys-rich UniProtKB/Swiss-Prot
  Disintegrin_CS UniProtKB/Swiss-Prot
  Disintegrin_dom UniProtKB/Swiss-Prot
  Disintegrin_dom_sf UniProtKB/Swiss-Prot
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot
  Peptidase_M12B UniProtKB/Swiss-Prot
  Peptidase_M12B_N UniProtKB/Swiss-Prot
  Reprolysin_adamalysin UniProtKB/Swiss-Prot
KEGG Report mmu:11500 UniProtKB/Swiss-Prot
MGD MGI:107247 ENTREZGENE
NCBI Gene 11500 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/Swiss-Prot
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 7 UniProtKB/Swiss-Prot
Pfam ADAM_CR UniProtKB/Swiss-Prot
  Disintegrin UniProtKB/Swiss-Prot
  Pep_M12B_propep UniProtKB/Swiss-Prot
  Reprolysin UniProtKB/Swiss-Prot
PhenoGen Adam7 PhenoGen
PRINTS DISINTEGRIN UniProtKB/Swiss-Prot
PROSITE ADAM_MEPRO UniProtKB/Swiss-Prot
  DISINTEGRIN_1 UniProtKB/Swiss-Prot
  DISINTEGRIN_2 UniProtKB/Swiss-Prot
SMART ACR UniProtKB/Swiss-Prot
  DISIN UniProtKB/Swiss-Prot
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
  SSF57552 UniProtKB/Swiss-Prot
UniProt ADAM7_MOUSE UniProtKB/Swiss-Prot
  F8VQC6 ENTREZGENE
  O35227 ENTREZGENE
  Q3TNV5_MOUSE UniProtKB/TrEMBL
UniProt Secondary F8VQC6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Adam7  a disintegrin and metallopeptidase domain 7  9230104J12Rik  RIKEN cDNA 9230104J12 gene  Data merged from RGD:1609123 737654 PROVISIONAL