Dapk3 (death-associated protein kinase 3) - Rat Genome Database

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Gene: Dapk3 (death-associated protein kinase 3) Rattus norvegicus
Analyze
Symbol: Dapk3
Name: death-associated protein kinase 3
RGD ID: 621766
Description: Enables ATP binding activity; protein C-terminus binding activity; and protein serine/threonine kinase activity. Involved in several processes, including intracellular signal transduction; neuron differentiation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in several cellular components, including actin filament; membrane raft; and nucleus. Orthologous to human DAPK3 (death associated protein kinase 3); PARTICIPATES IN urinary bladder cancer pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DAP kinase 3; DAP-like kinase; Dapkl; Death-associated like kinase; dlk; MYPT1 kinase; ZIP-kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,524,182 - 8,532,552 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl78,524,183 - 8,532,558 (-)Ensembl
Rnor_6.0711,392,436 - 11,400,855 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,392,437 - 11,400,805 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,559,842 - 11,568,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,007,997 - 10,016,365 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1710,007,996 - 10,016,365 (-)NCBI
Celera76,712,067 - 6,720,435 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
amenorrhea  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
benzo[a]pyrene  (EXP,ISO)
bexarotene  (EXP)
bisphenol A  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
cannabidiol  (EXP)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
diazinon  (EXP)
dioxygen  (ISO)
elemental selenium  (ISO)
ethanol  (EXP,ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
hydrogen cyanide  (ISO)
isobutanol  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methylphenidate  (ISO)
motexafin gadolinium  (ISO)
oxybenzone  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
selenium atom  (ISO)
sodium fluoride  (ISO)
thioacetamide  (EXP)
Tributyltin oxide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. DAP-like kinase interacts with the rat homolog of Schizosaccharomyces pombe CDC5 protein, a factor involved in pre-mRNA splicing and required for G2/M phase transition. Engemann H, etal., Nucleic Acids Res 2002 Mar 15;30(6):1408-17.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Guenebeaud C, etal., Mol Cell. 2010 Dec 22;40(6):863-76. doi: 10.1016/j.molcel.2010.11.021.
5. Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures. Henshall DC, etal., J Neurochem 2003 Sep;86(5):1260-70.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis. Page G, etal., FEBS Lett 1999 Nov 26;462(1-2):187-91.
9. Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis. Page G, etal., Oncogene. 1999 Dec 2;18(51):7265-73.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. DAPK catalytic activity in the hippocampus increases during the recovery phase in an animal model of brain hypoxic-ischemic injury. Schumacher AM, etal., Biochim Biophys Acta 2002 Nov 4;1600(1-2):128-37.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. The association of death-associated protein kinase hypermethylation with early recurrence in superficial bladder cancers. Tada Y, etal., Cancer Res 2002 Jul 15;62(14):4048-53.
Additional References at PubMed
PMID:9488481   PMID:9840928   PMID:10356987   PMID:12917339   PMID:15096528   PMID:15489334   PMID:17087515   PMID:18239682   PMID:18310078   PMID:18505470   PMID:18995835   PMID:19373133  
PMID:19541925   PMID:20038585   PMID:21454679   PMID:21487036   PMID:21880706   PMID:22235829   PMID:23071094   PMID:23454120   PMID:25931508   PMID:26111663   PMID:30851272  


Genomics

Comparative Map Data
Dapk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,524,182 - 8,532,552 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl78,524,183 - 8,532,558 (-)Ensembl
Rnor_6.0711,392,436 - 11,400,855 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,392,437 - 11,400,805 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,559,842 - 11,568,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,007,997 - 10,016,365 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1710,007,996 - 10,016,365 (-)NCBI
Celera76,712,067 - 6,720,435 (-)NCBICelera
Cytogenetic Map7q11NCBI
DAPK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,958,453 - 3,971,099 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl193,958,453 - 3,971,123 (-)EnsemblGRCh38hg38GRCh38
GRCh37193,958,451 - 3,971,097 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,909,452 - 3,920,826 (-)NCBINCBI36hg18NCBI36
Build 34193,909,451 - 3,920,826NCBI
Celera193,895,592 - 3,906,968 (-)NCBI
Cytogenetic Map19p13.3NCBI
HuRef193,721,681 - 3,733,014 (-)NCBIHuRef
CHM1_1193,958,113 - 3,969,502 (-)NCBICHM1_1
T2T-CHM13v2.0193,937,706 - 3,950,355 (-)NCBI
Dapk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,018,821 - 81,029,031 (+)NCBIGRCm39mm39
GRCm39 Ensembl1081,018,839 - 81,029,031 (+)Ensembl
GRCm381081,182,987 - 81,193,197 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,183,005 - 81,193,197 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,645,752 - 80,655,942 (+)NCBIGRCm37mm9NCBIm37
MGSCv361080,587,134 - 80,596,127 (+)NCBImm8
Celera1082,203,364 - 82,213,553 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Dapk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,810,474 - 4,823,259 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554954,809,475 - 4,822,210 (+)NCBIChiLan1.0ChiLan1.0
DAPK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1193,934,496 - 3,946,011 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,934,496 - 3,946,011 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0192,984,806 - 2,996,782 (-)NCBIMhudiblu_PPA_v0panPan3
DAPK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,590,199 - 55,603,883 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,590,223 - 55,602,682 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,315,718 - 55,329,927 (+)NCBI
ROS_Cfam_1.02056,250,289 - 56,264,535 (+)NCBI
ROS_Cfam_1.0 Ensembl2056,250,314 - 56,263,999 (+)Ensembl
UMICH_Zoey_3.12055,306,274 - 55,320,466 (+)NCBI
UNSW_CanFamBas_1.02055,788,043 - 55,802,254 (+)NCBI
UU_Cfam_GSD_1.02055,986,748 - 56,000,993 (+)NCBI
Dapk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,576,995 - 215,590,047 (+)NCBI
SpeTri2.0NW_0049365882,246,142 - 2,257,733 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAPK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,759,022 - 74,779,954 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,758,962 - 74,776,355 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2275,303,427 - 75,320,026 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DAPK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.163,713,179 - 3,729,223 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl63,712,170 - 3,727,929 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660814,517,737 - 4,535,148 (+)NCBIVero_WHO_p1.0
Dapk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,621,696 - 5,625,601 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248285,616,839 - 5,626,849 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH127807  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,524,183 - 8,524,363 (+)MAPPERmRatBN7.2
Rnor_6.0711,392,438 - 11,392,617NCBIRnor6.0
Rnor_5.0711,559,844 - 11,560,023UniSTSRnor5.0
RGSC_v3.4710,007,998 - 10,008,177UniSTSRGSC3.4
Celera76,712,068 - 6,712,247UniSTS
Cytogenetic Map7q11UniSTS
RH139169  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,525,035 - 8,525,172 (+)MAPPERmRatBN7.2
Rnor_6.0711,393,290 - 11,393,426NCBIRnor6.0
Rnor_5.0711,560,696 - 11,560,832UniSTSRnor5.0
RGSC_v3.4710,008,850 - 10,008,986UniSTSRGSC3.4
Celera76,712,920 - 6,713,056UniSTS
RH 3.4 Map2880.3UniSTS
Cytogenetic Map7q11UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:53
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000027634
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 57 41 19 41 5 8 74 35 41 11 5
Low 1 3 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027634   ⟹   ENSRNOP00000027634
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,524,183 - 8,532,552 (-)Ensembl
Rnor_6.0 Ensembl711,392,437 - 11,400,805 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096134   ⟹   ENSRNOP00000081984
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,524,183 - 8,532,558 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113082   ⟹   ENSRNOP00000094423
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,524,237 - 8,532,552 (-)Ensembl
RefSeq Acc Id: NM_022546   ⟹   NP_071991
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,524,183 - 8,532,552 (-)NCBI
Rnor_6.0711,392,437 - 11,400,805 (-)NCBI
Rnor_5.0711,559,842 - 11,568,242 (-)NCBI
RGSC_v3.4710,007,997 - 10,016,365 (-)RGD
Celera76,712,067 - 6,720,435 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240991   ⟹   XP_006241053
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,524,182 - 8,532,451 (-)NCBI
Rnor_6.0711,392,436 - 11,400,722 (-)NCBI
Rnor_5.0711,559,842 - 11,568,242 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240993   ⟹   XP_006241055
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,524,182 - 8,532,295 (-)NCBI
Rnor_6.0711,392,436 - 11,400,722 (-)NCBI
Rnor_5.0711,559,842 - 11,568,242 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595099   ⟹   XP_017450588
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,524,182 - 8,532,539 (-)NCBI
Rnor_6.0711,392,436 - 11,400,721 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079856   ⟹   XP_038935784
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,524,182 - 8,532,436 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_071991   ⟸   NM_022546
- UniProtKB: O88764 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006241053   ⟸   XM_006240991
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006241055   ⟸   XM_006240993
- Peptide Label: isoform X2
- UniProtKB: O88764 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017450588   ⟸   XM_017595099
- Peptide Label: isoform X2
- UniProtKB: O88764 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027634   ⟸   ENSRNOT00000027634
RefSeq Acc Id: XP_038935784   ⟸   XM_039079856
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000081984   ⟸   ENSRNOT00000096134
RefSeq Acc Id: ENSRNOP00000094423   ⟸   ENSRNOT00000113082
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88764-F1-model_v2 AlphaFold O88764 1-448 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694985
Promoter ID:EPDNEW_R5509
Type:initiation region
Name:Dapk3_1
Description:death-associated protein kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,400,796 - 11,400,856EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621766 AgrOrtholog
BioCyc Gene G2FUF-35005 BioCyc
Ensembl Genes ENSRNOG00000020383 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000027634 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000081984 ENTREZGENE
  ENSRNOP00000081984.1 UniProtKB/TrEMBL
  ENSRNOP00000094423.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027634 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000096134 ENTREZGENE
  ENSRNOT00000096134.1 UniProtKB/TrEMBL
  ENSRNOT00000113082.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599435 IMAGE-MGC_LOAD
InterPro DAPK3_STKc UniProtKB/Swiss-Prot
  Kinase-like_dom UniProtKB/Swiss-Prot
  Prot_kinase_cat_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_prot_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:64391 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72441 IMAGE-MGC_LOAD
NCBI Gene 64391 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Dapk3 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP Kinase_like UniProtKB/Swiss-Prot
UniProt A0A8I5ZTC3_RAT UniProtKB/TrEMBL
  A0A8I6GL62_RAT UniProtKB/TrEMBL
  DAPK3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Dapk3  Death-associated protein kinase 3  Dapkl  Death-associated like kinase  Symbol and Name updated 1299863 APPROVED
2002-08-07 Dapkl  Death-associated like kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation catalytic activity and protein levels increase after nerve growth factor (NGF)-induced differentiation 632627