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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Neurodevelopmental Disorders | | ISO | RGD:1351337 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:28191889 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Neurodevelopmental Disorders | | ISO | RGD:1351337 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:28191889 | |
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# | Reference Title | Reference Citation |
1. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
2. | Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics. | Lee IC, etal., J Biol Chem. 2014 Sep 26;289(39):26989-7003. doi: 10.1074/jbc.M114.588079. Epub 2014 Aug 8. |
3. | Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization. | Leung T, etal., Mol Cell Biol 1998 Jan;18(1):130-40. |
4. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
5. | GOA pipeline | RGD automated data pipeline |
6. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
7. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
8. | A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow. | Tan I, etal., Cell. 2008 Oct 3;135(1):123-36. doi: 10.1016/j.cell.2008.09.018. |
Cdc42bpb (Rattus norvegicus - Norway rat) |
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CDC42BPB (Homo sapiens - human) |
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Cdc42bpb (Mus musculus - house mouse) |
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Cdc42bpb (Chinchilla lanigera - long-tailed chinchilla) |
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CDC42BPB (Pan paniscus - bonobo/pygmy chimpanzee) |
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CDC42BPB (Canis lupus familiaris - dog) |
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Cdc42bpb (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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CDC42BPB (Sus scrofa - pig) |
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CDC42BPB (Chlorocebus sabaeus - green monkey) |
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Cdc42bpb (Heterocephalus glaber - naked mole-rat) |
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Variants in Cdc42bpb
441 total Variants ![]() |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
RH127478 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 38 | 44 | 34 | 13 | 34 | 1 | 3 | 74 | 35 | 40 | 11 | 1 |
Low | 5 | 13 | 7 | 6 | 7 | 7 | 8 | 1 | 7 | ||||
Below cutoff |
RefSeq Transcripts | NM_053620 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_006240562 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_005505433 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AF021936 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AY277590 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CB748377 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH474034 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JACYVU010000169 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000039059 ⟹ ENSRNOP00000036487 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000080623 ⟹ ENSRNOP00000075663 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | NM_053620 ⟹ NP_446072 | ||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006240562 ⟹ XP_006240624 | ||||||||||||||||
RefSeq Status: | |||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XR_005505433 | ||||||||
RefSeq Status: | |||||||||
Type: | NON-CODING | ||||||||
Position: |
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Protein RefSeqs | NP_446072 | (Get FASTA) | NCBI Sequence Viewer |
XP_006240624 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAC02942 | (Get FASTA) | NCBI Sequence Viewer |
AAP34403 | (Get FASTA) | NCBI Sequence Viewer | |
EDL97476 | (Get FASTA) | NCBI Sequence Viewer | |
EDL97477 | (Get FASTA) | NCBI Sequence Viewer | |
EDL97478 | (Get FASTA) | NCBI Sequence Viewer | |
EDL97479 | (Get FASTA) | NCBI Sequence Viewer | |
Q7TT49 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_446072 ⟸ NM_053620 |
- UniProtKB: | O54875 (UniProtKB/Swiss-Prot), Q7TT49 (UniProtKB/Swiss-Prot) |
- Sequence: |
RefSeq Acc Id: | XP_006240624 ⟸ XM_006240562 |
- Peptide Label: | isoform X1 |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000075663 ⟸ ENSRNOT00000080623 |
RefSeq Acc Id: | ENSRNOP00000036487 ⟸ ENSRNOT00000039059 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q7TT49-F1-model_v2 | AlphaFold | Q7TT49 | 1-1713 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13694839 | ||||||||
Promoter ID: | EPDNEW_R5361 | ||||||||
Type: | initiation region | ||||||||
Name: | Cdc42bpb_1 | ||||||||
Description: | CDC42 binding protein kinase beta | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:621753 | AgrOrtholog |
BioCyc Gene | G2FUF-35853 | BioCyc |
Ensembl Genes | ENSRNOG00000009675 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Ensembl Protein | ENSRNOP00000036487 | ENTREZGENE |
ENSRNOP00000036487.2 | UniProtKB/Swiss-Prot | |
ENSRNOP00000075663.2 | UniProtKB/TrEMBL | |
Ensembl Transcript | ENSRNOT00000039059 | ENTREZGENE |
ENSRNOT00000039059.4 | UniProtKB/Swiss-Prot | |
ENSRNOT00000080623.2 | UniProtKB/TrEMBL | |
Gene3D-CATH | 1.20.5.340 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
2.30.29.30 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
3.30.60.20 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Transferase(Phosphotransferase) domain 1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
InterPro | AGC-kinase_C | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
C1-like_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
CNH_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
CRIB_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
DAG/PE-bd | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KELK | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Kinase-like_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
MRCKB_STKc | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Myotonic_dystrophy_kinase_coil | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PE/DAG-bd | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PH-like_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PH_domain | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Prot_kinase_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Ser/Thr_kinase_AS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:113960 | UniProtKB/Swiss-Prot |
NCBI Gene | 113960 | ENTREZGENE |
PANTHER | MYOTONIC DYSTROPHY S/T KINASE-RELATED | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PTHR22988:SF34 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | C1_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
CNH | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
DMPK_coil | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KELK | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pkinase | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Cdc42bpb | PhenoGen |
PRINTS | DAGPEDOMAIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PROSITE | AGC_KINASE_CTER | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
CNH | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
CRIB | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PH_DOMAIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PROTEIN_KINASE_ST | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
ZF_DAG_PE_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
ZF_DAG_PE_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SMART | CNH | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PBD | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
S_TK_X | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
S_TKc | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SM00109 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SM00233 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Superfamily-SCOP | PH domain-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
SSF56112 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SSF57889 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Tricorn protease domain 2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
UniProt | A0A0G2KB58_RAT | UniProtKB/TrEMBL |
MRCKB_RAT | UniProtKB/Swiss-Prot | |
O54875 | ENTREZGENE | |
Q7TT49 | ENTREZGENE | |
UniProt Secondary | O54875 | UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2016-01-13 | Cdc42bpb | CDC42 binding protein kinase beta | Cdc42bpb | CDC42 binding protein kinase beta (DMPK-like) | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2008-09-26 | Cdc42bpb | CDC42 binding protein kinase beta (DMPK-like) | Cdc42bpb | Cdc42 binding protein kinase beta | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2004-12-14 | Cdc42bpb | Cdc42-binding protein kinase beta | Symbol and Name status set to approved | 1299863 | APPROVED | ||
2002-08-07 | Cdc42bpb | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
Note Type | Note | Reference |
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gene_domains | contains a kinase domain, cysteine-rich domain, pleckstrin-like domain, and p21 GTPase binding domain | 632451 |