Ces1e (carboxylesterase 1E) - Rat Genome Database

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Gene: Ces1e (carboxylesterase 1E) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ces1e (Ensembl: Ces1d)
Name: carboxylesterase 1E (Ensembl:carboxylesterase 1D)
RGD ID: 621508
Description: Enables retinyl-palmitate esterase activity. Predicted to be involved in lipid catabolic process. Located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to human CES1 (carboxylesterase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: carboxyesterase ES-3; carboxylesterase 1; Ces1; egasyn; ES-HTEL; Es22; esterase 22; liver carboxylesterase 3; LOC683107; MGC156521; pI 5.5 esterase; similar to carboxylesterase 1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81930,006,173 - 30,042,628 (+)NCBIGRCr8
mRatBN7.21913,833,154 - 13,869,627 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1913,796,623 - 13,912,035 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1915,542,278 - 15,571,859 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01920,737,029 - 20,766,618 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01923,682,303 - 23,712,070 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_5.01926,133,775 - 26,134,125 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01926,347,402 - 26,354,168 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41914,887,900 - 14,924,363 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11914,892,725 - 14,929,187 (+)NCBI
Celera1913,766,930 - 13,801,741 (+)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Molecular cloning and expression of rat hepatic neutral cholesteryl ester hydrolase. Ghosh S, etal., Biochim Biophys Acta 1995 Dec 7;1259(3):305-12.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, etal., Mamm Genome. 2010 Oct;21(9-10):427-41. Epub 2010 Oct 8.
5. The carboxylesterase family exhibits C-terminal sequence diversity reflecting the presence or absence of endoplasmic-reticulum-retention sequences. Medda S and Proia RL, Eur J Biochem 1992 Jun 15;206(3):801-6.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Cloning and sequencing of rat liver carboxylesterase ES-3 (egasyn). Robbi M and Beaufay H, Biochem Biophys Res Commun 1994 Sep 30;203(3):1404-11.
11. Nucleotide sequence of cDNA coding for rat liver pI 6.1 esterase (ES-10), a carboxylesterase located in the lumen of the endoplasmic reticulum. Robbi M, etal., Biochem J 1990 Jul 15;269(2):451-8.
12. Cloning and sequencing of rat liver carboxylesterase ES-4 (microsomal palmitoyl-CoA hydrolase). Robbi M, etal., Biochem J 1996 Feb 1;313 ( Pt 3):821-6.
13. Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate. Sanghani SP, etal., Eur J Biochem 2002 Sep;269(18):4387-98.
14. Rat kidney carboxylesterase. Cloning, sequencing, cellular localization, and relationship to rat liver hydrolase. Yan B, etal., J Biol Chem 1994 Nov 25;269(47):29688-96.
Additional References at PubMed
PMID:12477932   PMID:15825828   PMID:17764701   PMID:19187434   PMID:19225040  


Genomics

Variants

.
Variants in Ces1e
335 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:64
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000020775, ENSRNOT00000074479
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat

Markers in Region
CES2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21913,837,454 - 13,837,605 (+)MAPPERmRatBN7.2
mRatBN7.21913,926,882 - 13,927,033 (+)MAPPERmRatBN7.2
Rnor_6.01915,294,979 - 15,295,129NCBIRnor6.0
Rnor_6.01915,158,908 - 15,159,058NCBIRnor6.0
Rnor_5.01926,263,742 - 26,263,892UniSTSRnor5.0
Rnor_5.01926,392,061 - 26,392,211UniSTSRnor5.0
RGSC_v3.41914,892,454 - 14,892,604UniSTSRGSC3.4
RGSC_v3.41914,981,939 - 14,982,089UniSTSRGSC3.4
Celera1913,771,227 - 13,771,377UniSTS
Cytogenetic Map19p11UniSTS


Expression


Sequence


RefSeq Acc Id: NM_031565   ⟹   NP_113753
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81930,006,173 - 30,042,628 (+)NCBI
mRatBN7.21913,833,154 - 13,869,627 (+)NCBI
Rnor_5.01926,133,775 - 26,134,125 (+)NCBI
Rnor_5.01926,347,402 - 26,354,168 (+)NCBI
RGSC_v3.41914,887,900 - 14,924,363 (+)RGD
Celera1913,766,930 - 13,801,741 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_113753 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA57158 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070163.2
  ENSRNOP00000072835.2
  ENSRNOP00000075184.2
  ENSRNOP00000082621.1
  ENSRNOP00000088578
  ENSRNOP00000088578.1
  ENSRNOP00000096820.1
GenBank Protein Q63108 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113753   ⟸   NM_031565
- Peptide Label: precursor
- UniProtKB: Q63108 (UniProtKB/Swiss-Prot),   A0A8I6AA76 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Carboxylesterase type B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63108-F1-model_v2 AlphaFold Q63108 1-561 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621508 AgrOrtholog
BioCyc Gene G2FUF-6407 BioCyc
Ensembl Genes ENSRNOG00000015438 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078874.2 UniProtKB/TrEMBL
  ENSRNOT00000083500.2 UniProtKB/TrEMBL
  ENSRNOT00000085762.2 UniProtKB/TrEMBL
  ENSRNOT00000101266.1 UniProtKB/TrEMBL
  ENSRNOT00000103881 ENTREZGENE
  ENSRNOT00000103881.1 UniProtKB/TrEMBL
  ENSRNOT00000110686.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29225 UniProtKB/TrEMBL
NCBI Gene 29225 ENTREZGENE
PANTHER CARBOXYLESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARBOXYLESTERASE 1E-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARBOXYLESTERASE 1F UniProtKB/TrEMBL
  LIVER CARBOXYLESTERASE 1-RELATED UniProtKB/TrEMBL
Pfam COesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ces1e PhenoGen
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015438 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JX75_RAT UniProtKB/TrEMBL
  A0A0G2K3Z4_RAT UniProtKB/TrEMBL
  A0A0G2K9Y7_RAT UniProtKB/TrEMBL
  A0A8I5ZUX9_RAT UniProtKB/TrEMBL
  A0A8I6AA76 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AML8_RAT UniProtKB/TrEMBL
  EST1E_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-12 Ces1e  carboxylesterase 1E  LOC683107  similar to carboxylesterase 1  Data merged from RGD:1590459 737654 PROVISIONAL
2010-11-18 Ces1e  carboxylesterase 1E  Es22  esterase 22  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Es22  esterase 22  Ces1  carboxylesterase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC683107  similar to carboxylesterase 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-08-07 Ces1  carboxylesterase 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains 2 potential N-linked glycosylation sites and a HXEL consensus sequence for retaining proteins to the endoplasmic reticulum 632434
gene_expression mRNA and protein expressed in liver and proximal tubules of the kidney 632432
gene_homology aa sequence shares 90% identity with mouse Es22 632432
gene_protein mature protein consists of 543 aa residues plus an 18 aa signal peptide at the N terminus 632434
gene_protein protein masses 62 kDa 632435