Adam6 (ADAM metallopeptidase domain 6A) - Rat Genome Database

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Gene: Adam6 (ADAM metallopeptidase domain 6A) Rattus norvegicus
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Symbol: Adam6 (Ensembl: Adam6a)
Name: ADAM metallopeptidase domain 6A (Ensembl:a disintegrin and metallopeptidase domain 6A)
RGD ID: 621472
Description: Predicted to enable metalloendopeptidase activity. Involved in male gonad development. Predicted to be located in cell surface. Predicted to be part of protein-containing complex. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. Orthologous to human ADAM6 (ADAM metallopeptidase domain 6 (pseudogene)); INTERACTS WITH 2-methoxyethanol; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: a disintegrin and metallopeptidase domain 6; a disintegrin and metallopeptidase domain 6A; a disintegrin and metalloproteinase domain 6; Adam6a; tMDC IV; TMDCIV
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86138,488,008 - 138,490,496 (+)NCBIGRCr8
mRatBN7.26132,666,974 - 132,669,462 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx6132,831,539 - 132,834,027 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06133,230,764 - 133,233,252 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06132,505,448 - 132,507,936 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06138,432,550 - 138,435,038 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6138,432,550 - 138,435,035 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06147,426,645 - 147,429,133 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46138,590,268 - 138,592,756 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16138,596,454 - 138,598,940 (+)NCBI
Celera6130,181,108 - 130,183,596 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Rat MDC family of proteins: sequence analysis, tissue distribution, and expression in prepubertal and adult rat testis. Frayne J, etal., Mol Reprod Dev 1997 Oct;48(2):159-67.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Chronological gene expression of ADAMs during testicular development: prespermatogonia (gonocytes) express fertilin beta (ADAM2). Rosselot C, etal., Dev Dyn. 2003 Jul;227(3):458-67.
Additional References at PubMed
PMID:19129510   PMID:21339297  


Genomics

Comparative Map Data
Adam6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86138,488,008 - 138,490,496 (+)NCBIGRCr8
mRatBN7.26132,666,974 - 132,669,462 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx6132,831,539 - 132,834,027 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06133,230,764 - 133,233,252 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06132,505,448 - 132,507,936 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06138,432,550 - 138,435,038 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6138,432,550 - 138,435,035 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06147,426,645 - 147,429,133 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46138,590,268 - 138,592,756 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16138,596,454 - 138,598,940 (+)NCBI
Celera6130,181,108 - 130,183,596 (+)NCBICelera
Cytogenetic Map6q32NCBI
ADAM6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814105,969,729 - 105,972,269 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,969,729 - 105,972,269 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,970,168 - 105,971,166 (-)EnsemblGRCh38hg38GRCh38
GRCh3714106,435,818 - 106,438,358 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614105,506,864 - 105,509,403 (-)NCBINCBI36Build 36hg18NCBI36
Celera1486,366,419 - 86,368,958 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1486,568,723 - 86,571,224 (-)NCBIHuRef
CHM1_114106,306,686 - 106,309,225 (-)NCBICHM1_1
T2T-CHM13v2.014100,240,816 - 100,243,356 (-)NCBIT2T-CHM13v2.0
Adam6a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912113,507,528 - 113,510,034 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12113,507,528 - 113,510,085 (+)EnsemblGRCm39 Ensembl
GRCm3812113,543,908 - 113,546,414 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12113,543,908 - 113,546,465 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712114,782,119 - 114,784,625 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612113,991,716 - 113,994,222 (+)NCBIMGSCv36mm8
Celera12114,727,041 - 114,729,547 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1262.12NCBI

Variants

.
Variants in Adam6
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:78
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000056829
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
7 4 2 17 27 36 12 25 12 2 54 31 12 28 24

Sequence


Ensembl Acc Id: ENSRNOT00000056829   ⟹   ENSRNOP00000053671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6138,432,550 - 138,435,035 (+)Ensembl
RefSeq Acc Id: NM_138906   ⟹   NP_620261
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86138,488,008 - 138,490,496 (+)NCBI
mRatBN7.26132,666,974 - 132,669,462 (+)NCBI
Rnor_6.06138,432,550 - 138,435,038 (+)NCBI
Rnor_5.06147,426,645 - 147,429,133 (+)NCBI
RGSC_v3.46138,590,268 - 138,592,756 (+)RGD
Celera6130,181,108 - 130,183,596 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_620261 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA70328 (Get FASTA)   NCBI Sequence Viewer  
  EDL97376 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620261   ⟸   NM_138906
- Peptide Label: precursor
- UniProtKB: P70535 (UniProtKB/TrEMBL),   A6KC05 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053671   ⟸   ENSRNOT00000056829
Protein Domains
Disintegrin   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9N4-F1-model_v2 AlphaFold G3V9N4 1-751 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694866
Promoter ID:EPDNEW_R5389
Type:multiple initiation site
Name:Adam6_1
Description:a disintegrin and metallopeptidase domain 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06138,432,534 - 138,432,594EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621472 AgrOrtholog
BioCyc Gene G2FUF-35741 BioCyc
Ensembl Genes ENSRNOG00000037524 Ensembl
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Blood-coag_inhib_Disintegrin UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
KEGG Report rno:192271 UniProtKB/TrEMBL
NCBI Gene 192271 ENTREZGENE
PANTHER A DISINTEGRIN AND METALLOPEPTIDASE DOMAIN 6-RELATED UniProtKB/TrEMBL
  ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
PhenoGen Adam6 PhenoGen
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037524 RatGTEx
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Disintegrin UniProtKB/TrEMBL
  Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt A6KC05 ENTREZGENE, UniProtKB/TrEMBL
  P70535 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 Adam6  ADAM metallopeptidase domain 6A  Adam6a  a disintegrin and metallopeptidase domain 6A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-01-07 Adam6a  a disintegrin and metallopeptidase domain 6A  Adam6  a disintegrin and metallopeptidase domain 6  Name and Symbol changed 629549 APPROVED
2005-01-20 Adam6  a disintegrin and metallopeptidase domain 6    a disintegrin and metalloproteinase domain 6  Name updated 1299863 APPROVED
2002-08-07 Adam6  a disintegrin and metalloproteinase domain 6      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in germ cells and somatic cells 631879