Clcn7 (chloride channel, voltage-sensitive 7) - Rat Genome Database
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Gene: Clcn7 (chloride channel, voltage-sensitive 7) Mus musculus
Analyze
Symbol: Clcn7
Name: chloride channel, voltage-sensitive 7
RGD ID: 62127
Description: Predicted to have chloride transmembrane transporter activity. Predicted to be involved in response to pH. Predicted to localize to cytoplasmic vesicle and nucleoplasm. Is expressed in several structures, including early conceptus; heart and pericardium; nervous system; oocyte; and submandibular gland primordium. Used to study autosomal dominant osteopetrosis 2 and autosomal recessive osteopetrosis 4. Human ortholog(s) of this gene implicated in autosomal dominant osteopetrosis 2 and autosomal recessive osteopetrosis 4. Orthologous to human CLCN7 (chloride voltage-gated channel 7); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA409691; AW538136; chloride channel 7 alpha subunit; chloride channel protein 7; ClC-; ClC-7; D17Wsu51e; H(+)/Cl(-) exchange transporter 7
Orthologs:
Homo sapiens (human) : CLCN7 (chloride voltage-gated channel 7)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Clcn7 (chloride voltage-gated channel 7)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Clcn7 (chloride voltage-gated channel 7)
Pan paniscus (bonobo/pygmy chimpanzee) : CLCN7 (chloride voltage-gated channel 7)
Canis lupus familiaris (dog) : CLCN7 (chloride voltage-gated channel 7)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Clcn7 (chloride voltage-gated channel 7)
Sus scrofa (pig) : CLCN7 (chloride voltage-gated channel 7)
Chlorocebus sabaeus (African green monkey) : CLCN7 (chloride voltage-gated channel 7)
Heterocephalus glaber (naked mole-rat) : Clcn7 (chloride voltage-gated channel 7)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,352,353 - 25,381,077 (+)NCBI
GRCm381725,133,378 - 25,162,103 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,133,391 - 25,162,104 (+)EnsemblGRCm38mm10GRCm38
MGSCv371725,270,339 - 25,299,044 (+)NCBIGRCm37mm9NCBIm37
MGSCv361724,860,994 - 24,889,699 (+)NCBImm8
Celera1725,662,706 - 25,691,659 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal autophagy  (IAGP)
abnormal bone marrow cavity morphology  (IAGP)
abnormal bone marrow morphology  (IAGP)
abnormal bone ossification  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal chloride level  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal hair shaft melanin granule distribution  (IAGP)
abnormal head morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal hippocampus neuron morphology  (IAGP)
abnormal hippocampus pyramidal cell morphology  (IAGP)
abnormal lysosome morphology  (IAGP)
abnormal lysosome physiology  (IAGP)
abnormal neocortex morphology  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal osteoclast morphology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal posture  (IAGP)
abnormal retinal pigment epithelium morphology  (IAGP)
abnormal stratification in cerebral cortex  (IAGP)
abnormal tooth eruption  (IAGP)
abnormal trabecular bone morphology  (IAGP)
absent photoreceptor inner segment  (IAGP)
absent photoreceptor outer segment  (IAGP)
accumulation of giant lysosomes in kidney/renal tubule cells  (IAGP)
astrocytosis  (IAGP)
cerebral cortex pyramidal cell degeneration  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone resorption  (IAGP)
decreased bone strength  (IAGP)
decreased bone trabecular spacing  (IAGP)
decreased compact bone area  (IAGP)
decreased compact bone thickness  (IAGP)
decreased survivor rate  (IAGP)
enhanced autophagy  (IAGP)
enlarged lateral ventricles  (IAGP)
failure of tooth eruption  (IAGP)
hippocampal neuron degeneration  (IAGP)
hippocampus pyramidal cell degeneration  (IAGP)
increased areal bone mineral density  (IAGP)
increased body weight  (IAGP)
increased bone mass  (IAGP)
increased bone mineral content  (IAGP)
increased bone mineral density  (IAGP)
increased bone trabecula number  (IAGP)
increased bone volume  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating parathyroid hormone level  (IAGP)
increased osteoblast cell number  (IAGP)
increased osteoclast cell number  (IAGP)
increased trabecular bone thickness  (IAGP)
increased trabecular bone volume  (IAGP)
limb grasping  (IAGP)
loss of cortex neurons  (IAGP)
loss of hippocampal neurons  (IAGP)
lysosomal protein accumulation  (IAGP)
microgliosis  (IAGP)
myelofibrosis  (IAGP)
neurodegeneration  (IAGP)
optic nerve degeneration  (IAGP)
osteopetrosis  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
Purkinje cell degeneration  (IAGP)
respiratory failure  (IAGP)
retinal degeneration  (IAGP)
short limbs  (IAGP)
small cranium  (IAGP)
thin retinal inner nuclear layer  (IAGP)
thin retinal outer nuclear layer  (IAGP)
tonic seizures  (IAGP)
tremors  (IAGP)
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10500249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15489334   PMID:15706348   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:16525474   PMID:16985003   PMID:17105730   PMID:17110406   PMID:17543594   PMID:18799693   PMID:18958510   PMID:19661288   PMID:20121924   PMID:20430974  
PMID:20448277   PMID:20566682   PMID:20599900   PMID:21107136   PMID:21267068   PMID:21441306   PMID:21677750   PMID:21873635   PMID:22564416   PMID:23115349   PMID:24103576   PMID:24185277  
PMID:24820037   PMID:25663454   PMID:25798587   PMID:26346547   PMID:26598607   PMID:26829236   PMID:27746321   PMID:28942122   PMID:29351414   PMID:29501587   PMID:30865697   PMID:31155284  
PMID:32290105  


Genomics

Comparative Map Data
Clcn7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,352,353 - 25,381,077 (+)NCBI
GRCm381725,133,378 - 25,162,103 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,133,391 - 25,162,104 (+)EnsemblGRCm38mm10GRCm38
MGSCv371725,270,339 - 25,299,044 (+)NCBIGRCm37mm9NCBIm37
MGSCv361724,860,994 - 24,889,699 (+)NCBImm8
Celera1725,662,706 - 25,691,659 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
CLCN7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl161,444,934 - 1,475,084 (-)EnsemblGRCh38hg38GRCh38
GRCh38161,444,935 - 1,475,028 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37161,494,934 - 1,525,085 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,435,345 - 1,465,013 (-)NCBINCBI36hg18NCBI36
Build 34161,435,345 - 1,465,013NCBI
Celera161,707,535 - 1,737,366 (-)NCBI
Cytogenetic Map16p13.3NCBI
HuRef161,421,403 - 1,451,021 (-)NCBIHuRef
CHM1_1161,494,934 - 1,525,081 (-)NCBICHM1_1
Clcn7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01014,492,844 - 14,518,167 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,492,844 - 14,516,894 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01014,308,276 - 14,332,371 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41014,379,803 - 14,403,898 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11014,379,802 - 14,403,898 (+)NCBI
Celera1013,824,431 - 13,848,527 (+)NCBICelera
Cytogenetic Map10q12NCBI
Clcn7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,761,498 - 15,791,635 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544215,762,369 - 15,791,635 (+)NCBIChiLan1.0ChiLan1.0
CLCN7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1161,498,432 - 1,518,783 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl161,498,432 - 1,519,951 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01664,599 - 95,016 (-)NCBIMhudiblu_PPA_v0panPan3
CLCN7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl639,331,170 - 39,364,991 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1639,331,100 - 39,356,477 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Clcn7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366942,444,321 - 2,467,734 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLCN7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl340,398,114 - 40,420,960 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1340,397,807 - 40,420,960 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,102,528 - 42,126,038 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLCN7
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl51,355,016 - 1,383,695 (-)Ensembl
ChlSab1.151,355,558 - 1,383,755 (-)NCBI
Clcn7
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249132,140,358 - 2,194,695 (-)NCBI

Position Markers
AW538136  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381725,161,510 - 25,161,621UniSTSGRCm38
MGSCv371725,298,455 - 25,298,566UniSTSGRCm37
Celera1725,691,070 - 25,691,181UniSTS
Cytogenetic Map17A3.3UniSTS
Whitehead/MRC_RH17315.0UniSTS
RH124883  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381725,161,852 - 25,162,019UniSTSGRCm38
MGSCv371725,298,797 - 25,298,964UniSTSGRCm37
Celera1725,691,412 - 25,691,579UniSTS
Cytogenetic Map17A3.3UniSTS
RH125850  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381725,161,849 - 25,162,098UniSTSGRCm38
MGSCv371725,298,794 - 25,299,043UniSTSGRCm37
Celera1725,691,409 - 25,691,658UniSTS
Cytogenetic Map17A3.3UniSTS
cM Map1710.0UniSTS
Whitehead/MRC_RH17312.31UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357902Obq19_mobesity QTL 19 (mouse)Not determined17125443244Mouse
12910982Pifs2_mpeptide-induced fatal syndrome 2 (mouse)17125970523Mouse
1357743Lith3_mlithogenic gene 3 (mouse)Not determined17125975624Mouse
1300613Pcyts4_mplasmacytoma susceptibility 4 (mouse)Not determined17126862710Mouse
1301615Cfld3_mcystic fibrosis lung disease 3 (mouse)Not determined17126862710Mouse
1302100Circp2_mcircadian photosensitivity 2 (mouse)Not determined17128979566Mouse
12910527Nrq1a_mnoise-induced hearing loss resistant QTL 1a (mouse)17128979566Mouse
12910528Nrq1_mnoise-induced hearing loss resistant QTL 1 (mouse)17128979566Mouse
13524851Asrq8_macoustic startle response 8 (mouse)17130809908Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17312791337128037Mouse
1357680Idd23_minsulin dependent diabetes susceptibility 23 (mouse)Not determined17392461526182159Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17392461548559063Mouse
1301327Lmr7_mleishmaniasis resistance 7 (mouse)Not determined17480447727496965Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined480447745359340Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17480447746158776Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17480447747574740Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined480447765330362Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17667496240674962Mouse
4141608Phl1_mprogressive hearing loss 1 (mouse)Not determined17765701129268449Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17836594042366175Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17836594042366175Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171065914544659245Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1098759739053168Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1166699745667145Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171177921045779210Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171223281346232813Mouse
1558807Ceat1_mchronic experimental autoimmune thyroiditis 1 (mouse)Not determined171241779526182159Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171242798746427987Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171390439847904522Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171484267848842786Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171484267848842786Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171484267848842786Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171484267848842786Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171660074750600869Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171660074750600869Mouse
1301505Tir1_mtrypanosome infection response 1 (mouse)Not determined171660074750600869Mouse
1302038Radpf1_mradiation pulmonary fibrosis 1 (mouse)Not determined171661519333600869Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171681096950811104Mouse
1302042Acsns3_mAngiostrongylus costaricensis nematode susceptibility 3 (mouse)Not determined171724323451243371Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171724323451243371Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171724323451243371Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171724323451243371Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171724323451243371Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171795643651959238Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171819938152202007Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171820316552205351Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171883413352834133Mouse
12910769Rtmq1_mrenal tumor modifier QTL 1 (mouse)172268105525502498Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172430185958301973Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172485760955405969Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1893
Count of miRNA genes:660
Interacting mature miRNAs:833
Transcripts:ENSMUST00000040729, ENSMUST00000159426, ENSMUST00000159773, ENSMUST00000160961, ENSMUST00000161153, ENSMUST00000162722, ENSMUST00000162862
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001317404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001782075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_385328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC130711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK009435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK032674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK128981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK176963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY491413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB769566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC054799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY124882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000040729   ⟹   ENSMUSP00000035964
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1725,133,391 - 25,162,104 (+)Ensembl
RefSeq Acc Id: ENSMUST00000159426
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1725,158,655 - 25,159,742 (+)Ensembl
RefSeq Acc Id: ENSMUST00000159773   ⟹   ENSMUSP00000125546
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1725,145,809 - 25,150,586 (+)Ensembl
RefSeq Acc Id: ENSMUST00000160961   ⟹   ENSMUSP00000124194
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1725,136,622 - 25,162,098 (+)Ensembl
RefSeq Acc Id: ENSMUST00000162722
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1725,133,465 - 25,146,543 (+)Ensembl
RefSeq Acc Id: ENSMUST00000162862   ⟹   ENSMUSP00000124527
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1725,133,391 - 25,162,099 (+)Ensembl
RefSeq Acc Id: ENSMUST00000233633   ⟹   ENSMUSP00000156968
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1725,133,391 - 25,162,104 (+)Ensembl
RefSeq Acc Id: NM_001317404   ⟹   NP_001304333
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391725,355,605 - 25,381,077 (+)NCBI
GRCm381725,136,631 - 25,162,103 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011930   ⟹   NP_036060
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391725,352,365 - 25,381,077 (+)NCBI
GRCm381725,133,391 - 25,162,103 (+)NCBI
MGSCv371725,270,339 - 25,299,044 (+)RGD
Celera1725,662,706 - 25,691,659 (+)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_001782075
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391725,352,353 - 25,381,074 (+)NCBI
GRCm381725,133,380 - 25,162,100 (+)NCBI
Sequence:
RefSeq Acc Id: XR_385328
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391725,352,353 - 25,381,074 (+)NCBI
GRCm381725,133,378 - 25,162,100 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036060   ⟸   NM_011930
- Peptide Label: isoform 1
- UniProtKB: O70496 (UniProtKB/Swiss-Prot),   Q6RUT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001304333   ⟸   NM_001317404
- Peptide Label: isoform 2
- UniProtKB: E9PYL4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000125546   ⟸   ENSMUST00000159773
RefSeq Acc Id: ENSMUSP00000035964   ⟸   ENSMUST00000040729
RefSeq Acc Id: ENSMUSP00000156968   ⟸   ENSMUST00000233633
RefSeq Acc Id: ENSMUSP00000124194   ⟸   ENSMUST00000160961
RefSeq Acc Id: ENSMUSP00000124527   ⟸   ENSMUST00000162862
Protein Domains
CBS

Promoters
RGD ID:13675118
Promoter ID:EPDNEW_M21708
Type:initiation region
Name:Clcn7_1
Description:Mus musculus chloride channel, voltage-sensitive 7 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M21709  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381725,133,421 - 25,133,481EPDNEW
RGD ID:13675120
Promoter ID:EPDNEW_M21709
Type:initiation region
Name:Clcn7_2
Description:Mus musculus chloride channel, voltage-sensitive 7 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M21708  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381725,136,635 - 25,136,695EPDNEW
RGD ID:6827935
Promoter ID:MM_KWN:22585
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000077220,   OTTMUST00000077267
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361725,270,169 - 25,270,669 (+)MPROMDB
RGD ID:6827939
Promoter ID:MM_KWN:22586
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:UC008AZW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361725,272,631 - 25,273,657 (+)MPROMDB
RGD ID:6827937
Promoter ID:MM_KWN:22587
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000077268,   OTTMUST00000081086
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361725,281,781 - 25,283,382 (+)MPROMDB
RGD ID:6827936
Promoter ID:MM_KWN:22588
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000077269
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361725,287,316 - 25,288,532 (+)MPROMDB
RGD ID:6847370
Promoter ID:MM_ACW:22074
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain
Transcripts:CLCN7.ESEP07-UNSPLICED,   CLCN7.FSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361725,289,466 - 25,290,017 (+)MPROMDB
RGD ID:6827940
Promoter ID:MM_KWN:22589
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain
Transcripts:OTTMUST00000077271
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361725,294,616 - 25,296,392 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1347048 AgrOrtholog
Ensembl Genes ENSMUSG00000036636 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000035964 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000124194 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000124527 UniProtKB/TrEMBL
  ENSMUSP00000125546 UniProtKB/TrEMBL
  ENSMUSP00000156968 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000040729 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000159773 UniProtKB/TrEMBL
  ENSMUST00000160961 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000162862 UniProtKB/TrEMBL
  ENSMUST00000233633 UniProtKB/TrEMBL
Gene3D-CATH 1.10.3080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CBS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl-channel_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl-channel_volt-gated UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl_channel-7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:26373 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1347048 ENTREZGENE
NCBI Gene 26373 ENTREZGENE
Pfam CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage_CLC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Clcn7 PhenoGen
PRINTS CLCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLCHANNEL7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81340 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.270587 ENTREZGENE
UniProt A0A3B2W4I8_MOUSE UniProtKB/TrEMBL
  CLCN7_MOUSE UniProtKB/Swiss-Prot
  E9PYL4 ENTREZGENE, UniProtKB/TrEMBL
  F6SUM2_MOUSE UniProtKB/TrEMBL
  F7BK14_MOUSE UniProtKB/TrEMBL
  O70496 ENTREZGENE
  Q6RUT9 ENTREZGENE, UniProtKB/TrEMBL
  Q8CCI9_MOUSE UniProtKB/TrEMBL
  Q99JQ6_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-10-20 Clcn7  chloride channel, voltage-sensitive 7    chloride channel 7  Symbol and/or name change 5135510 APPROVED