Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | PLEKHA5 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PLEKHA5 mRNA | CTD | PMID:22079256 | 1,2-dimethylhydrazine | multiple interactions | ISO | Plekha5 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of PLEKHA5 mRNA] | CTD | PMID:22206623 | 1,2-dimethylhydrazine | decreases expression | ISO | Plekha5 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of PLEKHA5 mRNA | CTD | PMID:22206623 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Plekha5 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PLEKHA5 mRNA | CTD | PMID:19770486 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PLEKHA5 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PLEKHA5 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Plekha5 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PLEKHA5 mRNA | CTD | PMID:21570461 and PMID:24680724 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Plekha5 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PLEKHA5 mRNA | CTD | PMID:20819909 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Plekha5 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PLEKHA5 gene] | CTD | PMID:20819909 | 3,3',4,4',5-pentachlorobiphenyl | increases expression | EXP | | 6480464 | 3 more ... | CTD | PMID:23196670 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | PLEKHA5 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PLEKHA5 mRNA | CTD | PMID:28628672 | 4-hydroxyphenyl retinamide | increases expression | ISO | Plekha5 (Mus musculus) | 6480464 | Fenretinide results in increased expression of PLEKHA5 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of PLEKHA5 mRNA | CTD | PMID:24780913 | aflatoxin B1 | decreases methylation | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of PLEKHA5 gene | CTD | PMID:27153756 | Aflatoxin B2 alpha | decreases methylation | ISO | PLEKHA5 (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of PLEKHA5 intron | CTD | PMID:30157460 | all-trans-retinoic acid | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of PLEKHA5 mRNA | CTD | PMID:21934132 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PLEKHA5 mRNA | CTD | PMID:16483693 | antirheumatic drug | increases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of PLEKHA5 mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of PLEKHA5 mRNA | CTD | PMID:33212167 | arsane | affects methylation | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Arsenic affects the methylation of PLEKHA5 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Arsenic affects the methylation of PLEKHA5 gene | CTD | PMID:25304211 | arsenite(3-) | multiple interactions | ISO | PLEKHA5 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to PLEKHA5 mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | multiple interactions | ISO | Plekha5 (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of PLEKHA5 mRNA] | CTD | PMID:22228805 | benzo[a]pyrene | affects methylation | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PLEKHA5 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of PLEKHA5 mRNA | CTD | PMID:20106945 and PMID:21632981 | benzo[a]pyrene | increases expression | ISO | Plekha5 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of PLEKHA5 mRNA | CTD | PMID:22228805 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 and PMID:20018196 | benzo[e]pyrene | decreases methylation | ISO | PLEKHA5 (Homo sapiens) | 6480464 | benzo(e)pyrene results in decreased methylation of PLEKHA5 intron | CTD | PMID:30157460 | bisphenol A | increases expression | ISO | Plekha5 (Mus musculus) | 6480464 | bisphenol A results in increased expression of PLEKHA5 mRNA | CTD | PMID:26063408 | bisphenol A | affects methylation | ISO | PLEKHA5 (Homo sapiens) | 6480464 | bisphenol A affects the methylation of PLEKHA5 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of PLEKHA5 mRNA | CTD | PMID:33670352 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PLEKHA5 mRNA | CTD | PMID:25181051 and PMID:30816183 | bisphenol F | multiple interactions | ISO | PLEKHA5 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PLEKHA5 mRNA | CTD | PMID:28628672 | caffeine | decreases phosphorylation | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of PLEKHA5 protein | CTD | PMID:35688186 | cefaloridine | decreases expression | EXP | | 6480464 | Cephaloridine results in decreased expression of PLEKHA5 mRNA | CTD | PMID:18500788 | cisplatin | increases phosphorylation | ISO | Plekha5 (Mus musculus) | 6480464 | Cisplatin results in increased phosphorylation of PLEKHA5 protein | CTD | PMID:22006019 | clofibrate | decreases expression | ISO | Plekha5 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of PLEKHA5 mRNA | CTD | PMID:23811191 | cobalt dichloride | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of PLEKHA5 mRNA | CTD | PMID:19320972 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of PLEKHA5 mRNA | CTD | PMID:20187946 | cocaine | increases expression | EXP | | 6480464 | Cocaine results in increased expression of PLEKHA5 mRNA | CTD | PMID:17898221 | coumarin | increases phosphorylation | ISO | PLEKHA5 (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of PLEKHA5 protein | CTD | PMID:35688186 | coumestrol | multiple interactions | ISO | PLEKHA5 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 more ... | CTD | PMID:19167446 | coumestrol | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of PLEKHA5 mRNA | CTD | PMID:19167446 | dexamethasone | multiple interactions | ISO | PLEKHA5 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PLEKHA5 mRNA | CTD | PMID:28628672 | dicrotophos | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of PLEKHA5 mRNA | CTD | PMID:28302478 | doxorubicin | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of PLEKHA5 mRNA | CTD | PMID:29803840 | elemental selenium | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Selenium results in decreased expression of PLEKHA5 mRNA | CTD | PMID:19244175 | Enterolactone | multiple interactions | ISO | PLEKHA5 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PLEKHA5 mRNA | CTD | PMID:19167446 | fipronil | increases expression | EXP | | 6480464 | fipronil results in increased expression of PLEKHA5 mRNA | CTD | PMID:23962444 | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of PLEKHA5 mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | ISO | Plekha5 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of PLEKHA5 mRNA] | CTD | PMID:22206623 | formaldehyde | increases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of PLEKHA5 mRNA | CTD | PMID:23649840 | FR900359 | affects phosphorylation | ISO | PLEKHA5 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of PLEKHA5 protein | CTD | PMID:37730182 | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of PLEKHA5 mRNA | CTD | PMID:24136188 | Heptachlor epoxide | increases expression | ISO | Plekha5 (Mus musculus) | 6480464 | Heptachlor Epoxide results in increased expression of PLEKHA5 mRNA | CTD | PMID:25270620 | hydrogen peroxide | affects expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of PLEKHA5 mRNA | CTD | PMID:20044591 | indometacin | multiple interactions | ISO | PLEKHA5 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PLEKHA5 mRNA | CTD | PMID:28628672 | irinotecan | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Irinotecan analog results in decreased expression of PLEKHA5 mRNA | CTD | PMID:18927307 | ivermectin | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of PLEKHA5 protein | CTD | PMID:32959892 | melphalan | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Melphalan results in decreased expression of PLEKHA5 mRNA | CTD | PMID:22363485 | mercury dichloride | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Mercuric Chloride results in decreased expression of PLEKHA5 mRNA | CTD | PMID:27188386 | methapyrilene | decreases methylation | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Methapyrilene results in decreased methylation of PLEKHA5 intron | CTD | PMID:30157460 | methotrexate | increases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Methotrexate results in increased expression of PLEKHA5 mRNA | CTD | PMID:24449571 | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of PLEKHA5 gene | CTD | PMID:35440735 | methylparaben | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | methylparaben results in decreased expression of PLEKHA5 mRNA | CTD | PMID:31745603 | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of PLEKHA5 gene | CTD | PMID:33148267 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PLEKHA5 mRNA | CTD | PMID:20360939 | paracetamol | affects expression | ISO | Plekha5 (Mus musculus) | 6480464 | Acetaminophen affects the expression of PLEKHA5 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of PLEKHA5 mRNA | CTD | PMID:33387578 | paracetamol | increases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of PLEKHA5 mRNA | CTD | PMID:22230336 | paracetamol | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of PLEKHA5 mRNA | CTD | PMID:21420995 | perfluorohexanesulfonic acid | decreases expression | ISO | Plekha5 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in decreased expression of PLEKHA5 mRNA | CTD | PMID:37995155 | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of PLEKHA5 gene | CTD | PMID:33148267 | phenethyl caffeate | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PLEKHA5 mRNA | CTD | PMID:20360939 | phenobarbital | affects expression | ISO | Plekha5 (Mus musculus) | 6480464 | Phenobarbital affects the expression of PLEKHA5 mRNA | CTD | PMID:23091169 | piperonyl butoxide | decreases expression | EXP | | 6480464 | Piperonyl Butoxide results in decreased expression of PLEKHA5 mRNA | CTD | PMID:22484513 | pirinixic acid | decreases expression | ISO | Plekha5 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of PLEKHA5 mRNA | CTD | PMID:23811191 | potassium chromate | multiple interactions | ISO | PLEKHA5 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PLEKHA5 mRNA | CTD | PMID:22079256 | potassium chromate | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of PLEKHA5 mRNA | CTD | PMID:22079256 | potassium dichromate | decreases expression | ISO | Plekha5 (Mus musculus) | 6480464 | Potassium Dichromate results in decreased expression of PLEKHA5 mRNA | CTD | PMID:23608068 | quercetin | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of PLEKHA5 mRNA | CTD | PMID:21632981 | resveratrol | multiple interactions | ISO | PLEKHA5 (Homo sapiens) | 6480464 | [Coumestrol co-treated with resveratrol] results in decreased expression of PLEKHA5 mRNA | CTD | PMID:19167446 | selenium atom | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Selenium results in decreased expression of PLEKHA5 mRNA | CTD | PMID:19244175 | temozolomide | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of PLEKHA5 mRNA | CTD | PMID:31758290 | thimerosal | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of PLEKHA5 mRNA | CTD | PMID:27188386 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of PLEKHA5 mRNA | CTD | PMID:34492290 | triptonide | decreases expression | ISO | Plekha5 (Mus musculus) | 6480464 | triptonide results in decreased expression of PLEKHA5 mRNA | CTD | PMID:33045310 | valdecoxib | increases expression | EXP | | 6480464 | valdecoxib results in increased expression of PLEKHA5 mRNA | CTD | PMID:24136188 | valproic acid | decreases expression | ISO | Plekha5 (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of PLEKHA5 mRNA | CTD | PMID:21427059 | valproic acid | increases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of PLEKHA5 mRNA | CTD | PMID:19101580 more ... | valproic acid | decreases methylation | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of PLEKHA5 gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PLEKHA5 mRNA | CTD | PMID:25979313 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of PLEKHA5 mRNA | CTD | PMID:23034163 | vorinostat | decreases expression | ISO | PLEKHA5 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of PLEKHA5 mRNA | CTD | PMID:27188386 | |