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Gene: Mylk2 (myosin light chain kinase 2) Rattus norvegicus
Symbol: Mylk2
Name: myosin light chain kinase 2
RGD ID: 620934
Description: Exhibits myosin light chain binding activity and myosin light chain kinase activity. Involved in several processes, including positive regulation of fast-twitch skeletal muscle fiber contraction; regulation of neuronal synaptic plasticity; and synaptic vesicle transport. Localizes to several cellular components, including dendritic spine; postsynaptic density; and synaptic vesicle. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 1. Orthologous to human MYLK2 (myosin light chain kinase 2); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
Also known as: Klmc; Mlck; MLCK2; myosin light chain kinase 2, skeletal muscle; myosin light chain kinase 2, skeletal/cardiac muscle; myosin, light polypeptide kinase 2
Homo sapiens (human) : MYLK2 (myosin light chain kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Mylk2 (myosin, light polypeptide kinase 2, skeletal muscle)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mylk2 (myosin light chain kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MYLK2 (myosin light chain kinase 2)
Canis lupus familiaris (dog) : MYLK2 (myosin light chain kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mylk2 (myosin light chain kinase 2)
Sus scrofa (pig) : MYLK2 (myosin light chain kinase 2)
Chlorocebus sabaeus (African green monkey) : MYLK2 (myosin light chain kinase 2)
Heterocephalus glaber (naked mole-rat) : Mylk2 (myosin light chain kinase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03148,386,185 - 148,397,851 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,386,189 - 148,399,501 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,789,177 - 154,800,843 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,252,183 - 143,263,849 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13143,157,804 - 143,169,471 (+)NCBI
Celera3140,125,983 - 140,137,649 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Mylk2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620934
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.