Mylk2 (myosin light chain kinase 2) - Rat Genome Database

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Gene: Mylk2 (myosin light chain kinase 2) Rattus norvegicus
Analyze
Symbol: Mylk2
Name: myosin light chain kinase 2
RGD ID: 620934
Description: Enables myosin light chain binding activity and myosin light chain kinase activity. Involved in several processes, including positive regulation of fast-twitch skeletal muscle fiber contraction; regulation of neuronal synaptic plasticity; and synaptic vesicle transport. Located in several cellular components, including dendritic spine; postsynaptic density; and synaptic vesicle. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 1. Orthologous to human MYLK2 (myosin light chain kinase 2); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Klmc; Mlck; MLCK2; myosin light chain kinase 2, skeletal muscle; myosin light chain kinase 2, skeletal/cardiac muscle; myosin, light polypeptide kinase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23141,376,450 - 141,388,357 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,376,691 - 141,387,728 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3145,281,467 - 145,293,306 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03153,865,278 - 153,877,118 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03151,604,816 - 151,616,654 (+)NCBIRnor_WKY
Rnor_6.03148,386,185 - 148,397,851 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,386,189 - 148,399,501 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,789,177 - 154,800,843 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,252,183 - 143,263,849 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13143,157,804 - 143,169,471 (+)NCBI
Celera3140,125,983 - 140,137,649 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. An MLCK-dependent window in late G1 controls S phase entry of proliferating rodent hepatocytes via ERK-p70S6K pathway. Bessard A, etal., Hepatology. 2006 Jul;44(1):152-63.
2. Increased phosphorylation of myosin light chain associated with slow-to-fast transition in rat soleus. Bozzo C, etal., Am J Physiol Cell Physiol. 2003 Sep;285(3):C575-83. Epub 2003 May 14.
3. Nerve influence on myosin light chain phosphorylation in slow and fast skeletal muscles. Bozzo C, etal., FEBS J. 2005 Nov;272(22):5771-85.
4. Roles of Rho-associated kinase and myosin light chain kinase in morphological and migratory defects of focal adhesion kinase-null cells. Chen BH, etal., J Biol Chem 2002 Sep 13;277(37):33857-63.
5. Non-muscle myosin II and myosin light chain kinase are downstream targets for vasopressin signaling in the renal collecting duct. Chou CL, etal., J Biol Chem. 2004 Nov 19;279(47):49026-35. Epub 2004 Aug 30.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Myosin light chain kinase and acto-myosin contractility modulate activation of the ERK cascade downstream of oncogenic Ras. Helfman DM and Pawlak G, J Cell Biochem. 2005 Aug 1;95(5):1069-80.
8. Visualization of synaptic vesicle movement in intact synaptic boutons using fluorescence fluctuation spectroscopy. Jordan R, etal., Biophys J. 2005 Sep;89(3):2091-102. Epub 2005 Jun 24.
9. Myosin light chain kinase regulates synaptic plasticity and fear learning in the lateral amygdala. Lamprecht R, etal., Neuroscience. 2006;139(3):821-9. Epub 2006 Mar 2.
10. Myosin light-chain phosphorylation in diabetic cardiomyopathy in rats. Liu X, etal., Metabolism. 1997 Jan;46(1):71-5.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. Dual serotonergic regulation of ventricular contractile force through 5-HT2A and 5-HT4 receptors induced in the acute failing heart. Qvigstad E, etal., Circ Res. 2005 Aug 5;97(3):268-76. Epub 2005 Jul 7.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Isolation of the cDNA encoding rat skeletal muscle myosin light chain kinase. Sequence and tissue distribution. Roush CL, etal., J Biol Chem 1988 Jul 25;263(21):10510-6.
20. Dependence of metastatic cancer cell invasion on MLCK-catalyzed phosphorylation of myosin regulatory light chain. Tohtong R, etal., Prostate Cancer Prostatic Dis. 2003;6(3):212-6.
Additional References at PubMed
PMID:2465691   PMID:16260603   PMID:16448786   PMID:16606832   PMID:16822834   PMID:17419808   PMID:17991897   PMID:18511912   PMID:18621396   PMID:21209319   PMID:21556048   PMID:22100921  
PMID:30680929  


Genomics

Comparative Map Data
Mylk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23141,376,450 - 141,388,357 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,376,691 - 141,387,728 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3145,281,467 - 145,293,306 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03153,865,278 - 153,877,118 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03151,604,816 - 151,616,654 (+)NCBIRnor_WKY
Rnor_6.03148,386,185 - 148,397,851 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,386,189 - 148,399,501 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,789,177 - 154,800,843 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,252,183 - 143,263,849 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13143,157,804 - 143,169,471 (+)NCBI
Celera3140,125,983 - 140,137,649 (+)NCBICelera
Cytogenetic Map3q41NCBI
MYLK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382031,819,356 - 31,834,684 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2031,819,308 - 31,834,689 (+)EnsemblGRCh38hg38GRCh38
GRCh372030,407,159 - 30,422,487 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362029,871,045 - 29,886,153 (+)NCBINCBI36Build 36hg18NCBI36
Build 342029,871,044 - 29,886,153NCBI
Celera2027,163,525 - 27,178,847 (+)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2027,196,099 - 27,211,421 (+)NCBIHuRef
CHM1_12030,311,075 - 30,326,398 (+)NCBICHM1_1
T2T-CHM13v2.02033,543,964 - 33,559,292 (+)NCBIT2T-CHM13v2.0
Mylk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,753,265 - 152,764,985 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2152,753,272 - 152,764,988 (+)EnsemblGRCm39 Ensembl
GRCm382152,911,281 - 152,923,065 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,911,352 - 152,923,068 (+)EnsemblGRCm38mm10GRCm38
MGSCv372152,737,088 - 152,748,801 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362152,602,793 - 152,614,506 (+)NCBIMGSCv36mm8
Celera2158,729,121 - 158,740,905 (+)NCBICelera
Cytogenetic Map2H1NCBI
Mylk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542229,141,348 - 29,154,927 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542229,141,699 - 29,154,927 (-)NCBIChiLan1.0ChiLan1.0
MYLK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12029,243,391 - 29,258,508 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2029,243,391 - 29,258,508 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02028,113,024 - 28,128,142 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MYLK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12421,284,309 - 21,297,889 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2421,284,352 - 21,309,363 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2420,931,709 - 20,945,281 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02421,971,185 - 21,984,754 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2421,971,219 - 21,984,750 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12421,249,626 - 21,263,199 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02421,354,931 - 21,368,484 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02421,785,552 - 21,799,121 (+)NCBIUU_Cfam_GSD_1.0
Mylk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640170,351,409 - 170,364,586 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648518,782,887 - 18,795,948 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493648518,782,890 - 18,795,942 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYLK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,499,887 - 35,513,093 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11735,499,828 - 35,513,096 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21740,365,367 - 40,378,618 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYLK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,207,013 - 36,223,292 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl236,207,901 - 36,223,307 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605090,691,023 - 90,706,346 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mylk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624741680,016 - 693,908 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624741680,230 - 693,895 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mylk2
34 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:48
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000011255
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 11 8
Low 1 10 36 22 19 22 3 1 19 11
Below cutoff 1 33 14 12 12 46 29 14

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011255   ⟹   ENSRNOP00000011255
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3141,376,691 - 141,387,728 (+)Ensembl
Rnor_6.0 Ensembl3148,386,189 - 148,399,501 (+)Ensembl
RefSeq Acc Id: NM_057209   ⟹   NP_476557
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23141,376,512 - 141,388,357 (+)NCBI
Rnor_6.03148,386,185 - 148,397,851 (+)NCBI
Rnor_5.03154,789,177 - 154,800,843 (+)NCBI
RGSC_v3.43143,252,183 - 143,263,849 (+)RGD
Celera3140,125,983 - 140,137,649 (+)RGD
Sequence:
RefSeq Acc Id: XR_005501754
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23141,376,450 - 141,388,355 (+)NCBI
RefSeq Acc Id: XR_005501755
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23141,376,450 - 141,385,698 (+)NCBI
Protein Sequences
Protein RefSeqs NP_476557 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41625 (Get FASTA)   NCBI Sequence Viewer  
  EDL86035 (Get FASTA)   NCBI Sequence Viewer  
  P20689 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_476557   ⟸   NM_057209
- UniProtKB: G3V731 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011255   ⟸   ENSRNOT00000011255
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20689-F1-model_v2 AlphaFold P20689 1-610 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620934 AgrOrtholog
BioCyc Gene G2FUF-47240 BioCyc
Ensembl Genes ENSRNOG00000008235 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000011255 ENTREZGENE
  ENSRNOP00000011255.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011255 ENTREZGENE
  ENSRNOT00000011255.6 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MLCK2_STKc UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117558 UniProtKB/Swiss-Prot
NCBI Gene 117558 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mylk2 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3V731 ENTREZGENE, UniProtKB/TrEMBL
  MYLK2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-07-21 Mylk2  myosin light chain kinase 2  Mylk2  myosin, light polypeptide kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27 Mylk2  myosin, light polypeptide kinase 2  Mylk2  myosin light chain kinase 2, skeletal muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Mylk2  myosin light chain kinase 2, skeletal muscle      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Mylk2  myosin light chain kinase 2, skeletal muscle      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation induced to accumulate at the cell periphery by constitutively active Rho-kinase in FAK(+/+) cells 727389