Akap4 (A-kinase anchoring protein 4) - Rat Genome Database

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Gene: Akap4 (A-kinase anchoring protein 4) Rattus norvegicus
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Symbol: Akap4
Name: A-kinase anchoring protein 4
RGD ID: 620828
Description: Predicted to enable protein kinase A binding activity. Predicted to be involved in flagellated sperm motility and protein localization. Predicted to act upstream of or within several processes, including establishment of protein localization; sperm flagellum assembly; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to be located in Z disc; perinuclear region of cytoplasm; and sperm flagellum. Predicted to be active in cytoplasm; sperm fibrous sheath; and sperm principal piece. Orthologous to human AKAP4 (A-kinase anchoring protein 4); PARTICIPATES IN protein kinase A (PKA) signaling pathway; INTERACTS WITH ammonium chloride; bisphenol A; perfluorododecanoic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 75 kDa fibrous sheath protein; A kinase (PRKA) anchor protein 4; A-kinase anchor protein 4; AKAP-4; major sperm fibrous sheath protein; PRKA4; protein kinase A-anchoring protein 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X15,435,391 - 15,445,684 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX15,435,410 - 15,445,684 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX20,251,578 - 20,261,972 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X19,821,331 - 19,831,725 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,086,288 - 16,096,682 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X16,296,027 - 16,306,078 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX16,296,735 - 16,306,078 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X17,081,382 - 17,091,111 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X27,515,009 - 27,524,606 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X27,568,477 - 27,578,075 (-)NCBI
CeleraX15,510,282 - 15,520,669 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cilium  (ISO)
cytoplasm  (IBA,IEA)
motile cilium  (ISO,ISS)
perinuclear region of cytoplasm  (IEA,ISO)
sperm connecting piece  (IEA,ISO)
sperm end piece  (IEA,ISO)
sperm fibrous sheath  (IBA,IEA,ISO)
sperm midpiece  (IEA,ISO)
sperm principal piece  (IBA,IEA,ISO)
Z disc  (IEA,ISO)

Molecular Function
protein binding  (ISO)
protein kinase A binding  (IBA,IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A-kinase anchoring proteins: from protein complexes to physiology and disease. Carnegie GK, etal., IUBMB Life. 2009 Apr;61(4):394-406.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility. Miki K, etal., Dev Biol 2002 Aug 15;248(2):331-42.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Localized effects of cAMP mediated by distinct routes of protein kinase A. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
Additional References at PubMed
PMID:8088444   PMID:9822690   PMID:9852104   PMID:12606363   PMID:15385410   PMID:16687649   PMID:17923693   PMID:21630459   PMID:21715716   PMID:30137358   PMID:30745215  


Genomics

Comparative Map Data
Akap4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X15,435,391 - 15,445,684 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX15,435,410 - 15,445,684 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX20,251,578 - 20,261,972 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X19,821,331 - 19,831,725 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,086,288 - 16,096,682 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X16,296,027 - 16,306,078 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX16,296,735 - 16,306,078 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X17,081,382 - 17,091,111 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X27,515,009 - 27,524,606 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X27,568,477 - 27,578,075 (-)NCBI
CeleraX15,510,282 - 15,520,669 (-)NCBICelera
Cytogenetic MapXq12NCBI
AKAP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X50,190,777 - 50,201,007 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX50,190,777 - 50,201,007 (-)EnsemblGRCh38hg38GRCh38
GRCh37X49,955,420 - 49,965,658 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X49,842,151 - 49,852,404 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X49,658,457 - 49,668,040NCBI
CeleraX54,024,511 - 54,034,765 (-)NCBICelera
Cytogenetic MapXp11.22NCBI
HuRefX47,427,699 - 47,437,860 (-)NCBIHuRef
CHM1_1X50,035,048 - 50,045,361 (-)NCBICHM1_1
T2T-CHM13v2.0X49,508,429 - 49,518,665 (-)NCBIT2T-CHM13v2.0
Akap4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X6,933,754 - 6,944,848 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX6,933,758 - 6,944,848 (+)EnsemblGRCm39 Ensembl
GRCm38X7,067,515 - 7,078,609 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,067,519 - 7,078,609 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X6,644,645 - 6,655,735 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X6,224,469 - 6,235,378 (+)NCBIMGSCv36mm8
MGSCv36X3,237,368 - 3,248,069 (+)NCBIMGSCv36mm8
CeleraX4,385,111 - 4,395,986 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.17NCBI
Akap4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555431,357,997 - 1,367,897 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555431,358,086 - 1,367,838 (+)NCBIChiLan1.0ChiLan1.0
AKAP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1X51,612,573 - 51,625,268 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X42,396,399 - 42,406,725 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X50,109,391 - 50,119,651 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX50,109,367 - 50,119,658 (-)Ensemblpanpan1.1panPan2
AKAP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X42,935,831 - 42,946,248 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX42,935,815 - 42,946,149 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX17,313,189 - 17,323,613 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X43,074,974 - 43,085,399 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX43,074,994 - 43,085,299 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X43,060,826 - 43,071,242 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X43,048,110 - 43,058,530 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X43,143,002 - 43,153,434 (-)NCBIUU_Cfam_GSD_1.0
Akap4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X35,452,021 - 35,462,091 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367211,692,623 - 1,702,348 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367211,692,623 - 1,700,256 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKAP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX43,885,394 - 43,895,981 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X43,885,584 - 43,895,142 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X48,812,671 - 48,822,999 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AKAP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X47,046,209 - 47,056,961 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX47,046,240 - 47,056,319 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666086628,681 - 638,923 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akap4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248931,759,045 - 1,767,918 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248931,759,148 - 1,767,831 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Akap4
30 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat

Markers in Region
U10341  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X15,435,405 - 15,435,507 (+)MAPPERmRatBN7.2
Rnor_6.0X16,296,042 - 16,296,143NCBIRnor6.0
Rnor_5.0X17,081,397 - 17,081,498UniSTSRnor5.0
CeleraX15,510,297 - 15,510,398UniSTS
Cytogenetic MapXq13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 7
Medium
Low 1 1 6 1 2 2 3 1 1 2
Below cutoff 16 13 9 7 9 3 5 4 5 16 3 3

Sequence


RefSeq Acc Id: ENSRNOT00000003939   ⟹   ENSRNOP00000003939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX15,435,410 - 15,445,684 (-)Ensembl
Rnor_6.0 EnsemblX16,296,735 - 16,306,078 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102856   ⟹   ENSRNOP00000088271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX15,435,410 - 15,442,370 (-)Ensembl
RefSeq Acc Id: NM_024402   ⟹   NP_077378
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X15,435,391 - 15,445,684 (-)NCBI
Rnor_6.0X16,296,027 - 16,306,078 (-)NCBI
Rnor_5.0X17,081,382 - 17,091,111 (-)NCBI
RGSC_v3.4X27,515,009 - 27,524,606 (-)RGD
CeleraX15,510,282 - 15,520,669 (-)RGD
Sequence:
RefSeq Acc Id: XM_039100088   ⟹   XP_038956016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X15,435,400 - 15,445,044 (-)NCBI
Protein Sequences
Protein RefSeqs NP_077378 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956016 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB62877 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003939
  ENSRNOP00000003939.7
  ENSRNOP00000088271
  ENSRNOP00000088271.1
GenBank Protein O35774 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077378   ⟸   NM_024402
- UniProtKB: O35774 (UniProtKB/Swiss-Prot),   A6KPB5 (UniProtKB/TrEMBL),   F1LMR8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003939   ⟸   ENSRNOT00000003939
RefSeq Acc Id: XP_038956016   ⟸   XM_039100088
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A7I7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000088271   ⟸   ENSRNOT00000102856
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35774-F1-model_v2 AlphaFold O35774 1-847 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701752
Promoter ID:EPDNEW_R12276
Type:initiation region
Name:Akap4_1
Description:A-kinase anchoring protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X16,306,132 - 16,306,192EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620828 AgrOrtholog
BioCyc Gene G2FUF-2876 BioCyc
Ensembl Genes ENSRNOG00000002921 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003939 ENTREZGENE
  ENSRNOT00000003939.7 UniProtKB/TrEMBL
  ENSRNOT00000102856 ENTREZGENE
  ENSRNOT00000102856.1 UniProtKB/TrEMBL
InterPro AKAP_110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AKAP_110_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RII_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPHK1-interactor_AKAP_110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79254 UniProtKB/Swiss-Prot
NCBI Gene 79254 ENTREZGENE
PANTHER A-KINASE ANCHOR PROTEIN 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10226 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AKAP_110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RII_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Akap4 PhenoGen
RatGTEx ENSRNOG00000002921 RatGTEx
SMART AKAP_110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A7I7 ENTREZGENE, UniProtKB/TrEMBL
  A6KPB5 ENTREZGENE, UniProtKB/TrEMBL
  AKAP4_RAT UniProtKB/Swiss-Prot
  F1LMR8 ENTREZGENE, UniProtKB/TrEMBL
  O35774 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Akap4  A-kinase anchoring protein 4  Akap4  A kinase (PRKA) anchor protein 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Akap4  A kinase (PRKA) anchor protein 4  Akap4  A-kinase anchor protein 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Akap4  A-kinase anchor protein 4    75 kDa fibrous sheath protein  Name updated 1299863 APPROVED
2002-08-07 Akap4  75 kDa fibrous sheath protein      Symbol and Name status set to provisional 70820 PROVISIONAL