Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | SLC25A27 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | |
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Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | SLC25A27 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | |
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# | Reference Title | Reference Citation |
1. | UCP4 overexpression improves fatty acid oxidation and insulin sensitivity in L6 myocytes. | Gao CL, etal., J Bioenerg Biomembr. 2011 Apr;43(2):109-18. doi: 10.1007/s10863-011-9344-9. Epub 2011 May 24. |
2. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
3. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
4. | Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. | Liu D, etal., Neuromolecular Med. 2006;8(3):389-414. |
5. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
6. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
7. | GOA pipeline | RGD automated data pipeline |
8. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
9. | Comprehensive gene review and curation | RGD comprehensive gene curation |
10. | Comparative analysis of uncoupling protein 4 distribution in various tissues under physiological conditions and during development. | Smorodchenko A, etal., Biochim Biophys Acta. 2009 Oct;1788(10):2309-19. Epub 2009 Jul 30. |
11. | Role of mitochondrial uncoupling protein 4 in rat inner ear. | Smorodchenko A, etal., Mol Cell Neurosci. 2011 Aug;47(4):244-53. Epub 2011 Mar 11. |
12. | Mitochondrial proton leak and the uncoupling protein 1 homologues. | Stuart JA, etal., Biochim Biophys Acta 2001 Mar 1;1504(1):144-58. |
13. | Domoic acid induced spinal cord lesions in adult mice: evidence for the possible molecular pathways of excitatory amino acids in spinal cord lesions. | Xu R, etal., Neurotoxicology. 2008 Jul;29(4):700-7. Epub 2008 May 1. |
14. | Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia. | Yasuno K, etal., Am J Med Genet B Neuropsychiatr Genet. 2007 Mar 5;144B(2):250-3. |
15. | Overexpression of uncoupling protein 4 promotes proliferation and inhibits apoptosis and differentiation of preadipocytes. | Zhang M, etal., Life Sci. 2006 Sep 5;79(15):1428-35. Epub 2006 Apr 27. |
PMID:10025957 | PMID:14651853 | PMID:15464300 | PMID:18614015 | PMID:18992805 | PMID:23266757 | PMID:23800309 | PMID:26934480 |
Slc25a27 (Rattus norvegicus - Norway rat) |
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SLC25A27 (Homo sapiens - human) |
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Slc25a27 (Mus musculus - house mouse) |
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Slc25a27 (Chinchilla lanigera - long-tailed chinchilla) |
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SLC25A27 (Pan paniscus - bonobo/pygmy chimpanzee) |
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SLC25A27 (Canis lupus familiaris - dog) |
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Slc25a27 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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SLC25A27 (Sus scrofa - pig) |
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SLC25A27 (Chlorocebus sabaeus - green monkey) |
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Slc25a27 (Heterocephalus glaber - naked mole-rat) |
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Variants in Slc25a27
202 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 72 | 2 | |||||||||||
Low | 1 | 29 | 39 | 28 | 3 | 28 | 5 | 7 | 2 | 31 | 39 | 9 | 5 |
Below cutoff | 2 | 14 | 18 | 13 | 15 | 13 | 3 | 4 | 4 | 2 | 3 |
RefSeq Transcripts | NM_053500 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_006244610 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006244611 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006244612 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_008766882 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039084299 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039084300 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039084302 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039084303 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063267787 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AJ300162 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AJ300163 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AJ300164 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AY512661 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH473987 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000009 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000052068 ⟹ ENSRNOP00000039207 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000098372 ⟹ ENSRNOP00000094770 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000098398 ⟹ ENSRNOP00000082945 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_053500 ⟹ NP_445952 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006244610 ⟹ XP_006244672 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006244611 ⟹ XP_006244673 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006244612 ⟹ XP_006244674 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_008766882 ⟹ XP_008765104 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039084299 ⟹ XP_038940227 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039084300 ⟹ XP_038940228 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039084302 ⟹ XP_038940230 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039084303 ⟹ XP_038940231 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_063267787 ⟹ XP_063123857 | ||||||||
Type: | CODING | ||||||||
Position: |
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Protein RefSeqs | NP_445952 | (Get FASTA) | NCBI Sequence Viewer |
XP_006244672 | (Get FASTA) | NCBI Sequence Viewer | |
XP_006244673 | (Get FASTA) | NCBI Sequence Viewer | |
XP_006244674 | (Get FASTA) | NCBI Sequence Viewer | |
XP_008765104 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038940227 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038940228 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038940230 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038940231 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063123857 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAR97577 | (Get FASTA) | NCBI Sequence Viewer |
CAC20898 | (Get FASTA) | NCBI Sequence Viewer | |
CAC20899 | (Get FASTA) | NCBI Sequence Viewer | |
CAC20900 | (Get FASTA) | NCBI Sequence Viewer | |
EDM18699 | (Get FASTA) | NCBI Sequence Viewer | |
EDM18700 | (Get FASTA) | NCBI Sequence Viewer | |
EDM18701 | (Get FASTA) | NCBI Sequence Viewer | |
EDM18702 | (Get FASTA) | NCBI Sequence Viewer | |
EDM18703 | (Get FASTA) | NCBI Sequence Viewer | |
EDM18704 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000039207 | ||
ENSRNOP00000039207.4 | |||
ENSRNOP00000082945.1 | |||
ENSRNOP00000094770 | |||
ENSRNOP00000094770.1 |
RefSeq Acc Id: | NP_445952 ⟸ NM_053500 |
- UniProtKB: | Q9EPH7 (UniProtKB/TrEMBL), A6JJ30 (UniProtKB/TrEMBL), A6JJ28 (UniProtKB/TrEMBL), F7F692 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006244673 ⟸ XM_006244611 |
- Peptide Label: | isoform X2 |
- UniProtKB: | Q9EPH6 (UniProtKB/TrEMBL), A0A8I6ALR4 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006244674 ⟸ XM_006244612 |
- Peptide Label: | isoform X4 |
- UniProtKB: | A6JJ28 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006244672 ⟸ XM_006244610 |
- Peptide Label: | isoform X1 |
- UniProtKB: | Q9EPH5 (UniProtKB/TrEMBL), A6JJ28 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_008765104 ⟸ XM_008766882 |
- Peptide Label: | isoform X3 |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000039207 ⟸ ENSRNOT00000052068 |
RefSeq Acc Id: | XP_038940227 ⟸ XM_039084299 |
- Peptide Label: | isoform X5 |
RefSeq Acc Id: | XP_038940231 ⟸ XM_039084303 |
- Peptide Label: | isoform X8 |
RefSeq Acc Id: | XP_038940228 ⟸ XM_039084300 |
- Peptide Label: | isoform X5 |
RefSeq Acc Id: | XP_038940230 ⟸ XM_039084302 |
- Peptide Label: | isoform X7 |
RefSeq Acc Id: | ENSRNOP00000094770 ⟸ ENSRNOT00000098372 |
RefSeq Acc Id: | ENSRNOP00000082945 ⟸ ENSRNOT00000098398 |
RefSeq Acc Id: | XP_063123857 ⟸ XM_063267787 |
- Peptide Label: | isoform X6 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q6R5J6-F1-model_v2 | AlphaFold | Q6R5J6 | 1-275 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
Database | Acc Id | Source(s) |
AGR Gene | RGD:620787 | AgrOrtholog |
BioCyc Gene | G2FUF-28118 | BioCyc |
Ensembl Genes | ENSRNOG00000010592 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000052068 | ENTREZGENE |
ENSRNOT00000052068.4 | UniProtKB/TrEMBL | |
ENSRNOT00000098372.1 | UniProtKB/TrEMBL | |
ENSRNOT00000098398.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 1.50.40.10 | UniProtKB/TrEMBL |
InterPro | Mitochondrial_sb/sol_carrier | UniProtKB/TrEMBL |
Mt_carrier_dom | UniProtKB/TrEMBL | |
KEGG Report | rno:85262 | UniProtKB/TrEMBL |
NCBI Gene | 85262 | ENTREZGENE |
PANTHER | MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED | UniProtKB/TrEMBL |
MITOCHONDRIAL UNCOUPLING PROTEIN 4 | UniProtKB/TrEMBL | |
Pfam | Mito_carr | UniProtKB/TrEMBL |
PhenoGen | Slc25a27 | PhenoGen |
PROSITE | SOLCAR | UniProtKB/TrEMBL |
RatGTEx | ENSRNOG00000010592 | RatGTEx |
Superfamily-SCOP | Mitoch_carrier | UniProtKB/TrEMBL |
UniProt | A0A8I5ZVX7_RAT | UniProtKB/TrEMBL |
A0A8I6ALR4 | ENTREZGENE, UniProtKB/TrEMBL | |
A6JJ28 | ENTREZGENE, UniProtKB/TrEMBL | |
A6JJ30 | ENTREZGENE, UniProtKB/TrEMBL | |
F7F692 | ENTREZGENE, UniProtKB/TrEMBL | |
Q6R5J6_RAT | UniProtKB/TrEMBL | |
Q9EPH5 | ENTREZGENE, UniProtKB/TrEMBL | |
Q9EPH6 | ENTREZGENE, UniProtKB/TrEMBL | |
Q9EPH7 | ENTREZGENE | |
UniProt Secondary | Q9EPH7 | UniProtKB/TrEMBL |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2005-01-20 | Slc25a27 | solute carrier family 25, member 27 | Ucp4 | uncoupling protein UCP-4 | Symbol and Name updated | 1299863 | APPROVED |
2002-08-07 | Ucp4 | uncoupling protein UCP-4 | Symbol and Name status set to provisional | 70820 | PROVISIONAL |