Hcn3 (hyperpolarization-activated cyclic nucleotide-gated potassium channel 3) - Rat Genome Database

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Gene: Hcn3 (hyperpolarization-activated cyclic nucleotide-gated potassium channel 3) Rattus norvegicus
Analyze
Symbol: Hcn3
Name: hyperpolarization-activated cyclic nucleotide-gated potassium channel 3
RGD ID: 620691
Description: Predicted to enable voltage-gated potassium channel activity and voltage-gated sodium channel activity. Involved in cellular response to dopamine. Located in cone cell pedicle; dendrite; and neuronal cell body. Biomarker of Parkinson's disease. Orthologous to human HCN3 (hyperpolarization activated cyclic nucleotide gated potassium channel 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hyperpolarization-activated, cyclic nucleotide-gated potassium channel 3; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,849,635 - 176,867,726 (-)NCBIGRCr8
mRatBN7.22174,551,861 - 174,567,459 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,551,680 - 174,565,966 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,698,627 - 181,711,803 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,721,001 - 179,734,174 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,320,946 - 174,334,027 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,458,851 - 188,471,916 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,454,853 - 188,471,988 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,875,210 - 207,888,575 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,224,322 - 181,237,190 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12181,174,427 - 181,187,296 (-)NCBI
Celera2168,495,658 - 168,508,727 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Dopamine depletion induced up-regulation of HCN3 enhances rebound excitability of basal ganglia output neurons. Meurers BH, etal., Neurobiol Dis. 2009 Apr;34(1):178-88.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain. Monteggia LM, etal., Brain Res Mol Brain Res 2000 Sep 30;81(1-2):129-39.
5. HCN channels are expressed differentially in retinal bipolar cells and concentrated at synaptic terminals. Muller F, etal., Eur J Neurosci 2003 May;17(10):2084-96.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain. Notomi T and Shigemoto R, J Comp Neurol. 2004 Apr 5;471(3):241-76.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues. Shi W, etal., Circ Res 1999 Jul 9;85(1):e1-6.
12. Diabetes alters protein expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits in rat nodose ganglion cells. Tu H, etal., Neuroscience. 2010 Jan 13;165(1):39-52. doi: 10.1016/j.neuroscience.2009.10.002. Epub 2009 Oct 6.
13. Hyperpolarization-activated channels in trigeminal ganglia innervating healthy and pulp-exposed teeth. Wells JE, etal., Int Endod J. 2007 Sep;40(9):715-21. Epub 2007 Jul 23.
14. Declines in levels of hyperpolarization-activated cation (HCN) channels in the rat ovary after cisplatin exposure. Yeh J, etal., Reprod Sci. 2009 Oct;16(10):986-94. Epub 2009 Jul 7.
Additional References at PubMed
PMID:15923185   PMID:16175581   PMID:18450385   PMID:21753027   PMID:21798320   PMID:22694806   PMID:22748890   PMID:23382386   PMID:26341471   PMID:27496876   PMID:27569278   PMID:32962418  


Genomics

Comparative Map Data
Hcn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,849,635 - 176,867,726 (-)NCBIGRCr8
mRatBN7.22174,551,861 - 174,567,459 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,551,680 - 174,565,966 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,698,627 - 181,711,803 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,721,001 - 179,734,174 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,320,946 - 174,334,027 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,458,851 - 188,471,916 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,454,853 - 188,471,988 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,875,210 - 207,888,575 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,224,322 - 181,237,190 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12181,174,427 - 181,187,296 (-)NCBI
Celera2168,495,658 - 168,508,727 (-)NCBICelera
Cytogenetic Map2q34NCBI
HCN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,277,463 - 155,289,848 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1155,277,463 - 155,289,848 (+)EnsemblGRCh38hg38GRCh38
GRCh371155,247,254 - 155,259,639 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361153,513,998 - 153,526,262 (+)NCBINCBI36Build 36hg18NCBI36
Celera1128,320,546 - 128,332,814 (+)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1126,609,528 - 126,621,951 (+)NCBIHuRef
CHM1_11156,642,633 - 156,655,054 (+)NCBICHM1_1
T2T-CHM13v2.01154,416,023 - 154,428,409 (+)NCBIT2T-CHM13v2.0
Hcn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,054,082 - 89,067,538 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,053,381 - 89,067,503 (-)EnsemblGRCm39 Ensembl
GRCm38389,146,775 - 89,160,284 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,146,074 - 89,160,196 (-)EnsemblGRCm38mm10GRCm38
MGSCv37388,950,697 - 88,964,079 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36389,232,702 - 89,246,084 (-)NCBIMGSCv36mm8
Celera389,180,461 - 89,193,863 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.01NCBI
Hcn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555451,730,940 - 1,742,065 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555451,730,940 - 1,744,439 (+)NCBIChiLan1.0ChiLan1.0
HCN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2194,554,612 - 94,567,019 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,285,942 - 94,298,347 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01130,621,991 - 130,634,402 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11134,227,404 - 134,240,120 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1134,227,404 - 134,240,120 (+)Ensemblpanpan1.1panPan2
HCN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,272,756 - 42,282,770 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,273,571 - 42,282,595 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,757,808 - 41,773,533 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0742,136,070 - 42,151,801 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl742,141,810 - 42,151,845 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,915,938 - 41,931,660 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,969,733 - 41,985,635 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0742,253,734 - 42,269,448 (-)NCBIUU_Cfam_GSD_1.0
Hcn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505825,729,923 - 25,740,189 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365804,760,241 - 4,772,583 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365804,760,289 - 4,770,571 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HCN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl494,547,416 - 94,560,106 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1494,545,919 - 94,560,105 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24103,327,690 - 103,342,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HCN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1208,546,609 - 8,558,911 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl208,545,720 - 8,558,056 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660387,887,885 - 7,899,940 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hcn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248852,272,935 - 2,281,588 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248852,271,991 - 2,281,575 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hcn3
69 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:103
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000027785
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
61457Niddm8Non-insulin dependent diabetes mellitus QTL 84.10.01blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2174543008175950118Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921175950118Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2172982062175950118Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 37
Low 3 4 41 25 19 25 6 6 37 35 41 11 6
Below cutoff 37 16 16 16 2 5 2

Sequence


RefSeq Acc Id: ENSRNOT00000027785   ⟹   ENSRNOP00000027785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,551,680 - 174,565,966 (-)Ensembl
Rnor_6.0 Ensembl2188,454,853 - 188,471,988 (-)Ensembl
RefSeq Acc Id: NM_053685   ⟹   NP_446137
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,849,635 - 176,863,653 (-)NCBI
mRatBN7.22174,551,861 - 174,565,879 (-)NCBI
Rnor_6.02188,458,851 - 188,471,916 (-)NCBI
Rnor_5.02207,875,210 - 207,888,575 (-)NCBI
RGSC_v3.42181,224,322 - 181,237,190 (-)RGD
Celera2168,495,658 - 168,508,727 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101556   ⟹   XP_038957484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,849,635 - 176,862,779 (-)NCBI
mRatBN7.22174,551,866 - 174,564,931 (-)NCBI
RefSeq Acc Id: XM_039101557   ⟹   XP_038957485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,849,635 - 176,863,322 (-)NCBI
mRatBN7.22174,551,866 - 174,565,608 (-)NCBI
RefSeq Acc Id: XM_039101558   ⟹   XP_038957486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,849,635 - 176,862,779 (-)NCBI
mRatBN7.22174,551,866 - 174,564,931 (-)NCBI
RefSeq Acc Id: XM_039101559   ⟹   XP_038957487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,849,635 - 176,856,177 (-)NCBI
mRatBN7.22174,551,866 - 174,558,403 (-)NCBI
RefSeq Acc Id: XM_063281144   ⟹   XP_063137214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,849,635 - 176,867,725 (-)NCBI
RefSeq Acc Id: XM_063281145   ⟹   XP_063137215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,849,635 - 176,867,726 (-)NCBI
RefSeq Acc Id: XM_063281147   ⟹   XP_063137217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,849,635 - 176,867,725 (-)NCBI
RefSeq Acc Id: NP_446137   ⟸   NM_053685
- UniProtKB: Q9JKA8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027785   ⟸   ENSRNOT00000027785
RefSeq Acc Id: XP_038957485   ⟸   XM_039101557
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038957486   ⟸   XM_039101558
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038957484   ⟸   XM_039101556
- Peptide Label: isoform X1
- UniProtKB: A6J6C2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957487   ⟸   XM_039101559
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063137215   ⟸   XM_063281145
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063137217   ⟸   XM_063281147
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063137214   ⟸   XM_063281144
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JKA8-F1-model_v2 AlphaFold Q9JKA8 1-780 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620691 AgrOrtholog
BioCyc Gene G2FUF-52451 BioCyc
Ensembl Genes ENSRNOG00000020444 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055025522 UniProtKB/Swiss-Prot
  ENSRNOG00060032702 UniProtKB/Swiss-Prot
  ENSRNOG00065024981 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027785 ENTREZGENE
  ENSRNOT00000027785.4 UniProtKB/Swiss-Prot
  ENSRNOT00055044044 UniProtKB/Swiss-Prot
  ENSRNOT00060056704 UniProtKB/Swiss-Prot
  ENSRNOT00065042906 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/Swiss-Prot
  Helix hairpin bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Jelly Rolls UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/Swiss-Prot
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom_sf UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_N UniProtKB/Swiss-Prot
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114245 UniProtKB/Swiss-Prot
NCBI Gene 114245 ENTREZGENE
PANTHER I[[H]] CHANNEL, ISOFORM E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POTASSIUM/SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_N UniProtKB/Swiss-Prot
PhenoGen Hcn3 PhenoGen
PRINTS EAGCHANLFMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020444 RatGTEx
  ENSRNOG00055025522 RatGTEx
  ENSRNOG00060032702 RatGTEx
  ENSRNOG00065024981 RatGTEx
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP cAMP-binding domain-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6J6C2 ENTREZGENE, UniProtKB/TrEMBL
  HCN3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9QZW5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Hcn3  hyperpolarization-activated cyclic nucleotide-gated potassium channel 3    hyperpolarization-activated, cyclic nucleotide-gated potassium channel 3  Name updated 1299863 APPROVED
2002-08-07 Hcn3  hyperpolarization-activated, cyclic nucleotide-gated potassium channel 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the supraoptic nucleus of the hypothalamus 70760
gene_product member of a family of hyperpolarization-activated cyclic nucleotide-gated channels 70760