Ackr3 (atypical chemokine receptor 3) - Rat Genome Database

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Gene: Ackr3 (atypical chemokine receptor 3) Rattus norvegicus
Analyze
Symbol: Ackr3
Name: atypical chemokine receptor 3
RGD ID: 620601
Description: Predicted to enable chemokine binding activity; chemokine receptor activity; and scavenger receptor activity. Involved in positive regulation of mesenchymal stem cell migration. Located in cytoplasm; nucleus; and plasma membrane. Orthologous to human ACKR3 (atypical chemokine receptor 3); PARTICIPATES IN cytokine mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-X-C chemokine receptor type 7; chemokine (C-X-C motif) receptor 7; chemokine orphan receptor 1; Cmkor1; CXC-R7; CXCR-7; Cxcr7; G-protein coupled receptor RDC1 homolog; RDC-1; Rdc1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2990,799,682 - 90,811,246 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl990,799,686 - 90,811,237 (+)Ensembl
Rnor_6.0997,355,881 - 97,367,455 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl997,355,924 - 97,367,445 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0997,046,816 - 97,058,382 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4989,343,528 - 89,355,053 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1989,548,296 - 89,559,818 (+)NCBI
Celera988,347,205 - 88,358,728 (+)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6alpha-methylprednisolone  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
azathioprine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
calciol  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibenzofuran  (EXP)
diclofenac  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
heparin  (EXP)
hexadecanoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
melphalan  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
mifepristone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel dichloride  (ISO)
oxaliplatin  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
prednisolone  (ISO)
propiconazole  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium dodecyl sulfate  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle. Albee LJ, etal., Open Biol. 2018 Jan;8(1). pii: rsob.170207. doi: 10.1098/rsob.170207.
2. Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure. Cueille C, etal., Biochem Biophys Res Commun 2002 Jun 7;294(2):340-6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Identification of three prolactin-related hormones as markers of invasive trophoblasts in the rat. Toft DJ and Linzer DI, Biol Reprod 2000 Aug;63(2):519-25.
11. Heteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function. Tripathi A, etal., Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1659-68. doi: 10.1073/pnas.1417564112. Epub 2015 Mar 16.
12. CXCR-7 receptor promotes SDF-1alpha-induced migration of bone marrow mesenchymal stem cells in the transient cerebral ischemia/reperfusion rat hippocampus. Wang Y, etal., Brain Res. 2014 Aug 5;1575:78-86. doi: 10.1016/j.brainres.2014.05.035. Epub 2014 Jun 9.
13. [Expression of chemokine receptor CXCR4 and CCR7 in laryngeal carcinoma]. Zhang L, etal., Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Nov;19(21):985-7, 991.
Additional References at PubMed
PMID:18513805   PMID:18615560   PMID:20388803   PMID:21418513   PMID:22300987   PMID:22457824   PMID:22940879   PMID:23289420   PMID:23383139   PMID:25032954   PMID:29146732   PMID:30551373  
PMID:33941256   PMID:34051857  


Genomics

Comparative Map Data
Ackr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2990,799,682 - 90,811,246 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl990,799,686 - 90,811,237 (+)Ensembl
Rnor_6.0997,355,881 - 97,367,455 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl997,355,924 - 97,367,445 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0997,046,816 - 97,058,382 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4989,343,528 - 89,355,053 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1989,548,296 - 89,559,818 (+)NCBI
Celera988,347,205 - 88,358,728 (+)NCBICelera
Cytogenetic Map9q36NCBI
ACKR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382236,537,122 - 236,582,354 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2236,567,787 - 236,582,354 (+)EnsemblGRCh38hg38GRCh38
GRCh372237,478,468 - 237,490,997 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362237,143,119 - 237,155,736 (+)NCBINCBI36hg18NCBI36
Build 342237,260,442 - 237,272,991NCBI
Celera2231,191,070 - 231,203,687 (+)NCBI
Cytogenetic Map2q37.3NCBI
HuRef2229,272,353 - 229,284,798 (+)NCBIHuRef
CHM1_12237,484,219 - 237,496,832 (+)NCBICHM1_1
T2T-CHM13v2.02237,060,357 - 237,072,880 (+)NCBI
Ackr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39190,131,702 - 90,143,446 (+)NCBIGRCm39mm39
GRCm39 Ensembl190,131,702 - 90,144,473 (+)Ensembl
GRCm38190,203,980 - 90,215,724 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl190,203,980 - 90,216,751 (+)EnsemblGRCm38mm10GRCm38
MGSCv37192,100,578 - 92,112,863 (+)NCBIGRCm37mm9NCBIm37
MGSCv36192,035,174 - 92,047,459 (+)NCBImm8
Celera193,147,393 - 93,159,682 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map145.28NCBI
Ackr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955453195,346 - 218,034 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955453195,346 - 218,034 (-)NCBIChiLan1.0ChiLan1.0
ACKR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B242,653,738 - 242,668,063 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B242,666,173 - 242,667,261 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B123,795,664 - 123,810,067 (+)NCBIMhudiblu_PPA_v0panPan3
ACKR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12547,327,921 - 47,339,632 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2547,327,963 - 47,339,622 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2547,833,792 - 47,835,768 (+)NCBI
ROS_Cfam_1.02547,675,583 - 47,687,325 (+)NCBI
ROS_Cfam_1.0 Ensembl2547,675,593 - 47,687,321 (+)Ensembl
UMICH_Zoey_3.12547,593,385 - 47,595,361 (+)NCBI
UNSW_CanFamBas_1.02547,386,571 - 47,388,546 (+)NCBI
UU_Cfam_GSD_1.02547,617,367 - 47,619,344 (+)NCBI
Ackr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303189,351,726 - 189,380,121 (+)NCBI
SpeTri2.0NW_0049365251,559,575 - 1,570,679 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACKR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15136,370,530 - 136,382,553 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115136,370,457 - 136,382,559 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215150,847,155 - 150,859,228 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACKR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110122,558,998 - 122,573,747 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl10122,571,853 - 122,572,941 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604076,827,681 - 76,842,164 (-)NCBIVero_WHO_p1.0
Ackr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248472,189,257 - 2,200,352 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248472,189,167 - 2,200,355 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AA997721  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2990,810,888 - 90,811,085 (+)MAPPERmRatBN7.2
Rnor_6.0997,367,098 - 97,367,294NCBIRnor6.0
Rnor_5.0997,058,025 - 97,058,221UniSTSRnor5.0
RGSC_v3.4989,354,702 - 89,354,898UniSTSRGSC3.4
Celera988,358,377 - 88,358,573UniSTS
RH 3.4 Map9783.99UniSTS
Cytogenetic Map9q35UniSTS
UniSTS:240533  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2990,809,700 - 90,810,054 (+)MAPPERmRatBN7.2
Rnor_6.0997,365,910 - 97,366,263NCBIRnor6.0
Rnor_5.0997,056,837 - 97,057,190UniSTSRnor5.0
RGSC_v3.4989,353,514 - 89,353,867UniSTSRGSC3.4
Celera988,357,189 - 88,357,542UniSTS
Cytogenetic Map9q35UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97927151191616855Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)98636963192058970Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:279
Count of miRNA genes:174
Interacting mature miRNAs:201
Transcripts:ENSRNOT00000026558
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 9 6 13 6 8 11 58 35 33 11 8
Low 48 35 6 35 16 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026558   ⟹   ENSRNOP00000026558
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl990,808,766 - 90,811,223 (+)Ensembl
Rnor_6.0 Ensembl997,355,924 - 97,367,445 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098919   ⟹   ENSRNOP00000091223
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl990,799,686 - 90,811,234 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108608   ⟹   ENSRNOP00000094961
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl990,799,694 - 90,811,204 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113813   ⟹   ENSRNOP00000088201
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl990,801,452 - 90,811,223 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115723   ⟹   ENSRNOP00000086994
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl990,803,254 - 90,811,234 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116518   ⟹   ENSRNOP00000083985
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl990,800,545 - 90,811,237 (+)Ensembl
RefSeq Acc Id: NM_053352   ⟹   NP_445804
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2990,799,717 - 90,811,240 (+)NCBI
Rnor_6.0997,355,924 - 97,367,449 (+)NCBI
Rnor_5.0997,046,816 - 97,058,382 (+)NCBI
RGSC_v3.4989,343,528 - 89,355,053 (+)RGD
Celera988,347,205 - 88,358,728 (+)RGD
Sequence:
RefSeq Acc Id: XM_006245479   ⟹   XP_006245541
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2990,799,682 - 90,811,246 (+)NCBI
Rnor_6.0997,355,881 - 97,367,455 (+)NCBI
Rnor_5.0997,046,816 - 97,058,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039084258   ⟹   XP_038940186
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2990,799,694 - 90,811,246 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_445804   ⟸   NM_053352
- UniProtKB: O89039 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006245541   ⟸   XM_006245479
- Peptide Label: isoform X1
- UniProtKB: O89039 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026558   ⟸   ENSRNOT00000026558
RefSeq Acc Id: XP_038940186   ⟸   XM_039084258
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000091223   ⟸   ENSRNOT00000098919
RefSeq Acc Id: ENSRNOP00000088201   ⟸   ENSRNOT00000113813
RefSeq Acc Id: ENSRNOP00000086994   ⟸   ENSRNOT00000115723
RefSeq Acc Id: ENSRNOP00000094961   ⟸   ENSRNOT00000108608
RefSeq Acc Id: ENSRNOP00000083985   ⟸   ENSRNOT00000116518

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O89039-F1-model_v2 AlphaFold O89039 1-362 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696849
Promoter ID:EPDNEW_R7373
Type:single initiation site
Name:Ackr3_1
Description:atypical chemokine receptor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0997,355,904 - 97,355,964EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620601 AgrOrtholog
BioCyc Gene G2FUF-26755 BioCyc
Ensembl Genes ENSRNOG00000019622 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000026558 UniProtKB/Swiss-Prot
  ENSRNOP00000083985 UniProtKB/Swiss-Prot
  ENSRNOP00000086994 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000088201 UniProtKB/Swiss-Prot
  ENSRNOP00000091223 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000094961 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026558 UniProtKB/Swiss-Prot
  ENSRNOT00000098919 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000108608 UniProtKB/Swiss-Prot
  ENSRNOT00000113813 UniProtKB/Swiss-Prot
  ENSRNOT00000115723 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000116518 UniProtKB/Swiss-Prot
InterPro ACKR3 UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:84348 UniProtKB/Swiss-Prot
NCBI Gene 84348 ENTREZGENE
PANTHER PTHR10489:SF931 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Ackr3 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  RDC1ORPHANR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
UniProt ACKR3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9JLZ0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-08-04 Ackr3  atypical chemokine receptor 3  Cxcr7  chemokine (C-X-C motif) receptor 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Cxcr7  chemokine (C-X-C motif) receptor 7  Cmkor1  chemokine orphan receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cmkor1  chemokine orphan receptor 1  Rdc1    Symbol updated 1299863 APPROVED
2002-08-07 Rdc1  chemokine orphan receptor 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in atria and ventricles of the heart 625420
gene_product member of the CGRP (calcitonin gene-related peptide) family 625420