Cdk16 (cyclin-dependent kinase 16) - Rat Genome Database

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Gene: Cdk16 (cyclin-dependent kinase 16) Rattus norvegicus
Analyze
Symbol: Cdk16
Name: cyclin-dependent kinase 16
RGD ID: 620584
Description: Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of transcription involved in G1/S transition of mitotic cell cycle; and secretion by cell. Located in synaptic vesicle. Orthologous to human CDK16 (cyclin dependent kinase 16); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cell division protein kinase 16; PCTAIRE protein kinase 1; PCTAIRE-1 protein kinase, alternatively spliced; PCTAIRE-motif protein kinase 1; Pctk1; serine/threonine-protein kinase PCTAIRE-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Cdk16_v2   Cdk16_v1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X1,492,814 - 1,504,309 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,492,814 - 1,504,148 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,526,769 - 1,538,316 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X5,002,471 - 5,014,018 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X1,317,829 - 1,329,324 (-)NCBIRnor_WKY
Rnor_6.0X1,707,285 - 1,718,821 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,707,289 - 1,718,637 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,500,716 - 2,512,252 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,910,972 - 12,916,939 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X12,915,537 - 12,927,071 (-)NCBI
CeleraX2,056,946 - 2,068,298 (-)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Expression of alternatively spliced PCTAIRE-1 mRNA in PC12 cells and neonatal rat brain. Gao CY, etal., Gene 1996 Oct 17;176(1-2):243-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein: implications in the regulation of its hexamerization and exocytosis. Liu Y, etal., J Biol Chem. 2006 Apr 14;281(15):9852-8. Epub 2006 Feb 6.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10727952   PMID:20534669   PMID:21335063   PMID:21982980   PMID:22184064   PMID:22796189   PMID:22798068  


Genomics

Comparative Map Data
Cdk16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X1,492,814 - 1,504,309 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,492,814 - 1,504,148 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,526,769 - 1,538,316 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X5,002,471 - 5,014,018 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X1,317,829 - 1,329,324 (-)NCBIRnor_WKY
Rnor_6.0X1,707,285 - 1,718,821 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,707,289 - 1,718,637 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,500,716 - 2,512,252 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,910,972 - 12,916,939 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X12,915,537 - 12,927,071 (-)NCBI
CeleraX2,056,946 - 2,068,298 (-)NCBICelera
Cytogenetic MapXq11NCBI
CDK16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,218,303 - 47,229,997 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX47,217,860 - 47,229,997 (+)EnsemblGRCh38hg38GRCh38
GRCh37X47,077,702 - 47,089,396 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X46,962,576 - 46,974,340 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X46,834,368 - 46,845,646NCBI
CeleraX51,272,820 - 51,284,689 (+)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX44,787,880 - 44,799,166 (+)NCBIHuRef
CHM1_1X47,109,023 - 47,120,894 (+)NCBICHM1_1
T2T-CHM13v2.0X46,627,994 - 46,639,688 (+)NCBIT2T-CHM13v2.0
Cdk16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,554,156 - 20,566,119 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,554,193 - 20,566,119 (+)EnsemblGRCm39 Ensembl
GRCm38X20,687,917 - 20,699,880 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,687,954 - 20,699,880 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X20,265,619 - 20,277,003 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X19,845,452 - 19,856,836 (+)NCBIMGSCv36mm8
CeleraX18,818,515 - 18,829,822 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.18NCBI
Cdk16
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516860,480 - 873,338 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955516860,474 - 873,338 (-)NCBIChiLan1.0ChiLan1.0
CDK16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X47,512,540 - 47,524,742 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,512,647 - 47,524,742 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X39,655,119 - 39,666,878 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CDK16
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X40,810,107 - 40,822,130 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX40,810,500 - 40,842,700 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,185,265 - 15,197,292 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X40,944,129 - 40,956,156 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX40,944,527 - 40,976,724 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X40,931,813 - 40,943,840 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X40,919,670 - 40,931,696 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X41,012,774 - 41,024,801 (+)NCBIUU_Cfam_GSD_1.0
Cdk16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,147,088 - 33,159,436 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650212,987,731 - 13,000,186 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493650212,987,736 - 13,000,186 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX41,835,987 - 41,848,574 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X41,836,268 - 41,848,580 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X46,765,046 - 46,776,665 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDK16
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,405,672 - 44,416,478 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX44,410,598 - 44,416,818 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660769,663,924 - 9,675,983 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdk16
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248873,986,217 - 3,999,000 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248873,986,218 - 3,998,379 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdk16
19 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1248
Count of miRNA genes:289
Interacting mature miRNAs:379
Transcripts:ENSRNOT00000011592, ENSRNOT00000064309
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70166Bp65Blood pressure QTL 655.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144797211374346Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat

Markers in Region
RH134860  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X1,493,276 - 1,493,471 (+)MAPPERmRatBN7.2
Rnor_6.0X1,707,748 - 1,707,942NCBIRnor6.0
Rnor_5.0X2,501,179 - 2,501,373UniSTSRnor5.0
RGSC_v3.4X12,910,443 - 12,910,637UniSTSRGSC3.4
CeleraX2,057,409 - 2,057,603UniSTS
Cytogenetic MapXq12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 49 33 19 33 8 11 74 35 41 11 8
Low 8 8 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011592   ⟹   ENSRNOP00000011592
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX1,492,814 - 1,499,607 (-)Ensembl
Rnor_6.0 EnsemblX1,708,278 - 1,714,061 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000064309   ⟹   ENSRNOP00000060222
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX1,492,814 - 1,504,148 (-)Ensembl
Rnor_6.0 EnsemblX1,707,289 - 1,718,637 (-)Ensembl
RefSeq Acc Id: NM_001004132   ⟹   NP_001004132
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X1,493,806 - 1,499,590 (-)NCBI
Rnor_6.0X1,708,277 - 1,714,061 (-)NCBI
Rnor_5.0X2,500,716 - 2,512,252 (-)NCBI
RGSC_v3.4X12,910,972 - 12,916,939 (-)RGD
CeleraX2,057,938 - 2,063,722 (-)NCBI
Sequence:
RefSeq Acc Id: NM_031077   ⟹   NP_112339
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X1,492,814 - 1,504,309 (-)NCBI
Rnor_6.0X1,707,285 - 1,718,637 (-)NCBI
Rnor_5.0X2,500,716 - 2,512,252 (-)NCBI
CeleraX2,056,946 - 2,068,298 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256617   ⟹   XP_006256679
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X1,492,814 - 1,499,568 (-)NCBI
Rnor_6.0X1,707,285 - 1,716,896 (-)NCBI
Rnor_5.0X2,500,716 - 2,512,252 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256618   ⟹   XP_006256680
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X1,492,814 - 1,503,868 (-)NCBI
Rnor_6.0X1,707,285 - 1,718,342 (-)NCBI
Rnor_5.0X2,500,716 - 2,512,252 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001004132   ⟸   NM_001004132
- UniProtKB: Q68G39 (UniProtKB/TrEMBL),   F1LM49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_112339   ⟸   NM_031077
- UniProtKB: F1LM49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256680   ⟸   XM_006256618
- Peptide Label: isoform X2
- UniProtKB: Q68G39 (UniProtKB/TrEMBL),   F1LM49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256679   ⟸   XM_006256617
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000011592   ⟸   ENSRNOT00000011592
RefSeq Acc Id: ENSRNOP00000060222   ⟸   ENSRNOT00000064309
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63686-F1-model_v2 AlphaFold Q63686 1-496 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620584 AgrOrtholog
BioCyc Gene G2FUF-3189 BioCyc
Ensembl Genes ENSRNOG00000008578 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000011592 ENTREZGENE
  ENSRNOP00000011592.8 UniProtKB/TrEMBL
  ENSRNOP00000060222 ENTREZGENE
  ENSRNOP00000060222.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011592 ENTREZGENE
  ENSRNOT00000011592.8 UniProtKB/TrEMBL
  ENSRNOT00000064309 ENTREZGENE
  ENSRNOT00000064309.5 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7112874 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81741 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93131 IMAGE-MGC_LOAD
NCBI Gene 81741 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdk16 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8J8YEJ1_RAT UniProtKB/TrEMBL
  CDK16_RAT UniProtKB/Swiss-Prot
  F1LM49 ENTREZGENE
  Q63686 ENTREZGENE
  Q68G39 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A140UHY2 UniProtKB/TrEMBL
  D4A7B3 UniProtKB/TrEMBL
  F1LM49 UniProtKB/TrEMBL
  Q63687 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Cdk16  cyclin-dependent kinase 16  Pctk1  PCTAIRE protein kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-24 Pctk1  PCTAIRE protein kinase 1  Pctk1  PCTAIRE-motif protein kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Pctk1  PCTAIRE-motif protein kinase 1    PCTAIRE-1 protein kinase, alternatively spliced  Name updated 1299863 APPROVED
2002-08-07 Pctk1  PCTAIRE-1 protein kinase, alternatively spliced      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in neonatal brain 633589
gene_transcript alternative splicing of a 5 exon produces two predicted proteins that differ in their N-terminal sequence but share identity downstream of the alternative splice site 633589