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Gene: Dpysl5 (dihydropyrimidinase-like 5) Rattus norvegicus
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Symbol:
Dpysl5
Name:
dihydropyrimidinase-like 5
RGD ID:
620467
Description:
Predicted to have microtubule binding activity. Involved in neuron differentiation. Localizes to protein-containing complex. Orthologous to human DPYSL5 (dihydropyrimidinase like 5); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
Crmp5; dihydropyrimidinase-related protein; dihydropyrimidinase-related protein 5; DRP-5; ULIP-6; Ulip6; UNC33-like phosphoprotein 6
RGD Orthologs
Alliance Genes
More Info
more info ...
More Info
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 6 26,939,696 - 27,024,129 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 6 26,939,697 - 27,024,129 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 6 36,243,597 - 36,265,372 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 6 25,557,972 - 25,642,140 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 6 25,560,924 - 25,645,093 (-) NCBI Celera 6 25,065,038 - 25,149,750 (-) NCBI Celera Cytogenetic Map 6 q14 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Disease Annotations - ClinVar
2,2',4,4'-Tetrabromodiphenyl ether increases expression EXP 6480464 2 more ... CTD PMID:27291303 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2 more ... CTD PMID:32109520 2,4-dibromophenyl 2,4,5-tribromophenyl ether decreases expression EXP 6480464 2 more ... CTD PMID:19954255 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of DPYSL5 mRNA CTD PMID:24780913 aflatoxin B1 affects methylation ISO RGD:733917 6480464 Aflatoxin B1 affects the methylation of DPYSL5 intron CTD PMID:30157460 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of DPYSL5 mRNA CTD PMID:16483693 amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of DPYSL5 mRNA CTD PMID:30779732 benzo[a]pyrene affects methylation ISO RGD:733917 6480464 Benzoapyrene affects the methylation of DPYSL5 5' UTR, Benzoapyrene affects the methylation of DPYSL5 promoter CTD PMID:27901495 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:733917 6480464 Diethylhexyl Phthalate results in decreased expression of DPYSL5 mRNA CTD PMID:31163220 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of DPYSL5 mRNA CTD PMID:25181051 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of DPYSL5 mRNA CTD PMID:30816183 bisphenol A increases expression ISO RGD:1331988 6480464 bisphenol A results in increased expression of DPYSL5 mRNA CTD PMID:26063408 butanal increases expression ISO RGD:733917 6480464 butyraldehyde results in increased expression of DPYSL5 mRNA CTD PMID:26079696 cisplatin multiple interactions ISO RGD:733917 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of DPYSL5 mRNA CTD PMID:27392435 cisplatin increases expression ISO RGD:733917 6480464 Cisplatin results in increased expression of DPYSL5 mRNA CTD PMID:27392435 copper(II) chloride increases expression ISO RGD:1331988 6480464 cupric chloride results in increased expression of DPYSL5 protein CTD PMID:29617964 dorsomorphin multiple interactions ISO RGD:733917 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1 more ... CTD PMID:27188386 ethanol increases expression EXP 6480464 Ethanol results in increased expression of DPYSL5 protein CTD PMID:23702218 ethanol affects expression ISO RGD:1331988 6480464 Ethanol affects the expression of DPYSL5 mRNA CTD PMID:30319688 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of DPYSL5 mRNA CTD PMID:18035473 fonofos increases methylation ISO RGD:733917 6480464 Fonofos results in increased methylation of DPYSL5 promoter CTD PMID:22847954 furan decreases expression EXP 6480464 furan results in decreased expression of DPYSL5 mRNA CTD PMID:25539665 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of DPYSL5 protein CTD PMID:19826936 parathion increases methylation ISO RGD:733917 6480464 Parathion results in increased methylation of DPYSL5 promoter CTD PMID:22847954 PCB138 decreases expression EXP 6480464 2 more ... CTD PMID:21673325 pentanal increases expression ISO RGD:733917 6480464 pentanal results in increased expression of DPYSL5 mRNA CTD PMID:26079696 phenylmercury acetate decreases expression ISO RGD:733917 6480464 Phenylmercuric Acetate results in decreased expression of DPYSL5 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:733917 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of DPYSL5 mRNA CTD PMID:27188386 propanal increases expression ISO RGD:733917 6480464 propionaldehyde results in increased expression of DPYSL5 mRNA CTD PMID:26079696 SB 431542 multiple interactions ISO RGD:733917 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1 more ... CTD PMID:27188386 silver atom decreases expression ISO RGD:1331988 6480464 Silver results in decreased expression of DPYSL5 mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:1331988 6480464 Silver results in decreased expression of DPYSL5 mRNA CTD PMID:27131904 sunitinib decreases expression ISO RGD:733917 6480464 Sunitinib results in decreased expression of DPYSL5 mRNA CTD PMID:31533062 terbufos increases methylation ISO RGD:733917 6480464 terbufos results in increased methylation of DPYSL5 promoter CTD PMID:22847954 titanium dioxide decreases expression ISO RGD:1331988 6480464 titanium dioxide results in decreased expression of DPYSL5 mRNA CTD PMID:23409001 trichostatin A decreases expression ISO RGD:733917 6480464 trichostatin A results in decreased expression of DPYSL5 mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions ISO RGD:733917 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of DPYSL5 mRNA CTD PMID:27188386 triclosan decreases expression ISO RGD:733917 6480464 Triclosan results in decreased expression of DPYSL5 mRNA CTD PMID:30510588 uranium atom increases expression ISO RGD:733917 6480464 Uranium results in increased expression of DPYSL5 mRNA CTD PMID:15672453 valproic acid increases expression ISO RGD:733917 6480464 Valproic Acid results in increased expression of DPYSL5 mRNA CTD PMID:23179753 valproic acid affects expression ISO RGD:733917 6480464 Valproic Acid affects the expression of DPYSL5 mRNA CTD PMID:25979313 valproic acid decreases methylation ISO RGD:733917 6480464 Valproic Acid results in decreased methylation of DPYSL5 gene CTD PMID:29154799
2,2',4,4'-Tetrabromodiphenyl ether (EXP) 2,3,7,8-Tetrachlorodibenzofuran (EXP) 2,4-dibromophenyl 2,4,5-tribromophenyl ether (EXP) 6-propyl-2-thiouracil (EXP) aflatoxin B1 (ISO) ammonium chloride (EXP) amphetamine (EXP) benzo[a]pyrene (ISO) bis(2-ethylhexyl) phthalate (ISO) bisphenol A (EXP,ISO) butanal (ISO) cisplatin (ISO)
References
Additional References at PubMed
Genomics
QTLs in Region (Rnor_6.0)
738023 Alc17 Alcohol consumption QTL 17 3.1 0.003 consumption behavior trait (VT:0002069) ethanol drink intake rate to body weight ratio (CMO:0001616) 6 1 35623029 Rat 1354616 Despr12 Despair related QTL 12 0.0012 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) 6 1 35623029 Rat 1549905 Stresp10 Stress response QTL 10 6.83 0.0066 stress-related behavior trait (VT:0010451) number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960) 6 1 35623029 Rat 2300176 Bmd51 Bone mineral density QTL 51 11.7 0.0001 femur mineral mass (VT:0010011) bone mineral density (CMO:0001226) 6 1 35623029 Rat 2300190 Bmd52 Bone mineral density QTL 52 11.2 0.0001 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 6 1 35623029 Rat 1331743 Uae28 Urinary albumin excretion QTL 28 4.5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 6 1 41917988 Rat 9589048 Scfw3 Subcutaneous fat weight QTL 3 4.57 0.001 subcutaneous adipose mass (VT:1000472) abdominal subcutaneous fat pad weight (CMO:0002069) 6 1 42388212 Rat 9589129 Insul24 Insulin level QTL 24 19.06 0.001 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 6 1 42388212 Rat 7411603 Foco13 Food consumption QTL 13 5.5 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 6 1 42388212 Rat 7411542 Bw127 Body weight QTL 127 5.5 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 6 1 42388212 Rat 8552962 Pigfal16 Plasma insulin-like growth factor 1 level QTL 16 9.4 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 6 1 42388212 Rat 2293709 Bss23 Bone structure and strength QTL 23 5.18 0.0001 femur morphology trait (VT:0000559) femur cross-sectional area (CMO:0001661) 6 1 43665660 Rat 2293650 Bss31 Bone structure and strength QTL 31 5.05 0.0001 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) 6 1 43665660 Rat 2293656 Bss28 Bone structure and strength QTL 28 6.79 0.0001 femur morphology trait (VT:0000559) femur midshaft cortical cross-sectional area (CMO:0001663) 6 1 43665660 Rat 7411584 Foco4 Food consumption QTL 4 4.3 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 6 1 44015370 Rat 738024 Sach5 Saccharine consumption QTL 5 3.9 0.00039 consumption behavior trait (VT:0002069) saccharin intake volume to total fluid intake volume ratio (CMO:0001601) 6 1 44570292 Rat 2301972 Bp325 Blood pressure QTL 325 4.8 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 6 1 75623393 Rat 1359023 Bp272 Blood pressure QTL 272 2.5 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 6 1120393 28706721 Rat 2292589 Emca10 Estrogen-induced mammary cancer QTL 10 0.048 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) 6 1120393 46120393 Rat 1354664 Slep2 Serum leptin concentration QTL 2 4.49 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) 6 1120393 75023446 Rat 1576309 Emca7 Estrogen-induced mammary cancer QTL 7 4 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 6 2537030 111715717 Rat 1578665 Bss16 Bone structure and strength QTL 16 4.4 femur morphology trait (VT:0000559) bone trabecular cross-sectional area (CMO:0002311) 6 6161722 76002731 Rat 1578668 Bmd14 Bone mineral density QTL 14 3.8 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) 6 6161722 76002731 Rat 4145119 Mcs25 Mammary carcinoma susceptibility QTL 25 0.0001 mammary gland integrity trait (VT:0010552) ratio of deaths to total study population during a period of time (CMO:0001023) 6 7009971 115379601 Rat 634322 Bw12 Body weight QTL 12 0 body mass (VT:0001259) body weight (CMO:0000012) 7 10173862 55173862 Rat 1300128 Rf16 Renal function QTL 16 3.89 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) 6 13122958 34367603 Rat 1300164 Rf15 Renal function QTL 15 3.12 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) 6 13122958 57516539 Rat 10401812 Kidm54 Kidney mass QTL 54 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) 6 16810107 61810107 Rat 10401800 Kidm49 Kidney mass QTL 49 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) 6 16810107 61810107 Rat 8552910 Pigfal5 Plasma insulin-like growth factor 1 level QTL 5 4.3 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 6 19417887 64417887 Rat 1641898 Colcr4 Colorectal carcinoma resistance QTL4 3.71 0.0007 intestine integrity trait (VT:0010554) well differentiated malignant colorectal tumor surface area measurement (CMO:0002077) 6 21515302 65784818 Rat 2293839 Kiddil2 Kidney dilation QTL 2 4.8 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) 6 22042854 84763421 Rat 2293841 Kiddil4 Kidney dilation QTL 4 4.4 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) 6 22042854 84763421 Rat