Efna5 (ephrin A5) - Rat Genome Database

Name: Efna5
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Efna5 (ephrin A5) Rattus norvegicus

Analyze

Symbol:

Efna5

Name:

ephrin A5

RGD ID:

620391

Description:

Enables ephrin receptor binding activity. Predicted to be involved in several processes, including axonogenesis; positive regulation of nervous system development; and regulation of cytoskeleton organization. Predicted to act upstream of or within several processes, including cellular response to follicle-stimulating hormone stimulus; cellular response to forskolin; and negative regulation of substrate adhesion-dependent cell spreading. Predicted to be located in adherens junction; basement membrane; and external side of plasma membrane. Predicted to be active in GABA-ergic synapse and plasma membrane. Orthologous to human EFNA5 (ephrin A5); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

AL-1; eph-related receptor tyrosine kinase ligand 7; ephrin-A5; LERK-7; Lerk7

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EFNA5 (ephrin A5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):	Efna5 (ephrin A5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Efna5 (ephrin A5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EFNA5 (ephrin A5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EFNA5 (ephrin A5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Efna5 (ephrin A5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EFNA5 (ephrin A5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EFNA5 (ephrin A5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Efna5 (ephrin A5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Efna5 (ephrin A5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	EFNA5 (ephrin A5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	efna5b (ephrin-A5b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	efn-4	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Ephrin	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	efna5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	102,316,753 - 102,595,480 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	102,320,295 - 102,597,413 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	110,731,253 - 111,005,043 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	9	115,846,837 - 116,120,820 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	9	114,197,132 - 114,470,919 (-)	NCBI	Rnor_WKY
Rnor_6.0	9	110,054,002 - 110,329,878 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	110,057,155 - 110,225,486 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	109,624,143 - 109,898,215 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	101,227,615 - 101,532,696 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	101,437,094 - 101,742,176 (-)	NCBI
Celera	9	99,743,743 - 100,016,279 (-)	NCBI		Celera
Cytogenetic Map	9	q37	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

anencephaly (ISS)

COVID-19 (ISO)

familial adenomatous polyposis 1 (ISO)

genetic disease (ISO)

Hereditary Neoplastic Syndromes (ISO)

Neurodevelopmental Disorders (ISO)

Reperfusion Injury (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,1-dichloroethene (ISO)

1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine (EXP)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

choline (ISO)

cocaine (EXP)

Cuprizon (EXP)

decabromodiphenyl ether (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

ethanol (ISO)

folic acid (ISO)

fulvestrant (ISO)

furosemide (EXP)

gentamycin (EXP)

indole-3-methanol (EXP)

L-methionine (ISO)

lipopolysaccharide (ISO)

melphalan (ISO)

methylmercury chloride (ISO)

N,N-diethyl-m-toluamide (EXP)

nickel sulfate (ISO)

ozone (EXP)

panobinostat (ISO)

paracetamol (ISO)

PD 0325901 (ISO)

permethrin (EXP)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

rimonabant (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

trichostatin A (ISO)

troglitazone (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (ISO)

axon guidance (IBA,ISO)

axonal fasciculation (NAS)

cellular response to follicle-stimulating hormone stimulus (ISO)

cellular response to forskolin (ISO)

collateral sprouting (ISO)

ephrin receptor signaling pathway (IBA,IEA,ISO,ISS)

negative chemotaxis (IEA)

negative regulation of substrate adhesion-dependent cell spreading (IEA,ISO)

positive regulation of collateral sprouting (ISO)

positive regulation of peptidyl-tyrosine phosphorylation (ISO,ISS)

positive regulation of synapse assembly (ISO)

regulation of actin cytoskeleton organization (IBA,IEA,ISO,ISS)

regulation of cell morphogenesis (IEA,ISO)

regulation of cell-cell adhesion (IBA,IEA,ISO,ISS)

regulation of focal adhesion assembly (IEA,ISO,ISS)

regulation of GTPase activity (IEA,ISO,ISS)

regulation of insulin secretion involved in cellular response to glucose stimulus (ISO,ISS)

regulation of microtubule cytoskeleton organization (IEA,ISO,ISS)

retinal ganglion cell axon guidance (ISO)

synaptic membrane adhesion (ISO)

Cellular Component

adherens junction (ISO)

basement membrane (ISO)

caveola (IEA)

cell periphery (ISO)

external side of plasma membrane (IEA,ISO,ISS)

GABA-ergic synapse (ISO)

plasma membrane (IBA,IEA,ISO,ISS)

side of membrane (IEA)

Molecular Function

chemorepellent activity (ISO)

ephrin receptor binding (IBA,IDA,IEA,IPI,ISO)

neurotrophin TRKB receptor binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ephrin - ephrin receptor bidirectional signaling axis (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Ephrin-A5 and EphA5 interaction induces synaptogenesis during early hippocampal development.	Akaneya Y, etal., PLoS One. 2010 Aug 31;5(8):e12486. doi: 10.1371/journal.pone.0012486.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation.	Winslow JW, etal., Neuron 1995 May;14(5):973-81.

Additional References at PubMed

PMID:9053851	PMID:9614241	PMID:11089974	PMID:11222144	PMID:11870224	PMID:15777695	PMID:15996548	PMID:16510508	PMID:17328773	PMID:17448994	PMID:19036963	PMID:22275477
PMID:23242526	PMID:23274893	PMID:24222347	PMID:29237529	PMID:29762250	PMID:32396496

Genomics

Comparative Map Data

Efna5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	102,316,753 - 102,595,480 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	102,320,295 - 102,597,413 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	110,731,253 - 111,005,043 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	9	115,846,837 - 116,120,820 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	9	114,197,132 - 114,470,919 (-)	NCBI	Rnor_WKY
Rnor_6.0	9	110,054,002 - 110,329,878 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	110,057,155 - 110,225,486 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	109,624,143 - 109,898,215 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	101,227,615 - 101,532,696 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	101,437,094 - 101,742,176 (-)	NCBI
Celera	9	99,743,743 - 100,016,279 (-)	NCBI		Celera
Cytogenetic Map	9	q37	NCBI

EFNA5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	107,376,894 - 107,670,937 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	5	107,376,894 - 107,670,937 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	106,712,595 - 107,006,638 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	106,744,250 - 107,034,495 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	106,744,249 - 107,034,495	NCBI
Celera	5	102,652,515 - 102,946,033 (-)	NCBI		Celera
Cytogenetic Map	5	q21.3	NCBI
HuRef	5	101,885,499 - 102,179,416 (-)	NCBI		HuRef
CHM1_1	5	106,145,383 - 106,439,350 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	107,879,857 - 108,173,778 (-)	NCBI		T2T-CHM13v2.0

Efna5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	62,909,949 - 63,188,431 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	62,911,179 - 63,188,312 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	62,602,957 - 62,881,317 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	62,604,184 - 62,881,317 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	62,952,306 - 63,230,666 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	62,290,210 - 62,566,779 (-)	NCBI		MGSCv36	mm8
Celera	17	66,941,186 - 67,218,870 (-)	NCBI		Celera
Cytogenetic Map	17	E1.1	NCBI
cM Map	17	32.57	NCBI

Efna5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	6,920,919 - 7,185,478 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	6,919,270 - 7,188,561 (+)	NCBI	ChiLan1.0	ChiLan1.0

EFNA5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	5	100,810,566 - 101,112,275 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	102,732,268 - 103,026,746 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	108,548,927 - 108,842,729 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	108,548,927 - 108,598,942 (-)	Ensembl	panpan1.1		panPan2

EFNA5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	4,272,138 - 4,546,527 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	4,272,518 - 4,542,049 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	5,666,868 - 5,947,210 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	4,163,164 - 4,443,229 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	4,169,390 - 4,439,740 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	4,102,672 - 4,382,928 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	4,131,173 - 4,411,046 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	4,274,587 - 4,554,692 (+)	NCBI		UU_Cfam_GSD_1.0

Efna5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	159,344,414 - 159,394,038 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936531	2,217,368 - 2,300,794 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936531	2,217,467 - 2,267,265 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EFNA5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	112,534,949 - 112,815,827 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	112,533,124 - 112,821,293 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	117,052,889 - 117,095,595 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EFNA5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	10,823,243 - 11,115,175 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	10,823,261 - 10,873,666 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666036	3,139,584 - 3,432,471 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Efna5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	25,341,132 - 25,611,564 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	25,336,851 - 25,611,698 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Efna5
1524 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	99
Count of miRNA genes:	80
Interacting mature miRNAs:	84
Transcripts:	ENSRNOT00000045096
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	25268044	114175309	Rat
1300134	Bp185	Blood pressure QTL 185	3.73		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	61381434	104821652	Rat
61385	Edpm9	Estrogen-dependent pituitary mass QTL 9	3.43	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	63869687	108869687	Rat
731171	Glom6	Glomerulus QTL 6	2.8	0.0003	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	9	64573531	109573531	Rat
1354626	Bvd1	Brain ventricular dilatation QTL 1	3.73	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	9	75712843	111552878	Rat
7794784	Mcs31	Mammary carcinoma susceptibility QTL 31	2.98		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	9	77813894	111552878	Rat
724547	Cm21	Cardiac mass QTL 21	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	9	79271511	102910209	Rat

Markers in Region

D9Got218

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	102,402,586 - 102,402,860 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	110,137,737 - 110,138,010	NCBI	Rnor6.0
Rnor_5.0	9	109,706,023 - 109,706,296	UniSTS	Rnor5.0
RGSC_v3.4	9	101,330,236 - 101,330,509	UniSTS	RGSC3.4
Celera	9	99,824,712 - 99,824,985	UniSTS
Cytogenetic Map	9	q37	UniSTS

RH141288

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	102,572,174 - 102,572,370 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	110,306,729 - 110,306,924	NCBI	Rnor6.0
Rnor_5.0	9	109,874,892 - 109,875,087	UniSTS	Rnor5.0
RGSC_v3.4	9	101,509,739 - 101,509,934	UniSTS	RGSC3.4
Celera	9	99,993,388 - 99,993,583	UniSTS
Cytogenetic Map	9	q37	UniSTS

EFNA5

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	102,321,143 - 102,321,341 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	110,057,076 - 110,057,273	NCBI	Rnor6.0
Rnor_5.0	9	109,627,376 - 109,627,573	UniSTS	Rnor5.0
RGSC_v3.4	9	101,227,582 - 101,227,779	UniSTS	RGSC3.4
Celera	9	99,743,710 - 99,743,907	UniSTS
Cytogenetic Map	9	q37	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		12	11	11		11			62	27	29	4
Low	3	21	37	22	13	22	1	1	12	8	11	7	1
Below cutoff		7	9	8	5	8	4	5			1		4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053903	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006245593	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473997	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000215	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U69279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000045096 ⟹ ENSRNOP00000039406

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	102,321,177 - 102,367,963 (-)	Ensembl
Rnor_6.0 Ensembl	9	110,057,155 - 110,225,486 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000096180 ⟹ ENSRNOP00000096410

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	102,320,295 - 102,597,413 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000096857 ⟹ ENSRNOP00000086477

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	102,321,177 - 102,597,413 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000116684 ⟹ ENSRNOP00000092647

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	102,321,177 - 102,520,068 (-)	Ensembl

RefSeq Acc Id:

NM_053903 ⟹ NP_446355

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	102,321,177 - 102,595,134 (-)	NCBI
Rnor_6.0	9	110,057,109 - 110,329,687 (-)	NCBI
Rnor_5.0	9	109,624,143 - 109,898,215 (-)	NCBI
RGSC_v3.4	9	101,227,615 - 101,532,696 (-)	RGD
Celera	9	99,743,743 - 100,016,279 (-)	RGD

Sequence:

show sequence

GAGAGGCGCGTCGGGGGCTCCGCCGCTGGCTAGGCGTGATGTTGCACGTGGAGATGTTGACGCT
GCTCTTTCTGGTGCTCTGGATGTGTGTGTTCAGCCAGGACCCGGGCTCCAAAGTCGTCGCCGAC
CGCTACGCCGTCTACTGGAACAGCAGCAACCCCAGATTCCAGAGGGGTGACTACCACATCGATG
TCTGTATCAATGACTACCTGGATGTTTTCTGCCCTCACTATGAGGACTCTGTACCAGAGGATAA
GACTGAGCGCTATGTCCTGTACATGGTGAATTTTGATGGCTACAGTGCCTGCGACCACACATCC
AAAGGGTTCAAGAGATGGGAATGTAACCGGCCTCACTCTCCAAACGGACCGCTGAAGTTCTCGG
AGAAATTCCAGCTCTTCACTCCCTTTTCTTTAGGATTTGAATTCAGGCCAGGCCGAGAGTATTT
CTACATCTCCTCTGCAATCCCAGACAATGGAAGAAGATCCTGCCTAAAGCTCAAAGTCTTTGTG
AGGCCAACAAACAGCTGTATGAAAACTATAGGTGTTCGTGATCGTGTTTTCGATGTTAACGACA
AAGTAGAAAATTCATTAGAACCAGCAGATGACACCGTACATGAGTCAGCCGAGCCATCCCGCGG
AGAGAACGCGGCACAAACACCAAGGATACCCAGCCGCCTTTTGGCAATCCTACTGTTCCTCCTG
GCGATGCTTTTGACATTATAGCACAGTCTCCTCCCGTCACCTGTCACAGAAAACATCAGGGTCT

hide sequence

RefSeq Acc Id:

XM_006245593 ⟹ XP_006245655

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	102,316,753 - 102,595,480 (-)	NCBI
Rnor_6.0	9	110,054,002 - 110,329,878 (-)	NCBI
Rnor_5.0	9	109,624,143 - 109,898,215 (-)	NCBI

Sequence:

show sequence

GCCCTTCAGTGGGGGGTGCGAGTTTGTCCCCCCCAGTCCACCGCCTTCTTCTCTCTCTTCCTCC
TCCTCTTCCTCCCGCGCTCGCCGCGCGCCTCTCGCCCCCTTCGTCTTATTTATTCCTATTTATT
TGGCGTCCGCTCTCTCCGTCTGCCCCTCTCCCTCCCTCCCCCTGGATCCCCGCTCTCTCCCCGG
AGTGGCGCGTCGGGGGCTCTGCCGCTGGCTAGGCGTGATGTTGCACGTGGAGATGTTGACGCTG
CTCTTTCTGGTGCTCTGGATGTGTGTGTTCAGCCAGGACCCGGGCTCCAAAGTCGTCGCCGACC
GCTACGCCGTCTACTGGAACAGCAGCAACCCCAGATTCCAGAGGGGTGACTACCACATCGATGT
CTGTATCAATGACTACCTGGATGTTTTCTGCCCTCACTATGAGGACTCTGTACCAGAGGATAAG
ACTGAGCGCTATGTCCTGTACATGGTGAATTTTGATGGCTACAGTGCCTGCGACCACACATCCA
AAGGGTTCAAGAGATGGGAATGTAACCGGCCTCACTCTCCAAACGGACCGCTGAAGTTCTCGGA
GAAATTCCAGCTCTTCACTCCCTTTTCTTTAGGATTTGAATTCAGGCCAGGCCGAGAGTATTTC
TACATCTCCTCTGCAATCCCAGACAATGGAAGAAGATCCTGCCTAAAGCTCAAAGTCTTTGTGA
GGCCAACAAATGACACCGTACATGAGTCAGCCGAGCCATCCCGCGGAGAGAACGCGGCACAAAC
ACCAAGGATACCCAGCCGCCTTTTGGCAATCCTACTGTTCCTCCTGGCGATGCTTTTGACATTA
TAGCACAGTCTCCTCCCGTCACCTGTCACAGAAAACATCAGGGTCTTGGAACACCAGAGATCCA
CCTAAACTGCTCATCCCAAGAAGGGACTTGTTATCGGTTTTTGGCAGATGTCAGATTTTTGTTT
TCTTTCCTTCCGCCTGATTTTTAAGCAACAACTTGGGGTTGTTTGGGGGCGGGGGCTAAACTAG
TTGCTGCCCCCTTCACCCTGCCCCACCCCCTAGCCCTTGCCCTTGACTCCTCTCAACCCCCTTC
CCAATTAAATGGAGTCCAGATAAAAATGCCAGATTGTCGTAGTGACAGCAGAGGGTCTTGGCCT
CCTGTGCATTGTCCTCTAGAGCTCACCTCCGTAAGCTCAGGGTGTTGACCGTATGCACACGAGA
GAAAATATGGGCAGATGCTGCCTGTAATGTCCAGGCCCAAGAGGGGTGGCCTCTCCTATAGAAT
ACCTACGCCTTCACAGTCCGACAGGAAGGTGATTGTGTGGAATGTGGTGTTGGCCCGTCAGGTC
CAGAGGGGCAGAGTTAAGAATAGGCATAATATTATACCACATCCTCTAGGAGTGTAGAAGTGAG
CAGGCTTCTCAAAGGTCCAGATACTAGTTTTTATTTCATCAAATGGGACTGTCTTGAAGCATTT
TCTTTTTTTCCCCAGCAAAACTTGGGCTGTGTCAAAGAAGCCTCTCCTCCCAGAAGGAGGGTTG
GATGCAGGGATGCTAATACAGAGGAAGTGCGACACTGAGAAAAATGAGCTGTTACTGGGGGTGC
GAGTGCCTCTAACTTTTTAGTGACTGGGCAGTGCATACCCGAGGGTTTATTTTTTTTTTTTCCT
TTAAATACAGTTCACCATGGTGCTACAACTTTTTTTTCTTTTTAGGAGTTCAAAGAGGCATTTT
TATGAATAAAGTGACCTTCCCCAAGGCTGCCAAGCCAGGGTTGATGAGTAGAGAGTAGAATAGC
TTTGGCTACTCCTCTGGGGACAATATGTACAAGGAAAGAGAGTCTGGCCAGAGGAGGTGCGATT
TGGCTTTGCTGGAGCTCCAGTGTGCTGTGGCCTTTCCCCAACTCCCACCCCGATACCCACGTTC
TGTTCCGTGCTCCGTGACTACAAGGGGACTCAGACACAAACCCTGTCACCAGGAGAGTCAGTCA
GCACTACTTGGGAGGGCTAAAGGGAAATTTGGAATAAAAGTTCCAAAGTTTGGAATAAGAAATT
CAAGTGTTGATTTTTATCTCCTTTCCCTTTCTGACACAGCCTGAAGCGTAGGGGGAACACATGT
TTGTTTATCTGTGGGATATAAACAAGATGGAGTCCCAAAGACTTTGACAAAATATTTTTTTAAA
AATCCACTAGAATAGAAAATACATTATTTAGATATACTTTATGCTGAGAGCGAGTATATATATG
CTTGTCCTATTTAAACTTGTGAGGAAAAAGTGGTATCCCTTGATACATTTAGAAACACAGGGGG
TTATCTTGTTTCATAGTAGGGTTGGGGCAGAAGAATGAACACAGAATGACCCTGTTTTTAAAGA
ACCTTAGCATGGCCAAGGGGGCAGTTACAGCCAATTGCGAGGAAACACAAGCCGTGGGGTTTCC
CCTCGTGGGGTGTCGAGAATTTCAAATCCCAAAGCCTAGACAGGGAATAACGTAGACCAAGGAA
AGGCGACCTAGCCTACTTTTGCTATTGTACGACATCAACAGAACCACGCCTTTGTCAACAAGCA
AGTCAGTAAATGCAACGATCAGGTGATGTGGAAAATTGAGGGCATTCCAGTTTAAGACAAAGAA
TAAGGATTTTTTTTTATATATTCGTTTTTAAGATGTATATGTAAAAAAAAAGAGTTCACATTAT
AGATGGACTTCATGAATCGGAAATTGCTTAGAATTGTGAGTGGTTTCAAACTAGAAAAATATGT
GAGTGGAAGGCAGCTGTGAACGAACTGCACCCTAGAGAGTTGTACGCACGTTGGAATGTAAGCT
GGGCTTACTTACCTGGTCCCTTTGGAGTAGAGGCGACTGGAGTCTGCTCTCACCTGAACCATGT
GACCGGAGTCGCCAGCCTCAAAGATATATAGTTAGTTCTCTTCCCTCTTCTCCCAACACCCGAG
ACCTCTCTGGAGTTGCAGAGTCTCATCACAGAAGGCGCCCGCCATTTCACCGAAACGGAACTTC
AAAGCATTGGATTTCTTGGCCTTTATTTATCGCTCGACACTCTCAGTGATATCCAGATATATTC
TTTTCATTAATAGTTACAGGTTTGTGGGTTAGTGGGATTTCAGTAAAGGGAGAAAAAAAAAATC
CCTTCTAAGATGGGTCAATAGAACCAAGATAAAACTGCATGTTACTACAGTCAAGGACACCAAG
TGATCCTGTGATGATTCCAGTTAGTCCTAAAGGCATTAGCAGTACTAATGTCATTGTAGAAATG
GTGAGTTCTGTGATTCTAGCATTTGTCTCTAACAAATGATCAAATAATTCCTCATGGCCCTCTC
TGCCATTGTCTTTCATTTCCCACTGTGCAATTAGACCCTTTTTACTTCACTGCCGTGCCACCGA
TGATTAAGTTAAAAAATGAAAAAAAAAAAAAGAAAAAAGAAAAAAAGAAAAACCTTCCACGCCA
GTAGACAATATGCGTTTTACCTGTGACATAACCTTAGCTAATACGCTTGTGCAGAGTTTTCAAG
ACGATTGGTGTCAGACAGTTTTTAATCTTGTCCAAAAAATAATAATAATAATAATAATGCGCTG
GTGGCTTTTTGTGGTGTTGTTACAGTCCTCTGTGGGCTTAGGATGTCGGTGCAACTTGGTAGTT
GGTTTAATTTTAAAATCAATGGAAAAACAGGAAGGGCAGCCCTGGAGCCCCTAGCCCCAGTTGG
TCAAACCCCAGCGACCTTTGCCCCTGGTTGCCAAGGGCTTTGCAACATGAAGCAGGGAATAAAG
ATCTGTCTGTTTAGTGGATACTGTGTATCCTTTAATAGACCAGGTAACAGTTCGTGTTAGTTTT
AGACTATTGTTTTGTACTGTACTTTCTTGGGTGGCAGAGGAAAGAAAAGTTAAAATGTTAAAAA
AAAAAAAAACTGCGTTCTTTAATTCTGTATTATTAGCGACCTCTGTTGTATATAGTGTTTGATA
ATAAAGTATTAATTTGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_446355	(Get FASTA)	NCBI Sequence Viewer
	XP_006245655	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC05801	(Get FASTA)	NCBI Sequence Viewer
	EDL91840	(Get FASTA)	NCBI Sequence Viewer
	EDL91841	(Get FASTA)	NCBI Sequence Viewer
	P97605	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_446355 ⟸ NM_053903
- Peptide Label:	precursor
- UniProtKB:	P97605 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MLHVEMLTLLFLVLWMCVFSQDPGSKVVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCPH YEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGF EFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVRDRVFDVNDKVENSLEPADDTV HESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL hide sequence

RefSeq Acc Id:	XP_006245655 ⟸ XM_006245593
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6GLK9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLHVEMLTLLFLVLWMCVFSQDPGSKVVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCPH YEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGF EFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNDTVHESAEPSRGENAAQTPRIPSRLLAILL FLLAMLLTL hide sequence

RefSeq Acc Id:

ENSRNOP00000039406 ⟸ ENSRNOT00000045096

RefSeq Acc Id:

ENSRNOP00000086477 ⟸ ENSRNOT00000096857

RefSeq Acc Id:

ENSRNOP00000092647 ⟸ ENSRNOT00000116684

RefSeq Acc Id:

ENSRNOP00000096410 ⟸ ENSRNOT00000096180

Protein Domains

Ephrin RBD

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P97605-F1-model_v2	AlphaFold	P97605	1-228	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620391	AgrOrtholog
BioCyc Gene	G2FUF-26540	BioCyc
Ensembl Genes	ENSRNOG00000034177	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000039406.3	UniProtKB/TrEMBL
	ENSRNOP00000086477	ENTREZGENE
	ENSRNOP00000086477.1	UniProtKB/TrEMBL
	ENSRNOP00000092647.1	UniProtKB/TrEMBL
	ENSRNOP00000096410	ENTREZGENE
	ENSRNOP00000096410.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000045096.3	UniProtKB/TrEMBL
	ENSRNOT00000096180	ENTREZGENE
	ENSRNOT00000096180.1	UniProtKB/TrEMBL
	ENSRNOT00000096857	ENTREZGENE
	ENSRNOT00000096857.1	UniProtKB/TrEMBL
	ENSRNOT00000116684.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.420	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Cupredoxin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ephrin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ephrin-A_Ecto	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ephrin_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ephrin_RBD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:116683	UniProtKB/Swiss-Prot
NCBI Gene	116683	ENTREZGENE
PANTHER	EPHRIN-A5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11304	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Ephrin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Efna5	PhenoGen
PRINTS	EPHRIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	EPHRIN_RBD_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EPHRIN_RBD_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF49503	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6A627_RAT	UniProtKB/TrEMBL
	A0A8I6AFY3_RAT	UniProtKB/TrEMBL
	A0A8I6GLK9	ENTREZGENE, UniProtKB/TrEMBL
	EFNA5_RAT	UniProtKB/Swiss-Prot
	G3V989_RAT	UniProtKB/TrEMBL
	P97605	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-01-20	Efna5	ephrin A5		eph-related receptor tyrosine kinase ligand 7	Name updated	1299863	APPROVED
2002-08-07	Efna5	eph-related receptor tyrosine kinase ligand 7			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	mRNA expressed exclusively in nervous system, predominantly in hippocampus and cortex	728210
gene_process	may be important for neuronal pathfinding	728210
gene_product	member of the ephrin gene family, an emerging ligand family for the Eph receptor tyrosine kinases	728210

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Annotations - PID (archival)