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Gene: Ackr2 (atypical chemokine receptor 2) Rattus norvegicus

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Symbol:

Ackr2

Name:

atypical chemokine receptor 2

RGD ID:

620323

Description:

Predicted to enable C-C chemokine binding activity; C-C chemokine receptor activity; and scavenger receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within signal transduction. Predicted to be located in several cellular components, including actin filament; cytosol; and nucleus. Predicted to be active in external side of plasma membrane. Orthologous to human ACKR2 (atypical chemokine receptor 2); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

C-C chemokine receptor D6; CC-chemokine-binding receptor JAB61; Ccbp2; CCR10-related receptor; chemokine binding protein 2; chemokine-binding protein 2; chemokine-binding protein D6; D6; MGC105345

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ACKR2 (atypical chemokine receptor 2)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Ackr2 (atypical chemokine receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ackr2 (atypical chemokine receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ACKR2 (atypical chemokine receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ACKR2 (atypical chemokine receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ackr2 (atypical chemokine receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ACKR2 (atypical chemokine receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ACKR2 (atypical chemokine receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ackr2 (atypical chemokine receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Ackr2 (atypical chemokine receptor 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ACKR2 (atypical chemokine receptor 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	npr-20	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	130,438,703 - 130,451,106 (+)	NCBI		GRCr8
mRatBN7.2	8	121,559,563 - 121,573,633 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	121,561,211 - 121,573,582 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	127,162,299 - 127,163,985 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	125,361,373 - 125,363,059 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	123,190,782 - 123,192,468 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	130,526,521 - 130,543,566 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	130,538,651 - 130,542,227 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	129,653,559 - 129,719,044 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	127,026,528 - 127,028,214 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	127,046,266 - 127,047,951 (-)	NCBI
Celera	8	120,695,513 - 120,697,199 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital muscular dystrophy-dystroglycanopathy type A8 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

bromobenzene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cocaine (EXP)

dextran sulfate (ISO)

dicrotophos (ISO)

diethylstilbestrol (ISO)

endosulfan (EXP)

furan (EXP)

genistein (ISO)

hexachlorobenzene (EXP)

hydrogen peroxide (ISO)

inulin (ISO)

lead(0) (ISO)

nitrofen (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

rac-lactic acid (ISO)

silicon dioxide (ISO)

sulforaphane (ISO)

testosterone (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (ISO)

triptonide (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium-mediated signaling (IBA)

cell chemotaxis (IBA)

chemokine-mediated signaling pathway (IEA)

chemotaxis (IEA)

G protein-coupled receptor signaling pathway (IEA)

immune response (IBA)

inflammatory response (IEA)

positive regulation of cytosolic calcium ion concentration (IBA)

signal transduction (IEA,ISO)

vesicle-mediated transport (IEA)

Cellular Component

actin filament (ISO,ISS)

cytosol (ISO)

early endosome (IEA)

endosome (IEA)

external side of plasma membrane (IBA)

intracellular membrane-bounded organelle (ISO)

membrane (IEA)

nuclear membrane (ISO)

nucleoplasm (ISO)

plasma membrane (IEA,ISO,ISS)

recycling endosome (IEA)

Molecular Function

C-C chemokine binding (IBA,ISO)

C-C chemokine receptor activity (IBA,ISO)

chemokine receptor activity (IEA,ISO)

G protein-coupled receptor activity (IEA)

protein binding (ISO)

scavenger receptor activity (ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3.	Bonini JA, etal., DNA Cell Biol 1997 Oct;16(10):1249-56.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Chemokines: a new classification system and their role in immunity.	Zlotnik A and Yoshie O, Immunity 2000 Feb;12(2):121-7.

Additional References at PubMed

PMID:9139699	PMID:9324304	PMID:12477932	PMID:23633677

Genomics

Comparative Map Data

Ackr2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	130,438,703 - 130,451,106 (+)	NCBI		GRCr8
mRatBN7.2	8	121,559,563 - 121,573,633 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	121,561,211 - 121,573,582 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	127,162,299 - 127,163,985 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	125,361,373 - 125,363,059 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	123,190,782 - 123,192,468 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	130,526,521 - 130,543,566 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	130,538,651 - 130,542,227 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	129,653,559 - 129,719,044 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	127,026,528 - 127,028,214 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	127,046,266 - 127,047,951 (-)	NCBI
Celera	8	120,695,513 - 120,697,199 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

ACKR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	42,809,445 - 42,867,286 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	42,804,752 - 42,887,974 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	42,850,937 - 42,908,778 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	42,825,968 - 42,883,779 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	42,825,979 - 42,883,778	NCBI
Celera	3	42,788,881 - 42,846,689 (+)	NCBI		Celera
Cytogenetic Map	3	p22.1	NCBI
HuRef	3	42,894,146 - 42,951,926 (+)	NCBI		HuRef
CHM1_1	3	42,800,945 - 42,858,775 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	42,825,036 - 42,882,863 (+)	NCBI		T2T-CHM13v2.0

Ackr2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	121,727,421 - 121,740,177 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	121,727,421 - 121,740,140 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	121,898,355 - 121,911,075 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	121,898,355 - 121,911,074 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	121,807,582 - 121,820,182 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	121,747,162 - 121,759,762 (+)	NCBI		MGSCv36	mm8
Celera	9	122,381,256 - 122,385,967 (+)	NCBI		Celera
Cytogenetic Map	9	F4	NCBI
cM Map	9	72.71	NCBI

Ackr2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	27,992,341 - 28,011,618 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	27,990,786 - 28,020,203 (-)	NCBI	ChiLan1.0	ChiLan1.0

ACKR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	42,767,712 - 42,830,715 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	42,772,474 - 42,832,592 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	42,710,724 - 42,772,396 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	43,778,475 - 43,831,763 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	43,788,312 - 43,835,453 (+)	Ensembl	panpan1.1		panPan2

ACKR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	11,904,020 - 11,962,291 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	11,960,981 - 11,962,135 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	11,878,374 - 11,940,755 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	12,193,659 - 12,256,608 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	23	11,995,895 - 12,058,588 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	12,138,213 - 12,200,764 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	12,141,806 - 12,204,207 (+)	NCBI		UU_Cfam_GSD_1.0

Ackr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	199,920,315 - 199,978,872 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936695	2,273,797 - 2,274,951 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936695	2,272,978 - 2,274,982 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACKR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	26,288,584 - 26,329,581 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	26,291,583 - 26,329,506 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	28,974,396 - 28,993,716 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ACKR2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	4,272,340 - 4,313,929 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	4,312,645 - 4,313,799 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	162,884,569 - 162,900,086 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ackr2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	76,901,098 - 76,902,219 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	76,900,112 - 76,918,805 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ackr2
76 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	64
Count of miRNA genes:	52
Interacting mature miRNAs:	61
Transcripts:	ENSRNOT00000026343
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	93535351	123900184	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	95718998	123900184	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	95718998	123900184	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	82460758	122812818	Rat

Markers in Region

PMC24402P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	121,571,048 - 121,571,381 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	130,541,008 - 130,541,340	NCBI	Rnor6.0
Rnor_5.0	8	129,716,486 - 129,716,818	UniSTS	Rnor5.0
RGSC_v3.4	8	127,027,620 - 127,027,952	UniSTS	RGSC3.4
Celera	8	120,695,775 - 120,696,107	UniSTS
Cytogenetic Map	8	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	41	106	77	76	45	25	45	6	174	89	86	23	48	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001433059	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_078621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595421	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080719	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080721	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC086449	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U92803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000026343 ⟹ ENSRNOP00000026343

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	121,561,211 - 121,573,582 (+)	Ensembl
Rnor_6.0 Ensembl	8	130,538,651 - 130,542,227 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097400 ⟹ ENSRNOP00000081718

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	121,564,137 - 121,573,582 (+)	Ensembl

RefSeq Acc Id:

NM_078621 ⟹ NP_511176

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	130,448,286 - 130,449,972 (+)	NCBI
mRatBN7.2	8	121,570,787 - 121,572,473 (+)	NCBI
Rnor_6.0	8	130,540,746 - 130,542,432 (+)	NCBI
Rnor_5.0	8	129,653,559 - 129,719,044 (+)	NCBI
RGSC_v3.4	8	127,026,528 - 127,028,214 (-)	RGD
Celera	8	120,695,513 - 120,697,199 (+)	RGD

Sequence:

show sequence

TCTGTGTCTGTGTGTGTTTAAATGTTCGTGTGTGTGAGCATGTGCGTGTGGATGTCAGAGGACA
GGCTCATGTCAGTTTCTTCTGAGCTAGTGCTGGCCTGTGAGCTTCTGATGCTTCCTTCTCTGTC
TCTTCCTTCAGGATTGTAGCTGTGCCTTCTGCCTCTAGCTTTGTGTGGGTGCCAAGGATGTGTG
CGCGGCGAGCGCTTTGCCCGCTGAACCATCTCCTCAGGCCCTCACTGCGGCTTTTGTTTCCTGC
AGAACTCGAGACATGCCCACCATCGCTTCTCCCCTGCCTCTCGCCACCACCGGTCCTGAGAACG
GCAGCTCCATCTACGACTATGACTACTTGGATGACGTGACTGTCTTGGTTTGCAGCAAAGATGA
GGTCCTGTCCTTTGGCAGAGTCTTTCTGCCGGTGGTCTACAGCCTGATCTTTGTGCTGGGCCTG
GCCGGCAACCTCCTTCTCCTGGTGGTATTGCTCCACTCTGTGCCTCAACGACGACGGATGATTG
AGCTGTACCTGCTGAACCTGGCTGTCTCCAACCTCTTGTTTGTAGTGACGATGCCCTTCTGGGC
CATCTCTGTGGCCTGGCATTGGGTTTTCGGCAGTTTCCTGTGCAAGGTGGTGAGCACTCTCTAC
TCTATTAACTTTTACTGTGGCATCTTCTTCATCACCTGCATGAGTCTGGACAAATACCTGGAGA
TTGTCCACGCTCAGCCCCTCCACAGACCCAAGACCCGGTTCAGGAACCTGCTTCTCATTGTCAT
GGTGTGGATCACAGCCCTGGCTGTCTCTGTCCCAGAAATGGTCTTTGTGAAGGTCCACCAGACC
TTAGATGGTGTGTGGCACTGCTATGCCGATTTTGGCGGACATGCAACCATTTGGAAGCTGTACC
TGCGCTTCCAGATGAACCTCCTGGGGTTTCTCTTCCCACTGTTGGCCATGATTTTCTTTTACTC
CCGCATCGGTTGTGTTCTGGTCAGGCTGAGGCCACCGGGACAGGGCCGGGCTCTGAGGACGGCT
GCGGCCCTGGTGGTAGTCTTCTTCCTGCTGTGGTTCCCGTACAACCTCACCTTGTTCCTGCACT
CGCTGCTGGATCTGCATGTCTTTGGGAACTGTGAGATCAGCCACCGTCTGGACTATATGTTGCA
GGTGACAGAGAGCCTGGCCTTCTCCCATTGTTGCTTCACCCCAGTCCTCTATGCCTTCTCCAGT
CACAGTTTCCGCCAGTACCTTAAAGCGGTTCTGTCCGTGGTGCTGAGACGGCACCAGGCACCTG
GCACCGCCCACGCCCCTCCATGTAGCCATTCGGAGAGCAGCAGGGTTACTGCCCAGGAAGATGT
GGTCAGCATGAACGACCTTGGCGAGAGGCAGGCTGACATCTCCCTTAACAAGGGGGAGATAGGA
AATAATTAATCCCCGGGTCTGGGAACGGTGGTTCTCTCTGAGGGACAGCATGGCCGTGCTTGCT
GCTTGCCCCAGTGGTTTCCAACCACCAGCAGTCTTTGTTCACTACTGCCTCTCCCTCCTTCCAC
TTCCTGATCCCATACTCACTGATGAACCACTGCAGCTCTTCACTGATCTCCGCTTCCGTCCTGG
CGCTTCTGTGGCTTTTCCTGGCCCCCGGCAGCCAATGAGGACACTCCATTCTTGGCCATAAAGG
CCATAAAGATATAAAACCTTCAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039080718 ⟹ XP_038936646

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	130,440,794 - 130,451,106 (+)	NCBI
mRatBN7.2	8	121,559,566 - 121,573,633 (+)	NCBI

RefSeq Acc Id:

XM_039080719 ⟹ XP_038936647

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	130,438,703 - 130,451,106 (+)	NCBI
mRatBN7.2	8	121,559,566 - 121,573,633 (+)	NCBI

RefSeq Acc Id:

XM_039080721 ⟹ XP_038936649

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	130,440,794 - 130,451,106 (+)	NCBI
mRatBN7.2	8	121,559,563 - 121,573,633 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001419988	(Get FASTA)	NCBI Sequence Viewer
	NP_511176	(Get FASTA)	NCBI Sequence Viewer
	XP_038936646	(Get FASTA)	NCBI Sequence Viewer
	XP_038936647	(Get FASTA)	NCBI Sequence Viewer
	XP_038936649	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB61572	(Get FASTA)	NCBI Sequence Viewer
	AAH86449	(Get FASTA)	NCBI Sequence Viewer
	EDL76813	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026343
	ENSRNOP00000110589
	ENSRNOP00000111612
GenBank Protein	O09027	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_511176 ⟸ NM_078621

- UniProtKB:

O09027 (UniProtKB/Swiss-Prot), Q5U1W0 (UniProtKB/TrEMBL), A6I464 (UniProtKB/TrEMBL), A0A8I6G8C2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPTIASPLPLATTGPENGSSIYDYDYLDDVTVLVCSKDEVLSFGRVFLPVVYSLIFVLGLAGNL
LLLVVLLHSVPQRRRMIELYLLNLAVSNLLFVVTMPFWAISVAWHWVFGSFLCKVVSTLYSINF
YCGIFFITCMSLDKYLEIVHAQPLHRPKTRFRNLLLIVMVWITALAVSVPEMVFVKVHQTLDGV
WHCYADFGGHATIWKLYLRFQMNLLGFLFPLLAMIFFYSRIGCVLVRLRPPGQGRALRTAAALV
VVFFLLWFPYNLTLFLHSLLDLHVFGNCEISHRLDYMLQVTESLAFSHCCFTPVLYAFSSHSFR
QYLKAVLSVVLRRHQAPGTAHAPPCSHSESSRVTAQEDVVSMNDLGERQADISLNKGEIGNN

hide sequence

Ensembl Acc Id:

ENSRNOP00000026343 ⟸ ENSRNOT00000026343

RefSeq Acc Id:	XP_038936649 ⟸ XM_039080721
- Peptide Label:	isoform X1
- UniProtKB:	O09027 (UniProtKB/Swiss-Prot), Q5U1W0 (UniProtKB/TrEMBL), A6I464 (UniProtKB/TrEMBL), A0A8I6G8C2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038936646 ⟸ XM_039080718
- Peptide Label:	isoform X1
- UniProtKB:	O09027 (UniProtKB/Swiss-Prot), Q5U1W0 (UniProtKB/TrEMBL), A6I464 (UniProtKB/TrEMBL), A0A8I6G8C2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038936647 ⟸ XM_039080719
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000081718 ⟸ ENSRNOT00000097400

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O09027-F1-model_v2	AlphaFold	O09027	1-382	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620323	AgrOrtholog
BioCyc Gene	G2FUF-28676	BioCyc
Ensembl Genes	ENSRNOG00000019472	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000026343	ENTREZGENE
	ENSRNOT00000145003	ENTREZGENE
	ENSRNOT00000169098	ENTREZGENE
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7304127	IMAGE-MGC_LOAD
InterPro	Chemokine_rcpt	UniProtKB/Swiss-Prot
	CXCR4/ACKR2	UniProtKB/Swiss-Prot
	GPCR1	UniProtKB/Swiss-Prot
	GPCR_Rhodpsn	UniProtKB/Swiss-Prot
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105345	IMAGE-MGC_LOAD
NCBI Gene	140473	ENTREZGENE
PANTHER	ATYPICAL CHEMOKINE RECEPTOR 2	UniProtKB/Swiss-Prot
	CELL ADHESION MOLECULE	UniProtKB/Swiss-Prot
Pfam	7tm_1	UniProtKB/Swiss-Prot
PhenoGen	Ackr2	PhenoGen
PRINTS	CCCHEMOKINER	UniProtKB/Swiss-Prot
	CXCCHMKINER4	UniProtKB/Swiss-Prot
	GPCRRHODOPSN	UniProtKB/Swiss-Prot
PROSITE	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000019472	RatGTEx
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot
UniProt	A0A8I6G8C2	ENTREZGENE, UniProtKB/TrEMBL
	A6I464	ENTREZGENE
	ACKR2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q5U1W0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-07-31	Ackr2	atypical chemokine receptor 2	Ccbp2	chemokine binding protein 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Ccbp2	chemokine binding protein 2	D6	CC-chemokine-binding receptor JAB61	Symbol and Name updated	1299863	APPROVED
2002-08-07	D6	CC-chemokine-binding receptor JAB61			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in placenta and fetal liver	632634
gene_physical_interaction	binds to monocyte chemoattractant protein (MCP)-1 and MCP-3	632634
gene_product	belongs to G protein-coupled superfamily of seven-transmembrane serpentine receptors	632634

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar