Zdhhc7 (zinc finger DHHC-type palmitoyltransferase 7) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways
Gene: Zdhhc7 (zinc finger DHHC-type palmitoyltransferase 7) Rattus norvegicus
Analyze
Symbol: Zdhhc7
Name: zinc finger DHHC-type palmitoyltransferase 7
RGD ID: 620205
Description: Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in several processes, including cellular response to hormone stimulus; protein localization to membrane; and regulation of protein localization. Predicted to be located in nucleoplasm. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC7 (zinc finger DHHC-type palmitoyltransferase 7); INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acyltransferase ZDHHC7; DHHC-7; DHHC7; membrane-associated DHHC7 zinc finger protein; palmitoyltransferase ZDHHC7; putative zinc finger protein SERZ-1; Sertoli cell gene with a zinc finger domain; Serz-1; Serz1; zinc finger DHHC domain-containing protein 7; zinc finger, DHHC domain containing 7; zinc finger, DHHC-type containing 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21948,139,309 - 48,156,673 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1948,139,527 - 48,156,673 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1954,933,859 - 54,951,009 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01955,614,590 - 55,631,738 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01957,828,379 - 57,845,521 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01952,733,161 - 52,750,307 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,733,161 - 52,750,307 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01963,480,614 - 63,497,760 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41950,406,074 - 50,423,220 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11950,410,954 - 50,428,101 (-)NCBI
Celera1947,395,638 - 47,412,788 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Identification of a novel gene product, Sertoli cell gene with a zinc finger domain, that is important for FSH activation of testicular Sertoli cells. Chaudhary J and Skinner MK, Endocrinology 2002 Feb;143(2):426-35.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:15603741   PMID:16647879   PMID:18596047   PMID:19001095   PMID:22031296   PMID:23034182   PMID:23687301   PMID:25253725   PMID:25301068   PMID:27380321   PMID:28057756  
PMID:28196865  


Genomics

Comparative Map Data
Zdhhc7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21948,139,309 - 48,156,673 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1948,139,527 - 48,156,673 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1954,933,859 - 54,951,009 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01955,614,590 - 55,631,738 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01957,828,379 - 57,845,521 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01952,733,161 - 52,750,307 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,733,161 - 52,750,307 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01963,480,614 - 63,497,760 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41950,406,074 - 50,423,220 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11950,410,954 - 50,428,101 (-)NCBI
Celera1947,395,638 - 47,412,788 (-)NCBICelera
Cytogenetic Map19q12NCBI
ZDHHC7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381684,974,175 - 85,027,631 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1684,974,175 - 85,011,535 (-)EnsemblGRCh38hg38GRCh38
GRCh371685,007,781 - 85,045,141 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361683,565,573 - 83,602,642 (-)NCBINCBI36Build 36hg18NCBI36
Build 341683,565,572 - 83,602,642NCBI
Celera1669,310,278 - 69,347,352 (-)NCBICelera
Cytogenetic Map16q24.1NCBI
HuRef1670,760,932 - 70,797,769 (-)NCBIHuRef
CHM1_11686,419,590 - 86,456,676 (-)NCBICHM1_1
T2T-CHM13v2.01691,040,795 - 91,094,281 (-)NCBIT2T-CHM13v2.0
Zdhhc7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398120,807,834 - 120,828,211 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8120,807,629 - 120,828,221 (-)EnsemblGRCm39 Ensembl
GRCm388120,081,091 - 120,103,900 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8120,080,890 - 120,101,482 (-)EnsemblGRCm38mm10GRCm38
MGSCv378122,604,995 - 122,625,372 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368122,967,072 - 122,987,449 (-)NCBIMGSCv36mm8
Celera8124,301,540 - 124,321,926 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map868.93NCBI
Zdhhc7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955541397,748 - 432,501 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955541398,364 - 426,330 (-)NCBIChiLan1.0ChiLan1.0
ZDHHC7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan116100,643,554 - 100,680,964 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01665,643,906 - 65,681,301 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11684,982,607 - 85,019,622 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1684,982,607 - 85,019,622 (-)Ensemblpanpan1.1panPan2
ZDHHC7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1567,554,310 - 67,580,042 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl567,566,563 - 67,578,556 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha567,568,312 - 67,594,091 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0567,786,224 - 67,812,010 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl567,786,136 - 67,812,380 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1567,802,185 - 67,827,971 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0567,636,627 - 67,662,382 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0568,051,462 - 68,077,242 (+)NCBIUU_Cfam_GSD_1.0
Zdhhc7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934927,421,797 - 27,445,943 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366413,175,338 - 3,199,484 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366413,175,338 - 3,199,487 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZDHHC7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl63,786,325 - 3,817,957 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.163,786,330 - 3,817,960 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.264,215,849 - 4,247,456 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZDHHC7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1570,379,228 - 70,419,885 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl570,379,179 - 70,401,139 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660475,324,504 - 5,366,536 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zdhhc7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247461,715,809 - 1,740,075 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247461,715,907 - 1,740,414 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zdhhc7
53 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:182
Count of miRNA genes:128
Interacting mature miRNAs:145
Transcripts:ENSRNOT00000023405
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat

Markers in Region
RH129286  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21948,139,629 - 48,139,831 (+)MAPPERmRatBN7.2
Rnor_6.01952,733,264 - 52,733,465NCBIRnor6.0
Rnor_5.01963,480,717 - 63,480,918UniSTSRnor5.0
RGSC_v3.41950,406,177 - 50,406,378UniSTSRGSC3.4
Celera1947,395,741 - 47,395,942UniSTS
Cytogenetic Map19q12UniSTS
AI029017  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21948,139,587 - 48,140,212 (+)MAPPERmRatBN7.2
Rnor_6.01952,733,222 - 52,733,846NCBIRnor6.0
Rnor_5.01963,480,675 - 63,481,299UniSTSRnor5.0
RGSC_v3.41950,406,135 - 50,406,759UniSTSRGSC3.4
Celera1947,395,699 - 47,396,323UniSTS
RH 3.4 Map19653.0UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 36 20 19 20 8 11 74 35 41 11 8
Low 21 21 21
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000023405   ⟹   ENSRNOP00000023405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1948,139,527 - 48,156,673 (-)Ensembl
Rnor_6.0 Ensembl1952,733,161 - 52,750,307 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112395   ⟹   ENSRNOP00000080214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1948,139,527 - 48,146,301 (-)Ensembl
RefSeq Acc Id: NM_133394   ⟹   NP_596885
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21948,139,527 - 48,156,673 (-)NCBI
Rnor_6.01952,733,161 - 52,750,307 (-)NCBI
Rnor_5.01963,480,614 - 63,497,760 (-)NCBI
RGSC_v3.41950,406,074 - 50,423,220 (-)RGD
Celera1947,395,638 - 47,412,788 (-)RGD
Sequence:
RefSeq Acc Id: XM_039097438   ⟹   XP_038953366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21948,139,309 - 48,145,978 (-)NCBI
RefSeq Acc Id: NP_596885   ⟸   NM_133394
- UniProtKB: Q2TGK0 (UniProtKB/Swiss-Prot),   Q923G5 (UniProtKB/Swiss-Prot),   A6IZL6 (UniProtKB/TrEMBL),   A6IZL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023405   ⟸   ENSRNOT00000023405
RefSeq Acc Id: XP_038953366   ⟸   XM_039097438
- Peptide Label: isoform X1
- UniProtKB: Q923G5 (UniProtKB/Swiss-Prot),   Q2TGK0 (UniProtKB/Swiss-Prot),   A6IZL6 (UniProtKB/TrEMBL),   A6IZL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000080214   ⟸   ENSRNOT00000112395
Protein Domains
DHHC   Palmitoyltransferase DHHC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q923G5-F1-model_v2 AlphaFold Q923G5 1-308 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620205 AgrOrtholog
BioCyc Gene G2FUF-5495 BioCyc
Ensembl Genes ENSRNOG00000017342 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023405 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000080214.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023405 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000112395.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621307 IMAGE-MGC_LOAD
InterPro Palmitoyltrfase_DHHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170906 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72319 IMAGE-MGC_LOAD
NCBI Gene 170906 ENTREZGENE
PANTHER PALMITOYLTRANSFERASE ZDHHC7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DHHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Zdhhc7 PhenoGen
PROSITE DHHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6G6A6_RAT UniProtKB/TrEMBL
  A6IZL5 ENTREZGENE, UniProtKB/TrEMBL
  A6IZL6 ENTREZGENE, UniProtKB/TrEMBL
  Q2TGK0 ENTREZGENE
  Q923G5 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q2TGK0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-11 Zdhhc7  zinc finger DHHC-type palmitoyltransferase 7  Zdhhc7  zinc finger, DHHC-type containing 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-17 Zdhhc7  zinc finger, DHHC-type containing 7  Zdhhc7  zinc finger, DHHC domain containing 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Zdhhc7  zinc finger, DHHC domain containing 7  Serz-1  putative zinc finger protein SERZ-1  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-08-07 Serz-1  putative zinc finger protein SERZ-1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function can inhibit FSH-induced transferrin promoter activation 70388