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Gene: Slc8a3 (solute carrier family 8 member A3) Rattus norvegicus
Symbol: Slc8a3
Name: solute carrier family 8 member A3
Description: Exhibits calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration and calcium:sodium antiporter activity. Involved in cellular response to cAMP; metal ion transport; and telencephalon development. Localizes to several cellular components, including dendritic spine; integral component of postsynaptic membrane; and sarcolemma. Biomarker of brain ischemia and status epilepticus. Orthologous to human SLC8A3 (solute carrier family 8 member A3); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; acrylamide; amiodarone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: na(+)/Ca(2+)-exchange protein 3; Ncx3; sodium/calcium exchanger 3; solute carrier family 8 (sodium/calcium exchanger), member 3; solute carrier family 8 member 3
Homo sapiens (human) : SLC8A3 (solute carrier family 8 member A3)  HGNC  Alliance
Mus musculus (house mouse) : Slc8a3 (solute carrier family 8 (sodium/calcium exchanger), member 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc8a3 (solute carrier family 8 member A3)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC8A3 (solute carrier family 8 member A3)
Canis lupus familiaris (dog) : SLC8A3 (solute carrier family 8 member A3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc8a3 (solute carrier family 8 member A3)
Sus scrofa (pig) : SLC8A3 (solute carrier family 8 member A3)
Chlorocebus sabaeus (African green monkey) : SLC8A3 (solute carrier family 8 member A3)
Heterocephalus glaber (naked mole-rat) : Slc8a3 (solute carrier family 8 member A3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.06104,889,500 - 105,099,408 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6104,891,376 - 105,097,054 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06113,051,977 - 113,067,568 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.06113,212,215 - 113,244,454 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46105,012,888 - 105,159,942 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16105,016,343 - 105,163,398 (-)NCBI
Celera698,727,252 - 98,860,656 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Slc8a3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620197
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.