Magt1 (magnesium transporter 1) - Rat Genome Database

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Gene: Magt1 (magnesium transporter 1) Rattus norvegicus
Analyze
Symbol: Magt1
Name: magnesium transporter 1
RGD ID: 620094
Description: Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in cognition; magnesium ion transport; and protein N-linked glycosylation via asparagine. Predicted to be located in endoplasmic reticulum. Predicted to be part of oligosaccharyltransferase complex. Human ortholog(s) of this gene implicated in X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia and congenital disorder of glycosylation Icc. Orthologous to human MAGT1 (magnesium transporter 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1; Iag2; IAP; implantation-associated protein; magnesium transporter protein 1; oligosaccharyl transferase subunit MAGT1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X75,104,040 - 75,145,247 (-)NCBIGRCr8
mRatBN7.2X71,038,489 - 71,079,704 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX71,038,489 - 71,079,699 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX72,549,506 - 72,588,568 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X76,049,823 - 76,088,885 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X73,612,998 - 73,652,060 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X77,023,423 - 77,061,603 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX77,020,402 - 77,061,667 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X56,146,028 - 56,184,208 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X94,095,479 - 94,133,659 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X94,168,934 - 94,207,092 (-)NCBI
CeleraX72,353,918 - 72,392,096 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15835887   PMID:18455129   PMID:19717468   PMID:19946888   PMID:25135935   PMID:26358767   PMID:30704530   PMID:31036665  


Genomics

Comparative Map Data
Magt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X75,104,040 - 75,145,247 (-)NCBIGRCr8
mRatBN7.2X71,038,489 - 71,079,704 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX71,038,489 - 71,079,699 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX72,549,506 - 72,588,568 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X76,049,823 - 76,088,885 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X73,612,998 - 73,652,060 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X77,023,423 - 77,061,603 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX77,020,402 - 77,061,667 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X56,146,028 - 56,184,208 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X94,095,479 - 94,133,659 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X94,168,934 - 94,207,092 (-)NCBI
CeleraX72,353,918 - 72,392,096 (-)NCBICelera
Cytogenetic MapXq22NCBI
MAGT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X77,825,747 - 77,895,568 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX77,825,747 - 77,899,271 (-)EnsemblGRCh38hg38GRCh38
GRCh37X77,081,244 - 77,151,065 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X76,968,517 - 77,037,583 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X76,888,006 - 76,957,072NCBI
CeleraX77,322,738 - 77,391,930 (-)NCBICelera
Cytogenetic MapXq21.1NCBI
HuRefX70,668,637 - 70,736,760 (-)NCBIHuRef
CHM1_1X76,974,589 - 77,043,753 (-)NCBICHM1_1
T2T-CHM13v2.0X76,263,304 - 76,330,626 (-)NCBIT2T-CHM13v2.0
Magt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X105,011,690 - 105,055,408 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX105,011,690 - 105,055,512 (-)EnsemblGRCm39 Ensembl
GRCm38X105,968,084 - 106,011,802 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX105,968,084 - 106,011,906 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X103,163,423 - 103,207,238 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X102,172,936 - 102,214,495 (-)NCBIMGSCv36mm8
CeleraX92,821,884 - 92,865,614 (-)NCBICelera
Cytogenetic MapXDNCBI
cM MapX47.36NCBI
Magt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555571,290,615 - 1,336,198 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555571,294,408 - 1,336,164 (-)NCBIChiLan1.0ChiLan1.0
MAGT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X77,408,743 - 77,477,831 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X77,412,354 - 77,481,442 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X67,009,590 - 67,078,691 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X77,122,801 - 77,190,690 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX77,122,801 - 77,190,690 (-)Ensemblpanpan1.1panPan2
MAGT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X60,122,021 - 60,186,457 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX60,128,571 - 60,186,507 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX51,135,133 - 51,199,577 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X61,360,509 - 61,425,186 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX61,365,458 - 61,425,243 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X59,066,835 - 59,130,908 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X60,676,273 - 60,741,764 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X60,264,710 - 60,329,424 (-)NCBIUU_Cfam_GSD_1.0
Magt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X42,172,097 - 42,212,171 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366832,735,217 - 2,775,679 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366832,737,545 - 2,775,679 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAGT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX61,894,965 - 61,958,517 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X61,894,237 - 61,958,511 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X70,812,442 - 70,877,270 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAGT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X66,798,408 - 66,829,249 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX66,797,359 - 66,829,263 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606714,678,349 - 14,732,000 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Magt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248363,077,425 - 3,144,004 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248363,076,940 - 3,144,004 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Magt1
91 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:19
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000068479
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 10 74 35 38 11 8
Low 1 3
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000081671   ⟹   ENSRNOP00000072000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX71,045,671 - 71,079,676 (-)Ensembl
Rnor_6.0 EnsemblX77,038,394 - 77,061,593 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083643   ⟹   ENSRNOP00000075434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX71,040,636 - 71,079,699 (-)Ensembl
Rnor_6.0 EnsemblX77,020,431 - 77,061,604 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089386   ⟹   ENSRNOP00000073419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX71,038,489 - 71,079,638 (-)Ensembl
Rnor_6.0 EnsemblX77,020,402 - 77,061,667 (-)Ensembl
RefSeq Acc Id: NM_053946   ⟹   NP_446398
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X75,106,154 - 75,145,212 (-)NCBI
mRatBN7.2X71,040,604 - 71,079,662 (-)NCBI
Rnor_6.0X77,023,423 - 77,061,603 (-)NCBI
Rnor_5.0X56,146,028 - 56,184,208 (-)NCBI
RGSC_v3.4X94,095,479 - 94,133,659 (-)RGD
CeleraX72,353,918 - 72,392,096 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099413   ⟹   XP_038955341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X75,104,040 - 75,145,247 (-)NCBI
mRatBN7.2X71,038,489 - 71,079,704 (-)NCBI
RefSeq Acc Id: XM_063279756   ⟹   XP_063135826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X75,104,040 - 75,145,212 (-)NCBI
Protein Sequences
Protein RefSeqs NP_446398 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955341 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135826 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB63294 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072000
  ENSRNOP00000072000.2
  ENSRNOP00000073419
  ENSRNOP00000073419.2
  ENSRNOP00000075434.2
GenBank Protein O35777 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446398   ⟸   NM_053946
- Peptide Label: precursor
- UniProtKB: O35777 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073419   ⟸   ENSRNOT00000089386
RefSeq Acc Id: ENSRNOP00000072000   ⟸   ENSRNOT00000081671
RefSeq Acc Id: ENSRNOP00000075434   ⟸   ENSRNOT00000083643
RefSeq Acc Id: XP_038955341   ⟸   XM_039099413
- Peptide Label: isoform X1
- UniProtKB: O35777 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063135826   ⟸   XM_063279756
- Peptide Label: isoform X2
- UniProtKB: G3V9X8 (UniProtKB/TrEMBL)
Protein Domains
Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35777-F1-model_v2 AlphaFold O35777 1-335 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701900
Promoter ID:EPDNEW_R12422
Type:initiation region
Name:Magt1_1
Description:magnesium transporter 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X77,061,604 - 77,061,664EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620094 AgrOrtholog
BioCyc Gene G2FUF-1928 BioCyc
Ensembl Genes ENSRNOG00000051408 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081671 ENTREZGENE
  ENSRNOT00000081671.2 UniProtKB/TrEMBL
  ENSRNOT00000083643.2 UniProtKB/TrEMBL
  ENSRNOT00000089386.2 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro OligosaccharylTrfase_OST3/OST6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116967 UniProtKB/Swiss-Prot
NCBI Gene 116967 ENTREZGENE
PANTHER PTHR12692 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12692:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam OST3_OST6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Magt1 PhenoGen
RatGTEx ENSRNOG00000051408 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A096MJ31_RAT UniProtKB/TrEMBL
  A0A0G2K5G6_RAT UniProtKB/TrEMBL
  G3V9X8 ENTREZGENE, UniProtKB/TrEMBL
  MAGT1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-22 Magt1  magnesium transporter 1  Iag2  implantation-associated protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Iag2  implantation-associated protein  IAG2    Symbol updated 1299863 APPROVED
2002-08-07 IAG2  implantation-associated protein      Symbol and Name status set to provisional 70820 PROVISIONAL