Mark1 (microtubule affinity regulating kinase 1) - Rat Genome Database

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Gene: Mark1 (microtubule affinity regulating kinase 1) Rattus norvegicus
Analyze
Symbol: Mark1
Name: microtubule affinity regulating kinase 1
RGD ID: 619882
Description: Enables ATP binding activity; magnesium ion binding activity; and protein kinase activity. Involved in several processes, including intracellular signal transduction; neuron migration; and protein phosphorylation. Located in cytoplasm and cytoskeleton. Orthologous to human MARK1 (microtubule affinity regulating kinase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 9-cis-retinoic acid; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MAP/microtubule affinity-regulating kinase 1; serine/threonine-protein kinase MARK1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21396,450,189 - 96,555,304 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1396,451,487 - 96,555,173 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1398,957,791 - 99,061,914 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.013100,356,587 - 100,460,278 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01397,540,024 - 97,644,155 (-)NCBIRnor_WKY
Rnor_6.013102,808,254 - 102,942,863 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13102,808,253 - 102,942,863 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013107,485,344 - 107,589,704 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413100,905,369 - 101,009,161 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113101,094,411 - 101,198,263 (-)NCBI
Celera1395,968,489 - 96,018,212 (-)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Drewes G, etal., Cell 1997 Apr 18;89(2):297-308.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neurons. Schaar BT, etal., Neuron. 2004 Jan 22;41(2):203-13.
Additional References at PubMed
PMID:14976552   PMID:16238695   PMID:17728463   PMID:18492799   PMID:21145462   PMID:23666762   PMID:25931508   PMID:25932647  


Genomics

Comparative Map Data
Mark1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21396,450,189 - 96,555,304 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1396,451,487 - 96,555,173 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1398,957,791 - 99,061,914 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.013100,356,587 - 100,460,278 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01397,540,024 - 97,644,155 (-)NCBIRnor_WKY
Rnor_6.013102,808,254 - 102,942,863 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13102,808,253 - 102,942,863 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013107,485,344 - 107,589,704 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413100,905,369 - 101,009,161 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113101,094,411 - 101,198,263 (-)NCBI
Celera1395,968,489 - 96,018,212 (-)NCBICelera
Cytogenetic Map13q26NCBI
MARK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381220,528,136 - 220,664,461 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1220,528,136 - 220,664,461 (+)EnsemblGRCh38hg38GRCh38
GRCh371220,701,478 - 220,837,803 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361218,768,191 - 218,904,422 (+)NCBINCBI36Build 36hg18NCBI36
Build 341217,089,962 - 217,225,667NCBI
Celera1193,920,723 - 194,057,269 (+)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1191,375,808 - 191,512,424 (+)NCBIHuRef
CHM1_11221,974,021 - 222,110,252 (+)NCBICHM1_1
T2T-CHM13v2.01219,767,527 - 219,904,166 (+)NCBIT2T-CHM13v2.0
Mark1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391184,628,621 - 184,732,152 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1184,628,986 - 184,731,767 (-)EnsemblGRCm39 Ensembl
GRCm381184,896,424 - 184,999,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1184,896,789 - 184,999,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv371186,720,303 - 186,823,428 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361186,598,391 - 186,700,267 (-)NCBIMGSCv36mm8
Celera1191,860,242 - 191,963,269 (-)NCBICelera
Cytogenetic Map1H5NCBI
Mark1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555203,086,887 - 3,205,525 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555203,087,581 - 3,205,525 (-)NCBIChiLan1.0ChiLan1.0
MARK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11201,150,316 - 201,286,201 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1201,150,310 - 201,286,201 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01196,114,714 - 196,251,166 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MARK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13815,270,523 - 15,341,934 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3815,273,004 - 15,340,448 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3815,268,336 - 15,385,001 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03815,263,226 - 15,379,605 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3815,262,280 - 15,379,579 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13815,270,806 - 15,387,062 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03815,625,161 - 15,741,308 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03815,905,948 - 16,022,402 (+)NCBIUU_Cfam_GSD_1.0
Mark1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934456,357,812 - 56,419,056 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366501,605,487 - 1,667,297 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366501,607,480 - 1,672,591 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MARK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl109,980,383 - 10,104,867 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1109,980,277 - 10,106,507 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MARK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1258,876,945 - 9,019,780 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl258,879,201 - 9,019,598 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660559,155,904 - 9,298,871 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mark1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248353,986,642 - 4,101,388 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248353,987,023 - 4,101,428 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mark1
371 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:225
Count of miRNA genes:159
Interacting mature miRNAs:184
Transcripts:ENSRNOT00000003198
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
D13Mit15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21396,512,579 - 96,512,789 (+)MAPPERmRatBN7.2
Rnor_6.013102,870,610 - 102,870,817NCBIRnor6.0
Rnor_5.013107,546,551 - 107,546,758UniSTSRnor5.0
RGSC_v3.413100,966,402 - 100,966,609RGDRGSC3.4
RGSC_v3.413100,966,403 - 100,966,610UniSTSRGSC3.4
RGSC_v3.113101,155,416 - 101,155,877RGD
Celera1396,029,857 - 96,030,064UniSTS
RH 3.4 Map13656.1UniSTS
RH 3.4 Map13656.1RGD
Cytogenetic Map13q26UniSTS
RH138446  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21396,459,086 - 96,459,209 (+)MAPPERmRatBN7.2
Rnor_6.013102,817,149 - 102,817,271NCBIRnor6.0
Rnor_5.013107,492,944 - 107,493,066UniSTSRnor5.0
RGSC_v3.413100,912,969 - 100,913,091UniSTSRGSC3.4
Celera1395,976,089 - 95,976,211UniSTS
RH 3.4 Map13654.1UniSTS
Cytogenetic Map13q26UniSTS
BF418092  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21396,520,436 - 96,520,545 (+)MAPPERmRatBN7.2
Rnor_6.013102,878,465 - 102,878,573NCBIRnor6.0
Rnor_5.013107,554,406 - 107,554,514UniSTSRnor5.0
RGSC_v3.413100,974,258 - 100,974,366UniSTSRGSC3.4
Celera1396,037,712 - 96,037,820UniSTS
RH 3.4 Map13654.1UniSTS
Cytogenetic Map13q26UniSTS
AI176765  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21396,451,780 - 96,451,953 (+)MAPPERmRatBN7.2
Rnor_6.013102,809,843 - 102,810,015NCBIRnor6.0
Rnor_5.013107,485,638 - 107,485,810UniSTSRnor5.0
RGSC_v3.413100,905,663 - 100,905,835UniSTSRGSC3.4
Celera1395,968,783 - 95,968,955UniSTS
RH 3.4 Map13654.8UniSTS
Cytogenetic Map13q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 14 3 74 20 31
Low 3 29 56 40 16 40 8 11 15 10 11 8
Below cutoff 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003198   ⟹   ENSRNOP00000003198
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1396,451,487 - 96,555,173 (-)Ensembl
Rnor_6.0 Ensembl13102,809,549 - 102,942,863 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080309   ⟹   ENSRNOP00000074213
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1396,451,487 - 96,501,971 (-)Ensembl
Rnor_6.0 Ensembl13102,808,253 - 102,857,551 (-)Ensembl
RefSeq Acc Id: NM_053947   ⟹   NP_446399
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21396,451,487 - 96,555,173 (-)NCBI
Rnor_6.013102,809,549 - 102,942,863 (-)NCBI
Rnor_5.013107,485,344 - 107,589,704 (-)NCBI
RGSC_v3.413100,905,369 - 101,009,161 (-)RGD
Celera1395,968,489 - 96,018,212 (-)RGD
Sequence:
RefSeq Acc Id: XM_039090282   ⟹   XP_038946210
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21396,450,194 - 96,555,304 (-)NCBI
RefSeq Acc Id: XM_039090284   ⟹   XP_038946212
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21396,450,189 - 96,489,634 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_446399   ⟸   NM_053947
- UniProtKB: O08678 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074213   ⟸   ENSRNOT00000080309
RefSeq Acc Id: ENSRNOP00000003198   ⟸   ENSRNOT00000003198
RefSeq Acc Id: XP_038946212   ⟸   XM_039090284
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038946210   ⟸   XM_039090282
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q1K3 (UniProtKB/TrEMBL)
Protein Domains
KA1   Protein kinase   UBA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08678-F1-model_v2 AlphaFold O08678 1-793 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619882 AgrOrtholog
BioCyc Gene G2FUF-16995 BioCyc
Ensembl Genes ENSRNOG00000002339 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000003198 ENTREZGENE
  ENSRNOP00000003198.6 UniProtKB/TrEMBL
  ENSRNOP00000074213 ENTREZGENE
  ENSRNOP00000074213.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003198 ENTREZGENE
  ENSRNOT00000003198.7 UniProtKB/TrEMBL
  ENSRNOT00000080309 ENTREZGENE
  ENSRNOT00000080309.2 UniProtKB/TrEMBL
InterPro KA1/Ssp2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KA1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MARK1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117016 UniProtKB/Swiss-Prot
NCBI Gene 117016 ENTREZGENE
PANTHER PTHR24346:SF21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam KA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mark1 PhenoGen
PROSITE KA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103243 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K7H9_RAT UniProtKB/TrEMBL
  A0A8L2Q1K3 ENTREZGENE, UniProtKB/TrEMBL
  MARK1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Mark1  microtubule affinity regulating kinase 1  Mark1  MAP/microtubule affinity-regulating kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Mark1  MAP/microtubule affinity-regulating kinase 1      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Mark1  MAP/microtubule affinity-regulating kinase 1      Symbol and Name status set to provisional 70820 PROVISIONAL