Gabrr2 (gamma-aminobutyric acid type A receptor subunit rho 2) - Rat Genome Database

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Gene: Gabrr2 (gamma-aminobutyric acid type A receptor subunit rho 2) Rattus norvegicus
Analyze
Symbol: Gabrr2
Name: gamma-aminobutyric acid type A receptor subunit rho 2
RGD ID: 61902
Description: Enables GABA-A receptor activity; protein domain specific binding activity; and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in several processes, including chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to act upstream of or within gamma-aminobutyric acid signaling pathway and visual perception. Is active in GABA-ergic synapse. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human GABRR2 (gamma-aminobutyric acid type A receptor subunit rho2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GABA(A) receptor subunit rho-2; GABA(C) receptor; gamma-aminobutyric acid (GABA) A receptor, rho 2; gamma-aminobutyric acid (GABA) receptor, rho 2; gamma-aminobutyric acid (GABA-A) receptor subunit rho 2; gamma-aminobutyric acid (GABA-A) receptor, subunit rho 2; gamma-aminobutyric acid (GABA-C) receptor, subunit rho 2; gamma-aminobutyric acid A receptor, rho 2; gamma-aminobutyric acid receptor subunit rho-2; gamma-aminobutyric acid type A receptor rho 2 subunit
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2547,445,280 - 47,489,929 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl547,452,150 - 47,489,809 (+)Ensembl
Rnor_6.0548,303,366 - 48,341,571 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl548,303,366 - 48,341,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0552,888,136 - 52,924,364 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4549,349,963 - 49,387,218 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1549,350,141 - 49,387,397 (+)NCBI
Celera546,209,552 - 46,246,823 (+)NCBICelera
Cytogenetic Map5q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Evidence for a functional role of GABA receptors in the rat mature hippocampus. Alakuijala A, etal., Eur J Neurosci. 2006 Jan;23(2):514-20. doi: 10.1111/j.1460-9568.2005.04572.x.
2. ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. Croci C, etal., J Biol Chem 2003 Feb 21;278(8):6128-35.
3. gamma-Aminobutyric acidA rho receptor subunits in the developing rat hippocampus. Didelon F, etal., J Neurosci Res 2002 Mar 15;67(6):739-44.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. Ma DQ, etal., Am J Hum Genet. 2005 Sep;77(3):377-88. Epub 2005 Jul 15.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Identification of GABAA receptor subunits in rat retina: cloning of the rat GABAA receptor rho 2-subunit cDNA. Ogurusu T, etal., J Neurochem 1995 Sep;65(3):964-8.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12019334   PMID:12706246   PMID:15617751   PMID:18201822  


Genomics

Comparative Map Data
Gabrr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2547,445,280 - 47,489,929 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl547,452,150 - 47,489,809 (+)Ensembl
Rnor_6.0548,303,366 - 48,341,571 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl548,303,366 - 48,341,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0552,888,136 - 52,924,364 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4549,349,963 - 49,387,218 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1549,350,141 - 49,387,397 (+)NCBI
Celera546,209,552 - 46,246,823 (+)NCBICelera
Cytogenetic Map5q21NCBI
GABRR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38689,254,464 - 89,315,299 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl689,254,464 - 89,315,299 (-)EnsemblGRCh38hg38GRCh38
GRCh37689,964,183 - 90,025,018 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36690,023,958 - 90,081,686 (-)NCBINCBI36hg18NCBI36
Build 34690,023,957 - 90,081,673NCBI
Celera690,385,736 - 90,443,478 (-)NCBI
Cytogenetic Map6q15ENTREZGENE
HuRef687,183,652 - 87,241,843 (-)NCBIHuRef
CHM1_1690,064,781 - 90,122,809 (-)NCBICHM1_1
T2T-CHM13v2.0690,463,740 - 90,524,560 (-)NCBI
Gabrr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39433,057,715 - 33,095,865 (+)NCBIGRCm39mm39
GRCm39 Ensembl433,062,999 - 33,095,865 (+)Ensembl
GRCm38433,057,712 - 33,095,865 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl433,062,999 - 33,095,865 (+)EnsemblGRCm38mm10GRCm38
MGSCv37433,150,087 - 33,182,840 (+)NCBIGRCm37mm9NCBIm37
MGSCv36433,391,725 - 33,424,478 (+)NCBImm8
Celera432,803,825 - 32,840,866 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map414.64NCBI
GABRR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1690,398,602 - 90,459,596 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl690,401,811 - 90,459,468 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0687,123,527 - 87,185,547 (-)NCBIMhudiblu_PPA_v0panPan3
GABRR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11248,492,607 - 48,537,961 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1248,431,379 - 48,538,037 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1248,298,970 - 48,344,788 (-)NCBI
ROS_Cfam_1.01249,300,885 - 49,346,708 (-)NCBI
ROS_Cfam_1.0 Ensembl1249,236,816 - 49,346,733 (-)Ensembl
UMICH_Zoey_3.11248,616,699 - 48,663,008 (-)NCBI
UNSW_CanFamBas_1.01248,515,291 - 48,561,811 (-)NCBI
UU_Cfam_GSD_1.01248,708,571 - 48,754,457 (-)NCBI
Gabrr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494683,520,034 - 83,579,800 (-)NCBI
SpeTri2.0NW_0049365102,891,136 - 2,949,428 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABRR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl157,222,558 - 57,332,720 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1157,287,265 - 57,332,342 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2164,065,021 - 64,110,481 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GABRR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11314,015,862 - 14,074,742 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1314,016,672 - 14,073,757 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040190,333,419 - 190,400,995 (-)NCBIVero_WHO_p1.0
Gabrr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247994,841,898 - 4,900,172 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247994,841,856 - 4,900,704 (+)NCBIHetGla_female_1.0hetGla2


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:29
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000009973
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 8 55 40 19 40 7 10 36 28 29 11 7
Below cutoff 1 35 2 1 1 1 1 36 7 12 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009973   ⟹   ENSRNOP00000009973
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl547,452,150 - 47,489,809 (+)Ensembl
Rnor_6.0 Ensembl548,303,366 - 48,341,571 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081825   ⟹   ENSRNOP00000068931
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl548,313,599 - 48,341,642 (+)Ensembl
RefSeq Acc Id: NM_017292   ⟹   NP_058988
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2547,452,150 - 47,489,809 (+)NCBI
Rnor_6.0548,303,366 - 48,341,571 (+)NCBI
Rnor_5.0552,888,136 - 52,924,364 (+)NCBI
RGSC_v3.4549,349,963 - 49,387,218 (+)RGD
Celera546,209,552 - 46,246,823 (+)RGD
Sequence:
RefSeq Acc Id: XM_008763611   ⟹   XP_008761833
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2547,461,982 - 47,489,929 (+)NCBI
Rnor_6.0548,313,261 - 48,341,380 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109380   ⟹   XP_038965308
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2547,445,280 - 47,489,618 (+)NCBI
RefSeq Acc Id: XM_039109381   ⟹   XP_038965309
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2547,445,280 - 47,486,735 (+)NCBI
RefSeq Acc Id: XM_039109382   ⟹   XP_038965310
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2547,445,280 - 47,489,618 (+)NCBI
RefSeq Acc Id: XM_039109383   ⟹   XP_038965311
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2547,470,317 - 47,489,929 (+)NCBI
RefSeq Acc Id: XM_039109384   ⟹   XP_038965312
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2547,445,280 - 47,478,651 (+)NCBI
RefSeq Acc Id: XM_039109385   ⟹   XP_038965313
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2547,445,280 - 47,489,929 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058988   ⟸   NM_017292
- Peptide Label: precursor
- UniProtKB: P47742 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008761833   ⟸   XM_008763611
- Peptide Label: isoform X4
- UniProtKB: A0A0G2JU21 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068931   ⟸   ENSRNOT00000081825
RefSeq Acc Id: ENSRNOP00000009973   ⟸   ENSRNOT00000009973
RefSeq Acc Id: XP_038965313   ⟸   XM_039109385
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038965308   ⟸   XM_039109380
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038965310   ⟸   XM_039109382
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038965309   ⟸   XM_039109381
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038965312   ⟸   XM_039109384
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038965311   ⟸   XM_039109383
- Peptide Label: isoform X5

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47742-F1-model_v2 AlphaFold P47742 1-465 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
5 49386831 49386832 A G snv SS/JrHsdMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61902 AgrOrtholog
BioCyc Gene G2FUF-41707 BioCyc
Ensembl Genes ENSRNOG00000007490 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000009973 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009973 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot
  2.70.170.10 UniProtKB/Swiss-Prot
InterPro GABAA/Glycine_rcpt UniProtKB/Swiss-Prot
  GABAAa_rho2_rcpt UniProtKB/Swiss-Prot
  GABAAa_rho_rcpt UniProtKB/Swiss-Prot
  Neur_chan_lig-bd UniProtKB/Swiss-Prot
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot
  Neur_channel UniProtKB/Swiss-Prot
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot
  Neuro_actylchol_rec UniProtKB/Swiss-Prot
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot
KEGG Report rno:29695 UniProtKB/Swiss-Prot
NCBI Gene 29695 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot
  Neur_chan_memb UniProtKB/Swiss-Prot
PhenoGen Gabrr2 PhenoGen
PRINTS GABAARECEPTR UniProtKB/Swiss-Prot
  GABAARRHO UniProtKB/Swiss-Prot
  GABAARRHO2 UniProtKB/Swiss-Prot
  NRIONCHANNEL UniProtKB/Swiss-Prot
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot
  SSF90112 UniProtKB/Swiss-Prot
TIGR TC215093
TIGRFAMs LIC UniProtKB/Swiss-Prot
UniProt A0A0G2JU21 ENTREZGENE
  GBRR2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Gabrr2  gamma-aminobutyric acid type A receptor subunit rho 2  Gabrr2  gamma-aminobutyric acid type A receptor rho 2 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Gabrr2  gamma-aminobutyric acid type A receptor rho 2 subunit  Gabrr2  gamma-aminobutyric acid (GABA) A receptor, rho 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-16 Gabrr2  gamma-aminobutyric acid (GABA) A receptor, rho 2  Gabrr2  gamma-aminobutyric acid (GABA) receptor, rho 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 Gabrr2  gamma-aminobutyric acid (GABA) receptor, rho 2  Gabrr2  gamma-aminobutyric acid (GABA-C) receptor, subunit rho 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Gabrr2  gamma-aminobutyric acid (GABA-C) receptor, subunit rho 2    gamma-aminobutyric acid A receptor, rho 2  Name updated 1299863 APPROVED
2002-06-10 Gabrr2  gamma-aminobutyric acid A receptor, rho 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference