Nrgn (neurogranin) - Rat Genome Database

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Gene: Nrgn (neurogranin) Rattus norvegicus
Analyze
Symbol: Nrgn
Name: neurogranin
RGD ID: 61833
Description: Enables calmodulin binding activity; phosphatidic acid binding activity; and phosphatidylinositol-3,4,5-trisphosphate binding activity. Involved in associative learning; modulation of chemical synaptic transmission; and telencephalon development. Located in several cellular components, including dendritic spine head; neuronal cell body; and trans-Golgi network transport vesicle membrane. Is active in glutamatergic synapse and postsynaptic membrane. Biomarker of hypothyroidism and visual epilepsy. Orthologous to human NRGN (neurogranin); INTERACTS WITH 1,4-dithiothreitol; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BICKS; neurogranin (protein kinase C substrate RC3); neurogranin (protein kinase C substrate, RC3); ng; protein kinase C substrate 7.5 kDa protein; RC3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8845,444,223 - 45,452,417 (-)NCBIGRCr8
mRatBN7.2837,255,462 - 37,263,659 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl837,256,930 - 37,257,516 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx841,271,907 - 41,280,115 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0839,554,961 - 39,563,169 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0837,417,880 - 37,426,088 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0840,015,049 - 40,023,193 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl840,015,049 - 40,023,193 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0840,015,873 - 40,024,017 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4838,790,596 - 38,799,077 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1838,799,361 - 38,807,843 (-)NCBI
Celera837,191,658 - 37,199,870 (+)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,4-dithiothreitol  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',3,3',6,6'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloramine T  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
diallyl trisulfide  (ISO)
diiodine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fisetin  (EXP)
flavonoids  (EXP)
fluoxetine  (EXP)
genistein  (EXP)
gentamycin  (EXP)
ketamine  (EXP)
L-1,4-dithiothreitol  (EXP)
Lasiocarpine  (ISO)
lipopolysaccharide  (ISO)
methimazole  (ISO)
methylmercury chloride  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
naphthalene  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pentachlorophenol  (EXP)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phytoestrogen  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
testosterone  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Neurogranin in the development of the rat telencephalon. Alvarez-Bolado G, etal., Neuroscience. 1996 Jul;73(2):565-80.
2. Levothyroxin restores hypothyroidism-induced impairment of LTP of hippocampal CA1: electrophysiological and molecular studies. Alzoubi KH, etal., Exp Neurol. 2005 Oct;195(2):330-41.
3. Dendritic translocation of RC3/neurogranin mRNA in normal aging, Alzheimer disease and fronto-temporal dementia. Chang JW, etal., J Neuropathol Exp Neurol. 1997 Oct;56(10):1105-18.
4. Neurogranin binds to phosphatidic acid and associates to cellular membranes. Dominguez-Gonzalez I, etal., Biochem J. 2007 May 15;404(1):31-43.
5. Antibodies to postsynaptic PKC substrate neurogranin prevent long-term potentiation in hippocampal CA1 neurons. Fedorov NB, etal., Eur J Neurosci. 1995 Apr 1;7(4):819-22.
6. Activity-dependent translocation of neurogranin to neuronal nuclei. Garrido-Garcia A, etal., Biochem J. 2009 Dec 10;424(3):419-29. doi: 10.1042/BJ20091071.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Pre- and postsynaptic localization of RC3/neurogranin in the adult rat spinal cord: an immunohistochemical study. Houben MP, etal., J Neurosci Res. 2000 Mar 15;59(6):750-9.
10. Characterization of a 7.5-kDa protein kinase C substrate (RC3 protein, neurogranin) from rat brain. Huang KP, etal., Arch Biochem Biophys. 1993 Sep;305(2):570-80.
11. [Prenatal restraint stress decreases neurogranin expression in rat offspring hippocampus]. Li H, etal., Sheng Li Xue Bao. 2007 Jun 25;59(3):299-304.
12. Selective recognition of phosphatidylinositol 3,4,5-trisphosphate by a synthetic peptide. Lu PJ and Chen CS, J Biol Chem. 1997 Jan 3;272(1):466-72.
13. Differential regulation of primary protein kinase C substrate (MARCKS, MLP, GAP-43, RC3) mRNAs in the hippocampus during kainic acid-induced seizures and synaptic reorganization. McNamara RK and Lenox RH, J Neurosci Res. 2000 Nov 1;62(3):416-26.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Sleep deprivation differentially alters the mRNA and protein levels of neurogranin in rat brain. Neuner-Jehle M, etal., Brain Res. 1995 Jul 10;685(1-2):143-53.
17. Neurogranin is locally concentrated in rat cortical and hippocampal neurons. Neuner-Jehle M, etal., Brain Res. 1996 Sep 9;733(1):149-54.
18. Regulation of synaptic plasticity genes during consolidation of fear conditioning. Ressler KJ, etal., J Neurosci. 2002 Sep 15;22(18):7892-902.
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Structure and regulation of the gene encoding the neuron-specific protein kinase C substrate neurogranin (RC3 protein). Sato T, etal., J Biol Chem 1995 Apr 28;270(17):10314-22.
22. The nature of the compensatory response to low thyroid hormone in the developing brain. Sharlin DS, etal., J Neuroendocrinol. 2010 Mar;22(3):153-65. doi: 10.1111/j.1365-2826.2009.01947.x. Epub 2009 Dec 23.
23. Localization of RC3 (neurogranin) in rat brain subcellular fractions. Watson JB, etal., Brain Res Mol Brain Res. 1994 Dec;27(2):323-8.
24. Subtractive cDNA cloning of RC3, a rodent cortex-enriched mRNA encoding a novel 78 residue protein. Watson JB, etal., J Neurosci Res 1990 Aug;26(4):397-408.
25. Localization of the protein kinase C phosphorylation/calmodulin-binding substrate RC3 in dendritic spines of neostriatal neurons. Watson JB, etal., Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8581-5.
26. Neurogranin enhances synaptic strength through its interaction with calmodulin. Zhong L, etal., EMBO J. 2009 Oct 7;28(19):3027-39. doi: 10.1038/emboj.2009.236. Epub 2009 Aug 27.
Additional References at PubMed
PMID:12718558   PMID:12950461   PMID:15046861   PMID:15262982   PMID:15389613   PMID:18305102   PMID:20654708   PMID:21198977   PMID:22458599   PMID:22848456   PMID:22871113   PMID:24821301  
PMID:25547065   PMID:26084473   PMID:31020616   PMID:31691647   PMID:35678097  


Genomics

Comparative Map Data
Nrgn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8845,444,223 - 45,452,417 (-)NCBIGRCr8
mRatBN7.2837,255,462 - 37,263,659 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl837,256,930 - 37,257,516 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx841,271,907 - 41,280,115 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0839,554,961 - 39,563,169 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0837,417,880 - 37,426,088 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0840,015,049 - 40,023,193 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl840,015,049 - 40,023,193 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0840,015,873 - 40,024,017 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4838,790,596 - 38,799,077 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1838,799,361 - 38,807,843 (-)NCBI
Celera837,191,658 - 37,199,870 (+)NCBICelera
Cytogenetic Map8q22NCBI
NRGN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811124,739,942 - 124,747,210 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11124,739,942 - 124,747,210 (+)EnsemblGRCh38hg38GRCh38
GRCh3711124,609,838 - 124,617,106 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611124,114,952 - 124,122,309 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411124,114,951 - 124,122,309NCBI
Celera11121,770,006 - 121,777,279 (+)NCBICelera
Cytogenetic Map11q24.2NCBI
HuRef11120,552,258 - 120,559,543 (+)NCBIHuRef
CHM1_111124,495,926 - 124,503,199 (+)NCBICHM1_1
T2T-CHM13v2.011124,768,605 - 124,775,873 (+)NCBIT2T-CHM13v2.0
Nrgn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39937,455,789 - 37,464,041 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl937,455,788 - 37,464,200 (-)EnsemblGRCm39 Ensembl
GRCm38937,544,493 - 37,552,745 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl937,544,492 - 37,552,904 (-)EnsemblGRCm38mm10GRCm38
MGSCv37937,352,078 - 37,360,330 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36937,294,164 - 37,302,480 (-)NCBIMGSCv36mm8
Celera934,761,619 - 34,769,859 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map920.78NCBI
Nrgn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541225,809,512 - 25,818,237 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541225,809,512 - 25,818,237 (+)NCBIChiLan1.0ChiLan1.0
NRGN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29125,435,369 - 125,442,680 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111126,540,227 - 126,547,550 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011119,566,934 - 119,574,248 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111123,482,202 - 123,487,969 (+)NCBIpanpan1.1PanPan1.1panPan2
NRGN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.159,673,107 - 9,679,819 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl59,673,809 - 9,679,799 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha59,717,970 - 9,724,685 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.059,612,706 - 9,619,416 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.159,684,878 - 9,691,574 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.059,655,270 - 9,661,983 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.059,691,811 - 9,698,514 (-)NCBIUU_Cfam_GSD_1.0
Nrgn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947106,944,036 - 106,951,546 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367431,196,433 - 1,197,610 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367431,191,716 - 1,199,108 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRGN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl951,969,823 - 51,977,228 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1951,967,313 - 51,977,197 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2957,482,955 - 57,492,694 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NRGN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11115,888,289 - 115,895,809 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1115,894,095 - 115,894,313 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604310,222,773 - 10,230,087 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nrgn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624927753,956 - 762,662 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624927753,967 - 762,663 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nrgn
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:79
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000014404
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82664491246711092Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
70206Alc20Alcohol consumption QTL 202drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)83084815440713225Rat
61337Bp22Blood pressure QTL 225.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815442692818Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat

Markers in Region
RH125210  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2837,255,957 - 37,256,145 (+)MAPPERmRatBN7.2
Rnor_6.0840,015,542 - 40,015,729NCBIRnor6.0
Rnor_5.0840,016,366 - 40,016,553UniSTSRnor5.0
RGSC_v3.4838,791,089 - 38,791,276UniSTSRGSC3.4
Celera837,199,190 - 37,199,377UniSTS
Cytogenetic Map8q21UniSTS
UniSTS:224475  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2837,256,061 - 37,256,163 (+)MAPPERmRatBN7.2
Rnor_6.0840,015,646 - 40,015,747NCBIRnor6.0
Rnor_5.0840,016,470 - 40,016,571UniSTSRnor5.0
RGSC_v3.4838,791,193 - 38,791,294UniSTSRGSC3.4
Celera837,199,172 - 37,199,273UniSTS
Cytogenetic Map8q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 7
Medium 1 2 20 20 5 20 55 12 2
Low 2 41 34 18 14 18 8 11 12 35 28 9 8
Below cutoff 3 3 3 1

Sequence


RefSeq Acc Id: ENSRNOT00000014404   ⟹   ENSRNOP00000014404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl837,256,930 - 37,257,516 (-)Ensembl
Rnor_6.0 Ensembl840,015,049 - 40,023,193 (-)Ensembl
RefSeq Acc Id: NM_024140   ⟹   NP_077054
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8845,444,223 - 45,452,417 (-)NCBI
mRatBN7.2837,255,465 - 37,263,659 (-)NCBI
Rnor_6.0840,015,049 - 40,023,193 (-)NCBI
Rnor_5.0840,015,873 - 40,024,017 (-)NCBI
RGSC_v3.4838,790,596 - 38,799,077 (-)RGD
Celera837,191,658 - 37,199,870 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_077054 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42023 (Get FASTA)   NCBI Sequence Viewer  
  AAA80223 (Get FASTA)   NCBI Sequence Viewer  
  EDL84070 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014404.3
  ENSRNOP00055013334
  ENSRNOP00060015782
  ENSRNOP00065022344
GenBank Protein Q04940 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077054   ⟸   NM_024140
- UniProtKB: Q04940 (UniProtKB/Swiss-Prot),   A0A8L2UIU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014404   ⟸   ENSRNOT00000014404
Protein Domains
Collagen-like   IQ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q04940-F1-model_v2 AlphaFold Q04940 1-78 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695862
Promoter ID:EPDNEW_R6387
Type:initiation region
Name:Nrgn_1
Description:neurogranin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0840,023,097 - 40,023,157EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61833 AgrOrtholog
BioCyc Gene G2FUF-31064 BioCyc
Ensembl Genes ENSRNOG00000010688 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055009766 UniProtKB/Swiss-Prot
  ENSRNOG00060011886 UniProtKB/Swiss-Prot
  ENSRNOG00065016951 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014404.4 UniProtKB/TrEMBL
  ENSRNOT00055016539 UniProtKB/Swiss-Prot
  ENSRNOT00060020109 UniProtKB/Swiss-Prot
  ENSRNOT00065028270 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64356 UniProtKB/Swiss-Prot
NCBI Gene 64356 ENTREZGENE
Pfam PF00612 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nrgn PhenoGen
PROSITE PS50096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010688 RatGTEx
  ENSRNOG00055009766 RatGTEx
  ENSRNOG00060011886 RatGTEx
  ENSRNOG00065016951 RatGTEx
SMART SM00015 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2UIU9 ENTREZGENE, UniProtKB/TrEMBL
  A6KRK6_RAT UniProtKB/TrEMBL
  NEUG_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Nrgn  neurogranin      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 78-amino acid 729177
gene_regulation gene expression stimulated by phorbol 12-myristate 13-acetate 729177