Ncf2<sup>em1Mcwi</sup> (neutrophil cytosolic factor 2; zinc finger nuclease induced mutant 1, Medical College of Wisconsin) - Rat Genome Database

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Gene: Ncf2em1Mcwi (neutrophil cytosolic factor 2; zinc finger nuclease induced mutant 1, Medical College of Wisconsin) Rattus norvegicus
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Symbol: Ncf2em1Mcwi
Name: neutrophil cytosolic factor 2; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
RGD ID: 5144089
Description: This allele was made by ZFN mutagenesis. The resulting mutation is a 5-bp frameshift deletion in exon 2 (del 253-257)
ASSOCIATED WITH decreased NAD(P)H oxidase activity; decreased susceptibility to hypertension; ASSOCIATED WITH proteinuria; renal fibrosis
Type: allele  of Ncf2  
Previously known as: Ncf2em1Mcwi
Is Marker For: Strains:   SS-Ncf2em1Mcwi   SS-Ncf2em1Mcwi-/-   SS-Nox4em2Ncf2em1Mcwi   SS-Tg(Slc12a1-Ncf2-2A-Luc)-Ncf2em1Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map13 RGD


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension. Feng D, etal., Cell Metab. 2012 Feb 8;15(2):201-8. doi: 10.1016/j.cmet.2012.01.003.
2. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
3. PhysGen Knockouts PhysGen Knockout strains
4. Role of Nox4 and p67phox subunit of Nox2 in ROS production in response to increased tubular flow in the mTAL of Dahl salt-sensitive rats. Zheleznova NN, etal., Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F450-8. doi: 10.1152/ajprenal.00187.2016. Epub 2016 Jun 8.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Ncf2em1Mcwi-var1 chr13 64958217 64958221 GAGAA - deletion mRatBN7.2
Ncf2em1Mcwi-var1 chr13 70229196 70229200 GAGAA - deletion Rnor_6.0
Ncf2em1Mcwi-var1 chr13 75200283 75200287 GAGAA - deletion Rnor_5.0
Ncf2em1Mcwi-var1 chr13 75200283 75200287 GAGAA - deletion Rnor_5.0
Ncf2em1Mcwi-var1 chr13 75200283 75200287 GAGAA - deletion Rnor_5.0

Related Rat Strains
The following Strains have been annotated to Ncf2em1Mcwi


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001100984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information