Ncf2<sup>em1Mcwi</sup> (neutrophil cytosolic factor 2; zinc finger nuclease induced mutant 1,Mcwi) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ncf2em1Mcwi (neutrophil cytosolic factor 2; zinc finger nuclease induced mutant 1,Mcwi) Rattus norvegicus
Analyze
Symbol: Ncf2em1Mcwi
Name: neutrophil cytosolic factor 2; zinc finger nuclease induced mutant 1,Mcwi
RGD ID: 5144089
Description: This allele was made by ZFN mutagenesis. The resulting mutation is a 5-bp frameshift deletion in exon 2 (del 253-257)
ASSOCIATED WITH decreased NAD(P)H oxidase activity; decreased susceptibility to hypertension; salt-sensitive hypertension; ASSOCIATED WITH proteinuria; renal fibrosis
Type: allele  of Ncf2  
Previously known as: Ncf2^[em1Mcwi]; Ncf2em1Mcwi; neutrophil cytosolic factor 2; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
Is Marker For: Strains:   SS-Ncf2em1Mcwi   SS-Ncf2em1Mcwi-/-   SS-Nox4em2Ncf2em1Mcwi   SS-Tg(Slc12a1-Ncf2-2A-Luc)-Ncf2em1Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map13 RGD


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension. Feng D, etal., Cell Metab. 2012 Feb 8;15(2):201-8. doi: 10.1016/j.cmet.2012.01.003.
2. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
3. PhysGen Knockouts PhysGen Knockout strains
4. Role of Nox4 and p67phox subunit of Nox2 in ROS production in response to increased tubular flow in the mTAL of Dahl salt-sensitive rats. Zheleznova NN, etal., Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F450-8. doi: 10.1152/ajprenal.00187.2016. Epub 2016 Jun 8.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Ncf2em1Mcwi-var1 chr13 64958217 64958221 GAGAA - deletion mRatBN7.2
Ncf2em1Mcwi-var1 chr13 70229196 70229200 GAGAA - deletion Rnor_6.0
Ncf2em1Mcwi-var1 chr13 75200283 75200287 GAGAA - deletion Rnor_5.0
Ncf2em1Mcwi-var1 chr13 75200283 75200287 GAGAA - deletion Rnor_5.0
Ncf2em1Mcwi-var1 chr13 75200283 75200287 GAGAA - deletion Rnor_5.0
Ncf2em1Mcwi-var1 chr13 75200283 75200287 GAGAA - deletion Rnor_5.0

Related Rat Strains
The following Strains have been annotated to Ncf2em1Mcwi
SS-Ncf2em1Mcwi-/-     SS-Ncf2em1Mcwi     SS-Nox4em2Ncf2em1Mcwi     SS-Tg(Slc12a1-Ncf2-2A-Luc)-Ncf2em1Mcwi    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001100984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-27 Ncf2em1Mcwi  neutrophil cytosolic factor 2; zinc finger nuclease induced mutant 1,Mcwi  Ncf2em1Mcwi  neutrophil cytosolic factor 2; zinc finger nuclease induced mutant 1, Medical College of Wisconsin  Name changed 629549 APPROVED