Plekha7<sup>em4Mcwi</sup> (pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin)

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Gene: Plekha7^em4Mcwi (pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin) Rattus norvegicus

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Symbol:

Plekha7^em4Mcwi

Name:

pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin

RGD ID:

5143979

Description:

This allele was made by ZFN mutagenesis. The resulting mutation is a 19-bp frameshift deletion in exon 8 (del 638-656)
ASSOCIATED WITH decreased susceptibility to hypertension; decreased systemic vascular resistance; decreased urine albumin level; ASSOCIATED WITH Cardiac Fibrosis; glomerulosclerosis; hypertension

Type:

allele of Plekha7

Previously known as:

Plekha7^[em4Mcwi]; Plekha7em4Mcwi

Is Marker For:

Strains: SS-Plekha7^em4Mcwi SS-Plekha7^em4Mcwi-/-

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Cytogenetic Map	1		RGD

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cardiac Fibrosis (IMP)

glomerulosclerosis (IMP)

hypertension (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased susceptibility to hypertension (IMP)

decreased systemic vascular resistance (IMP)

decreased urine albumin level (IMP)

decreased urine protein level (IMP)

increased cardiac output (IMP)

increased cardiac stroke volume (IMP)

increased vasodilation (IMP)

salt-sensitive hypertension (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat.	Endres BT, etal., Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18.
2.	Knockout rats via embryo microinjection of zinc-finger nucleases.	Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
3.	PhysGen Knockouts	PhysGen Knockout strains

Genomics

Allelic Variants

Name	Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Assembly
Plekha7em4Mcwi-var1	chr1	170420191	170420209	GTCATCTCCCCGGTGGCCC	-	deletion	mRatBN7.2
Plekha7em4Mcwi-var1	chr1	185483638	185483656	GTCATCTCCCCGGTGGCCC	-	deletion	Rnor_6.0

Related Rat Strains

The following Strains have been annotated to Plekha7^em4Mcwi

SS-Plekha7^em4Mcwi-/- SS-Plekha7^em4Mcwi

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001144861	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype