Mstn<sup>em1Mcwi</sup> (myostatin; zinc finger nuclease induced mutant 1, Medical College of Wisconsin)

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Gene: Mstn^em1Mcwi (myostatin; zinc finger nuclease induced mutant 1, Medical College of Wisconsin) Rattus norvegicus

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Symbol:

Mstn^em1Mcwi

Name:

myostatin; zinc finger nuclease induced mutant 1, Medical College of Wisconsin

RGD ID:

5143964

Description:

This allele was made by ZFN mutagenesis. The resulting mutation deletes part of exon 2 and its splice acceptor (v3.4 del 45429512-45429528)
ASSOCIATED WITH increased body weight; increased skeletal muscle fiber size; increased skeletal muscle mass

Type:

allele of Mstn

Previously known as:

Mstn^[em1Mcwi]; Mstnem1Mcwi

Is Marker For:

Strains: SS-Mstn^em1Mcwi SS-Mstn^em1Mcwi-/-

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Cytogenetic Map	9		RGD

Annotation Click to see Annotation Detail View

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

increased body weight (IMP)

increased skeletal muscle fiber size (IMP)

increased skeletal muscle mass (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Knockout rats via embryo microinjection of zinc-finger nucleases.	Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2.	Changes in skeletal muscle and tendon structure and function following genetic inactivation of myostatin in rats.	Mendias CL, etal., J Physiol. 2015 Apr 15;593(8):2037-52. doi: 10.1113/jphysiol.2014.287144. Epub 2015 Feb 25.
3.	PhysGen Knockouts	PhysGen Knockout strains

Genomics

Allelic Variants

Name	Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Assembly
Mstnem1Mcwi-var1	chr9	48456663	48456680	TTAGAAAGTCAGCTGCAA	-	deletion	mRatBN7.2

Related Rat Strains

The following Strains have been annotated to Mstn^em1Mcwi

SS-Mstn^em1Mcwi-/- SS-Mstn^em1Mcwi

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019151	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype