MIR3614 (microRNA 3614) - Rat Genome Database
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Pathways
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Gene: MIR3614 (microRNA 3614) Homo sapiens
Analyze
Symbol: MIR3614
Name: microRNA 3614
RGD ID: 5134844
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-3614
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1756,891,270 - 56,891,355 (-)EnsemblGRCh38hg38GRCh38
GRCh381756,891,270 - 56,891,355 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371754,968,631 - 54,968,716 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map17q22NCBI
HuRef1750,329,206 - 50,329,291 (-)NCBIHuRef
CHM1_11755,033,876 - 55,033,961 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
paracetamol  (EXP)

References
Additional References at PubMed
PMID:16381832   PMID:20459774   PMID:21037258   PMID:21199797   PMID:21807764   PMID:29045406   PMID:30143393   PMID:30797711  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:47446
Count of gene targets:16446
Count of transcripts:35845
Interacting mature miRNAs:hsa-miR-3614-3p, hsa-miR-3614-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000581261
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1756,891,270 - 56,891,355 (-)Ensembl
RefSeq Acc Id: NR_037408
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381756,891,270 - 56,891,355 (-)NCBI
GRCh371754,968,631 - 54,968,716 (-)ENTREZGENE
HuRef1750,329,206 - 50,329,291 (-)ENTREZGENE
CHM1_11755,033,876 - 55,033,961 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1		 pathogenic
GRCh38/hg38 17q22(chr17:56683505-58084939)x1 copy number loss See cases [RCV000135409] Chr17:56683505..58084939 [GRCh38]
Chr17:54760866..56162300 [GRCh37]
Chr17:52115865..53517299 [NCBI36]
Chr17:17q22		 pathogenic
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2		 pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3		 pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR3614 COSMIC
Ensembl Genes ENSG00000284542 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000581261 ENTREZGENE
GTEx ENSG00000284542 GTEx
HGNC ID HGNC:38995 ENTREZGENE
Human Proteome Map MIR3614 Human Proteome Map
miRBase MI0016004 ENTREZGENE
NCBI Gene 100500827 ENTREZGENE
RNAcentral URS00003D4175 RNACentral
  URS000042BE4B RNACentral
  URS000075E293 RNACentral