MIR4731 (microRNA 4731) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: MIR4731 (microRNA 4731) Homo sapiens
Analyze
Symbol: MIR4731
Name: microRNA 4731
RGD ID: 5134200
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1715,251,627 - 15,251,696 (-)EnsemblGRCh38hg38GRCh38
GRCh381715,251,627 - 15,251,696 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371715,154,944 - 15,155,013 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map17p12NCBI
CHM1_11715,163,699 - 15,163,768 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Schizophrenia  (IAGP)
References

References - curated
1. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
Additional References at PubMed
PMID:16381832   PMID:21199797   PMID:27331623   PMID:31699367   PMID:31957033   PMID:32401347  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:92051
Count of gene targets:25520
Count of transcripts:69111
Interacting mature miRNAs:hsa-miR-4731-3p, hsa-miR-4731-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage entire extraembryonic component
High
Medium 1 1 4 1 1 1
Low 27 7 17 3 22 3 61 16 51 29 38 35 4 13 2
Below cutoff 8 1 1 5 13 11 15 4 13 7 3 5

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000580859
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1715,251,627 - 15,251,696 (-)Ensembl
RefSeq Acc Id: NR_039884
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381715,251,627 - 15,251,696 (-)NCBI
GRCh371715,154,944 - 15,155,013 (-)ENTREZGENE
CHM1_11715,163,699 - 15,163,768 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17p12(chr17:15249474-15259215)x1 copy number loss See cases [RCV000052046] Chr17:15249474..15259215 [GRCh38]
Chr17:15152791..15162532 [GRCh37]
Chr17:15093516..15103257 [NCBI36]
Chr17:17p12
pathogenic|uncertain significance
GRCh38/hg38 17p12(chr17:14208455-15588434)x1 copy number loss See cases [RCV000136830] Chr17:14208455..15588434 [GRCh38]
Chr17:14111772..15491748 [GRCh37]
Chr17:14052497..15432473 [NCBI36]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12(chr17:14208455-15538755)x3 copy number gain See cases [RCV000137634] Chr17:14208455..15538755 [GRCh38]
Chr17:14111772..15442069 [GRCh37]
Chr17:14052497..15382794 [NCBI36]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12(chr17:14208455-15538755)x1 copy number loss See cases [RCV000137635] Chr17:14208455..15538755 [GRCh38]
Chr17:14111772..15442069 [GRCh37]
Chr17:14052497..15382794 [NCBI36]
Chr17:17p12
pathogenic|likely pathogenic|conflicting data from submitters
GRCh38/hg38 17p12-11.2(chr17:15210400-18280816)x3 copy number gain See cases [RCV000137171] Chr17:15210400..18280816 [GRCh38]
Chr17:15113717..18184130 [GRCh37]
Chr17:15054442..18124855 [NCBI36]
Chr17:17p12-11.2
pathogenic|likely pathogenic
GRCh38/hg38 17p12(chr17:14671118-15952996)x1 copy number loss See cases [RCV000137782] Chr17:14671118..15952996 [GRCh38]
Chr17:14574435..15856310 [GRCh37]
Chr17:14515160..15797035 [NCBI36]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12(chr17:14208455-15579558)x1 copy number loss See cases [RCV000138441] Chr17:14208455..15579558 [GRCh38]
Chr17:14111772..15482872 [GRCh37]
Chr17:14052497..15423597 [NCBI36]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12(chr17:15190283-15952996)x3 copy number gain See cases [RCV000139242] Chr17:15190283..15952996 [GRCh38]
Chr17:15093600..15856310 [GRCh37]
Chr17:15034325..15797035 [NCBI36]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12(chr17:14186983-15570276)x3 copy number gain See cases [RCV000141380] Chr17:14186983..15570276 [GRCh38]
Chr17:14090300..15473590 [GRCh37]
Chr17:14031025..15414315 [NCBI36]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12(chr17:14184616-15581044)x3 copy number gain See cases [RCV000140927] Chr17:14184616..15581044 [GRCh38]
Chr17:14087933..15484358 [GRCh37]
Chr17:14028658..15425083 [NCBI36]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12(chr17:14184616-15581544)x3 copy number gain See cases [RCV000141701] Chr17:14184616..15581544 [GRCh38]
Chr17:14087933..15484858 [GRCh37]
Chr17:14028658..15425583 [NCBI36]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12(chr17:14184616-15581544)x1 copy number loss See cases [RCV000141702] Chr17:14184616..15581544 [GRCh38]
Chr17:14087933..15484858 [GRCh37]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12(chr17:14184616-15588218)x1 copy number loss See cases [RCV000141736] Chr17:14184616..15588218 [GRCh38]
Chr17:14087933..15491532 [GRCh37]
Chr17:14028658..15432257 [NCBI36]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12(chr17:14179737-15571773)x1 copy number loss See cases [RCV000142266] Chr17:14179737..15571773 [GRCh38]
Chr17:14083054..15475087 [GRCh37]
Chr17:14023779..15415812 [NCBI36]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12(chr17:14179737-15664355)x3 copy number gain See cases [RCV000142324] Chr17:14179737..15664355 [GRCh38]
Chr17:14083054..15567669 [GRCh37]
Chr17:14023779..15508394 [NCBI36]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12(chr17:15140036-15708439)x3 copy number gain See cases [RCV000142461] Chr17:15140036..15708439 [GRCh38]
Chr17:15043353..15611753 [GRCh37]
Chr17:14984078..15552478 [NCBI36]
Chr17:17p12
uncertain significance
GRCh38/hg38 17p12-11.2(chr17:15066799-17472457)x1 copy number loss See cases [RCV000143046] Chr17:15066799..17472457 [GRCh38]
Chr17:14970116..17375771 [GRCh37]
Chr17:14910841..17316496 [NCBI36]
Chr17:17p12-11.2
pathogenic
GRCh38/hg38 17p12(chr17:14208455-15579558)x3 copy number gain See cases [RCV000142839] Chr17:14208455..15579558 [GRCh38]
Chr17:14111772..15482872 [GRCh37]
Chr17:14052497..15423597 [NCBI36]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12(chr17:14184470-15586786)x1 copy number loss See cases [RCV000143299] Chr17:14184470..15586786 [GRCh38]
Chr17:14087787..15490100 [GRCh37]
Chr17:14028512..15430825 [NCBI36]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12(chr17:14184616-15597331)x3 copy number gain See cases [RCV000143303] Chr17:14184616..15597331 [GRCh38]
Chr17:14087933..15500645 [GRCh37]
Chr17:14028658..15441370 [NCBI36]
Chr17:17p12
pathogenic|conflicting data from submitters
GRCh38/hg38 17p12(chr17:14208455-15538752)x3 copy number gain See cases [RCV000148118] Chr17:14208455..15538752 [GRCh38]
Chr17:14111772..15442066 [GRCh37]
Chr17:14052497..15382791 [NCBI36]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12(chr17:14208455-15538752)x1 copy number loss See cases [RCV000148121] Chr17:14208455..15538752 [GRCh38]
Chr17:14111772..15442066 [GRCh37]
Chr17:14052497..15382791 [NCBI36]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12(chr17:14208455-15538752)x3 copy number gain See cases [RCV000050791] Chr17:14208455..15538752 [GRCh38]
Chr17:14111772..15442066 [GRCh37]
Chr17:14052497..15382791 [NCBI36]
Chr17:17p12
pathogenic|conflicting interpretations of pathogenicity|conflicting data from submitters
GRCh38/hg38 17p12(chr17:14126296-15659587)x3 copy number gain See cases [RCV000051843] Chr17:14126296..15659587 [GRCh38]
Chr17:14029613..15562901 [GRCh37]
Chr17:13970338..15503626 [NCBI36]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12(chr17:14186983-15578926)x3 copy number gain See cases [RCV000051845] Chr17:14186983..15578926 [GRCh38]
Chr17:14090300..15482240 [GRCh37]
Chr17:14031025..15422965 [NCBI36]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12(chr17:14186983-15563870)x3 copy number gain See cases [RCV000051848] Chr17:14186983..15563870 [GRCh38]
Chr17:14090300..15467184 [GRCh37]
Chr17:14031025..15407909 [NCBI36]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12-11.2(chr17:15234685-20620700)x3 copy number gain See cases [RCV000051849] Chr17:15234685..20620700 [GRCh38]
Chr17:15138002..20524013 [GRCh37]
Chr17:15078727..20464605 [NCBI36]
Chr17:17p12-11.2
pathogenic
GRCh38/hg38 17p12-11.2(chr17:10892259-17964282)x3 copy number gain See cases [RCV000052476] Chr17:10892259..17964282 [GRCh38]
Chr17:10795576..17867596 [GRCh37]
Chr17:10736301..17808321 [NCBI36]
Chr17:17p12-11.2
pathogenic
GRCh38/hg38 17p12(chr17:14208255-15538893)x3 copy number gain See cases [RCV000054325] Chr17:14208255..15538893 [GRCh38]
Chr17:14111572..15442207 [GRCh37]
Chr17:14052297..15382932 [NCBI36]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12(chr17:14208255-15538893)x1 copy number loss See cases [RCV000054326] Chr17:14208255..15538893 [GRCh38]
Chr17:14111572..15442207 [GRCh37]
Chr17:14052297..15382932 [NCBI36]
Chr17:17p12
pathogenic
GRCh38/hg38 17p12(chr17:14208455-15538752)x1 copy number loss See cases [RCV000050794] Chr17:14208455..15538752 [GRCh38]
Chr17:14111772..15442066 [GRCh37]
Chr17:14052497..15382791 [NCBI36]
Chr17:17p12
pathogenic
NR_039884.1(MIR4731):n.(?_-9031)_(1_70)del deletion Autosomal recessive Dejerine-Sottas syndrome [RCV000008960]|Hereditary liability to pressure palsies [RCV000008961] Chr17:15259094..15260727 [GRCh38]
Chr17:17p11.2
pathogenic
NC_000017.10:g.(?_15133096)_(15165152_?)dup duplication Charcot-Marie-Tooth disease, type I [RCV000817927] Chr17:15229779..15261835 [GRCh38]
Chr17:15133096..15165152 [GRCh37]
Chr17:17p12
pathogenic
NM_000304.3(PMP22):c.-34-?_*1140del deletion Charcot-Marie-Tooth disease, type I [RCV000230266] Chr17:15229777..15260761 [GRCh38]
Chr17:15133094..15164078 [GRCh37]
Chr17:17p12
pathogenic
NM_000304.3(PMP22):c.-34-?_*1140dup1657 duplication Charcot-Marie-Tooth disease, type I [RCV000234470] Chr17:15229777..15260761 [GRCh38]
Chr17:15133094..15164078 [GRCh37]
Chr17:17p12
pathogenic
NC_000017.11:g.(?_14178908)_(15518547_?)del deletion Schizophrenia [RCV000754199] Chr17:14178908..15518547 [GRCh38]
Chr17:17p12
likely pathogenic
NC_000017.11:g.(?_14183541)_(15573247_?)del deletion Autistic disorder of childhood onset [RCV000754200] Chr17:14183541..15573247 [GRCh38]
Chr17:17p12
likely pathogenic
NC_000017.11:g.(?_15239461)_(15260737_?)del deletion Charcot-Marie-Tooth disease, type I [RCV000813337] Chr17:15239461..15260737 [GRCh38]
Chr17:15142778..15164054 [GRCh37]
Chr17:17p12
pathogenic
NC_000017.10:g.(?_15134228)_(15164050_?)dup duplication Charcot-Marie-Tooth disease, type I [RCV000808642] Chr17:15230911..15260733 [GRCh38]
Chr17:15134228..15164050 [GRCh37]
Chr17:17p12
pathogenic
NC_000017.10:g.(?_15142778)_(15164054_?)dup duplication Charcot-Marie-Tooth disease, type I [RCV000812012] Chr17:15239461..15260737 [GRCh38]
Chr17:15142778..15164054 [GRCh37]
Chr17:17p12
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR4731 COSMIC
Ensembl Genes ENSG00000265110 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000580859 ENTREZGENE
GTEx ENSG00000265110 GTEx
HGNC ID HGNC:41597 ENTREZGENE
Human Proteome Map MIR4731 Human Proteome Map
miRBase MI0017368 ENTREZGENE
NCBI Gene 100616125 ENTREZGENE
RNAcentral URS000015C522 RNACentral
  URS00005E08E8 RNACentral
  URS000075A4A3 RNACentral