MIR4741 (microRNA 4741) - Rat Genome Database

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Gene: MIR4741 (microRNA 4741) Homo sapiens
Analyze
Symbol: MIR4741
Name: microRNA 4741
RGD ID: 5134194
HGNC Page HGNC:41661
Description: Located in extracellular vesicle.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-4741
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381822,933,349 - 22,933,438 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1822,933,349 - 22,933,438 (+)EnsemblGRCh38hg38GRCh38
GRCh371820,513,312 - 20,513,401 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map18q11.2NCBI
HuRef1817,367,949 - 17,368,038 (+)NCBIHuRef
CHM1_11820,440,483 - 20,440,572 (+)NCBICHM1_1
T2T-CHM13v2.01823,126,473 - 23,126,562 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
chromium(6+)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:16381832   PMID:21037258   PMID:21199797   PMID:28798470  


Genomics

Variants

.
Variants in MIR4741
7 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 18p11.32-q23(chr18:149089-80234391)x3 copy number gain See cases [RCV000134110] Chr18:149089..80234391 [GRCh38]
Chr18:149089..77992274 [GRCh37]
Chr18:139089..76093265 [NCBI36]
Chr18:18p11.32-q23		 pathogenic
GRCh38/hg38 18p11.32-q23(chr18:118760-80254946)x3 copy number gain See cases [RCV000138656] Chr18:118760..80254946 [GRCh38]
Chr18:118760..78012829 [GRCh37]
Chr18:108760..76113817 [NCBI36]
Chr18:18p11.32-q23		 pathogenic|conflicting data from submitters
GRCh38/hg38 18p11.32-q23(chr18:149089-80254936)x3 copy number gain See cases [RCV000139397] Chr18:149089..80254936 [GRCh38]
Chr18:149089..78012819 [GRCh37]
Chr18:139089..76113807 [NCBI36]
Chr18:18p11.32-q23		 pathogenic
GRCh38/hg38 18q11.1-12.1(chr18:20949378-34363455)x3 copy number gain See cases [RCV000141646] Chr18:20949378..34363455 [GRCh38]
Chr18:18529339..31943419 [GRCh37]
Chr18:16783337..30197417 [NCBI36]
Chr18:18q11.1-12.1		 pathogenic
GRCh38/hg38 18p11.32-q23(chr18:136227-80256240)x3 copy number gain See cases [RCV000142244] Chr18:136227..80256240 [GRCh38]
Chr18:136227..78014123 [GRCh37]
Chr18:126227..76115097 [NCBI36]
Chr18:18p11.32-q23		 pathogenic
GRCh38/hg38 18q11.1-12.3(chr18:20941324-40360620)x3 copy number gain See cases [RCV000142226] Chr18:20941324..40360620 [GRCh38]
Chr18:18521285..37940584 [GRCh37]
Chr18:16775283..36194582 [NCBI36]
Chr18:18q11.1-12.3		 pathogenic
GRCh38/hg38 18q11.1-22.3(chr18:20962119-74691446)x3 copy number gain See cases [RCV000143057] Chr18:20962119..74691446 [GRCh38]
Chr18:18542080..72403402 [GRCh37]
Chr18:16796078..70532390 [NCBI36]
Chr18:18q11.1-22.3		 pathogenic
GRCh38/hg38 18p11.22-q11.2(chr18:8779843-24685379)x3 copy number gain See cases [RCV000143075] Chr18:8779843..24685379 [GRCh38]
Chr18:8779841..22265343 [GRCh37]
Chr18:8769841..20519341 [NCBI36]
Chr18:18p11.22-q11.2		 pathogenic
GRCh38/hg38 18p11.32-q23(chr18:136226-80256240)x3 copy number gain See cases [RCV000143218] Chr18:136226..80256240 [GRCh38]
Chr18:136226..78014123 [GRCh37]
Chr18:126226..76115097 [NCBI36]
Chr18:18p11.32-q23		 pathogenic
GRCh38/hg38 18p11.32-q23(chr18:148963-80252149)x3 copy number gain See cases [RCV000148072] Chr18:148963..80252149 [GRCh38]
Chr18:148963..78010032 [GRCh37]
Chr18:138963..76111023 [NCBI36]
Chr18:18p11.32-q23		 pathogenic
GRCh38/hg38 18p11.21-q11.2(chr18:13340112-23409879) copy number gain See cases [RCV000143455] Chr18:13340112..23409879 [GRCh38]
Chr18:13340111..20989843 [GRCh37]
Chr18:13330111..19243841 [NCBI36]
Chr18:18p11.21-q11.2		 pathogenic
GRCh38/hg38 18p11.32-q23(chr18:53345-80209986)x3 copy number gain See cases [RCV000052501] Chr18:53345..80209986 [GRCh38]
Chr18:53345..77967869 [GRCh37]
Chr18:43345..76068860 [NCBI36]
Chr18:18p11.32-q23		 pathogenic
GRCh38/hg38 18p11.32-q23(chr18:148763-80252290)x3 copy number gain See cases [RCV000052507] Chr18:148763..80252290 [GRCh38]
Chr18:148763..78010173 [GRCh37]
Chr18:138763..76111164 [NCBI36]
Chr18:18p11.32-q23		 pathogenic
GRCh38/hg38 18p11.32-q23(chr18:148963-80244381)x3 copy number gain See cases [RCV000052514] Chr18:148963..80244381 [GRCh38]
Chr18:148963..78002264 [GRCh37]
Chr18:138963..76103255 [NCBI36]
Chr18:18p11.32-q23		 pathogenic
GRCh38/hg38 18q11.1-23(chr18:20960320-80234429)x3 copy number gain See cases [RCV000052543] Chr18:20960320..80234429 [GRCh38]
Chr18:18540281..77992312 [GRCh37]
Chr18:16794279..76093303 [NCBI36]
Chr18:18q11.1-23		 pathogenic
GRCh38/hg38 18q11.1-12.1(chr18:20960320-28601877)x3 copy number gain See cases [RCV000052545] Chr18:20960320..28601877 [GRCh38]
Chr18:18540281..26181841 [GRCh37]
Chr18:16794279..24435839 [NCBI36]
Chr18:18q11.1-12.1		 pathogenic
GRCh38/hg38 18q11.1-11.2(chr18:20964726-25043457)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052547]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052547]|See cases [RCV000052547] Chr18:20964726..25043457 [GRCh38]
Chr18:18544687..22623421 [GRCh37]
Chr18:16798685..20877419 [NCBI36]
Chr18:18q11.1-11.2		 pathogenic
GRCh38/hg38 18q11.1-11.2(chr18:20964726-24937674)x3 copy number gain See cases [RCV000052548] Chr18:20964726..24937674 [GRCh38]
Chr18:18544687..22517638 [GRCh37]
Chr18:16798685..20771636 [NCBI36]
Chr18:18q11.1-11.2		 pathogenic
GRCh38/hg38 18q11.1-23(chr18:20989762-80209986)x3 copy number gain See cases [RCV000052549] Chr18:20989762..80209986 [GRCh38]
Chr18:18569723..77967869 [GRCh37]
Chr18:16823721..76068860 [NCBI36]
Chr18:18q11.1-23		 pathogenic
GRCh38/hg38 18p11.32-q23(chr18:148963-80252149)x3 copy number gain See cases [RCV000051048] Chr18:148963..80252149 [GRCh38]
Chr18:148963..78010032 [GRCh37]
Chr18:138963..76111023 [NCBI36]
Chr18:18p11.32-q23		 pathogenic
NM_002894.3(RBBP8):c.-250G>A single nucleotide variant Microcephaly with mental retardation and digital anomalies [RCV000341654]|Seckel syndrome [RCV000305459] Chr18:22933413 [GRCh38]
Chr18:20513376 [GRCh37]
Chr18:18q11.2		 uncertain significance
NM_002894.3(RBBP8):c.-288G>A single nucleotide variant Microcephaly with mental retardation and digital anomalies [RCV000386896]|Seckel syndrome [RCV000292217] Chr18:22933375 [GRCh38]
Chr18:20513338 [GRCh37]
Chr18:18q11.2		 likely benign
NM_002894.3(RBBP8):c.-252C>T single nucleotide variant Microcephaly with mental retardation and digital anomalies [RCV000340383]|Seckel syndrome [RCV000402867] Chr18:22933411 [GRCh38]
Chr18:20513374 [GRCh37]
Chr18:18q11.2		 benign
NM_002894.3(RBBP8):c.-225G>C single nucleotide variant Microcephaly with mental retardation and digital anomalies [RCV000301044]|Seckel syndrome [RCV000406394] Chr18:22933438 [GRCh38]
Chr18:20513401 [GRCh37]
Chr18:18q11.2		 uncertain significance
NM_002894.3(RBBP8):c.-269C>T single nucleotide variant Microcephaly with mental retardation and digital anomalies [RCV000387620]|Seckel syndrome [RCV000333170] Chr18:22933394 [GRCh38]
Chr18:20513357 [GRCh37]
Chr18:18q11.2		 uncertain significance
NM_002894.3(RBBP8):c.-265C>T single nucleotide variant Microcephaly with mental retardation and digital anomalies [RCV000289122]|Seckel syndrome [RCV000344140] Chr18:22933398 [GRCh38]
Chr18:20513361 [GRCh37]
Chr18:18q11.2		 uncertain significance
NM_002894.3(RBBP8):c.-253G>A single nucleotide variant Microcephaly with mental retardation and digital anomalies [RCV000290289]|Seckel syndrome [RCV000384575] Chr18:22933410 [GRCh38]
Chr18:20513373 [GRCh37]
Chr18:18q11.2		 uncertain significance
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:51008
Count of gene targets:16994
Count of transcripts:40418
Interacting mature miRNAs:hsa-miR-4741
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000579822
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1822,933,349 - 22,933,438 (+)Ensembl
RefSeq Acc Id: NR_039895
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381822,933,349 - 22,933,438 (+)NCBI
GRCh371820,513,312 - 20,513,401 (+)ENTREZGENE
HuRef1817,367,949 - 17,368,038 (+)ENTREZGENE
CHM1_11820,440,483 - 20,440,572 (+)NCBI
T2T-CHM13v2.01823,126,473 - 23,126,562 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR4741 COSMIC
Ensembl Genes ENSG00000284331 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000579822 ENTREZGENE
GTEx ENSG00000284331 GTEx
HGNC ID HGNC:41661 ENTREZGENE
Human Proteome Map MIR4741 Human Proteome Map
miRBase MI0017379 ENTREZGENE
NCBI Gene 100616139 ENTREZGENE
RNAcentral URS0000547F6A RNACentral
  URS000075C7BD RNACentral