MIR4722 (microRNA 4722) - Rat Genome Database

Name: MIR4722
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: MIR4722 (microRNA 4722) Homo sapiens

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Symbol:

MIR4722

Name:

microRNA 4722

Description:

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Type:

ncrna

RefSeq Status:

PROVISIONAL

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	88,716,278 - 88,716,337 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	16	88,782,686 - 88,782,745 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Cytogenetic Map	16	q24.3	NCBI
HuRef	16	74,478,573 - 74,478,632 (-)	NCBI		HuRef
CHM1_1	16	90,193,956 - 90,194,015 (-)	NCBI		CHM1_1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation (Toggle Annotation Detail/Summary View)

Gene-Chemical Interaction Annotations

References - curated

References - uncurated

Genomics

miRNA Target Status

Expression

Sequence

Nucleotide Sequences

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
NM_001012759.1(CTU2):c.804C>T (p.Cys268=)	single nucleotide variant	Malignant melanoma [RCV000071268]	Chr16:88713378 [GRCh38] Chr16:88779786 [GRCh37] Chr16:87307287 [NCBI36] Chr16:16q24.3	not provided
GRCh38/hg38 16q23.3-24.3(chr16:83988570-90081985)x3	copy number gain	See cases [RCV000135659]	Chr16:83988570..90081985 [GRCh38] Chr16:84022175..90148393 [GRCh37] Chr16:82579676..88675894 [NCBI36] Chr16:16q23.3-24.3	likely pathogenic
GRCh38/hg38 16q23.2-24.3(chr16:80946659-90081985)x3	copy number gain	See cases [RCV000136898]	Chr16:80946659..90081985 [GRCh38] Chr16:80980556..90148393 [GRCh37] Chr16:79538057..88675894 [NCBI36] Chr16:16q23.2-24.3	pathogenic\|likely pathogenic
GRCh38/hg38 16q22.1-24.3(chr16:70749398-90096995)x3	copy number gain	See cases [RCV000137495]	Chr16:70749398..90096995 [GRCh38] Chr16:70783301..90163403 [GRCh37] Chr16:69340802..88690904 [NCBI36] Chr16:16q22.1-24.3	pathogenic
GRCh38/hg38 16q24.2-24.3(chr16:87848216-90096995)x3	copy number gain	See cases [RCV000138161]	Chr16:87848216..90096995 [GRCh38] Chr16:87881822..90163403 [GRCh37] Chr16:86439323..88690904 [NCBI36] Chr16:16q24.2-24.3	likely pathogenic
GRCh38/hg38 16q23.3-24.3(chr16:83478453-89932910)x3	copy number gain	See cases [RCV000137980]	Chr16:83478453..89932910 [GRCh38] Chr16:83512058..89999318 [GRCh37] Chr16:82069559..88526819 [NCBI36] Chr16:16q23.3-24.3	likely pathogenic
GRCh38/hg38 16q21-24.3(chr16:65511483-90096995)x3	copy number gain	See cases [RCV000139426]	Chr16:65511483..90096995 [GRCh38] Chr16:65545386..90163403 [GRCh37] Chr16:64102887..88690904 [NCBI36] Chr16:16q21-24.3	pathogenic
GRCh38/hg38 16q23.1-24.3(chr16:75377981-90081992)x3	copy number gain	See cases [RCV000139302]	Chr16:75377981..90081992 [GRCh38] Chr16:75411879..90148400 [GRCh37] Chr16:73969380..88675901 [NCBI36] Chr16:16q23.1-24.3	pathogenic
GRCh38/hg38 16q24.2-24.3(chr16:88662702-88719577)x1	copy number loss	See cases [RCV000140351]	Chr16:88662702..88719577 [GRCh38] Chr16:88729110..88785985 [GRCh37] Chr16:87256611..87313486 [NCBI36] Chr16:16q24.2-24.3	benign
GRCh38/hg38 16q24.1-24.3(chr16:85552976-90096995)x3	copy number gain	See cases [RCV000139658]	Chr16:85552976..90096995 [GRCh38] Chr16:85586582..90163403 [GRCh37] Chr16:84144083..88690904 [NCBI36] Chr16:16q24.1-24.3	pathogenic
GRCh38/hg38 16q23.2-24.3(chr16:80717291-90096662)x3	copy number gain	See cases [RCV000141128]	Chr16:80717291..90096662 [GRCh38] Chr16:80751188..90163070 [GRCh37] Chr16:79308689..88690571 [NCBI36] Chr16:16q23.2-24.3	pathogenic
GRCh38/hg38 16q23.1-24.3(chr16:76336203-90088654)x3	copy number gain	See cases [RCV000141700]	Chr16:76336203..90088654 [GRCh38] Chr16:76370100..90155062 [GRCh37] Chr16:74927601..88682563 [NCBI36] Chr16:16q23.1-24.3	pathogenic
GRCh38/hg38 16q23.2-24.3(chr16:80067315-90057871)x3	copy number gain	See cases [RCV000142698]	Chr16:80067315..90057871 [GRCh38] Chr16:80101212..90124279 [GRCh37] Chr16:78658713..88651780 [NCBI36] Chr16:16q23.2-24.3	pathogenic
GRCh38/hg38 16q21-24.3(chr16:64389378-90081985)x3	copy number gain	See cases [RCV000142578]	Chr16:64389378..90081985 [GRCh38] Chr16:64423281..90148393 [GRCh37] Chr16:62980782..88675894 [NCBI36] Chr16:16q21-24.3	pathogenic\|likely pathogenic
GRCh38/hg38 16q12.2-24.3(chr16:52899183-90088654)x3	copy number gain	See cases [RCV000143425]	Chr16:52899183..90088654 [GRCh38] Chr16:52933095..90155062 [GRCh37] Chr16:51490596..88682563 [NCBI36] Chr16:16q12.2-24.3	pathogenic
GRCh38/hg38 16q24.1-24.3(chr16:86950106-89335814)x1	copy number loss	See cases [RCV000143624]	Chr16:86950106..89335814 [GRCh38] Chr16:86983712..89402222 [GRCh37] Chr16:85541213..87929723 [NCBI36] Chr16:16q24.1-24.3	pathogenic
GRCh38/hg38 16q23.1-24.3(chr16:78816291-90081985)x3	copy number gain	Global developmental delay [RCV000050840]\|See cases [RCV000050840]	Chr16:78816291..90081985 [GRCh38] Chr16:78850188..90148393 [GRCh37] Chr16:77407689..88675894 [NCBI36] Chr16:16q23.1-24.3	pathogenic
GRCh38/hg38 16q21-24.3(chr16:65313395-90081985)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052421]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052421]\|See cases [RCV000052421]	Chr16:65313395..90081985 [GRCh38] Chr16:65347298..90148393 [GRCh37] Chr16:63904799..88675894 [NCBI36] Chr16:16q21-24.3	pathogenic
GRCh38/hg38 16q22.1-24.3(chr16:70514631-90081985)x3	copy number gain	Hydronephrosis [RCV000052422]\|See cases [RCV000052422]	Chr16:70514631..90081985 [GRCh38] Chr16:70548534..90148393 [GRCh37] Chr16:69106035..88675894 [NCBI36] Chr16:16q22.1-24.3	pathogenic
GRCh38/hg38 16q23.1-24.3(chr16:76873569-90081985)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052423]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052423]\|See cases [RCV000052423]	Chr16:76873569..90081985 [GRCh38] Chr16:76907466..90148393 [GRCh37] Chr16:75464967..88675894 [NCBI36] Chr16:16q23.1-24.3	pathogenic
GRCh38/hg38 16q23.3-24.3(chr16:82173150-90081985)x3	copy number gain	Abnormal facial shape [RCV000052424]\|See cases [RCV000052424]	Chr16:82173150..90081985 [GRCh38] Chr16:82206755..90148393 [GRCh37] Chr16:80764256..88675894 [NCBI36] Chr16:16q23.3-24.3	pathogenic
GRCh38/hg38 16q24.1-24.3(chr16:84707538-90081985)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052425]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052425]\|See cases [RCV000052425]	Chr16:84707538..90081985 [GRCh38] Chr16:84741144..90148393 [GRCh37] Chr16:83298645..88675894 [NCBI36] Chr16:16q24.1-24.3	pathogenic
GRCh38/hg38 16q24.2-24.3(chr16:87853401-90081985)x3	copy number gain	Seizure [RCV000052428]\|See cases [RCV000052428]	Chr16:87853401..90081985 [GRCh38] Chr16:87887007..90148393 [GRCh37] Chr16:86444508..88675894 [NCBI36] Chr16:16q24.2-24.3	pathogenic
GRCh38/hg38 16q24.2-24.3(chr16:87306529-89269079)x1	copy number loss	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053362]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053362]\|See cases [RCV000053362]	Chr16:87306529..89269079 [GRCh38] Chr16:87340135..89335487 [GRCh37] Chr16:85897636..87862988 [NCBI36] Chr16:16q24.2-24.3	pathogenic
GRCh38/hg38 16q24.2-24.3(chr16:88159660-89506042)x1	copy number loss	Hemifacial hyperplasia [RCV000053363]\|See cases [RCV000053363]	Chr16:88159660..89506042 [GRCh38] Chr16:88193266..89572450 [GRCh37] Chr16:86750767..88099951 [NCBI36] Chr16:16q24.2-24.3	pathogenic
GRCh38/hg38 16q24.2-24.3(chr16:88640116-89530475)x1	copy number loss	Sensorineural hearing loss [RCV000053380]\|See cases [RCV000053380]	Chr16:88640116..89530475 [GRCh38] Chr16:88706524..89596883 [GRCh37] Chr16:87234025..88124384 [NCBI36] Chr16:16q24.2-24.3	pathogenic
GRCh38/hg38 16q24.2-24.3(chr16:88662702-89454555)x1	copy number loss	Global developmental delay [RCV000053381]\|See cases [RCV000053381]	Chr16:88662702..89454555 [GRCh38] Chr16:88729110..89520963 [GRCh37] Chr16:87256611..88048464 [NCBI36] Chr16:16q24.2-24.3	pathogenic

Additional Information

External Database Links

More on MIR4722
	Alliance Gene
	NCBI Gene
	Ensembl Gene
	JBrowse: hg19 hg38
	HGNC Report
	NCBI Genome Data Viewer

RGD Object Information
RGD ID:	5134178
Created:	2011-06-28
Species:	Homo sapiens
Last Modified:	2019-11-26
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

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