MIR4646 (microRNA 4646) - Rat Genome Database

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Gene: MIR4646 (microRNA 4646) Homo sapiens
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Symbol: MIR4646
Name: microRNA 4646
RGD ID: 5134148
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-4646
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl631,701,029 - 31,701,091 (-)EnsemblGRCh38hg38GRCh38
GRCh38631,701,029 - 31,701,091 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,668,806 - 31,668,868 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map6p21.33NCBI
HuRef631,455,039 - 31,455,101 (-)NCBIHuRef
CHM1_1631,670,942 - 31,671,004 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:21037258   PMID:21199797   PMID:28618313  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:56972
Count of gene targets:17527
Count of transcripts:40397
Interacting mature miRNAs:hsa-miR-4646-3p, hsa-miR-4646-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium
Low 31 21 38 22 50 23 41 18 32 10 31 46 1 8 24
Below cutoff 8 10 9 3 26 3 7 7 15 3 8 13 1 3

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000580775
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl631,701,029 - 31,701,091 (-)Ensembl
RefSeq Acc Id: NR_039789
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,701,029 - 31,701,091 (-)NCBI
GRCh37631,668,806 - 31,668,868 (-)ENTREZGENE
HuRef631,455,039 - 31,455,101 (-)ENTREZGENE
CHM1_1631,670,942 - 31,671,004 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR4646 COSMIC
Ensembl Genes ENSG00000266776 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000580775 ENTREZGENE
GTEx ENSG00000266776 GTEx
HGNC ID HGNC:41543 ENTREZGENE
Human Proteome Map MIR4646 Human Proteome Map
miRBase MI0017273 ENTREZGENE
NCBI Gene 100616230 ENTREZGENE
RNAcentral URS00001A6D0C RNACentral
  URS00005BBF99 RNACentral
  URS000075DE4B RNACentral